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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Geological Features and Reservoiring Mode of Shale Gas Reservoirs in Longmaxi Formation of the Jiaoshiba Area显示文摘This study is based on the sedimentation conditions, organic geochemistry, storage spaces, physical properties, lithology and gas content of the shale gas reservoirs in Longmaxi Formation of the Jiaoshiba area and the gas accumulation mode is summarized and then compared with that in northern America. The shale gas reservoirs in the Longmaxi Formation in Jiaoshiba have good geological conditions, great thickness of quality shales, high organic content, high gas content, good physical properties, suitable depth, good preservation conditions and good reservoir types. The quality shales at the bottom of the deep shelf are the main target interval for shale gas exploration and development. Shale gas in the Longmaxi Formation has undergone three main reservoiring stages:the early stage of hydrocarbon generation and compaction when shale gas reservoirs were first formed; the middle stage of deep burial and large-scale hydrocarbon generation, which caused the enrichment of reservoirs with shale gas; the late stage of uplift, erosion and fracture development when shale gas reservoirs were finally formed. | GUO Xusheng HU Dongfeng LI Yuping LIU Ruobing WANG Qingbo | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 28 |
| 3 | The complete mitochondrial genome of the Chinese oak silkmoth, Antheraea pernyi (Lepidoptera: Saturniidae)显示文摘我们从中国橡树丝绸蛾决定了 mitogenome 的完全的核苷酸顺序, Antheraea pernyi (鳞翅目:Saturniidae ) 。15,566 bp 通报染色体为鳞翅类的 mitogenomes 包含不正常的基因组织和顺序。mitogenome 在已知的鳞翅类的 mitogenome 序列之中包含最低 A+T 内容(80.16%) 。一个不平常的特征比作为是更多的 T 的出现,与一在偏斜度(−0.021 ) 稍微否定,在主要染色体海滨的作文。所有编码蛋白质的基因被 ATN 鳕鱼 ons 开始,除了细胞色素 oxidase 子单元我,它被在另外的 lepidopterans 观察了的 TTAG 顺序建议。所有转移 RNA (tRNAs ) 有 mitochondrial tRNA 的典型四叶苜蓿形的立体道路交叉点结构,除了 tRNA 重量的单位 (AGN), 哪个不能形成稳定的茎环结构的 DHU 手臂。二与一段超过 50 bp 排列了顺序块, 90% 顺序身份在 Saturniidae 和 Bombycoidae 种类的 A+T 富有的区域被识别。 | Yanqun Liu Yuping Li Minhui Pan Fangyin Dai Xuwei Zhu Cheng Lu Zhonghuai Xiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 21 |
| 4 | An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation显示文摘 | Rong Peijing Liu Aihua Zhang Jianguo Wang Yuping Yang Anchao Li Liang Ben Hui Li Liping Liu Rupeng He Wei Liu Huanguang Huang Feng Li Xia Wu Peng Zhu Bing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 5 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 6 | Fluxes of CH4 and N_2O from soil under a tropical seasonal rain forest in Xishuangbanna, Southwest China显示文摘从在在 Xishuangbanna 的热带季节的雨林下面的土壤的 CH4 和 N2O 流动,西南中国用关上的静态的房间技术和气体色层法方法被测量一年。三个处理被放在学习的地里:(A) 没有崽,有垃圾的(B) ,和有垃圾和幼苗的(C) 。结果证明在我们的学习的土壤是大气的 CH4 的一个水池和大气的 N2O 的来源。从处理 A, B,和 C 的观察吝啬的 CH4 流动是 50.0 ± 4.0, 35.9 ± 2.8, 31.6 ± 2.8 μ g C/(m2 · h ) ,分别地并且在 2003 的计算年度流动分别地是 4.1, 3.1,和 2.9 kgC/hm2。从处理 A, B,和 C 的观察吝啬的 N2O 流动是 30.9 ± 3.1, 28.2 ± 3.5, 50.2 ± 3 .7 μ g N/(m2 · h ) ,分别地并且在 2003 的计算年度流动分别地是 4.1, 3.1,和 2.9 kgC/hm2。从处理 A, B,和 C 的观察吝啬的 N2O 流动是 30.9 ± 3.1, 28.2 ± 3.5, 50.2 ± 3 .7 μ g N/(m2 · h ) ,分别地并且在 2003 的计算年度流动是 2.8, 2.6,和 3.7 kgN/hm 2 分别地。在 CH4 和 N2O 流动的季节变化在所有三个处理之中是重要的。垃圾的存在减少了 CH4 举起在湿季节期间(P < 0.05 ) ,然而并非在干旱期期间。调停幼苗的 N2O 排出物有类似的增加在期间湿并且干旱期,显示幼苗在两个季节增加了 N2O 排放。一种强壮的积极关系为处理 B 和处理 C 为所有三个处理,和在 CH4 流动和土壤温度之间的弱关系在 CH4 流动和土壤潮湿之间存在。N2O 流动为所有三个处理与土壤温度相关。 | YAN Yuping SHA Liqing CAO Min ZHENG Zheng TANG Jianwei WANG Yinghong ZHANG Yiping WANG Rui LIU Guangren WANG Yuesi SUN Yang | 2008 | Journal of Environmental Sciences2008，20，2： | 18 |
