| 1 | 利用二维应变定量检测整体和局部心肌功能:在肥厚型心肌病中的应用显示文摘OBJECTIVES: Recently, a novel method to measure strain from standard two-dimensional images has been developed. Our goal was to characterize global and regional systolic function abnormalities using this technique in patients with hypertrophic cardiomyopathy(HCM). BACKGROUND: Strain has been proposed as a sensitive tool to detect early systolic function abnormalities in HCM. However, the clinical application of conventional Doppler-derived strain has been limited by poor reproducibility and angle dependency. METHODS: Echocardiographic examinations were performed in 26 patients with nonobstructive HCM and 45 healthy subjects. Using a dedicated software package, bidimensional acquisitions were analyzed to measure longitudinal and transverse strain in apical views and circumferential and radial strain in parasternal short-axis view. RESULTS: Despite apparently normal left ventricular systolic function, all components of strain were significantly reduced in HCM. Average longitudinal, transverse, circumferential, and radial strain in patients with HCM and controls were -15.1± 6.2% versus -20.3± 5.6% , 23.3± 17.0% versus 27.2± 14.9% ,-16.8± 7.1% versus 19.6± 5.2% , and 25.2± 13.9% versus 36.8± 17.2% , respectively(all p< 0.001). In patients with asymmetrical HCM, longitudinal septal strain was significantly lower than for other left ventricular segments combined:-9.2± 4.7% versus-12.7± 7.1% (p=0.001). Average interobserver and intraobserver variabilities were 11% and 11.3% , respectively. CONCLUSIONS: Two-dimensional strain is a new simple, rapid, and reproducible method to measure different components of systolic strain. This technique identified early abnormalities in patients with HCM that have apparently normal left ventricular systolic function. | Serri K. Reant P. Lafitte M. S. Lafitte 孙凯 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，8： | 3 |
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