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| 1 | A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone显示文摘The transport of fluid, nutrients, and signaling molecules in the bone lacunar–canalicular system(LCS) is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching(FRAP) approach to quantify load-induced fluid and solute transport in the LCS in situ, but the measurements were limited to cortical regions 30–50 μm underneath the periosteum due to the constrains of laser penetration. With this work, we aimed to expand our understanding of load-induced fluid and solute transport in both trabecular and cortical bone using a multiscaled image-based finite element analysis(FEA)approach. An intact murine tibia was first re-constructed from micro CT images into a three-dimensional(3D)linear elastic FEA model, and the matrix deformations at various locations were calculated under axial loading. A segment of the above 3D model was then imported to the biphasic poroelasticity analysis platform(FEBio) to predict load-induced fluid pressure fields, and interstitial solute/fluid flows through LCS in both cortical and trabecular regions. Further, secondary flow effects such as the shear stress and/or drag force acting on osteocytes, the presumed mechano-sensors in bone, were derived using the previously developed ultrastructural model of Brinkman flow in the canaliculi. The material properties assumed in the FEA models were validated against previously obtained strain and FRAP transport data measured on the cortical cortex.Our results demonstrated the feasibility of this computational approach in estimating the fluid flux in the LCS and the cellular stimulation forces(shear and drag forces) for osteocytes in any cortical and trabecular bone locations, allowing further studies of how the activation of osteocytes correlates with in vivo functional bone formation. The study provides a promising platform to reveal potential cellular mechanisms underlying the anabolic power of exercises and physical activities in treating patients with skeletal deficiencies. | Lixia Fan Shaopeng Pei X Lucas Lu Liyun Wang | 2016 | Bone Research2016，4，3： | 2 |
| 2 | Internal carotid arterial stenosis:CT angiography with volume rendering显示文摘 | Godefroy O Lucas C | 1999 | Radiology1999，210，3： | 1 |
| 3 | Internal carotid arterial stenosis:CT angiography with volume rendering显示文摘 | Leclerc X Godefroy O Lucas C | 1999 | Radiology1999，210，： | 1 |
| 4 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 5 | Fertility of weaned sows after deep intrauterine insemination with a reduced number of frozen thawed spermatozoa 显示文摘 | Roca J Carvajal G Lucas X | 2003 | Theriogenology2003，60，1： | 1 |
| 6 | Application of chalcogenide glassbulks and fibers显示文摘 | Zhang X Ma H Lucas J | 2003 | Journal of Optoelectronics and AdvancedMaterials2003，5，13： | 1 |
| 7 | A new glass of infrared transmitting glass-ceramics based on controlled nucleation and growth of alkali hadlide in a sulfide based glass matrix 显示文摘 | Zhang X H Ma H L Lucas J | 2004 | J Non-Cryst Solids2004，337，： | 1 |
| 8 | Welding with high-frequency square-wave AC arcs 显示文摘 | Zeng X M Lucas J Ren Y Y | 1990 | lEE Proceedings A1990，137，4： | 1 |
| 9 | Internal carotid arterial steno- sis : CT angiography with volume rendering显示文摘 | Leclerc X Godefroy O Lucas C | 1999 | Radiology1999，210，3： | 1 |
| 10 | Influence of different agricultural practices (type of N-- fertilizer) on soil nitrous oxide emission显示文摘 | Henault C Devis X Lucas J L | 1998 | Biology and Fertility of Soils1998，27，： | 1 |
| 11 | Computed tomography angiography for the evaluation of carotid artery dissections 显示文摘 | Taschner CA Leclerc X Lucas C | 2005 | Front Neurol Neurosci2005，20，： | 1 |
| 12 | Computed tomography angiography for the evaluation of carotid artery dissections显示文摘 | Taschner C A Leclerc X Lucas C | 2005 | Front Neurol Neuroscl2005，20，： | 1 |
| 13 | Welding with high-frequency square-wave AC arcs显示文摘 | Zeng X M Lucas J Ren Y Y | 1990 | IEE Proceedings A1990，137，4： | 1 |
| 14 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 15 | Associations between living arrange-ments and health - related quality of life of urban elderly people : astudy from China显示文摘 | Sun X Lucas H Meng Q | 2011 | Qual of life Res2011，20，3： | 1 |
| 16 | Computed tomography angiography for the evaluation of carotid artery dissections显示文摘 | Taschner CA Leclerc X Lucas C | 2005 | Front Neurol Neurosci2005，20，： | 1 |
| 17 | Characterization of a neuronalκB -binding factor distinct from NF-κB显示文摘 | Moerman AM Mao X Lucas MM | 1999 | Brain Res Mol Brain Res1999，67，： | 1 |
| 18 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S Li R Zhang Z Li L Gu X Fan W Lucas W J Wang X Xie B Ni P | | 0，，： | 1 |
| 19 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S W Li R Q Zhang Z H Li L Gu X F Fan W Lucas W J Wang X W Xie B Y Ni P X Ren Y Zhu H M Li J Lin K Jin W W Fei Z J Li G C Staub J B Kilian A van der Vossen E A G Wu Y Guo J He J Jia Z Q Ren Y Tian G Lu Y Ruan J Qian W Wang M W Huang Q F Li B Xuan Z L | | 0，，12： | 1 |
| 20 | Internal carotid arterial stenosis: CT angiography with volume rendering 显示文摘 | Leelerc X Goderfroy O Lucas C | 1999 | Radiology1999，210，3： | 1 |
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