|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Complementary and alternative medicines in irritable bowel syndrome: An integrative view显示文摘Irritable bowel syndrome(IBS)is a common gastrointestinal disorder with a high incidence in the general population.The diagnosis of IBS is mainly based on exclusion of other intestinal conditions through the absence of inflammatory markers and specific antigens.The current pharmacological treatment approaches available focus on reducing symptom severity while often limiting quality of life because of significant side effects.This has led to an effectiveness gap for IBS patients that seek further relief to increase their quality of life.Complementary and alternative medicines(CAM)have been associated with a higher degree of symptom management and quality of life in IBS patients.Over the past decade,a number of important clinical trials have shown that specific herbal therapies(peppermint oil and Iberogast?),hypnotherapy,cognitive behavior therapy,acupuncture,and yoga present with improved treatment outcomes in IBS patients.We propose an integrative approach to treating the diverse symptoms of IBS by combining the benefits of and need for pharmacotherapy with known CAM therapies to provide IBS patients with the best treatment outcome achievable.Initial steps in this direction are already being considered with an increasing number of practitioners recommending CAM therapies to their patients if pharmacotherapy alone does not alleviate symptoms sufficiently. | Oliver Grundmann Saunjoo L Yoon | 2014 | World Journal of Gastroenterology2014，20，2： | 13 |
| 2 | Current state of surgical treatment of liver metastases from colorectal cancer显示文摘Hepatic resection is the procedure of choice for curative treatment of colorectal liver metastases(CLM).Objectives of surgical strategy are low intraoperative blood loss,short liver ischemic times and minor postoperative morbidity and mortality.Blood loss is an independent predictor of mortality and compromises,in common with postoperative complications,long-term outcome after hepatectomy for CLM.The type of liver resection has no impact on the outcome of patients with CLM;wedge resections are not inferior to anatomical resections in terms of tumor clearance,pattern of recurrence or survival.Despite the lack of proof of survival benef it,routine lymphadenectomy has been advocated,allowing the detection of microscopic lymph node metastases and with prognostic value.In experienced hands,minimally invasive liver surgery is safe with acceptable morbidity and mortality and oncological results comparable to open hepatic surgery,but with reduced blood loss and earlier recovery.The European Colorectal Metastases Treatment Group recommended treating up front with chemotherapy for patients with both resectable and unresectable CLM.However,neoadjuvant chemotherapy can induce damage to the remnant liver,dependent on the number of chemotherapy cycles.Therefore,in our opinion,preoperative chemotherapy should be reserved for patients whose CLM are marginally resectable or unresectable.A meta analysis of randomized trials dealing with perioperative chemotherapy for the treatment of resectable CLM demonstrated a benefit of systemic chemotherapy but did not answer the question of whether a neoadjuvant or adjuvant approach should be preferred.Analysis of the literature demonstrates that the results of specialized centers cannot be attained in the reality of comprehensive patient care.Reasons behind the commonly poorer results seen in cancer networks as compared with literature-based data are,on the one hand,geographical disparities in access to specialized surgical and medical care.On the other hand,a selection bias in the reports of the literature may be assumed.Studies of surgical resection for CLM derive almost exclusively from case series generally drawn from large academic centers where patient selection or surgical expertise is superior to what is found in many communities.Therefore,we may conclude that the comprehensive propagation of the standards outlined in this paper constitutes a major task in the near future to reduce the variations in survival of patients with CLM. | Reinhart T Grundmann | 2011 | World Journal of Gastrointestinal Surgery2011，3，12： | 8 |
