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| 1 | Antitussive activity of Triclisia dictyophylla of the family Menispermecae显示文摘Objective:To verify through a scientific mean the therapeutic use of the plant as an anti-tussive agent,by traditional medicine healers and also aid in the search for new drugs developments from plants.Methods:The roots of Triclisia dictyophylla were investigated for their antitussive properties.The plant was uprooted in the month of June 2003 at Igbodo,Delta State,Nigeria and was taken to the university of Nigeria Nsukka for taxonomy. The roots were chopped,ground and immersed in pure drinking water for 24 hours.After filtration, extraction was carried out using a Rotary evaporator,preliminary phytochemistry and acute toxicity studies were carried out.Antitussive study was carried out using a total of 42 young rats of average weight of 72.2 g.The rats were housed in standard animal house of the university and were allowed access to feeds and water but, were fasted for 12 hours prior to commencement of experiment.Specific and appropriate dosage of the crude extract and Codeine re - dissolved in water were administered orally 30 minutes prior to induction of cough. Cough was induced by exposing the animals to Sulphure dioxide gas for 3- minutes.Coughing was taken as number of Head-nods per minute,Stethoscope aided audible sounds and,or tears secretion.Percentage cough inhibition for crude extract and,or Codeine treated rats were compared with reference to control animals.Results were subjected to statistical analysis using SPSS 13.0.Results:A 10.2%extraction yield was got from a starting root initial weight of 320 g.The preliminary phytochemistry of the aqueous root extract revealed the presence of alkaloids,saponins,flavonoids,proteins,reducing sugars,steroids,resins fats/oils and glycosides. The Median lethal dose(LD_(50)) based on Lorke's 1983 method was 548 mg/kg The aqueous root extract at concentrations of 10 mg/kg,50 mg/kg,100 mg/kg and 200 mg/kg orally administered,inhibited cough in rats induced by sulphure dioxide gas by 16.67%,33.33%,50.00%and 83.33%respectively.While Codeine phosphate,a standard antitussive agent,at oral concentrations of 10 mg/kg and 20 mg/kg inhibited cough in rats induced by sulphure dioxide gas by 33.33%and 60.67%respectively.Conclusion:Earlier works by some authors had led to isolation of Morhinian Alkaloids from Triclisia dictyophylla thus most probably linking its mechanism of antitussive activity to that likable of Morphine.This study justifies the use of the plant in treatment of cough by Traditional Medicine Healers. | Azikiwe CCA Unekwe PC Amazu LU Luechai Srigernyaung Ezeani MC Nwosu PJC Ajugwo A | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，4： | 2 |
| 2 | Effect of adsorbents coated with titanium dioxide on the photocatalytic degradation of propoxur 显示文摘 | Lu MC Chen J N Chang K T etal | 1999 | Chemosphere1999，38，： | 1 |
| 3 | Inhibition of pbosphati- dylinositol 3-kinase delay B Ill/nor progression and blocks me- tastatic spread in a mouse model of thyroid cancer显示文摘 | Furuya F Lu C Willingham MC | 2007 | Carcino- genesis2007，28，12： | 1 |
| 4 | Harnessing in vivo siRNA delivery for drug discovery and therapeutic development 显示文摘 | Xie FY Woodle MC Lu PY | 2006 | Drug Discov Today2006，11，12： | 1 |
| 5 | We can do better:improving women's health in America 显示文摘 | Lu MC | 2008 | Curr Opin Obstet Gynecol2008，20，： | 1 |
| 6 | Increased risk and related factors of depression among patients with COPD: a population-based cohort study显示文摘 | Tsai TY Livneh H Lu MC | 2013 | BMC Public Health2013，13，： | 1 |
| 7 | Directed differentiation of mouse embryonic stem cells into thyroid follicular cells显示文摘 | Arufe MC Lu M Kubo A | 2006 | Endocrinology2006，147，6： | 1 |
| 8 | Directed differentiation of mouse embryonic stem cells into thyroid follicular cells显示文摘 | Arufe MC Lu M Kubo A | 2006 | Endocrinology2006，147，6： | 1 |
| 9 | Use of electrical stimulation at different current levels to promote recovery after peripheral nerve injury in rats显示文摘 | Lu MC Tsai CC Chen SC | 2009 | J Trauma2009，65，5： | 1 |
| 10 | Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis 显示文摘 | Lu MC Lai NS Chen HC | 2013 | Clin Exp Immunol2013，171，1： | 1 |
| 11 | Application of PHBHHx nanoparticles as sustained drug release carrier for ra?pamycin显示文摘 | Li MC Zhang YL Lu XY | 2013 | Journal of Xi'' an Jiaotong University (Medical sciences)2013，34，2： | 1 |
| 12 | Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation显示文摘 | Mc Kinsey T A Zhang C L Lu J | 2000 | Nature2000，408，6808： | 1 |
| 13 | Treating glioblastoma multiforme with selective high-dose liposomal doxorubicin chemotherapy induced by repeated focused ultrasound显示文摘 | Yang FY Teng MC Lu M | | 0，，： | 1 |
| 14 | Role of ALDP (ABCD1) and mitochondria in X-linked adrenoleukodystrophy显示文摘 | McGuinness MC Lu JF Zhang HP | | 0，，02： | 1 |
| 15 | Development of aberrant crypt loci in the colons of ob/ob and db/db mice: Evidence that leptin is not a promoter 显示文摘 | Ealey KN Lu S Archer MC | 2008 | Mol Carcinog2008，4，： | 1 |
| 16 | Light-directed,spatially addressable parallel chemical synthesis显示文摘 | Fodor SP Read JL Pirrung MC Stryer L Lu AT Solas D | 1991 | Science1991，251，4995： | 1 |
| 17 | Dual proteolytic pathways govern glycolysis and immune competence显示文摘 | Lu W Zhang Y Mc Donald DO | 2014 | Cell2014，159，： | 1 |
| 18 | Therapeutic potential and molecular mechanism of a novel ,potent, nonpeptide, Smac mimetic SM-16d in combination with TRAIL for cancer treatment 显示文摘 | Lu J Mc Eachern D Sun H | 2011 | Mol Cancer Ther2011，10，5： | 1 |
| 19 | Recommendations for preconception care显示文摘 | Lu MC | 2007 | Amn Fain Physician2007，76，： | 1 |
| 20 | Differences in FIB in serum and exhaled breath condensate from patients with exacerbated COPD or asthma attacks显示文摘 | Liu HC Lu MC Lin YC | 2014 | J Fonnos Med Assoc2014，113，12： | 1 |
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