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| 1 | Comparative study of galectin-3 and B-type natriuretic peptide as biomarkers for the diagnosis of heart failure显示文摘BackgroundHeart 失败(HF ) 是有复杂 pathophysiological 原因的普通疾病。HF 的诊断通常依靠病历和症状的全面分析,并且源于 echocardiography 和生物化学的测试。Galectin-3,在 HF 的相对新的 biomarker,被 US 食物药品管理局为 HF 在风险的层化作为一个标记在 2010 同意。我们与保存喷射部分(pEF ) 在病人为 HF 诊断作为 biomarker 估计了 galectin-3 并且把它的性能与 B 类型 natriuretic 的作比较肽(BNP ).MethodsThirty -- 有 HF (HFpEF 组) 的五个 pEF 病人和没有 HF (控制组) 的 43 个 pEF 病人被注册。在 HFpEF 和控制题目的 galectin-3 和 BNP 的血浆层次是坚定的。象为 HF 诊断的标记的 galectin-3 和 BNP 的敏感,特性,预兆的价值,和精确性被计算, galectin-3 和 BNP 的 compared.ResultsLevels 是 23.09 ±6.97 ng/mL 和 270.46 ±在 HFpEF 组的 330.41 pg/mL,和 16.74 ±2.75 ng/mL 和 59.94 ±在控制组的 29.93 pg/mL 分别地。在在二个组之间的 galectin-3 和 BNP 的层次的差别是重要的(P <0.01 ) 。作为为在学习题目的 HF 诊断的 biomarker,分别地, galectin-3 在 17.8 ng/mL 的截止价值显示出 94.3% 和 65.1% 的敏感和特性。分别地, BNP 在 100 pg/mL 的截止价值显示出 77.1% 和 90.7% 的敏感和特性。Galectin-3 是一显著地更敏感(P <0.05 ) 但是不太特定(P <0.01 ) biomarker 与 BNP 相比。在在 galectin-3 和 BNP 标记之间的积极预兆的价值,否定预兆的价值,和精确性的差别不是重要的(P >0.05 ) 。在操作典型曲线(95% 信心间隔) 的接收装置下面的区域是 0.891 (0.808-0.974 ) 并且(0.809-0.984 ) 分别地, 0.896 没有二之间的重要差别为 galectin-3 和 BNP 珍视(P >0.05 ) galectin-3 的 .ConclusionsThe 水平显著地与 HF 在病人被提高。Galectin-3 和 BNP 是为在有 pEF 的病人的 HF 的诊断的有用 biomarkers。 | Qiu-Sheng YIN Bing SHI Lan Dong Lei BI | 2014 | Journal of Geriatric Cardiology2014，11，1： | 29 |
| 2 | Good Manufacturing Practices production and analysis of a DNA vaccine against dental caries显示文摘 | Ya-ping YANG Yu-hong LI Ai-hua ZHANG Lan BI Ming-wen FAN | 2009 | Acta Pharmacologica Sinica2009，30，11： | 6 |
| 3 | NSHV trajectory prediction algorithm based on aerodynamic acceleration EMD decomposition显示文摘Aiming at the problem of gliding near space hypersonic vehicle(NSHV)trajectory prediction,a trajectory prediction method based on aerodynamic acceleration empirical mode decomposition(EMD)is proposed.The method analyzes the motion characteristics of the skipping gliding NSHV and verifies that the aerodynamic acceleration of the target has a relatively stable rule.On this basis,EMD is used to extract the trend of aerodynamic acceleration into multiple sub-items,and aggregate sub-items with similar attributes.Then,a prior basis function is set according to the aerodynamic acceleration stability rule,and the aggregated data are fitted by the basis function to predict its future state.After that,the prediction data of the aerodynamic acceleration are used to drive the system to predict the target trajectory.Finally,experiments verify the effectiveness of the method.In addition,the distribution of prediction errors in space is discussed,and the reasons are analyzed. | LI Fan XIONG Jiajun LAN Xuhui BI Hongkui CHEN Xin | 2021 | Journal of Systems Engineering and Electronics2021，32，1： | 6 |
| 4 | Experimental demonstration of ultra-large-scale terahertz all-dielectric metamaterials显示文摘All-dielectric metamaterials have emerged as a promising platform for low-loss and highly efficient terahertz devices. However, existing fabrication methods have difficulty in achieving a good balance between precision and cost. Here, inspired by the nano-template-assisted self-assembly method, we develop a micro-templateassisted self-assembly(MTAS) method to prepare large-scale, high-precision, and flexible ceramic microsphere all-dielectric metamaterials with an area exceeding 900 cm × 900 cm. Free from organic solvents, vacuum, and complex equipment, the MTAS method ensures low-cost and environmentally friendly fabrication. The ceramic microsphere resonators can be readily assembled into nearly arbitrary arrangements and complex aggregates, such as dimers, trimers, quadrumers, and chains. Finally, using the heat-shrinkable substrate and dipole coupling effect, a broadband reflector with a bandwidth of 0.15 THz and a reflection of up to 95% is demonstrated.This work provides a versatile and powerful platform for terahertz all-dielectric metamaterials, with potential to be applied in a wide variety of high-efficiency terahertz devices. | KE BI DAQUAN YANG JIA CHEN QINGMIN WANG HONGYA WU CHUWEN LAN YUPING YANG | 2019 | Photonics Research2019，7，4： | 5 |
