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| 1 | Metal exposure and Alzheimer's pathogenesis.显示文摘 | Liu G Huang W Moir RD Vanderburg CR Lai B Peng Z Tanzi RE Rogers JT Huang X | 2006 | 中国生物学文摘2006，20，9： | 8 |
| 2 | Six-minute walking test performance is associated with survival in cirrhotic patients显示文摘BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise limitations.Six minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary diseases.AIM To determine if it associates with mortality by analyzing 6MWT performance in patients with liver cirrhosis.METHODS A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and mortality.The distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages progresses.Patients who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and mortality.It is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention. | Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota Maria Lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 3 | Jack Hills锆石的安山质源区支持板块构造始于冥古代显示文摘地球最老的地壳组成和构造属性是地球科学研究中两个最基本的问题,但是由于缺乏合适年龄的岩石,难以进行约束。很多研究主要集中于西澳Jack Hills变质沉积岩中4.4~4.3 Ga的碎屑锆石,但是对其原岩性质的认识依然缺乏共识。对其原岩成分的推断主要基于锆石的Hf同位素组成,研究者普遍认为这些碎屑锆石来源于火成岩源区。 | Turner S Wilde S Worner G Schaefer B Lai Y J 袁超(编译) | 2020 | 矿物岩石地球化学通报2020，39，3： | 2 |
| 4 | Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker显示文摘Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photolithography was invented to fabricate stable metal microarrays on the surface of a cell-adhesion resistant and mechanically biomimetic poly(ethylene glycol) hydrogel; the linker is the key chemical in such a transfer strategy. This article reports the design and synthesis of a hetero-bifunctional macromonomer linker with a thiol group at one end and an acryloyl group at the other end. The bifunctional linker was characterized by GPC and 1H NMR, and the average number of thiol groups in the bifunctional linker was detected by Ellman's reagent. The regent stability under wet conditions was also confirmed by the model reactants. The resultant micropatterned surfaces are meaningful for future studies of cell behaviors on mechanically biomimetic matrixes. | SUN JianGuo GRAETER Stefan V TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong | 2014 | Science China Chemistry2014，57，4： | 2 |
| 5 | Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage显示文摘AIM:To evaluate whether desferrioxamine decreases ischemia and perfusion injury aggravated by cold storage(CS)in a rat liver perfusion model. METHODS:Isolated rat livers were kept in CS in University of Wisconsin Solution for 20 h at 4℃,then exposed to 25 min of warm ischemia(WI)at 37℃ followed by 2 h of warm perfusion(WP)at 37℃with oxygenated(95%oxygen and 5%carbon dioxide) Krebs-Henseleit buffer.Desferrioxamine(DFO),an iron chelator,was added at different stages of storage,ischemia and perfusion:in CS only,in WI only,in WP only, in WI and perfusion,or in all stages.Effluent samples were collected after CS and after WI.Perfusate samples and bile were collected every 30 min(0,0.5,1,1.5 and 2 h)during liver perfusion.Cellular injury was assessed by the determination of lactate dehydrogenase(LDH) and aspartate aminotransferase(AST)in the effluent and perfusate samples.Total iron was analysed in the perfusate samples.After WP,the liver was collected for the determination of liver swelling(wet to dry ratio) and liver morphological examination(hematoxylin and eosin staining). RESULTS:Increased CS time caused increased liver dysfunction during WP.After 2 h of WP,liver injury was indicated by increased release of AST(0.5 h CS:9.4± 2.2 U/g liver vs 20 h CS:45.9±10.8 U/g liver,P<0.05) and LDH(0.5 h CS:59±14 U/g liver vs 20 h CS:297 ±71 U/g liver,P<0.05).There was an associated increase in iron release into the perfusate(0.5 h CS:0.11 ±0.03μmoL/g liver vs 20 h CS:0.58±0.10μmoL/g liver,P<0.05)and reduction in bile flow(0.5 h CS: 194±12μL/g vs 20 h CS:71±8μL/g liver,P<0.05). When DFO was added during WI and WP following 20 h of CS,release of iron into the perfusate was de- creased(DFO absent 0.58±0.10μmoL/g liver vs DFO present 0.31±0.06μmoL/g liver,P<0.05),and liver function substantially improved with decreased release of AST(DFO absent 45.9±10.8 U/g liver vs DFO present 8.1±0.9 U/g liver,P<0.05)and LDH(DFO absent 297±71 U/g liver vs DFO present 56±7 U/g liver,P<0.05),and increased bile flow(DFO absent 71±8μL/g liver vs DFO present 237±36μL/g liver, P<0.05).DFO was also shown to improve liver morphology after WP.Cellular injury(the release of LDH and AST)was significantly reduced with the addition of DFO in CS medium but to a lesser extent compared to the addition of DFO in WP or WI and perfusion.There was no effect on liver swelling or bile flow when DFO was only added to the CS medium. CONCLUSION:DFO added during WI and perfusion decreased liver perfusion injury aggravated by extended CS. | Peter G Arthur Xian-Wa Niu Wen-Hua Huang Bastiaan DeBoer Ching Tat Lai Enrico Rossi John Joseph Gary P Jeffrey | 2013 | World Journal of Gastroenterology2013，19，5： | 2 |
| 6 | Feedback anticontrol of discrete chaos显示文摘 | Chen G Lai D | 1998 | International Journal of Bifurcation and Chaos1998，8，： | 2 |
| 7 | Synthesis of water-soluble hyperbranched polymer and its application in acrylic latex显示文摘 | Wang X X Lai G G Jiang Z G | 2006 | Europ Polym J2006，42，2： | 1 |
| 8 | Structure, expression, and activity of Tyro3,a neural adhesion-related receptor tyrosine kinase 显示文摘 | Lai C Gore M Lemke G | 1994 | Oncogene1994，9，： | 1 |
| 9 | Surface Seeding in ZSM-5 Membrane Perva- poration显示文摘 | Lai R Gavalas G R | 1998 | Ind Eng Chem Res1998，37，： | 1 |
| 10 | Feedback anticontroller of discrete chaos显示文摘 | Chen G Lai D | 1998 | Bifurcation and chaos1998，8，7： | 1 |
| 11 | Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis显示文摘 | Wang G Kwan BC Lai FM | | 0，，1： | 1 |
| 12 | Intrinsic and Extrinsic Motivation in Internet Usage显示文摘 | Teo SH Lim K G Lai Y C | | 0，，27： | 1 |
| 13 | Intrinsic and extrinsic motivation in Internet use 显示文摘 | Teo S H Lim K G Lai Y C | 1999 | The International Journal of Management Science1999，27，： | 1 |
| 14 | Intrinsic and extrinsic motivation in Internet usage显示文摘 | Teo T S H Lim V K G Lai R Y C | 1999 | Omega1999，27，1： | 1 |
| 15 | The Boston bowel preparation scale:a valid and reliable instrument for colonoscopy-oriented research显示文摘 | LAI E J CALDERWOOD A DOROS G | 2009 | Gastrointest Endosc2009，69，32： | 1 |
| 16 | Copper adsorption through chitosan immobilized on sand to demonstrate the feasibility for in situ soil decontamination显示文摘 | Mengwei Wan loana G Petrisor Hsuan-Ting Lai | 2004 | Carbohydrate Polymers2004，，55： | 1 |
| 17 | Messenger RNA expression of Podoeyte- associated molecules in urinary sediment of patients with lupus nephritis 显示文摘 | WANG G LAI FM TAM LS | 2007 | J Rheumatol2007，34，12： | 1 |
| 18 | Changes in masseter muscle following curved ostectomy of the prominent mandibular angle:an initial study with real-time 3D ultrasongraphy显示文摘 | MIN L LAI G XIN L | 2008 | J Oral Maxillofac Surg2008，66，12： | 1 |
| 19 | Diclofenac nanosuspensions: Influence of preparation procedure and crystal form on drug dissolution behaviour 显示文摘 | LAI F SINICO C ENNAS G at el | 2009 | Int J Pharm2009，373，： | 1 |
| 20 | Immunology and epilepsy显示文摘 | Najjar S Bembaum M Lai G | 2008 | Rev Neurol Dis2008，5，3： | 1 |
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