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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Millennial-centennial Scales Climate Changes of Holocene Indicated by Magnetic Susceptibility of High-resolution Section in Salawusu River Valley, China显示文摘The upmost segment (Holocene series) of the Milanggouwan stratigraphic section (MGS1) in the Salawusu River valley shows 11 sedimentary cycles of dune sands and fluvio-lacustrine facies, or dune sands and paleosols. The analysis of the magnetic susceptibility of this segment suggests that there are 11 magnetic susceptibility cycles with the value alternating from low to high, in which the layers of the dune sands correspond to the lower value of the magnetic susceptibility and the layers of fluvio-lacustrine facies and paleosols correspond to the higher peaks. The study reveals that the low and high magnetic susceptibility values indicate the climate dominated by cold-arid winter monsoon and warm-humid summer monsoon of East Asia, respectively, and the study area has experienced at least 22 times of millennial-centennial scales climate alternation from the cold-arid to the warm-humid during the Holocene. In terms of the time and the climate nature, the variations basically correspond to those of the North Atlantic and some records of cold-warm changes in China as well. They might be caused by the alternation of winter and summer monsoons in the Mu Us Desert induced by global climate fluctuations in the Holocene. | LU Yingxia LI Baosheng WEN Xiaohao QIU Shifan WANG Fengnian NIU Dongfeng LI Zhiwen | 2010 | Chinese Geographical Science2010，20，3： | 19 |
| 3 | Changes in nitrogen budget and potential risk to the environment over 20 years(1990–2010) in the agroecosystems of the Haihe Basin, China显示文摘The nitrogen balance can serve as an indicator of the risk to the environment of nitrogen loss from agricultural land. To investigate the temporal and spatial changes in agricultural nitrogen application and its potential threat to the environment of the Haihe Basin in China, we used a database of county-level agricultural statistics to calculate agricultural nitrogen input, output,surplus intensity, and use efficiency. Chemical fertilizer nitrogen input increased by 51.7% from1990 to 2000 and by 37.2% from 2000 to 2010, concomitant with increasing crop yields.Simultaneously, the nitrogen surplus intensity increased by 53.5% from 1990 to 2000 and by16.5% from 2000 to 2010, presenting a continuously increased environmental risk. Nitrogen use efficiency decreased from 0.46 in 1990 to 0.42 in 2000 and remained constant at 0.42 in 2010,partly due to fertilizer composition and type improvement. This level indicates that more than half of nitrogen inputs are lost in agroecosystems. Our results suggest that although the improvement in fertilizer composition and types has partially offset the decrease in nitrogen use efficiency, the environmental risk has still increased gradually over the past 20 years, along with the increase in crop yields and nitrogen application. It is important to achieve a better nitrogen balance through more effective management to significantly reduce the environmental risk,decrease nitrogen surplus intensity, and increase nitrogen use efficiency without sacrificing crop yields. | Mengmeng Zheng Hua Zheng Yingxia Wu Yi Xiao Yihua Du Weihua Xu Fei Lu Xiaoke Wang Zhiyun Ouyang | 2015 | Journal of Environmental Sciences2015，27，2： | 6 |
| 4 | Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection显示文摘Dear Editor,In recent years,the incidence of human infections caused by emerging or re-emerging pathogens has rapidly increased.Diseases that were once regional now have the ability to spread globally in a short amount of time and pose a wider threat to public health(Weaver et al.2018).Yellow fever virus(YFV,family Flaviviridae,genus Flavivirus)is a mosquito-borne flavivirus that causes yellow fever in humans and has been endemic in Africa and Latin America for many years(Domingo et al.2018). | Meng Li Beibei Wang Liqiang Li Gary Wong Yingxia Liu Jinmin Ma Jiandong Li Hongzhou Lu Mifang Liang Ang Li Xiuqing Zhang Yuhai Bi Hui Zeng | 2019 | Virologica Sinica2019，34，3： | 1 |
