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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 3 | The reflection of guided waves from circumferential notches in pipes 显示文摘 | Alleyne D N Lowe M J S Cawley P | 1998 | Trans ASME J of Appl Mech1998，65，： | 2 |
| 4 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | LOWE S E THEODOROU M K TRINCI A P J | 1985 | Journal of General Microbiology1985，131，： | 1 |
| 5 | Guided waves in curved pipes显示文摘 | DEMMA A CAWLEY P LOWE M J S | 2002 | Review of Progress in Quantitative Nondestructive Evaluation2002，21，： | 1 |
| 6 | Trade-offs re- lated to ecosystem engineering: a case study on stiff- ness of emerging macrophytes显示文摘 | Bouma T J deVries M B LowE | 2005 | Ecology2005，86，： | 1 |
| 7 | Pathogenesis and therapy of psoriasis 显示文摘 | Lowes M A Bowcock A M Krueger J G | 2007 | Nature2007，445，7130： | 1 |
| 8 | High-dose cytarabine (24 g/m2) in combination with idarubicin (HiDAC-3) results in high first-cycle response with limited gastrointestinal toxicity in adult acute myeloid leukaemia显示文摘 | Low M Lee D Coutsouvelis J | 2013 | Intern Med J2013，43，3： | 1 |
| 9 | Oxidative injury and apoptosis of dorsal ganglion neurons in chronic experimental diabetic neuropathy显示文摘 | Schmeichel A M Schmeizer J D Low P A | 2003 | Diabetes2003，52，： | 1 |
| 10 | Non-destructive testing of rock bolts using guided ultrasonic waves显示文摘 | Beard M D Lowe M J S | 2003 | Intl Journal of Rock Mechanics & Mining Science2003，40，： | 1 |
| 11 | Localization of the mel - anocortin-4 receptor (MC4-R)in neuroendocrine and autonomic control circuits in the brain 显示文摘 | MountjoyK G Mortrud M T Low M J | 1994 | Mol Endoefinol1994，8，10： | 1 |
| 12 | Defect detection in pipes using guided waves显示文摘 | LOWE M J S ALLEYNE D N CAWLEY P | 1998 | Ultrasonics1998，36，： | 1 |
| 13 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | Lowe S E Theodoron M K Trinci A P J | 1985 | J Gen Microbiol1985，131，： | 1 |
| 14 | Optimistic Synchronization in HLA-based Distributed Simulation 显示文摘 | X Wang S J Turner M Y H Low | 2005 | Simulation (S0037-5497)2005，81，4： | 1 |
| 15 | The relative importance of non-sea-salt sulphate and sea-salt aerosol to the marine cloud condensation nuclei population:Animproved multi-component aerosol-cloud droplet parametrization显示文摘 | O'Dowd C D Lowe J A Smith M H | 1999 | Quart J Roy Meteor Soc1999，125，556： | 1 |
| 16 | Non-destructive testing ofrock bolts using guided ultrasonic waves显示文摘 | BEARD MD LOWE M J S | 2003 | InternationalJournal of Rock Mechanics and Mining Sciences & Ge-omechanics Abstracts2003，40，4： | 1 |
| 17 | The floating hip显示文摘 | Liebergall M Lowe J Whitelaw GB | | 0，，： | 1 |
| 18 | Myocardial infarction in young people with normal coronary arteries显示文摘 | Restieanx N J Low C J S | 1998 | Heart1998，79，5： | 1 |
| 19 | Rationalizing the Activities of Diverse Cholecystokinin 2 Receptor Antagonists Using Molecular Field Points显示文摘 | Low C M R Vinter J G | 2008 | J Med Chem2008，51，3： | 1 |
| 20 | Grasshopper biodiversity and bioindicators in Australian tropical savannas:responses to disturbance in Kakadu National Park显示文摘 | Andersen A N Ludwig J A Lowe L M | 2001 | Austral Ecology2001，26，： | 1 |
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