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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | The use of fibrillation eyele length to determine spatial dispersion in electrophysiological properties and to characterize the underlying mechanism of fibrillation显示文摘 | Lammers W J E P Allessie M A llensma P L el al | 1986 | New Trends in Arrhythmias1986，2，1： | 1 |
| 3 | 查看详情显示文摘 | Lash T D Lammer A D Ferrence G M | | 0，，41： | 1 |
| 4 | Insulin in- hibits leptin receptor signaling in HEK293 cells at the level of Janus kinase-2: a potential mechanism for hyperinsulinemia-associated leptin resistance 显示文摘 | Kellerer M Lammers R Fritsche A | 2001 | Diabetologia2001，44，9： | 1 |
| 5 | Dynamic simulation of dispersed gas-liquid two-phase flow using a discrete bubble model显示文摘 | Delnoij E Lammers F A Kuipers J A M | 1997 | Chem Eng Sci1997，52，9： | 1 |
| 6 | Ireland's footprint: A time series for 1983-2001 显示文摘 | Lammers A Moles R Walsh C | 2008 | Land Use Policy2008，25，： | 1 |
| 7 | Legitimacy moderates the effect of power on approach 显示文摘 | Lammers J Galinsky A D Gordijn E H | 2008 | Psychological Science2008，，6： | 1 |
| 8 | Contrastenhanced three-dimensional transcranial color-coded sonography of intracranial stenosis显示文摘 | Klotzsch C Bozzato A Lammers G | 2002 | AJNR2002，30，： | 1 |
| 9 | The effects of accelerated growth rates and estrogen implants in prepubertal Holstein heifers on estimates of mammary development and subsequent reproduction and milk production 显示文摘 | Lammers B P Heinrichs A J Kensinger R S | 1999 | J Dairy Sci1999，82，： | 1 |
| 10 | A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects 显示文摘 | Minette P A Lammers J W | 1989 | J Appl Physiol1989，67，6： | 1 |
| 11 | Modeling of complex premixed burner systems by using flamelet-generated manifolds 显示文摘 | VAN OIJEN J A LAMMERS F A DE GOEY I P H | 2001 | Combustion and Flame2001，127，： | 1 |
| 12 | Shortterm hypofractionate radiotherapy followed by total mesorectal excision显示文摘 | Lammering G Hartmann K A Frenken M | 2000 | Strahlenther Onkol2000，176，12： | 1 |
| 13 | Lectin binding to small intestinal gobbler cells of newborn, suckling and weaned pigs显示文摘 | Jaeger L A Lammer C H Turek J J | 1989 | Am J Vet Res1989，50，： | 1 |
| 14 | Display and selection of chicken IgA Fab fragments显示文摘 | Wieland WH Orzaez D Lammers A | 2006 | Veterinary Immunology and Immunopathology2006，110，12： | 1 |
| 15 | Contrast-enhanced three-dimensional transcranial color-coded sonography of intracranial stenoses显示文摘 | Klotzsch C Bozzato A Lammers G | 2002 | Am J Neuroradiol2002，23，2： | 1 |
| 16 | Ireland' s footprint: a time series for 1983-2001 显示文摘 | LAMMERS A MOLES R WALSH C | 2008 | Land Use Policy2008，25，1： | 1 |
| 17 | The response of altering the ratio of dietary protein to energy on growth,feed efficiency, and mammary development in rapidly growing prepubertal heifers显示文摘 | Lammers B P Heinrichs A J | 2000 | J Dairy Sci2000，83，： | 1 |
| 18 | The response ofaltering the ratio of dietary protein to energy on growth, feed efficiency, and mammary developmentin rapidly growing prepubertal heifers 显示文摘 | LAMMERS B P HEINRICHS A J | 2000 | Journal of Dairy Science2000，83，5： | 1 |
| 19 | Ireland's footprint: a time series for 1983-2001显示文摘 | LAMMERS A MOLES R WALSH C | 2008 | Land Use Policy2008，25，1： | 1 |
| 20 | Optimal placement of piezoelectric actuators in adaptive truss structures显示文摘 | LAMMERING R JIA J ROGERS C A | 1994 | Journal of Sound and Vibration1994，171，1： | 1 |
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