| 7 | Prediction of Primary Climate Variability Modes at the Beijing Climate Center显示文摘Climate variability modes, usually known as primary climate phenomena, are well recognized as the most important predictability sources in subseasonal–interannual climate prediction. This paper begins by reviewing the research and development carried out, and the recent progress made, at the Beijing Climate Center(BCC) in predicting some primary climate variability modes. These include the El Ni?o–Southern Oscillation(ENSO), Madden–Julian Oscillation(MJO), and Arctic Oscillation(AO), on global scales, as well as the sea surface temperature(SST) modes in the Indian Ocean and North Atlantic, western Pacific subtropical high(WPSH), and the East Asian winter and summer monsoons(EAWM and EASM, respectively), on regional scales. Based on its latest climate and statistical models, the BCC has established a climate phenomenon prediction system(CPPS) and completed a hindcast experiment for the period 1991–2014. The performance of the CPPS in predicting such climate variability modes is systematically evaluated. The results show that skillful predictions have been made for ENSO, MJO, the Indian Ocean basin mode, the WPSH, and partly for the EASM, whereas less skillful predictions were made for the Indian Ocean Dipole(IOD) and North Atlantic SST Tripole, and no clear skill at all for the AO, subtropical IOD, and EAWM. Improvements in the prediction of these climate variability modes with low skill need to be achieved by improving the BCC's climate models, developing physically based statistical models as well as correction methods for model predictions.Some of the monitoring/prediction products of the BCC-CPPS are also introduced in this paper. | Hong-Li REN Fei-Fei JIN Lianchun SONG Bo LU Ben TIAN Jinqing ZUO Ying LIU Jie WU Chongbo ZHAO Yu NIE Peiqun ZHANG Jin BA Yujie WU Jianghua WAN Yuping YAN Fang ZHOU | 2017 | Journal of Meteorological Research2017，31，1： | 13 |
| 8 | Indirectly extruded biodegradable Zn-0.05wt%Mg alloy with improved strength and ductility: In vitro and in vivo studies显示文摘As compared to permanent orthopedic implants for load-bearing applications, biodegradable orthopedic implants have the advantage of no need for removing after healing, but they suffer from the 'trilemma' problem of compromising among sufficiently high mechanical properties, good biocompatibility and proper degradation rate conforming to the growth rate of new bones. In the present work, in vitro and in vivo studies of a Zn-0.05 wt%Mg alloy(namely, Zn-0.05 Mg alloy) were conducted with pure Zn as a control. The Zn-0.05 Mg alloy is composed of a small amount of Mg_2 Zn11 phase embedded in the refined Zn matrix with an average grain size of ~20 μm. The addition of 0.05 wt% Mg into Zn significantly increases the ultimate tensile strength up to 225 MPa and the elongation to fracture to 26%, but has little influence on the in vitro degradation rate. Both Zn and Zn-0.05 Mg alloy exhibit homogeneous in vitro degradation with a rate of about 0.15 mm/year. Based on the cytotoxicity evaluation, Zn and Zn-0.05 Mg alloy do not induce toxicity to L-929 cells, indicating that they have little toxicity to the general functions of the animal. An in vivo biocompatibility study of Zn and Zn-0.05 Mg alloy samples by placing them in a rabbit model for 4.12 and 24 weeks, respectively did not show any inflammatory cells, and demonstrated that new bone tissue formed at the bone/implant interface, suggesting that Zn and Zn-0.05 Mg alloy promote the formation of new bone tissue. The in vivo degradation of Zn and Zn-0.05 Mg alloy does not bring harm to the important organs and their cell structures. More interestingly, Zn and Zn-0.05 Mg alloy exhibit strong antibacterial activity against Escherichia coli and Staphylococcus aureus. The above results clearly demonstrate that the Zn-0.05 Mg alloy could be a potential biodegradable orthopedic implant material. | Chi Xiao Liqing Wang Yuping Ren Shineng Sun Erlin Zhang Chongnan Yan Qi Liu Xiaogang Sun Fenyong Shou Jingzhu Duan Huang Wang Gaowu Qin | 2018 | Journal of Materials Science & Technology2018，34，9： | 11 |
