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| 1 | Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography显示文摘AIM:To investigate foveal avascular zone(FAZ) and parafoveal vessel densities(PRVD) by means of optical coherence tomography angiography(OCTA) in diabetic patients with or without diabetic retinopathy(DR) and to assess the reproducibility of FAZ and PRVD measurements.METHODS:Sixty diabetic patients(60 eyes) with different stage of DR(graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners.FAZ area in all patients was also assessed using fluorescein angiography(FA).RESULTS:In subject with proliferative DR and with moderate-severe non proliferative DR,FAZ area was significantly increased compared to healthy controls(P=0.025 and P=0.050 respectively measured with OCTA and P=0.025 and P=0.048 respectively measured with FA).OCTA showed significantly less inter-observer variability compared to FA.Concordance correlation coefficient(CCC) for FAZ area measurements was 0.829(95%CI:0.736-0.891) P<0.001 with FA and 1.000(95%CI:0.999-1.000) P<0.001 with OCTA.CCC was 0.834(95%CI:0.746-0.893) P<0.001 and 0.890(95%CI:0.828-0.930) P<0.001 for parafoveal superficial and deep vessel density measurements,respectively.CONCLUSION:OCTA shows progressive increase of FAZ area and reduction of PRVD in both superficial and deep plexus at increasing DR severity.FAZ area and PRVD measurements using OCTA are highly reproducible. | Rodolfo Mastropasqua Lisa Toto Alessandra Mastropasqua Raffaella Aloia Chiara De Nicola Peter A Mattei Guido Di Marzio Marta Di Nicola Luca Di Antonio | 2017 | International Journal of Ophthalmology(English edition)2017，10，10： | 26 |
| 2 | 鲁豫皖三省麻疹监测试点项目效果评价显示文摘为了评价鲁、豫、皖三省麻疹监测合作项目的实施效果 ,综合三省项目进展报告、世界卫生组织现场评估报告、法定传染病报告系统、急性弛缓性麻痹病例监测系统和项目省开展的专项研究进行了分析。结果显示 :项目省麻疹疫苗强化免疫的效果不同 ;除有免疫史记录的病例比例 <80 %外 ,其它麻疹监测系统的关键指标都有明显提高 ;常规免疫接种率的报告质量提高不明显 ,漏报和报告表格过于复杂是重要的影响因素 ;实施风疹控制后 ,风疹的平均感染年龄从 1999年的 9 8岁 ,提高至 2 0 0 3年的 13 9岁。 | 左树岩 许青 郭万申 唐继海 夏伟 梁晓峰 lisa A Lee | 2004 | 中国计划免疫2004，10，5： | 18 |
| 3 | 豫鲁皖三省小学新生预防接种状况评估显示文摘为了解中国小学新生的预防接种状况 ,在豫鲁皖三省 ,按照便利原则抽取小学新生进行了描述性研究。共调查小学 18所 ,其中农村小学 8所、城市小学 10所 ;小学新生 2 2 35人 ,其中城市小学 14 12人 ,农村小学 82 4人。有预防接种证 12 84人 ,预防接种证持有率为 5 7 4 %。无预防接种证但在当地接种点查找到预防接种记录的 5 87人 ,占 2 6 3%。因此有预防接种记录的共 1871人 ,占 83 7%。在所有小学新生中完成口服脊髓灰质炎疫苗 (OPV)全程免疫的占 6 2 9% ,完成卡介苗 (BCG)免疫的占 81 9% ,完成麻疹疫苗 (MV)全程免疫的占 5 5 2 % ,完成乙型肝炎疫苗 (HepB)全程免疫的占 6 7 3% ,完成百白破联合疫苗 (DPT)全程免疫的占 70 3% ,接种白破联合疫苗 (TD)的占 32 7% ;也即缺种或漏种OPV、BCG、MV、HepB、DPT、TD儿童的比例依次为 :37 1%、18 1%、4 4 8%、32 7%、2 9 7%、6 7 3%。调查发现 ,城市小学新生预防接种证持有率、各种疫苗全程免疫接种率均高于农村小学 ;在城市小学新生中流动儿童预防接种证持有率、各种疫苗全程免疫接种率低于整体水平。如果在入学时严格查验预防接种情况 ,并对缺种或漏种的新生进行补种 ,可有效提高小学新生的接种率。对婴儿时未免疫的贫穷地区儿童、计划外出生儿童。 | 盛利 Lisa A Lee 左树岩 郭万申 余文周 许青 冯子健 | 2003 | 中国计划免疫2003，9，5： | 11 |
| 4 | Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer. | Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 5 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 6 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 7 | 感染兽类和人类的冠状病毒--控制疫情需要对它们的生物学和行为有详细的了解显示文摘冠状病毒已经存在了很多年,首次发现于20世纪60年代。这些病毒包括引起普通感冒的冠状病毒(HCoV-229E)和各种兽类与鸟类冠状病毒,例如可以感染家禽的传染性支气管炎病毒(infectious bronchitis virus,IBV)。冠状病毒通常会引起呼吸道或者胃肠道疾病,但是一些IBV毒株已证明能破坏鸡的输卵管,而其他的毒株可引起严重的肾脏疾病。 | Ng Lisa F P Hiscox Julian A 哈飞再(译者) 郑湃(审校者) | 2020 | 英国医学杂志中文版2020，23，6： | 4 |