| 5 | Hypoxia training attenuates left ventricular remodeling in rabbit with myocardial infarction显示文摘ObjectivePrevious 研究证明组织缺氧 preconditioning 能保护心脏的功能免于随后的心肌的梗塞损害。然而,在在心肌的梗塞以后室的左的组织缺氧的效果仍然是不清楚的。这研究因此试图调查在在兔子柱子的左室的改变上训练的组织缺氧的效果心肌的 infarction.MethodsAdult 男性兔子随机被划分成三个组:那么组织(假冒操作) ,组 MI (心肌的梗塞仅仅) 并且组 MI-HT (加组织缺氧训练的心肌的梗塞) 。心肌的梗塞被左室的分支结扎导致。训练的组织缺氧在一个比重低於脑脊髓液的房间被执行(在 4000 m 的高度有相等的状况, F i 为 1 h/day 的 O 214.9%) ,为四个星期的 5 天 / 星期。在端点,在血浆的脉管的 endothelial 生长因素(VEGF ) 被测量。梗塞尺寸和毛状的密度被组织学检测。左室的改变和功能被 echocardiography.ResultsAfter 估计 4 星期的实验,与这个组相比那么,在组 MI 的血浆 VEGF 层次(130.27 ±18.58 pg/mL, P <0.01 ) 并且 MI-HT (181.93 ±20.29 pg/mL, P <0.01 ) 显著地被增加。在组 MI-HT 的梗塞尺寸(29.67%±7.73%) 显著地被死亡,当时它的毛状的密度(816.0 ±122.2/mm 2) 显著地被增加。为组 MI 和 MI-HT,而左室的喷射部分被减少,左室的结束心脏舒张、结束收缩的尺寸被增加。与组 MI 相比,然而,组 MI-HT 减少了留给室结束心脏舒张(15.86 ±1.09 公里, P <0.05 ) 并且结束收缩的尺寸(12.10 ±1.20 公里, P <0.01 ) 显著地并且改进左室的喷射部分(54.39 ±12.74 公里, P <0.05 ) 训练可以改进的 .ConclusionHypoxia 让室的功能和还原剂与 MI 在兔子经由 angiogenesis 改变。 | Chun-Xiao WAN Yun-Feng LAN Hui JIANG Jie HUANG Rui-Sheng LI Sheng BI Jian-An LI | 2014 | Journal of Geriatric Cardiology2014，11，3： | 5 |
| 6 | A Novel Approach to Clean Tanning Technology显示文摘 | Jing Li Lan Yan Bi Shi Jing Zhang | 2013 | Journal of Chemistry and Chemical Engineering2013，7，12： | 5 |
| 7 | Roles of P-glycoprotein and multidrug resistance protein in transporting para-aminosalicylic acid and its N-acetylated metabolite in mice brain显示文摘目的: Para-aminosalicylic 酸(舞步) 在导致 manganism 的 neurotoxicity (manganism ) 的处理是有效的。在这研究,我们在通过血大脑障碍搬运舞步和它的 N-acetylated 代谢物 AcPAS 调查了 P-glycoprotein (MDR1a ) 和 multidrug 抵抗蛋白质(MRP ) 的角色。 | Lan HONG Cong XU Stefanie O'NEAL Hui-chang BI Min HUANG Wei ZHENG Su ZENG | 2014 | Acta Pharmacologica Sinica2014，35，12： | 4 |
| 8 | A Small-Divergence-Angle Orbital Angular Momentum Metasurface Antenna显示文摘Electromagnetic waves carrying an orbital angular momentum (OAM) are of great interest. However, most OAM antennas presentdisadvantages such as a complicated structure, low efficiency, and large divergence angle, which prevents their practicalapplications. So far, there are few papers and research focuses on the problem of the divergence angle. Herein, a metasurfaceantenna is proposed to obtain the OAM beams with a small divergence angle. The circular arrangement and phase gradient wereused to simplify the structure of the metasurface and obtain the small divergence angle, respectively. The proposed metasurfaceantenna presents a high transmission coefficient and effectively decreases the divergence angle of the OAM beam. All thetheoretical analyses and derivation calculations were validated by both simulations and experiments. This compact structurepaves the way to generate OAM beams with a small divergence angle. | Jianchun Xu Ke Bi Ru Zhang Yanan Hao Chuwen Lan Klaus D.McDonald-Maier Xiaojun Zhai Zidong Zhang Shanguo Huang | 2019 | Research2019，，1： | 3 |