| 9 | Hollow TiO2-x porous microspheres composed of wellcrystalline nanocrystals for high-performance lithiumion batteries显示文摘 | Chun Wang Faxing Wang Yujuan Zhao Yuhui Li Qin Yue Yupu Liu Yong Liu Ahmed A. Elzatahry Abdullah Al-Enizi Yuping Wu Yonghui Deng Dongyuan Zhao | 2016 | Nano Research2016，9，1： | 8 |
| 10 | CH4/N2 separation on methane molecules grade diameter channel molecular sieves with a CHA-type structure显示文摘Samples of methane molecules grade diameter channel CHA-type molecular sieves(Chabazite-K, SAPO-34 and SSZ-13) were investigated using the adsorption separation of CH4/N2 mixtures. The isotherms recorded for CH4 and N2 follow a typical type-Ι behavior, which were fitted well with the Sips model(R2>0.999) and the selectivity was calculated using IAST theory. The results reveal that Chabazite-K has the highest selectivity(SCH4/N= 5.5).2 SSZ-13 has the largest capacity, which can adsorb up to a maximum of 30.957 cm3·g-1(STP) of CH4, due to it having the largest pore volume and surface area, but the lowest selectivity(SCH4/N2= 2.5). From the breakthrough test, we can conclude that SSZ-13 may be a suitable candidate for the recovery of CH4 from low concentration methane(CH4<20%) based on its larger pore volume and higher CH4 capacity. Chabazite-K is more suited to the separation of high concentration methane(CH4>50%) due to its higher selectivity. | Hua Shang Yuping Li Jiaqi Liu Xuan Tang Jiangfeng Yang Jinping Li | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 8 |
| 11 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 12 | Whole-Process Pollution Control for Cost-Effective and Cleaner Chemical Production A Case Study of the Tungsten Industry in China显示文摘In this research,a methodology named whole-process pollution control(WPPC)is demonstrated that improves the effectiveness of process optimization.This methodology considers waste/emission treatment as a step of the whole production process with respect to the minimization of cost and environmental impact for the whole process.The following procedures are introduced in a WPPC process optimization:①a material and energy flow investigation and optimization based on a systematic understanding of the distribution and physiochemical properties of potential pollutants;②a process optimization to increase the utilization efficiency of different elements and minimize pollutant emissions;and③an evaluation to reveal the effectiveness of the optimization strategies.The production of ammonium paratungstate was chosen for the case study.Two factors of the different optimization schemes-namely the cost-effectiveness factor and the environmental impact indicator-were evaluated and compared.This research demonstrates that by considering the nature of potential pollutants,technological innovations,economic viability,environmental impacts,and regulation requirements,WPPC can efficiently optimize a metal production process. | Hongbin Cao He Zhao Di Zhang Chenming Liu Xiao Lin Yuping Li Pengge Ning Jiajun Sun Yi Zhang Zhi Sun | 2019 | Engineering2019，5，4： | 7 |
| 13 | A hybrid quantum-based PIO algorithm for global numerical optimization显示文摘A novel hybrid quantum-based pigeon-inspired optimization(PIO) algorithm for global numerical optimization is proposed to perceive deceptiveness and preserve diversity. In the proposed algorithm,the current best solution is regarded as a linear superposition of two probabilistic states, namely positive and deceptive. Through a quantum rotation gate, the positive probability is either enhanced or reset to balance exploration and exploitation. Simulation results reveal that the hybrid quantum-based PIO algorithm demonstrates an outstanding performance in global optimization owing to preserving diversity in the early evolution. As a result, the stability of the algorithm is enhanced so that the precision of optimization is improved statistically. The proposed algorithm is demonstrated to be effective for solving multimodal and non-convex problems in higher dimension with a smaller population size. | Boyi CHEN Hao LEI Haidong SHEN Yanbin LIU Yuping LU | 2019 | Science China(Information Sciences)2019，62，7： | 7 |
