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| 1 | Ankylosing spondylitis: etiology, pathogenesis, and treatments显示文摘Ankylosing spondylitis(AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain;additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen(HLA)?B27 and the interleukin?23/17 axis.However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies. | Wei Zhu Xuxia He Kaiyuan Cheng Linjie Zhang Di Chen Xiao Wang Guixing Qiu Xu Cao Xisheng Weng | 2019 | Bone Research2019，7，3： | 30 |
| 2 | Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned spaceflight显示文摘The Chinese space station will be built around 2020. As a national space laboratory, it will offer unique opportunities for studying the physiological effects of weightlessness and the efficacy of the countermeasures against such effects. In this paper, we described the development of countermeasure systems in the Chinese space program. To emphasize the need of the Chinese space program to implement its own program for developing countermeasures, we reviewed the literature on the negative physiological effects of weightlessness, the challenges of completing missions, the development of countermeasure devices, the establishment of countermeasure programs, and the efficacy of the countermeasure techniques in American and Russian manned spaceflights. In addition, a brief overview was provided on the Chinese research and development on countermeasures to discuss the current status and goals of the development of countermeasures against physiological problems associated with weightlessness. | Linjie Wang Zhili Li Cheng Tan Shujuan Liu Jianfeng Zhang Siyang He Peng Zou Weibo Liu Yinghui Li | 2019 | Frontiers of Medicine2019，13，2： | 9 |
| 3 | Hexagonal boron nitride:A metal-free catalyst for deep oxidative desulfurization of fuel oils显示文摘Oxidative desulfurization(ODS)has been proved to be an efficient strategy for the production of clean fuel oil.Numerous metal-based materials have been employed as excellent ODS catalysts,but being hindered by their high-cost and potential secondary pollution.In this work,we employed graphene analogous hexagonal boron nitride(h-BN)as a metal-free catalyst for ODS with hydrogen peroxide(H2O2)as the oxidant.The h-BN catalyst was characterized and proved to be a few-layered structure with relatively high specific surface areas.The h-BN catalyst showed a 99.4%of sulfur removal in fuel oil under the optimized reaction conditions.Besides,the h-BN can be recycled for 8 times without significant decrease in the catalytic performance.Detailed mechanism analysis found that it is the boron radicals in h-BN activated H2O2 to generate·OH species,which can readily oxidize sulfides to corresponding sulfones for separation.This work would provide another choice in choosing metal-free catalysts for ODS. | Peiwen Wu Linjie Lu Jing He Linlin Chen Yanhong Chao Minqiang He Fengxia Zhu Xiaozhong Chu Huaming Li Wenshuai Zhu | 2020 | Green Energy & Environment2020，5，2： | 3 |
| 4 | Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer显示文摘Colorectal cancer is one of the leading causes of cancer death worldwide.According to global genomic status,colorectal cancer can be classified into two main types:microsatellite-stable and microsatellite-instable tumors.Moreover,the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular mechanisms.Recently,mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal cancer.However,the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer,which accounts for the majority of colorectal cancer,remain unclear.In this study,we systematically investigated the functional role of altered mitochondrial DNA copy number in the survival and metastasis of microsatellite-stable colorectal cancer cells.Moreover,the underlying molecular mechanisms were also explored.Our results demonstrated that increased mitochondrial DNA copy number by forced mitochondrial transcription factor A expression significantly facilitated cell proliferation and inhibited apoptosis of microsatellitestable colorectal cancer cells both in vitro and in vivo.Moreover,we demonstrated that increased mitochondrial DNA copy number enhanced the metastasis of microsatellite-stable colorectal cancer cells.Mechanistically,the survival advantage conferred by increased mitochondrial DNA copy number was caused in large part by elevated mitochondrial oxidative phosphorylation.Furthermore,treatment with oligomycin significantly suppressed the survival and metastasis of microsatellite-stable colorectal cancer cells with increased mitochondrial DNA copy number.Our study provides evidence supporting a possible tumor-promoting role for mitochondrial DNA and uncovers the underlying mechanism,which suggests a potential novel therapeutic target for microsatellite-stable colorectal cancer. | Xiacheng Sun Lei Zhan Yibing Chen Gang Wang Linjie He Qian Wang Feng Zhou Fang Yang Jin Wu Yousheng Wu Jinliang Xing Xianli He Qichao Huang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 3 |