| 5 | Spectroscopic analysis of high electric field enhanced ionization in laser filaments in air for corona guiding显示文摘We report on a systematic experimental study on the fluorescence spectra produced from a femtosecond laser filament in air under a high electric field. The electric field alone was strong enough to create corona discharge(CD). Fluorescence spectra from neutral and ionic air molecules were measured and compared with pure high-voltage CD and pure laser filamentation(FIL). Among them, high electric field assisted laser FIL produced nitrogen fluorescence more efficiently than either pure CD or pure FIL processes. The nonlinear enhancement of fluorescence from the interaction of the laser filament and corona discharging electric field resulted in a more efficient ionization along the laser filament zone, which was confirmed by the spectroscopic measurement of both ionization-induced fluorescence and plasma-scattered 800 nm laser pulses. This is believed to be the key precursor process for filament-guided discharge. | Yingxia Wei Yaoxiang Liu Tie-Jun Wang Na Chen Jingjing Ju Yonghong Liu Haiyi Sun Cheng Wang Jiansheng Liu Haihe Lu See Leang Chin Ruxin Li | 2016 | High Power Laser Science and Engineering2016，4，1： | 1 |
| 6 | Immunological and metabolic characteristics of the Omicron variants infection显示文摘The Omicron variants of SARS-CoV-2,primarily authenticated in November 2021 in South Africa,has initiated the 5th wave of global pandemics.Here,we systemically examined immunological and metabolic characteristics of Omicron variants infection.We found Omicron resisted to neutralizing antibody targeting receptor binding domain(RBD)of wildtype SARS-CoV-2.Omicron could hardly be neutralized by sera of Corona Virus Disease 2019(COVID-19)convalescents infected with the Delta variant.Through mass spectrometry on MHC-bound peptidomes,we found that the spike protein of the Omicron variants could generate additional CD8+T cell epitopes,compared with Delta.These epitopes could induce robust CD8+T cell responses.Moreover,we found booster vaccination increased the cross-memory CD8+T cell responses against Omicron.Metabolic regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted the response of memory T cells.Consistently,a greater fraction of memory CD8+T cells existed in Omicron stimulated peripheral blood mononuclear cells(PBMCs).In addition,CD147 was also a receptor for the Omicron variants,and CD147 antibody inhibited infection of Omicron.CD147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar pneumonia.Taken together,our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron. | Jiejie Geng Xu Yang Kun Wang Ke Wang Ruo Chen Zhi-Nan Chen Chuan Qin Guizhen Wu Youchun Wang Ke Xu Peng Du Jiangning Liu Shirui Chen Tao Zhang Xiuxuan Sun Ting Guo Ying Shi Zheng Zhang Ding Wei Peng Lin Qingyi Wang Jing Yuan Jiuxin Qu Jin Zou Yingxia Liu Hongzhou Lu Ping Zhu Huijie Bian Liang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 7 | Clinical characteristics and vaccine effectiveness against SARS-CoV-2 Omicron subvariant BA.2 in the children显示文摘Dear Editor,The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has rapidly replaced the Delta variant as a dominating SARS-CoV-2 variant because of natural selection,which favors the variant with higher infectivity and stronger vaccine breakthrough ability.1 Among three lineages BA.1(B.1.1.529.1),BA.2(B.1.1.529.2),and BA.3(B.1.1.529.3)of Omicron,BA.2 is rising rapidly worldwide since January 2022 and become a new dominating“variant of concern”in China.2 With the current surge in Omicron in China,both the absolute number of children hospitalized with COVID-19 and the percentage of total COVID-19 hospitalizations have been boosting recently.Understanding the clinical characteristics of SARS-CoV-2 Omicron subvariant BA.2 in children and the protective effect of vaccines is of great help for epidemic prevention strategies.However,so far no sufficient experimental data have been reported about infectivity,disease severity,vaccine breakthrough capability,and antibody resistance from pediatric BA.2. | Xiaohe Li Liwen Wu Youzhi Qu Mengli Cao Jiaqi Feng Hua Huang Yi Liu Hongzhou Lu Quanying Liu Yingxia Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 8 | Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72显示文摘Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics. | Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 9 | Comparative neutralization profiles of naive and breakthrough infections with Delta,Omicron BA.1 and BA.2 variants of SARS-CoV-2显示文摘Dear Editor,Developing a variant-specific vaccine has drawn great concern due to the considerably altered antigenicity and immune evasion of the Omicron variant.Several recent studies have evaluated the immunogenicity of Omicron-based mRNA vaccines for both regular and booster vaccination and compared it with the wildtype(WT)SARS-CoV-2 counterpart in animal models. | Yang Yang Xiaohua Gong Jun Wang Shisong Fang Jiaqi Zhang Xuejiao Liao Yuan Guan Weihua Wu Yingxia Liu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
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