| 9 | Hypersonic Vehicle Trajectory Prediction Algorithm Based on Hough Transform显示文摘Trajectory prediction is a prerequisite for missile and high-speed vehicle guidance interception.To address the trajectory problem for the near space hypersonic unpowered gliding vehicle.Firstly,the trajectory prediction mechanism is analyzed.Based on the existing NSHV trajectory prediction method,the key techniques of trajectory prediction are discussed from the perspectives of prediction parameter selection and prediction parameter description.Then,a trajectory prediction method based on Hough transform is proposed.The core of the method is to select the longitude latitude,and high direction positions as prediction parameters,and use the Hough transform to fit the prior basis functions.In the latitude and longitude direction,the rationality of predicting parameters is discussed from two aspects:position extreme point and lateral maneuverability.In the height direction,for the NSHV oscillation drop characteristic,two Hough transforms are used to separate the periodic term from the linear term.In addition,we give the approximate interval of the parameter values of the method,and design a parameter adaptive scheme.Finally,trajectory prediction is performed on two different control patterns.The error of the prediction time of 100 s is within 25 km,and the results show the effectiveness of the proposed method. | LI Fan XIONG Jiajun LAN Xuhui BI Hongkui TAN Xiansi | 2021 | Chinese Journal of Electronics2021，30，5： | 2 |
| 10 | Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression显示文摘Pulmonary fibrosis(PF)is a chronic interstitial lung disease with no effective therapies.Galectin-3(Gal-3),a marker of oxidative stress,plays a key role in the pathogenesis of PF.Fibroblast-myofibroblast differentiation(FMD)is an important source of fibrotic cells in PF.Previous studies showed that melatonin(MT)exerted anti-fibrotic effect in many diseases including PF through its antioxidant activity.In the present study we investigated the relationships among Gal-3,NRF2,ROS in FMD and their regulation by MT.We established an in vitro model of FMD in TGF-β1-treated human fetal lung fibroblast1(HFL1)cells and a PF mouse model via bleomycin(BLM)intratracheal instillation.We found that Gal-3 expression was significantly increased both in vitro and in vivo.Knockdown of Gal-3 in HFL1 cells markedly attenuated TGF-β1-induced FMD process and ROS accumulation.In TGF-β1-treated HFL1 cells,pretreatment with NRF2-specific inhibitor ML385(5μM)significantly increased the levels of Gal-3,α-SMA and ROS,suggesting that the expression of Gal-3 was regulated by NRF2.Treatment with NRF2-activator MT(250μM)blockedα-SMA and ROS accumulation accompanied by reduced Gal-3 expression.In BLM-induced PF model,administration of MT(5 mg·kg^(−1)·d^(−1),ip for 14 or 28 days)significantly attenuated the progression of lung fibrosis through up-regulating NRF2 and down-regulating Gal-3 expression in lung tissues.These results suggest that Gal-3 regulates TGF-β1-induced pro-fibrogenic responses and ROS production in FMD,and MT activates NRF2 to block FMD process by down-regulating Gal-3 expression.This study provides a useful clue for a clinical strategy to prevent PF. | Yue-jiao Lan Ming-han Cheng Hui-min Ji Yu-qian Bi Yong-yue Han Chong-yang Yang Xuan Gu Jian Gao Hong-liang Dong | 2023 | Acta Pharmacologica Sinica2023，44，5： | 2 |
| 11 | Hepatoprotective effects of cathepsin B inhibitor on acute hepatic failure induced by lipopolysaccharide/D-galactosamine in mice显示文摘BACKGROUND:Increasing evidence suggests that the inactivation of cathepsin B attenuates hepatocyte apoptosis and liver damage.This study aimed to investigate the protective effects of a cathepsin B inhibitor(CA-074me) on lipopolysaccharide(LPS)/D-galactosamine(D-GalN)-induced acute hepatic failure(AHF) in mice.METHODS:Mice were intraperitoneally injected with a combination of LPS/D-GalN to induce AHF with or without CA-074me pretreatment.The cumulative survival rates were calculated 48 hours after the induction of AHF.As