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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Is cyberbullying worse than traditional bullying? Examining the differential roles of medium, publicity, and anonymity for the perceived severity of bullying显示文摘 | Sticca F Perren S | 2012 | J Youth Adolesc2012，42，5： | 1 |
| 3 | The syndrome of combined polar and paramedian thalamic infarction显示文摘 | Perren F Clarke S Bogousslavsky J | 2005 | Arch Neurol2005，62，8： | 1 |
| 4 | The Syndrome of combined po- lar and paramedian thalamic infarction显示文摘 | Perren F Clarke S Bogousslavsky J | 2005 | Arch Neurol2005，62，： | 1 |
| 5 | Microbubble potentiated transcranial duplex ultrasound enhances Ⅳ thrombolysis in acute stroke显示文摘 | Perren F Loulidi J Poglia D | 2008 | J Thromb Thrombolysis2008，25，2： | 1 |
| 6 | Vertebral artery hypoplasia:apredisposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，1： | 1 |
| 7 | Vertebral artery hypoplasia:A predisposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，： | 1 |
| 8 | From amaurosis fugax to asymptomatic bithalamic infarct显示文摘 | Emond H Landis T Perren F | 2009 | J Neurol2009，256，6： | 1 |
| 9 | Vertebral artery hypoplasia:a pre-disposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，22： | 1 |
| 10 | The syndrome of combined po- lar and paramedian thalamic infarction显示文摘 | Perren F Clarke S Bogousslavsky J | 2005 | Arch Neurol2005，62，： | 1 |
| 11 | Vertebral artery hypoplasia: a predisposing factor for posterior circulation stroke 显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，1： | 1 |
| 12 | Microbubble potentiated transcranial duplex ultrasound enhances thrombolysis in acute stroke显示文摘 | Perren F Loulidi J Poglia D | 2008 | J Thromb Thrombolysis2008，25，2： | 1 |
| 13 | Vertebral artery hypoplasia:A predisposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，1： | 1 |
| 14 | Glutathione reduced the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin:Results of a double blind randomised trial 显示文摘 | Smythj F Bowman A Perren T | 1997 | Ann Oncol1997，8，6： | 1 |
| 15 | Microbubble potentiated transcranial duplex ultrasound enhances Ⅳ thrombolysis in acute stroke显示文摘 | Perren F Loulidi J Poglia D | 2008 | J Thromb Thrombolysis2008，25，2： | 1 |
| 16 | Late adult onset of Langerhans cell histiocytosis mimicking glioblastoma multiforme显示文摘 | Perren F Fankhauser L Thiévent B | | 0，，01： | 1 |
| 17 | Power Doppler evaluation of revascularization in childhood moyamoya 显示文摘 | Perren F Meairs S Schmiedek P | 2005 | Neurology2005，64，3： | 1 |
| 18 | Validation of a one- dimensional model of the systemic arterial tree 显示文摘 | Reymond P Merenda F Perren F | 2009 | Am J Physiol Heart Circ Physiol2009，297，1： | 1 |
| 19 | Power Doppler evaluation of revascularization in childhood moyamoya显示文摘 | Meairs S Schmiedek P | 2005 | Neurology2005，64，： | 1 |
| 20 | Power Doppler imaging in detection of surgically Induced indirect neoangiogenesis in adult moyamoya disease显示文摘 | Horn P Vajkoczy P | 2005 | J Neurosurg2005，103，： | 1 |
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