| 3 | Primary colon resection or Hartmann's procedure in malignant left-sided large bowel obstruction? The use of stents as a bridge to surgery显示文摘There is still significant debate regarding the best surgical treatment for malignant left-sided large bowel obstruction.Primary resection and anastomosis offers the advantages of a definite procedure without need for further surgery.Its main disadvantages are related to the increased technical challenge and to the potential higher risk of anastomotic leakage that occurs in the emergency setting.Primary resection with end colostomy(Hartmann's procedure) is considered the safer option.Tan et al compared in a systematic review and meta-analysis the use of self-expanding metallic stents(SEMS) as a bridge to surgery vs emergency surgery in the management of acute malignant left-sided large bowel obstruction.The authors concluded that the technical and clinical success rates for stenting were lower than expected.SEMS was associated with a high incidence of clinical and silent perforation.Stenting instead of loop colostomy can be recommended only if the appropriate expertise is available in the hospital.The goal of stenting,a decrease of the stoma rate,may be advocated only if the complication rates of stenting are lower than those of stoma creation in the emergency situation.Until now,this was not demonstrated in a prospective randomized trial. | Reinhart T Grundmann | 2013 | World Journal of Gastrointestinal Surgery2013，5，1： | 5 |
| 4 | Exploring the utility of three nuclear regions to reconstruct reticulate evolution in the fern genus Asplenium显示文摘三个原子区域原子 ribosomal 内部抄录分隔符(nrITS ) 和二原子低拷贝的 genesgapCp 的 intron 区域,和 pgiC,在有一个叶绿体染色体的联合,区域被采用在蕨纲植物类 Asplenium 探索 reticulate 进化的模式。这是用在蕨纲植物的多重原子标记的 DNA 序列的第一研究中的一个。与 PCR 和几个拷贝放大很好的所有三个原子标记被克隆 PCR 产品恢复。所有三个原子区域由作为双 A 的混血儿恢复 neo-allotetraploid Asplenium adulterinum 显示出适合的结果。trichomanes 和双 A。viride。冲突结果为几个节点被获得。首先, gapCp 没在 A 之间区别。aethiopicum 和 A。praegracile 而另外的标记作为不同恢复了这二 taxa。在基因树之中的冲突在尊重被发现到 A。monanthes,叶绿体和 pgiC 建议了 A 的一种姐妹关系。monanthes 和 A。trichomanes 但是 gapCp 和 nrITS 嵌套 A。在 A 以内的 monanthes。normale。我们的结果证实:(i) 几个原子区域,特别地 gapCp 和 pgiC 的实用性,解开在蕨纲植物的 reticulate 进化和种类区别并且(ii ) 加亮需要采用超过一个原子区域在排序的 reticulate 事件对不完全的系上获得可靠假设。特别,如果一个人假设网状事件可能发生在更远的过去。就在蕨纲植物的 reticulate 进化的期望的高频率而言,柔韧、增进知识的原子 genomic 标记的建立是批评的在我们阐明的努力获得进一步的进步蕨纲植物进化。 | Harald SCHNEIDER Adriana NAVARRO-GOMEZ Stephen J. RUSSELL Stephen ANSELL Michal GRUNDMANN Johannes VOGEL | 2013 | Journal of Systematics and Evolution2013，51，2： | 4 |
| 5 | Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population显示文摘在有 TAXUS 和心脏的外科(句法) 的经皮的冠的干预之间的 BackgroundThe 协同作用分数在有复杂冠的动脉疾病的病人是为风险层化和 revascularization 策略选择的一个验证工具。学习是分析它的年龄相关的预示的 value.MethodsSYNTAX 分数的这的目的在经历经皮的冠的干预(一种总线标准) 的 1331 个所有来者病人被计算:463 个病人 75 年和 868 个病人 < 75 年。兴趣的结果是在一个和二 years.ResultsA 点的所有原因死亡为死亡的年龄和句法分数的重要相互作用被观察在二年(P 相互作用 = 0.019 ) 然而并非在一个年后续(P 相互作用 = 0.594 ) 。在 multivariable 分析,句法分数独立地在两个年龄组预言了 1 年的死亡(< 75 年,危险比率(HR ) :1.43, 95% 信心间隔(CI ) :1.03-2.00, P = 0.034;并且 75 年, HR:1.37, 95% CI:1.01-1.85, P = 0.042 ) ,但是在更年轻的病人之中的仅仅二年的死亡(< 75 年, HR:1.33, 95% CI:1.01-1.76, P = 0.041;并且 75 年, HR:1.11, 95% CI:0.87-1.41, P = 0.394 ) 。句法分数 tertiles 是有用的成层在两个的 1 年的死亡,病人 < 75 年(句法分数 < 9, 3.8% ;9-20, 5.3% ;20, 10.3% ;P = 0.004 ) 并且 75 年(句法分数 < 11, 5.7% ;11-22.5, 16.1% ;22.5, 18.7% ;P = 0.003 ) ,但是仅仅在病人之中的二年的死亡 < 75 年(句法分数 < 9, 6.5% ;9-20, 7.6% ;20, 15% ;P < 0.001 ) 并且不在 75 个岁病人之中(句法分数 < 11, 19.4% ;11-22.5, 26.3% ;22.5, 27.9% ;P = 0.138 ).ConclusionsAge 在一种总线标准以后在长术语的死亡上修改句法分数的影响。在病人之中 < 75 年,句法分数独立地在一种总线标准以后在一个和二年点预言死亡的风险,当时在病人之中它的预兆的角色在一种总线标准以后被限制到第一年的 75 年。进一步的研究被需要为在老病人之中选择最适当的 revascularization 策略评估句法分数的价值。 | Madeleine Eickhoff Stefanie Schupke Alexander Khandoga Julia Fabian Moritz Baquet David Jochheim David Grundmann Manuela Thienel Axel Bauer Hans Theiss Stefan Brunner Jorg Hausleiter Steffen Massberg Julinda Mehilli | 2018 | Journal of Geriatric Cardiology2018，15，9： | 3 |