well as changes in biochemical indicators and liver histology,hepatocyte apoptosis was assessed using a TUNEL method.Serum tumor necrosis factor-α(TNF-α) production,caspase-3,caspase-8,and caspase-9 activity was evaluated.Cytosolic cytochrome c and Bcl-2 expression were measured by Western blotting.RESULTS:The marked elevation in serum aminotransferase activity and prothrombin time found in LPS/D-GalN-treated mice was significantly improved by pretreatment with CA074me.The efficacy of CA-074me was also confirmed by histological analysis and TUNEL assay.The survival rate significantly improved in LPS/D-GalN-induced mice given CA-074me compared with untreated mice.LPS/D-GalNinduced caspase-3 and caspase-9 activation was remarkably suppressed by CA-074me.However,the increased levels of serum TNF-α and elevated caspase-8 activity in AHF mice were not significantly reduced by CA-074me.Moreover,CA074me sharply reduced the increased expression of cytosolic cytochrome c and markedly augmented Bcl-2 expression.CONCLUSION:These results suggest that CA-074me has a protective effect in acute hepatic failure induced by LPS/D-GalN. | Bing-Zhu Yan Li-Yan Chen Lan Kang Xiao-Ren Wang Man-Ru Bi Wei Wang Bao-Shan Yang | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，1： | 2 |
| 12 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 13 | Investigation of the Interaction between Flavonoids and Human Serum Albumin 显示文摘 | BI Shu-yun DING Lan TIAN Yuan | 2004 | Journal of Molecular Structure2004，703，： | 1 |
| 14 | Determination of sphingosine kinase ac tivity in biological samples by liquid chromatography-tandem mass spectrometry显示文摘 | Lan T Bi H Xu S | 2010 | Biomed Chromatogr2010，24，10： | 1 |
| 15 | Isolation and functional analysis of transcription factor GmWRKY57B from soybean显示文摘WRKY proteins are a large family of transcriptional regulators in higher plants involved in many biological processes, such as responses to biotic and abiotic stress, plant development and metabolism. In this study, a soybean cDNA library was constructed and screened by yeast one-hybrid system using the 3×W-box element as a bait, and consequently a transcription factor, named GmWRKY57B, a member of group 3 of WRKY family, was obtained. GmWRKY57B specifically binds to the W-box of the Arabidopsis NPR1 (AtNPR1) promoter in yeast cells. This specific binding was further confirmed with an in vitro electrophoretic mobility shift assay. RT-PCR analysis showed that GmWRKY57B was expressed at a similar level in root, stem and leaf of the soybean plant. Overexpression of the GmWRKY57B gene in tobacco conferred the transgenics tolerance to drought stress. This result indicated that the GmWRKY57B gene plays a role in plant tolerance to abiotic stress. | ZHANG Lan WANG XlaoPing BI YingDong ZHANG ChunYi FAN YunLiu WANG Lei | 2008 | Chinese Science Bulletin2008，53，22： | 1 |
| 16 | Trans-base and trans-vault low-velocity penetrating brain injury:A retrospective comparative study of characteristics,treatment,and outcomes显示文摘Low-velocity penetrating brain injury(LVPBI)caused by foreign bodies can pose life-threatening emergencies.Their complexity and lack of validated classification data have prevented standardization of clinical management.We aimed to compare the trans-base and trans-vault phenotypes of LVPBI to help provide guidance for clinical decision-making of such injury type.;A retrospective study on LVPBI patients managed at our institution from November 2013 to March 2020 was conducted.We included LVPBI patients admitted for the first time for surgery,and excluded those with multiple injuries,gunshot wounds,pregnancy,severe blunt head trauma,etc.Patients were categorized into trans-base