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| 1 | Mental and physical symptoms associated with lower social support for patients with hepatitis C显示文摘AIM: To systematically examine the impact of the hepatitis C virus (HCV) diagnosis on patients' level of social support in a large-scale study. METHODS: Patients evaluated and treated for HCV in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status as measured by the Hospital Anxiety and Depression Scale (HAD) and the Sickness Impact Profile (SIP), severity of liver disease, mode of acquisition, and physical and psychiatric comorbidities were collected from patients or abstracted from the medical record. All participants completed a semi-structured interview, addressing questions of social support. RESULTS: A total of 342 patients (mean age 45.2 years; 37% women) were enrolled. Ninety-two (27%) patients described lower levels of support by family and friends. Nearly half of the participants (45%) noted the loss of at least one relationship due to the disease. Fears related to transmitting the disease (25%) were common and often associated with ignorance or even discrimination by others (19%). Nearly one fifth of the patients did not share information about their disease with others to avoid being stigmatized. Lower levels of social support were significantly associated with living alone, being unemployed, being excluded from antiviral therapy, having psychiatric comorbidities, contracting HCV through intravenous drug use, having high levels of anxiety and depression as measured by the HAD and negative mood state as measured by the SIP. Patients reporting lower levels of social support also noted more physical symptoms as measured by the SIP. CONCLUSION: Patients with hepatitis C often face significant social problems, ranging from social isolation to familial stress. The most common concerns reflect a limited insight of patients and their relatives and friends about the disease, the risk factors for its spread, and about potential consequences. Our data suggest that educational interventions targeting support persons and the stressors identified in our findings may lessen or alleviate the social strains patients with hepatitis C experience. | Julie A Blasiole Laura Shinkunas Douglas R LaBrecque Robert M Arnold Susan L Zickmund | 2006 | World Journal of Gastroenterology2006，12，29： | 5 |
| 2 | Citrate esters as plasticizers for poly (lactic acid) 显示文摘 | Labrecque L V Kumar R A Dave V | 1997 | Journal of Applied Polymer Science1997，66，： | 1 |
| 3 | Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol显示文摘 | Labrecque L Royal I Surprenant DS | 2003 | Mol Biol Cell2003，14，1： | 1 |
| 4 | Magnetic lineations in the Pacific Jurassic quiet zone 显示文摘 | Cande S C Larson R L LaBrecque J L | 1978 | Earth and Planetary Science Letters1978，41，： | 1 |
| 5 | Consumer power : Evolution in the digital age显示文摘 | Labrecque L I | 2013 | Journal of Interactive Marketing2013，27，4： | 1 |
| 6 | Phytoextraction ofheavy metals by two Salicaceae clones in symbiosis witharbuscular mycorrhizal fungi during the second year of a fieldtrial显示文摘 | Bissonnette L St- Amaud M Labrecque M | 2010 | Plant and Soil2010，332，： | 1 |
| 7 | Combined inhibition of PDGF and VEGF receptors by ellagie acid ,a dietaryderived phe- nolic compound显示文摘 | Labrecque L Lamy S Chapus A | 2005 | Carcinogenesis2005，26，4： | 1 |
| 8 | Revised magnetic polarity time scale for late Cretaceous and Cenozoic time 显示文摘 | LaBrecque J L Kent D V Cande S C | 1977 | Geology1977，5，： | 1 |
| 9 | Effect of number of bipolar membranes and temperature on the performance of bipolar membrane electroacidifieation显示文摘 | Bazinet L Lamarche F Labrecque R | 1997 | Journal of Agricultural and Food Chemistry1997，45，： | 1 |
| 10 | Electroacidification of soybean proteins for production of isolate 显示文摘 | Bazinet L Lamarche F Labrecque R | 1997 | Food Technology1997，5，9： | 1 |
| 11 | Effect of KCl and soy protein concentrations on the performance of bipolar membrane electroacidiflcation 显示文摘 | Bazinet L Lamarche F Labrecque R | 1997 | Journal of Agricultural and Food Chemistry1997，45，： | 1 |
| 12 | Effect of number of bipolar membranes and temporamre on the performance of bipolar membrane electroacidification显示文摘 | Bazinet L Lamarche F Labrecque R | 1997 | Journal of Agricultural and Food Chemistry1997，45，： | 1 |
| 13 | Fostering Consumer-Brand Relationships in Social Media Environments:The Role of Parasocial interaction显示文摘 | Labrecque L I | 2014 | Journal of Interactive Marketing2014，28，2： | 1 |
| 14 | Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound显示文摘 | Labrecque L Lamy S Chapus A | 2005 | Carcinogenesis2005，26，4： | 1 |
| 15 | How much TCR does a T cell need? 显示文摘 | Labrecque N Whitfield L S Obst R | 2001 | Immunity2001，15，1： | 1 |
| 16 | Prone positioning can be safely performed in critically ill infants and children显示文摘 | Fineman L D Labrecque M A Shih M C | 2006 | Pediatr Crit Care Med2006，7，5： | 1 |
| 17 | Citrate esters as plasticizers for poly(lactic acid) 显示文摘 | L V Labrecque R A Kumar V Dave | 1997 | J Appl Polym Sci1997，，66： | 1 |
| 18 | Digital images of combined oceanic and continental data sets and their use in tectonic studies显示文摘 | Haxby W F Karner G D Labrecque J L | 1983 | EOS Transactions American Geophysical Union1983，64，： | 1 |
| 19 | Consumer power: Evolution in the Digital age显示文摘 | Labrecque L I vor Demesche J Mathwick C | 2013 | Journal of Interactive Marketing2013，27，4： | 1 |
| 20 | Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol显示文摘 | Labrecque L Royal I Surprenant DS | 2003 | Mol Biol Cell2003，14，1： | 1 |
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