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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Transparently curved metamaterial with broadband millimeter wave absorption显示文摘We present a conformal metamaterial with simultaneous optical transparency and broadband millimeter-wave absorption for a curved surface. By tailoring the reflection response of meta-atoms at oblique angles, it is possible to achieve excellent absorption performance from 26.5 to 40.0 GHz within a wide angular range from 0° to 60°for transverse-electric and transverse-magnetic waves. In the meantime, by employing transparent substrates,including polyvinyl chloride and polyethylene terephthalate, good optical transmittance(80.1%) and flexibility are obtained simultaneously. The reflectivity of a curved metallic surface coated with the proposed curved metamaterial is simulated and measured experimentally. Both results demonstrate excellent absorption performance of the metamaterial, which is highly favored for practical applications. | CHENG ZHANG JIN YANG WENKANG CAO WEI YUAN JUNCHEN KE LIUXI YANG QIANG CHENG TIEJUN CUI | 2019 | Photonics Research2019，7，4： | 7 |
| 3 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 4 | ANovelEndo-1,4-p-Glucanase Gene(LlpCell) Is Exclusively Expressed in Pollen and Pollen Tubes of Lilium longiflorum显示文摘A full—lerlgth cDNA(L/pCe//)encoding an endo-1,4-β-glucanase(EGase)was isolated from pollen tubes of Lilium longiflorum Thunb.by RT-PCR and RACE.The deduced protein,which iS predicted to be a compact globular protein,is of 490 amino acids.in cluding a putative 21 amino acid-signal peptide.LlpCell shares high level of homology(about50%)with plant secreted EGases,which bear apparently neither trans-membrane domain.nor cellulose—binding domain(CBD).LIpCell belongs to gycosyl hydrolase family 9.LlpOell transcripts were detected in pollen grains.germinating pollen and elongating pollen tubes with a similar level.whereas LlpCell transcripts were not detectable in all other lily tissues examined.The specific expression pattern suggests that LlpCell is confined to lily pollen germination and pollen tube elongation. | ZHOUWei HiroyukiTAKEDA LIUXi—Zhen NaokiNAKAGAWA NaokiSAKIJRAI HUANGJian LIYi—Qin | 2004 | Acta Botanica Sinica2004，46，2： | 2 |
| 5 | 显示文摘 | 张磊(ZangL) 刘晓燕(LiuXY) 沈晶晶(ShenJJ) 卢晓梅(LuXM) 范曲立(FanQL) 黄维(HuangW) | 2013 | 化学进展2013，25，： | 1 |
| 6 | Adjuvantradiotherapy aftermodi- fled IvRR-Lewis esophagectomy: can itprevent lymph node recur- rence of themed the Racic esophageal carcinoma 显示文摘 | Hen G Wang Z LiuXY | 2009 | Ann Thorac Surg2009，87，6： | 1 |
| 7 | Determinationofcypermethrin residuesin crucian carp tissuesbyMSPD/GCECD显示文摘 | ZhaoDD LiuXY ShiW R LiuRF | 2011 | Chromatographia2011，73，： | 1 |
| 8 | 显示文摘 | Liu Li Li Yu Fang Yue'e Chen Liuxi | 2005 | Carbohydrate Polymers2005，60，3： | 1 |
| 9 | Gene diagnosis and prognostic signifieance of lymph node micrometastasis after complete resection of histologically node-negative non-small cell lung cancer显示文摘 | Li SH Wang Z LiuXY | 2008 | World J Surg2008，32，8： | 1 |
| 10 | Developmentofwhitelightemittingdiode[J]显示文摘 | YinCA ZhaoCJ LiuXY etal | | 发光学报0，，： | 1 |
| 11 | HotcompressiondeformationbehaviorofasGECAPedCPGTiatroomtemGperaturewith120°die显示文摘 | LiuXY ZhaoXC YangXR etal | 2012 | RareMetalMaterialsandEnGgineering2012，04，： | 1 |
| 12 | Protective effect of shenfu injection on multipleorg and amageinrabbit显示文摘 | ZouHL YuJP HuangHB XiongGX | 1997 | Zhong hua Ma zui xue Za zhi(ChinJAnesthesiol)1997，17，7： | 1 |
| 13 | Restraint harness performance during flight maneuvers: a parametric study显示文摘 | DuCF LiuXY WangLZ | 2015 | Aerosp Med Hum Perform2015，86，5： | 1 |
| 14 | Self-catalysis of phthaloylchitosan for graft copo/ymerization of ε-caprolactone with chitosan 显示文摘 | Li Liu Liuxi Chen Yue' e Fang | 2006 | Macromolecur Rapid Communications2006，27，： | 1 |
| 15 | Researchdevelopmentofceramicprocessedbytapecasting显示文摘 | LiuXi Qiaoyingjie ZhangHe etal | 2010 | JournalofFunctionalMaterials2010，41，3： | 1 |
| 16 | ObservationofcurativeeffectinthetreatmentofanginapectorisofGuanmaining[J]显示文摘 | YAOSL WANGXL LIUXY etal | | 中草药0，，5： | 1 |
| 17 | 显示文摘 | 丛姣姣(CongJJ) 罗静(LuoJ) 高雅涵(GaoYH) 刘晓亚(LiuXY) | 2015 | 高分子通报2015，5，： | 1 |
| 18 | EffectsandmechanismsofGantaikangOilliverinjuryin-ducedbycarbontetracblorideinmice显示文摘 | HuYX(胡怡秀) LiuXY(刘秀英) HuYM(胡余明) eta1 | 2002 | 中国热带医学2002，2，： | 1 |
| 19 | Apparentarrivedbettertablettreatmentclinicalobservationofthevisualfatigue[J]显示文摘 | ZHENGXQ LIUL LiuXY etal | | 山东中医药大学学报0，，： | 1 |
| 20 | Pathogenicity of different iso lares of Vibrio harveyi in tiger prawn, Penaeus monodon 显示文摘 | Liuxy P C Lee K K Chen S N | 1996 | Lett Appl Microbiol1996，22，： | 1 |
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