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| 1 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 2 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 3 | 甲状腺术中喉返神经监测技术的标准化显示文摘目的在甲状腺手术中缺少术中神经监测(intra operative neuromonitoring,IONM)的标准化操作可导致结果变异性强,这些结果可产生错误信息并增加喉返神经损伤的危险性。因此有必要进行IONM操作的标准化。方法本研究共招募了289例进行过甲状腺切除术的患者(435根神经有危险),均由一位外科医师实施手术。每例患者均由同一位麻醉师使用EMG气管导管进行插管。每例患者均进行标准化IONM操作。该操作包括术前和术后对声带运动进行录像监测、保证电极在正确位置、喉返神经剥离前后刺激迷走神经并记录EMG信号,并摄像记录暴露的喉返神经。结果5例患者出现IONM波形异常,是由于电极错位所致,这一问题被立刻监测到。监测到1例患者在手术较早阶段出现非喉返神经损伤。甲状腺剥离时18例患者的神经失去了EMG信号,使用我们的标准化IONM操作后神经损伤的原因得以清楚阐明。结论标准化IONM操作不仅在消除错误的IONM结果方面有用且有帮助,而且有助于阐明喉返神经损伤的机制。在确定外科手术的缺陷并提高外科手术技巧后,本研究显著降低了神经麻痹的发生率。 | Chiang FY Lee KW | 2011 | 中国医学文摘(耳鼻咽喉科学)2011，26，1： | 3 |
| 4 | Vitamin K3-induced cell cycle arrest and apoptosis cell death are accompanied by altered expression of c-fos and c-myc in nasopharyngeal carcinoma cells显示文摘 | Wu FY Chang NT Chen WJ | 1993 | Oncogene1993，8，8： | 2 |
| 5 | Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages显示文摘 | Liu,YJ Lu,SH Xu,B Yang,RC Ren,Q Liu,B Lu,M Yan,FY Han,ZB Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 6 | 锌指抗病毒蛋白协同IFNβ抑制戊型肝炎病毒的复制显示文摘【据Journal of Viral Hepatitis 2021年8月报道】题:锌指抗病毒蛋白通过协同IFNβ抑制戊型肝炎病毒复制(作者:Yu WH等)戊型肝炎病毒(HEV)感染是导致全球急性病毒性肝炎的主要原因。然而,HEV与宿主相互作用的机制尚不清楚。锌指抗病毒蛋白(ZAP)是一种新型的IFN刺激基因,可与IFNβ协同作用抑制多种病毒的复制。本研究旨在探讨ZAP与HEV复制之间的相互作用。 | YU WH JI HB LONG FY 钱忠瑶 黄芬 | 2021 | 临床肝胆病杂志2021，37，10： | 2 |
| 7 | Regulation of nitric oxide synthesis in infectious and autoimmune diseases显示文摘 | Liew FY | 1994 | Immunol Lett1994，43，12： | 2 |
| 8 | Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites 显示文摘 | Garcia-Tsao G Lee FY Barden GE | 1995 | Gastroenterology1995，108，6： | 1 |
| 9 | Irritable bowel syndrome in the 21st century:perspectives from Asia or South-east Asia显示文摘 | Chang FY Lu C L | 2007 | Gastroenterol Hepatol2007，22，1： | 1 |
| 10 | Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells:role of mitogen-activated protein kinases and Nrf2显示文摘 | Anwar AA Li FY Leake DS | 2005 | Free Radic Biol Med2005，39，2： | 1 |
| 11 | Negative regulation of toll- like receptor-mediated immune responses显示文摘 | Liew FY Xu D Brint EK | 2005 | Nat Rev Immunol2005，5，： | 1 |
| 12 | Inhibition of gastric emptying by acarbose is correlated with GLP - 1 response and accompanied by CCK release显示文摘 | Enc FY Imerylyuz N Akin L | 2001 | AM J Physilo Gastrointest Liver Physiol2001，281，3： | 1 |
| 13 | Twin - to , twin-transfusionsyndrome : a comprehensive update显示文摘 | Habli M Lira FY Crorableholme T | 2009 | Clin Perinato12009，36，2： | 1 |
| 14 | Cucurb-itacin B induces apoptosis and S phase cell cycle arrest in BEL-7402human hepatocellular carcinoma cells and is effective via oral admin-istration显示文摘 | Chan KT Meng FY Li Q Ho CY Lam TS To Y | 2010 | Cancer Lett2010，294，1： | 1 |
| 15 | Guidelines for chemotherapy of tuberculosis in Taiwan显示文摘 | Chang FY Chang SC Chen YS | 2004 | J Microbiol Immunol Infect2004，37，6： | 1 |
| 16 | Anti-platelet and anti-thrombotic effects of triacetylshikimic acid in rats显示文摘 | Huang FY Xu QP Sun JN HONG Enrique | 2002 | J Cardiovascular pharmacology2002，39，： | 1 |
| 17 | Development of experimental chronic intraocular hypertension in the rabbit显示文摘 | Zhu MD Cai FY | 1992 | Aust N Z J Ophthalmol1992，20，3： | 1 |
| 18 | FK506 rescues peripheral nerve alIografts in acute rejection显示文摘 | Feng FY Ogden MA Myckatyn TM | 2001 | Nenrotrauma2001，18，2： | 1 |
| 19 | Translumial angio- plasty for atheroscerotic disease of the vertebral and basilar arteries 显示文摘 | Higashida RT Tsai FY Halbach W | 1993 | J Nettrosurg1993，78，1： | 1 |
| 20 | Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proin-flammatory cytokine expression in the CNS显示文摘 | Raghavendra V Tanga FY DeLeo JA | 2004 | Eur J Neurosci2004，20，2： | 1 |
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