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| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 3 | Processing aspects of the space shuttle orbiter's ceramic reusable surface insu- lation显示文摘 | Banas R P Gzowski E R Larson W L | 1983 | Ceram Eng Sci Proc1983，4，78： | 1 |
| 4 | Latest pulse of Earth : Evidence for a mid Cretaceous superplume 显示文摘 | Larson R L | 1991 | Geology1991，19，： | 1 |
| 5 | Changes in rhizosphere populations of selected physiological groups of bacteria related to substitution of specific pairs of chromosomes in spring wheat显示文摘 | Neal J L Larson R I Atkinson T G | 1973 | Plant Soil1973，39，： | 1 |
| 6 | Pollen-medi- ated gene flow from Kentucky bluegrass under cultivated field conditions显示文摘 | JOHNSON P G Larson S R Anderton A L | 2006 | Crop Science2006，46，5： | 1 |
| 7 | Management strategies to decrease calf death losses in beef herds显示文摘 | LARSON R L TYLER J W SCHULTZ L G | 2004 | J Am Vet Med Assoc2004，224，1： | 1 |
| 8 | Modeling infiltration during a steady rain显示文摘 | Mein R G Larson C L | 1973 | Water Resources Research1973，9，2： | 1 |
| 9 | Efficacy and safety of gemtuzumab ozogamicin in patients with CD33positive acute myeloid leukemia in first relapse显示文摘 | Sievers E L Larson R A Stadtmauer E A | 2001 | J Clin Oncol2001，，： | 1 |
| 10 | Geological consequences of superplumes显示文摘 | Sheridan R E Larson R L | 1992 | Geology1992，20，5： | 1 |
| 11 | Granulocyte-macrophage colony stimulating factor-induced immune priming of cyclophosphamide,doxorubicin,vincristine,and prednisone with rituximab chemoimmunotherapy in previously untreated patients with diffuse large B-cell lymphoma and mantle cell lympho显示文摘 | Karmali R Larson M L Wooldridge J E | | 0，，11： | 1 |
| 12 | The antioxidants of higher plants 显示文摘 | LARSON R L | 1988 | Phytochemistry1988，4，： | 1 |
| 13 | Geological consequences of superplumes显示文摘 | Larson R L | 1991 | Ge- ology1991，19，： | 1 |
| 14 | Onset of mid-Cretaceous greenhouse in the Barremian-Aptian: Igneous events and biological, sedimentary and geochemical response显示文摘 | LARSON R L ERBA E | 1999 | Paleoceanography1999，14，： | 1 |
| 15 | Worldwide correlation of Mesozoic magnetic anomalies, and its implications 显示文摘 | Larson R L Pitman W C I | 1972 | Geological Society of America Bulletin1972，83，： | 1 |
| 16 | Changes in rhizosphere populations of selected physiological groups of bacteria related to substitution of specific pairs of chromosomes in spring wheat显示文摘 | NEAL J L LARSON R I ATKINSON T G | 1973 | Plant and Soil1973，39，1： | 1 |
| 17 | Plate tectonic reconstructions of the Cretaceous and Cenozoic ocean basins显示文摘 | Scotese C R Gahagan L M Larson R L | 1988 | Tectonophysics1988，155，1234： | 1 |
| 18 | Magnetic lineations in the Pacific Jurassic quiet zone 显示文摘 | Cande S C Larson R L LaBrecque J L | 1978 | Earth and Planetary Science Letters1978，41，： | 1 |
| 19 | Geological consequences of superplumes显示文摘 | Larson R L | 1991 | Geology1991，19，： | 1 |
| 20 | Requirement for 3-Ketoacyl-CoA Thiolase-2 in Peroxisome Development,Fatty Acid Beta-Oxidation and Breakdown of Triacylglycerol in Lipid Bodies of Arabidopsis seedlings显示文摘 | Germain V Rylott E L Larson T R | 2001 | Plant J2001，28，： | 1 |
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