| 14 | On-chip erbium-doped lithium niobate microcavity laser显示文摘The commercialization of lithium niobate on insulator(LNOI) wafer has resulted in significant on-chip photonic integration application owing to its remarkable photonic,acousto-optic,electro-optic,and piezoelectric nature.In recent years,a variety of high-performance on-chip LNOI-based photonic devices have been realized.In this study,we developed a 1-mol% erbium-doped lithium niobate crystal and its LNOI on a silicon substrate and fabricated an erbium-doped LNOI microdisk with high quality factor(~1.05×105).C-band laser emission at ~1530 and ~1560 nm(linewidth 0.12 nm) from the high-Q erbium-doped LNOI microdisk was demonstrated with 974-and 1460-nm pumping,with the latter having better thermal stability.This microlaser would play an important role in the photonic integrated circuits of the lithium niobate platform. | YiAn Liu XiongShuo Yan JiangWei Wu Bing Zhu YuPing Chen XianFeng Chen | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，3： | 7 |
| 15 | Cloning and functional characterization of Rht8,a“Green Revolution”replacement gene in wheat显示文摘Dear Editor,Wheat(Triticum aestivum)is a major staple crop in the world and provides~20%of the food calories for human consumption(Appels et al.,2018).During the 1960s and 1970s,the introduction of two semi-dwarfing genes Rht-B1b and Rht-D1b in wheat varieties strikingly improved lodging resistance and harvest index,and therefore substantially increased grain yield,resulting in the well-known'Green Revolution'(Peng et al.,1999).However,plants carrying Rht-B1b and Rht-D1b suffer from several drawbacks. | Hongchun Xiong Chunyun Zhou Meiyu Fu Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Shirong Zhao Yuping Ding Yuting Li Jiazi Zhang Ke Wang Xuejun Li Luxiang Liu | 2022 | Molecular Plant2022，15，3： | 7 |
| 16 | Applications of gold nanorods in biomedical imaging and related fields显示文摘Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered. | MA ZhiYa XIA HongXing LIU YuPing LIU Bo CHEN Wei ZHAO YuanDi | 2013 | Chinese Science Bulletin2013，58，21： | 6 |
| 17 | An experiment-library least-squares method on on-line coal element contents analysis显示文摘A new experiment-library least-squares(experiment-LLs) method used in the neutron inelastic-scattering and thermal-capture analysis(NITA) technique for on-line coal analysis was developed,which has significantly decreased the non-linear radiation effects.In this method,sixty samples with preset elemental contents were made,from whose experimental spectra twenty single-element spectrum libraries corresponding to twenty kinds of coal were built using the least-squares method.The spectrum of the unknown sample was analyzed based on these twenty libraries to estimate its element contents.With the initial estimated result,the procedure of developing library and analysis was iterated to build a new library with the closest element contents to the unknown sample.Hence the experiment-LLs method can reduce non-linear radiation effects.The experiment-LLs method was performed on an improved coal analysis system which was equipped with a long-life 14 MeV pulsed-neutron generator,a bulk BGO detector with a temperature controller,a moisture meter and coal-smoothing device.The precisions of this system for ash content,water content,volatile content and calorific value have reached 1.0wt%,0.5wt%,1.0wt%,350 kJ/kg,respectively. | WANG HuiDong LU JingBin LU YuPing YANG Dong MA KeYan YANG Kang LIU YuMin CHENG DaoWen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 6 |
