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| 1 | Mental and physical symptoms associated with lower social support for patients with hepatitis C显示文摘AIM: To systematically examine the impact of the hepatitis C virus (HCV) diagnosis on patients' level of social support in a large-scale study. METHODS: Patients evaluated and treated for HCV in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status as measured by the Hospital Anxiety and Depression Scale (HAD) and the Sickness Impact Profile (SIP), severity of liver disease, mode of acquisition, and physical and psychiatric comorbidities were collected from patients or abstracted from the medical record. All participants completed a semi-structured interview, addressing questions of social support. RESULTS: A total of 342 patients (mean age 45.2 years; 37% women) were enrolled. Ninety-two (27%) patients described lower levels of support by family and friends. Nearly half of the participants (45%) noted the loss of at least one relationship due to the disease. Fears related to transmitting the disease (25%) were common and often associated with ignorance or even discrimination by others (19%). Nearly one fifth of the patients did not share information about their disease with others to avoid being stigmatized. Lower levels of social support were significantly associated with living alone, being unemployed, being excluded from antiviral therapy, having psychiatric comorbidities, contracting HCV through intravenous drug use, having high levels of anxiety and depression as measured by the HAD and negative mood state as measured by the SIP. Patients reporting lower levels of social support also noted more physical symptoms as measured by the SIP. CONCLUSION: Patients with hepatitis C often face significant social problems, ranging from social isolation to familial stress. The most common concerns reflect a limited insight of patients and their relatives and friends about the disease, the risk factors for its spread, and about potential consequences. Our data suggest that educational interventions targeting support persons and the stressors identified in our findings may lessen or alleviate the social strains patients with hepatitis C experience. | Julie A Blasiole Laura Shinkunas Douglas R LaBrecque Robert M Arnold Susan L Zickmund | 2006 | World Journal of Gastroenterology2006，12，29： | 5 |
| 2 | Hepato eellular carcinoma (HCC):a global perspective显示文摘 | Ferenci P Fried M Labrecque D | 2010 | J Clin Gastroenterol2010，44，4： | 1 |
| 3 | Effects of carrying a pregnancy and of method of delivery on urinary incontinence: a prospective cohort study 显示文摘 | Eason E Labrecque M Marcoux S | 2004 | BMC Pregnant and Childbirth2004，4，1： | 1 |
| 4 | Higher BMI is associated with worse asthma control and quality of Life but not asthma severity显示文摘 | Lavoie KL Bacon SL Labrecque M | | 0，，： | 1 |
| 5 | Two polymorphic variants of wild-type p53 differ biochemically and biologically显示文摘 | Thomas M Kalita A Labrecque S | 1999 | Mol Celt Bio11999，19，2： | 1 |
| 6 | Can a self- management education program for patients with chronic obstructive pulmonary disease improve quality of life? 显示文摘 | LABRECQUE M RABHI K LAURIN C | 2011 | Can Respir J2011，18，5： | 1 |
| 7 | Phytoextraction ofheavy metals by two Salicaceae clones in symbiosis witharbuscular mycorrhizal fungi during the second year of a fieldtrial显示文摘 | Bissonnette L St- Amaud M Labrecque M | 2010 | Plant and Soil2010，332，： | 1 |
| 8 | Two polymorphic variants of wild-type p53 differ biochemically and biologically显示文摘 | Thomas M Kalita A Labrecque S | 1999 | Mol Cell Biol1999，19，2： | 1 |
| 9 | Frequency and patterns of early recanalization after vasectomy显示文摘 | Labrecque M Hays M Chen-Mok M | 2006 | BMC Urol2006，6，： | 1 |
| 10 | Two polymorphic variants of wild-type p53 differ biochemically and biologically显示文摘 | Thomas M Kalita A Labrecque S | 1999 | Mol Cell Biol1999，19，： | 1 |
| 11 | Review ductile iron fifty years of continuous development显示文摘 | Labrecque C Gagne M | 1998 | Canadian metallurgical quarterly1998，，5： | 1 |
| 12 | Review ductile iron: fifty years of continuous development显示文摘 | Labrecque C Gagne M | 1998 | Canadian Metallurgical Quarterly1998，37，5： | 1 |
| 13 | Hepatocellular carcinoma(HCC):a global perspective 显示文摘 | FERENCI P FRIED M LABRECQUE D | 2010 | Journal of Clinical Gastroenterology2010，44，4： | 1 |
| 14 | The effects of noise on Occam's inversion of resistivity tomography data显示文摘 | LaBrecque D J Miletto M Daily W | 1996 | Geophysics1996，61，2： | 1 |
| 15 | Hepatocellular Carci- noma (HCC): A Global Perspective 显示文摘 | Ferenci P Fried M Labrecque D | 2010 | J Clin Gastroenterol2010，44，4： | 1 |
| 16 | Vasectomy surgical techniques : a systematic review 显示文摘 | Labrecque M Dufresne C Barone MA | 2004 | B MC Medicine2004，2，1： | 1 |
| 17 | Two polymorphic variants of wild type P53 differ biochemically and biologically 显示文摘 | Thomas M Kalita A Labrecque S | 1999 | Molecular and Cellular Biology1999，19，2： | 1 |
| 18 | Can a self- management education program for patients with chronic ob structive pulmonary disease improve quality of life 显示文摘 | Labrecque M Rabhi K Laurin C | 2011 | Can Respir J2011，18，5： | 1 |
| 19 | The Referral Process in a University Mental Health Center: The Level of Consumer Satis-Faction显示文摘 | Sabourin S Gendreau P Labrecque M | | Canadian Journal of Counselling0，，： | 1 |
| 20 | Two polymorphic variants of wild-type p53 differ biochemically and biologically显示文摘 | Thomas M Kalita A Labrecque S | 1999 | Mol Cell Bio1999，19，： | 1 |
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