| 6 | A numerical study of unidirectional solidification of a binary metal alloy under influence of a rotating magnetic field显示文摘 | P.A. Nikrityuk K. Eckert R. Grundmann | 2005 | International Journal of Heat and Mass Transfer2005，，7： | 2 |
| 7 | Contribution of Fluid Dynamics to Woodwind Instruments Investigations of Timbre and Pitch of Bassoon Bocals显示文摘The discussed topic of isolating certain parameters which describe the timbre in connection with bocals of bassoons is of major interest for manufacturers and artist likewise since a reduction in the overall shear stress of these kinds of technical diffusors is very helpful but not sufficient. The timbre seen from the side of the musician has to be the same. Up to now two criteria have been isolated which have a deep influence on the easier blowing of the bassoon and on the comparable timbre due to geometrical reasons. If the geometrical outer contour is designed carefully, it is possible to modify the shape and preserve the timbre. | Roger GRUNDMANN Johannes BAUMGART Andreas RICHTER Hans KRüGER | 2005 | Journal of Thermal Science2005，14，3： | 2 |
| 8 | Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family 显示文摘 | Grundmann U Abel J Bohn H | 1988 | Proc Natl Acad Sci1988，85，11： | 1 |
| 9 | Diagnostic und Therapies Magenkarzinoms-Workflow显示文摘 | Grundmann RT Hlscher AH Bembenek A | 2009 | Zentralbl Chir2009，134，： | 1 |
| 10 | Expression profiling of mammary carcinoma cell lines:correlation of in vitro invasiveness with expression of CD24 显示文摘 | Schindelmann S Windisch J Grundmann R | 2002 | Tumour Biol2002，23，3： | 1 |
| 11 | Narcotrend index versus bispeetral index as electroencephalogfam measures of anesthetic drug effect during propofol anesthesia 显示文摘 | Kreuer S Wilhelm W Grundmann U | 2004 | Anesth Analg2004，98，3： | 1 |
| 12 | Die konstitution des lycppins显示文摘 | Kuhn R Grundmann C | 1932 | Ber Deutsch chem Ges1932，65，： | 1 |
| 13 | Multicenter study using standardized protocols and reagents for evaluation of reproduc- ibility of PCR - based fingerprinting of Acinetobacter spp 显示文摘 | Grundmann HJ Towner KJ Dijkshoom L | 1997 | J Clin Microbiol1997，35，12： | 1 |
| 14 | Evaluation of the mecA femB duplex polymerase chain reaction for detection of methicillin-resistant Staphylococcus aureus显示文摘 | Jonas D Grundmann H Hartung D | 1999 | Eur J Clin Microbiol Infect Dis1999，18，9： | 1 |
| 15 | Kaempferol from the leaves ofApocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice显示文摘 | Grundmann O Nakajima JI Kamata K | 2009 | Phytomedicine2009，16，4： | 1 |
| 16 | Narcotrend index versus bispectral index as electroencephalogram measures of anesthetic drug effect during propofol anesthesia 显示文摘 | Kreuer S Wilhelm W Grundmann U | 2004 | Anesth Analg2004，98，： | 1 |
| 17 | How clonal is Staphylococ- cus aureus? 显示文摘 | Feil E J Cooper JE Grundmann H | 2003 | J Bacteriol2003，185，11： | 1 |
| 18 | MicroRNA-100 regulates neovascularization by suppres- sion of mammalian target of rapamycin in endothelial and vas- cular smooth muscle cells 显示文摘 | Grundmann S Hans FP Kirmiry S Heinke J Helbing T Blubm F et 02 | 2011 | Circulation2011，123，9： | 1 |
| 19 | The present status of quantum dot lasers 显示文摘 | GRUNDMANN M | 2000 | Phys E2000，5，： | 1 |
| 20 | MicroRNA-100 regulates neovascularization by suppression of mammalian target of rapamycin in endothelial and vascular smooth muscle cells显示文摘 | Grundmann S Hans FP Kinniry S | 2011 | Circulation2011，123，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员