| 18 | Solid Acid Used as Highly Efficient Catalyst for Esterification of Free Fatty Acids with Alcohols显示文摘Anovel solid acid catalyst, which was prepared from sodium alginate (SA) and metal chlorides and characterized with XRD and FT-IR spectrometry, was used for the preparation of biodiesel via esterification reaction. The study results showed that the aluminum-alginate complex prepared in a cheap and easy way exhibited high catalytic activity, and a 92.6% conversion of methyl oleate was obtained in the presence of 4m% of catalyst dosage upon refluxing for 3h of methanol and acid mixed in a molar ratio of 10:1. It should be noted that the catalyst can be applied to the esterification reaction of fatty acids with various carbon chain length on methanol or different short chain alcohols, indicating that the catalyst is suitable for the preparation of biodiesel from waste oils with a high acid value. | Zhang Qiuyun Li Hu Qin Wenting Liu Xiaofang Zhang Yuping Xue Wei Yang Song | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 6 |
| 19 | LA-ICP-MS U-Pb zircon dating of the Bozhushan granite in Southeast Yunnan显示文摘The LA-ICP-MS U-Pb zircon dating of eight typical samples from four units of the Bozhushan granite intrusion in southeastern Yunnan Province, constrains the age of acidic magmatic intrusion in this area. Both the oscillatory zoning and chondrite-normalized REE patterns characterized by LREE-depletion and HREE-enrichment with positive Ce anomaly and negative Eu anomaly indicate the magmatic genesis of these zircons. Eight zircon samples from the Bozhushan granite yielded a mean 206 Pb/ 238 U age of (85.58±1.0) Ma (MSWD=4.1) to (88.10±0.66) Ma (MSWD=1.8). These chronology data suggest an accurate isotopic age for the intrusion of the Bozhushan granite, and are different from the published age data of 48 to 111.5 Ma. The geochronology data of the Gejiu, Dulong and Dachang super-large deposits and related Yanshanian granites indicated that there occurred large-scale granitic magmatism and mineralization events in western Nanling region during the Late Cretaceous. | LI Kaiwen ZHANG Qian WANG Dapeng CAI Yi LIU Yuping | 2013 | Chinese Journal Of Geochemistry2013，32，2： | 5 |
| 20 | The Seismic Induced Soft Sediment Deformation Structures in the Middle Jurassic of Western Qaidamu Basin显示文摘Intervals of soft-sediment deformation structures are well-exposed in Jurassic lacustrine deposits in the western Qaidamu basin. Through field observation, many soft-sediment deformation structures can be identified, such as convoluted bedding, liquefied sand veins, load and flame structures, slump structures and sliding-overlapping structures. Based on their genesis, soft-sediment deformation structures can be classified as three types: seismic induced structures, vertical loading structures, and horizontal shear structures. Based on their geometry and genesis analysis, they are seismic-induced structures. According to the characteristics of convoluted bedding structures and liquefied sand veins, it can be inferred that there were earthquakes greater than magnitude 6 in the study area during the middle Jurassic. Furthermore, the study of the slump structures and sliding-overlapping structures indicates that there was a southeastern slope during the middle Jurassic. Since the distance from the study area to the Altyn Mountain and the Altyn fault is no more than 10km, it can be also inferred that the Altyn Mountain existed then and that the Altyn strike-slip fault was active during the middle Jurassic. | LI Yong SHAO Zhufu MAO Cui YANG Yuping LIU Shengxin | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 5 |
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