| 8 | Environmental magnetism: Principles and applications显示文摘 | Liu Qingsong Roberts Andrew P Larrasoa?a Juan C Banerjee Subir K Guyodo Yohan Tauxe Lisa Oldfield Frank | 2012 | EN2012，，4： | 3 |
| 9 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 10 | Biomarkers for colitis-associated colorectal cancer显示文摘Patients with extensive ulcerative colitis(UC) of more than eight years duration have an increased risk of colorectal cancer. Molecular biomarkers for dysplasia and cancer could have a great clinical value in managing cancer risk in these UC patients. Using a wide range of molecular techniques- including cutting-edge OMICS technologies- recent studies have identified clinically relevant biomarker candidates from a variety of biosamples, including colonic biopsies, blood, stool, and urine. While the challenge remains to validate these candidate biomarkers in multi-center studies and with larger patient cohorts, it is certain that accurate biomarkers of colitis-associated neoplasia would improve clinical management of neoplastic risk in UC patients. This review highlights the ongoing avenues of research in biomarker development for colitis-associated colorectal cancer. | Ru Chen Lisa A Lai Teresa A Brentnall Sheng Pan | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 11 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 12 | Perspectives on the clinical development of mmunotherapy in prostate cancer显示文摘 | Lisa M Cordes James L Gulley Ravi A Madan | 2018 | Asian Journal of Andrology2018，20，3： | 2 |
| 13 | Sledge Developing New Processes for COTS-Based Systems显示文摘 | Tricia Oberndorf Carol A | 2000 | IEEE Software2000，78，： | 1 |
| 14 | Differential expression of components of the cardiomyocyte adrenomedullin/intermedin receptor system following blood pressure red-uction in Nodeificient hypertension显示文摘 | Abdelrahman A M David B Lisa R S | 2005 | JPET Fast Forward2005，12，3： | 1 |
| 15 | Holmium:YAG laser ureterolithotripsy显示文摘 | Scarpa RM De Lisa A Porru D | 1999 | Eur Urol1999，35，3： | 1 |
| 16 | Partners in crime:the TGFβ and MAPK pathways in cancer progression显示文摘 | Douglas A Chapnick Lisa Warner Jennifer Bemet | | 0，，： | 1 |
| 17 | Newman breast cancer in sub-saharan africa: how does it relate to breast cancer in african-american women? 显示文摘 | Alero Fregene Lisa A | 2005 | Cancer2005，103，8： | 1 |
| 18 | Cross-correlation of optical micrecavity biosensor response with immobilized enzyme activity显示文摘 | Lisa A Delouise Peng Meng Kou Benjamin L Miller | 2005 | Anal Chem2005，77，： | 1 |
| 19 | The effects of trust and interde pendenee on relationship commitment: A trans-Athantie study 显示文摘 | INGE GEYSKENSA JAN-BENEDICT E M STEENKAMPB A LISA K SCHEERC | 1996 | Int J Res Marketing1996，13，4： | 1 |
| 20 | Reductive elimination of chlorinated ethylenes by zero-valent metals显示文摘 | ROBERTS A L LISA A T WILLIAM A A | 1996 | Environmental Science and Technol-ogy1996，30，8： | 1 |
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