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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 3 | Structural and mechanistic insights into the interaction between Rho and mammalian Dia显示文摘 | Rose R Weyand M Lammers M | 2005 | Nature2005，435，7041： | 1 |
| 4 | Finite element analysis of the behavior of shape memory alloys and their applications显示文摘 | Brinson L C Lammering R | 1993 | International Journal of Solids and Structures1993，30，23： | 1 |
| 5 | Lattice BGK direct numerical simulation of fully developed turbulence in incompressible plane channel flow 显示文摘 | Lammers P Beronov K Volkert R | 2006 | Computers and Fluids2006，35，10： | 1 |
| 6 | Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation显示文摘 | Hintzen R Q Lens S M Lammers K | 1995 | J Immunol1995，154，： | 1 |
| 7 | Insulin in- hibits leptin receptor signaling in HEK293 cells at the level of Janus kinase-2: a potential mechanism for hyperinsulinemia-associated leptin resistance 显示文摘 | Kellerer M Lammers R Fritsche A | 2001 | Diabetologia2001，44，9： | 1 |
| 8 | Ireland's footprint: A time series for 1983-2001 显示文摘 | Lammers A Moles R Walsh C | 2008 | Land Use Policy2008，25，： | 1 |
| 9 | Altered skin-temperature regulation in narcolepsy relates to sleep propensity 显示文摘 | Fronczek R Overeem S Lammers G J | 2006 | Sleep2006，29，11： | 1 |
| 10 | Insulin signal transduction: possible mechanism for insulin resistance显示文摘 | KELLERER M LAMMERS R HUH | 1999 | Experimental and Clinical Endocrinology and Diabetes1999，107，2： | 1 |
| 11 | The effects of accelerated growth rates and estrogen implants in prepubertal Holstein heifers on estimates of mammary development and subsequent reproduction and milk production 显示文摘 | Lammers B P Heinrichs A J Kensinger R S | 1999 | J Dairy Sci1999，82，： | 1 |
| 12 | Insulin inhibitsleptin receptor signalling in HEK293 celLs at the level ofjanus kinase-2 : a potential mechanism forhyperinsulinaemia-associated leptin resistance 显示文摘 | Kellerer M Lammers R Fritsche A9 | 2001 | Diabetologia2001，44，9： | 1 |
| 13 | Iwline deposited Cu (In,Ga) Sez solar cells: influence of deposition tempera ture and Na co-evaporation on carrier collection 显示文摘 | Lammer M Kniese R Powalla M | 2004 | Thin Solid Films2004，451，17： | 1 |
| 14 | Ireland' s footprint: a time series for 1983-2001 显示文摘 | LAMMERS A MOLES R WALSH C | 2008 | Land Use Policy2008，25，1： | 1 |
| 15 | Ireland's footprint: a time series for 1983-2001显示文摘 | LAMMERS A MOLES R WALSH C | 2008 | Land Use Policy2008，25，1： | 1 |
| 16 | Optimal placement of piezoelectric actuators in adaptive truss structures显示文摘 | LAMMERING R JIA J ROGERS C A | 1994 | Journal of Sound and Vibration1994，171，1： | 1 |
| 17 | Dynamin binds to SH3 domains of phospholipase Cgamma and GRB-2 显示文摘 | Seedorf K Kostka G Lammers R | 1994 | J Biol Chem1994，269，16： | 1 |
| 18 | Doppler imaging based on radar target precession显示文摘 | Lammers Yve H W Marr R A | 1993 | IEEE Transactions on Aerospace and Electronic Systems1993，29，1： | 1 |
| 19 | Insulin inhibits leptin receptor signaling in HEK293 cells at the level of janus kinase-2 :a potential mechanism for hyperinsuline mia-associated leptin resistance显示文摘 | Kellerer M Lammers R Fritsche A | 2001 | Diabetologia2001，44，9： | 1 |
| 20 | The role of a com- bined regimen with intravesical chemotherapy and hyperthermia in the management of non - muscle - invasive bladder cancer: a systematic review 显示文摘 | Lammers R J M Witjes J A Inman B A eta| | 2011 | European urology2011，60，1： | 1 |
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