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| 1 | Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats显示文摘Objective:To assess the effect of quercetin(flavonoid) against lindane induced alterations in lipid profile of wistar rats.Methods:Rats were administered orally with lindane(100 mg/kg body weight) and quercetin(10 mg/kg body weight) for 30 days.After the end of treatment period lipid profile was estimated in serum and tissue.Results:Elevated levels of serum cholesterol, triglycerides,low density lipoprotein(LDL),very Low Density Lipoprotein(VLDL) and tissue triglycerides,cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.Conclusions:Our study suggests that quercetin has hypolipidemic effect and offers protection against lindane induced toxicity in liver by restoring the altered levels of lipids.The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane. | Viswanadha Vijaya Padma Gurusamy Lalitha Nichokon Puthanveedu Shirony Rathinasamy Baskaran | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 9 |
| 2 | Low-noise 1.3 μm InAs/GaAs quantum dot laser monolithically grown on silicon显示文摘We report low-noise, high-performance single transverse mode 1.3 μm InAs/GaAs quantum dot lasers monolithically grown on silicon(Si) using molecular beam epitaxy. The fabricated narrow-ridge-waveguide Fabry–Perot(FP) lasers have achieved a room-temperature continuous-wave(CW) threshold current of 12.5 mA and high CW temperature tolerance up to 90°C. An ultra-low relative intensity noise of less than-150 dB∕Hz is measured in the 4–16 GHz range. Using this low-noise Si-based laser, we then demonstrate 25.6 Gb/s data transmission over13.5 km SMF-28. These low-cost FP laser devices are promising candidates to provide cost-effective solutions for use in uncooled Si photonics transmitters in inter/hyper data centers and metropolitan data links. | MENGYA LIAO SIMING CHEN ZHIXIN LIU YI WANG LALITHA PONNAMPALAM ZICHUAN ZHOU JIANG WU MINGCHU TANG SAMUEL SHUTTS ZIZHUO LIU PETER M.SMOWTON SIYUAN YU ALWYN SEEDS HUIYUN LIU | 2018 | Photonics Research2018，，11： | 7 |
| 3 | Managerial incentives and risk-taking显示文摘 | Jeffrey L. Coles Naveen D. Daniel Lalitha Naveen | 2005 | Journal of Financial Economics2005，，2： | 5 |
| 4 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 5 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 6 | Boards: Does one size fit all?显示文摘 | Jeffrey L. Coles Naveen D. Daniel Lalitha Naveen | 2007 | Journal of Financial Economics2007，，2： | 2 |
| 7 | Polymer-/Ceramic-based Dielectric Composites for Energy Storage and Conversion显示文摘Dielectric composites boost the family of energy storage and conversion materials as they can take full advantage of both the matrix and filler.This review aims at summarizing the recent progress in developing highperformance polymer-and ceramic-based dielectric composites,and emphases are placed on capacitive energy storage and harvesting,solid-state cooling,temperature stability,electromechanical energy interconversion,and high-power applications.Emerging fabrication techniques of dielectric composites such as 3D printing,electrospinning,and cold sintering are addressed,following by highlighted challenges and future research opportunities.The advantages and limitations of the typical theoretical calculation methods,such as finite-element,phase-field model,and machine learning methods,for designing high-performance dielectric composites are discussed.This review is concluded by providing a brief perspective on the future development of composite dielectrics toward energy and electronic devices. | Honghui Wu Fangping Zhuo Huimin Qiao Lalitha Kodumudi Venkataraman Mupeng Zheng Shuize Wang He Huang Bo Li Xinping Mao Qiaobao Zhang | 2022 | Energy & Environmental Materials2022，5，2： | 2 |
| 8 | Ceric ammonium nitrate supported HY-zeolite:An efficient catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes显示文摘Ceric ammonium nitrate(CAN) supported HY-zeolite has been used as an efficient catalyst for the onepot synthesis of 1,8-dioxo-octahydroxanthenes from the readily available 1,3-diketone and aromatic aldehydes under solvent-free conditions.The present methodology is cost-effective in addition to other advantages like high yields of products in shorter reaction time and simple workup procedure without the use of any injurious solvents. | Paramasivam Sivaguru Appaswami Lalitha | 2014 | Chinese Chemical Letters2014，25，2： | 2 |
| 9 | Detection and Localization of Load Redistribution Attacks on Large-scale Systems显示文摘A nearest-neighbor-based detector against load redistribution attacks is presented.The detector is designed to scale from small-scale to very large-scale systems while guaranteeing consistent detection performance.Extensive testing is performed on a realistic large-scale system to evaluate the perfor-mance of the proposed detector against a wide range of attacks,from simple random noise attacks to sophisticated load redistribution attacks.The detection capability is analyzed against different attack parameters to evaluate its sensitivity.A statistical test that leverages the proposed detector is introduced to identify which loads are likely to have been maliciously modified,thus,localizing the attack subgraph.This test is based on ascribing to each load a risk measure(probability of being attacked)and then computing the best posterior likelihood that minimizes log-loss. | Andrea Pinceti Lalitha Sankar Oliver Kosut | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，2： | 2 |
| 10 | Enhancing effect of malachite green on the development of hepatic pre-neo- plastic lesions induced by N-nitrosodiethylamine in rats 显示文摘 | Fernandes C Lalitha V S Rao K V K | 1991 | Carcinogenesis1991，12，5： | 1 |
| 11 | Influence of CdClz treatment on structural and optical properties of vacuum evapo- rated CdTe thin films 显示文摘 | Lalitha S Sathyamoorthy R Senthilarasu S | 2006 | Solar Energy Materials & Solar Cells2006，90，： | 1 |
| 12 | Determination of specific activity of recombinant hirudin using a thrombin titration method 显示文摘 | Lalitha L Jawed F | 1995 | Thromb Res1995，78，3： | 1 |
| 13 | Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium显示文摘 | Karthikeyan RS Leal SM Jr Prajna NV Dharmalingam K Geiser DM Pearlman E Lalitha P | | 0，，06： | 1 |
| 14 | Detection of genetically modified soya and maize: Impact of heat processing 显示文摘 | K R Vijayakumar Asha Martin Lalitha R Gowda | 2009 | Food Chemistry2009，117，： | 1 |
| 15 | Primer premier 5 显示文摘 | Lalitha S | 2000 | Biotech Software &Internet Report2000，1，6： | 1 |
| 16 | Brain abscess and other protean manifestation of actinomycosis显示文摘 | Koshi G Lalitha MK Samraj T | 1981 | Am J Trop Med Hyg1981，，： | 1 |
| 17 | Low molecular weight chitosans:preparation with the aid of papain and characterization显示文摘 | Vishu Kumar AB Varadaraj MC Lalitha RG | 2004 | Biochim Biophys Acta2004，1670，： | 1 |
| 18 | Risk factors for treatment outcome in fungal keratitis显示文摘 | Lalitha P Prajna N V Kabra A | 2006 | Ophthalmology2006，113，4： | 1 |
| 19 | Maternal dietary folate and/or vitamin B12 restrictions alter body composition (adiposity) and lipid metabo- lism in wistar rat offspring 显示文摘 | KUMAR K A LALITHA A PAVITHRA D | 2013 | The Journal of Nutritional Biochemistry2013，24，1： | 1 |
| 20 | Surface protection of copper in acid medium by azoles and surfactants显示文摘 | Lalitha A Ramesh S Rajeswari S | 2005 | Electrochimica Acta2005，51，： | 1 |
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