and trans-vault LVPBI groups based on the penetration pathway.Discharged patients were followed up by outpatient visit or telephone.The data were entered into the Electronic Medical Record system by clinicians,and subsequently derived by researchers.The demography and injury characteristics,treatment protocols,complications,and outcomes were analyzed and compared between the two groups.A t-test was used for analysis of normally distributed data,and a Mann-Whitney U test for non-parametric data.A generalized linear model was further established to determine whether the factors length of stay and performance scale score were influenced by each factor.;A total of 27 LVPBI patients were included in this analysis,comprised of 13(48.1%)trans-base cases and 14(51.9%)trans-vault cases.Statistical analyses suggested that trans-base LVPBI was correlated with deeper wounds;while the trans-vault phenotype was correlated with injury by metal foreign bodies.There was no difference in Glasgow Coma Scale score and the risk of intracranial hemorrhage between the two groups.Surgical approaches in the trans-base LVPBI group included subfrontal(n=5,38.5%),subtemporal(n=5,38.5%),lateral fissure(n=2,15.4%),and distal lateral(n=1,7.7%).All patients in the trans-vault group underwent a brain convex approach using the foreign body as reference(n=14,100%).Moreover,the two groups differed in application prerequisites for intracranial pressure monitoring and vessel-related treatment.Trans-base LVPBI was associated with higher rates of cranial nerve and major vessel injuries;in contrast,trans-vault LVPBI was associated with lower functional outcome scores.;Our findings suggest that trans-base and trans-vault LVPBIs differ in terms of characteristics,treatment,and outcomes.Further understanding of these differences may help guide clinical decisions and contribute to a better management of LVPBIs. | Yun Wu Tian-Ge Chen Si-Ming Chen Liang Zhou Meng Yuan Lei Wang Zi-Yuan Liu Chang-Long Bi Xiang-Ying Luo Song Lan Jin-Fang Liu | 2021 | Chinese Journal of Traumatology2021，24，5： | 1 |
| 17 | Instability of parasitic capacitance in T-shape-gate enhancementmode AlGaN/GaN MIS-HEMTs显示文摘Parasitic capacitances associated with overhangs of the T-shape-gate enhancement-mode(E-mode)GaN-based power device,were investigated by frequency/voltage-dependent capacitance-voltage and inductive-load switching measurements.The overhang capacitances induce a pinch-off voltage distinguished from that of the E-mode channel capacitance in the gate capacitance and the gatedrain capacitance characteristic curves.Frequency-and voltage-dependent tests confirm the instability caused by the trapping of interface/bulk states in the LPCVD-SiNx passivation dielectric.Circuit-level double pulse measurement also reveals its impact on switching transition for power switching applications. | Lan Bi Yixu Yao Qimeng Jiang Sen Huang Xinhua Wang Hao Jin Xinyue Dai Zhengyuan Xu Jie Fan Haibo Yin Ke Wei Xinyu Liu | 2022 | Journal of Semiconductors2022，43，3： | 1 |
| 18 | Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography-tandem mass spec- trometry显示文摘 | Lan T Bi H Liu W | 2011 | J Chromatogr B Analyt Technol Biomed Life Sci2011，879，78： | 1 |
| 19 | Reduction of excess sludge production in sequencing batch reactor (SBR) by lysis–cryptic growth using homogenization disruption显示文摘 | Wangcheng Lan Yiyong Li Qi Bi Yongyou Hu | 2013 | Bioresource Technology2013，，： | 1 |
| 20 | Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production,antibiotic resistance and dissemination during infection显示文摘 | Lan L Murray TS Kazmierczak BI | 2010 | Mol Microbiol2010，75，1： | 1 |
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