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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 3 | Formation of mesopores in USY zeolites:a case revisited显示文摘 | LUTZ W KURZHALS R KRYUKOVA G | 2010 | Zeitschrift für Anorganische und Allgemeine Chemie2010，8，： | 1 |
| 4 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 5 | The end of world population growth显示文摘 | Lutz W Sanderson W Scherbov S | 2001 | Nature2001，412，6846： | 1 |
| 6 | Remediation of U ( Ⅵ ) - contaminated water using zero - valent iron 显示文摘 | Abdelouas A Lutze W Nuttall E | 1999 | Earth & Planetary Sciences1999，328，： | 1 |
| 7 | Efficacy, Effectivenessand and Expected treatment response in psychotherapy显示文摘 | Lutz W | 2003 | Journal of Clinical Psychology2003，59，7： | 1 |
| 8 | Regulation ofrelB in dendritic cells by means of modulated association of vitamin D receptor and histone deacetylase 3 with the promotor显示文摘 | Dong X Lutz W Schroeder TM | 2005 | Proc Natl Acad Sci USA2005，102，16： | 1 |
| 9 | Abgasrtickfuhrung, Neue Abgaskuhler reduzieren Emissionen yon Dieselmotoren 显示文摘 | Eitel J Kramer W Lutz R | 2003 | ATZ2003，，9： | 1 |
| 10 | Defining and measuring rec- reational shopper identity 显示文摘 | Guiry M Magi A W Lutz R J | 2006 | Journal of the Academy of Marketing Science2006，54，1： | 1 |
| 11 | The carcinogenic potential of ethyl carbamate( urethane):risk assessment at human dietary intake levels显示文摘 | Schlatter J Lutz W K | 1990 | Food Chem Toxicol1990，28，3： | 1 |
| 12 | Gene p53 mutations,proteinp53,and anti-p53 antibodies as biomarkers of cancer process显示文摘 | Lutz W Nowakowska-Swirta E | | 0，，03： | 1 |
| 13 | DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates显示文摘 | Folmer O Black M Hoeh W Lutz R Vrijenhoek R | | 0，，05： | 1 |
| 14 | A cross-sectional study of muscle strength and mass in 45-to 78-yr-old men and women显示文摘 | FRONTERA W R HUGHES V A LUTZ K J | 1991 | J Appl Physiol1991，71，2： | 1 |
| 15 | Determination of blood serum oncoprotein NEU and antioncoprotein p-53-molecular biomarkers in various types of occupational exposure显示文摘 | KRAJEWSKA B LUTZ W PILACIK B | 1998 | Int J Occup Med Environ Health1998，11，4： | 1 |
| 16 | Setup error and motion during deep inspiration breath-hold breast ra- diotherapy measured with continuous portal imaging 显示文摘 | Lutz C M Poulsen P R Fledelius W | 2016 | Acta Oneol2016，55，2： | 1 |
| 17 | Dopamine D1 or D2 receptor blockade in the globus pallidus produces akinesia in the rat 显示文摘 | Hauber W Lutz S | 1999 | Behav Brain Res1999，106，12： | 1 |
| 18 | Metabolic profil- ing of glucuronides in human urine by LC-MS/ MS and partial least-squares discriminant anal- ysis for classification and prediction of gender 显示文摘 | Lutz U Lutz R W Lutz W K | 2006 | Analytical Chemistry2006，78，13： | 1 |
| 19 | Amphibians as model to study endo- crine disrupters 显示文摘 | Kloas W Lutz I | 2006 | Journal of Chromatography A2006，1130，1： | 1 |
| 20 | Immediate early gene X-1 interacts with proteins that modulate apoptosis 显示文摘 | Kumar R Lutz W Frank E | 2004 | Bio- chem Biophys Res Commun2004，323，4： | 1 |
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