| 5 | 3D-printing of integrated spheres as a superior support of phosphotungstic acid for deep oxidative desulfurization of fuel显示文摘Construction of catalysts with integral structure for oxidative reaction process is an essential promotion to catalysts in industrial application.In this work,a 3D printing method was employed to prepare 3D printed spheres(3D-PSs),followed by carbonization to form 3D carbon spheres(3D-CSs).Then,a 3D-CSs supported phosphotungstic acid(HPW/3D-CSs)was prepared for deep oxidative desulfurization.Compared with traditional powder catalysts,the as-prepared catalyst is easy to be operated and separated from oil products.The supported catalyst possesses excellent catalytic performance and the removal of DBT,4-MDBT and 4,6-DMDBT in fuel oil,reaching^100%of sulfur removal.The effects of various experimental parameters on desulfurization efficiency were considered to optimize reaction conditions.Moreover,the catalyst shows excellent thermal and chemical stability,with no obvious decrease in desulfurization activity after 5 cycles.GC–MS analysis indicates DBT sulfone was the solely oxidized product of DBT. | Jie Zhu Peiwen Wu Linlin Chen Jing He Yingcheng Wu Chao Wang Yanhong Chao Linjie Lu Minqiang He Wenshuai Zhu Huaming Li | 2020 | Journal of Energy Chemistry2020，29，6： | 2 |
| 6 | Effect of heating rate on the electrochemical performance of MnO_X@CNF nanocomposites as supercapacitor electrodes显示文摘Carbon nanofibers(CNFs)and MnOX@CNF nanocomposites(MCNFs)are fabricated by electrospinning and investigated as free-standing electrodes for supercapacitor.This work presents the effect of heating rate during carbonization on the electrochemical behavior of the as-prepared MCNFs electrodes in 6 mol/L KOH electrolyte.Results show that the MCNFs electrodes carbonized by relatively slower heating rate exhibit higher specific capacitance.The electronic conductivity of the slow heated MCNFs electrodes is better than that of the fast heated electrodes due to the better crystallinity of the MnOXnanoparticles and the graphitic carbon layers forming on the surface of the Mn-loaded CNFs.These MCNFs electrodes demonstrate elevated rate capability and improved cycling performance without adding any polymer binder or electronic conductor. | Lin Shi Haiyong He Yan Fang Yuying Jia Bin Luo Linjie Zhi | 2014 | Chinese Science Bulletin2014，59，16： | 2 |
| 7 | 3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering显示文摘Acellular tissue matrix scaffolds are much closer to tissue’s complex natural structure and biological characteristics,thus assess great advantages in cartilage engineering.We used rabbit costal cartilage to prepare acellular microfilaments and further 3D porous acellular cartilage scaffold via crosslinking.Poly(_L-lysine)/hyaluronic acid(PLL/HA)multilayer film was then built up onto the surface of the resulting porous scaffold.Furthermore,TGF-β3 was loaded into the PLL/HA multilayer film coated scaffold to obtain a 3D porous acellular cartilage scaffold with sustained releasing of TGF-β3 up to 60 days.The success of this project will provide a new way for the treatment of articular cartilage defects.Meanwhile,the anchoring and on-site sustained releasing of growth factors mediated by polyelectrolyte multilayered film can also provide a new method for improving the biocompatibility and the biofunctionality for other implanted biomaterials. | Yixing Huang Xingfang Yu Linjie He Xin Liao Shuo Wang Zhiyong Qian Liyan Shen | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 8 | Study on sulfur deposition damage model of fractured gas reservoirs with high-content H_(2)S显示文摘Due to extreme poison,strong corrosion,and complex precipitation and deposition of H_(2)S in the reservoir,it is very difficult and risky to investigate and explore drilling,completion,production and gas transportation.In the course of production of fractured gas reservoir with high H_(2)S content,formation pressure falls continually,which lead to decline of solubility of sulfur particles in gas phase.Sulfur particles which dissolve in gas phase originally in the formation should precipitate from gas phase after running up to saturation state and deposit at pore space and throat,sequentially resulting in formation porosity and permeability reduction.At present,the researches of sulfur deposition are mainly focused on the conventional gas reservoirs and sulfur deposition in the near wellbore region is generally estimated using Roberts'model.However,most of the gas reservoirs with high-content H2S are fractured gas reservoirs,classical damage model is no longer applicable to fractured gas reservoirs with high H2S content.In the present study,a sulfur deposition damage model is established.The refined model,based on non-Darcy flow,takes into consideration the effects of sulfur deposition,variation in gas properties and fracture.In addition,the effect of gas well production rate on formation permeability is also studied.The results show that formation permeability decreases with fracture aperture and gas well production rate increasing.The bigger gas well production rate is,the quicker sulfur precipitates.The sulfur deposition of fractured gas reservoir with high-content H_(2)S is mainly in the near wellbore zone,and the fracture aperture has a significant impact on the formation permeability in the near wellbore zone. | Linji He Xiao Guo | 2017 | Petroleum2017，3，3： | 1 |
| 9 | The effect of umbrella-type branching on the blood circulation and tumor targeting of star-branched PLA-PMPC copolymer micelles显示文摘The effect of branching on the blood circulation and tumor targeting of polymer nanovehicles in vivo was investigated in this study. For the purpose, star-branched poly(lactic acid) and poly(2-methacryloyloxyethyl phosphorylcholine)(PLA-PMPC)copolymers with umbrella-type AB3,(AB3)_(2), and(AB3)_(3) architecture were synthesized by branching at the PLA core. Micelles self-assembled from these copolymers were used to evaluate the effect of core branching on blood circulation and tumor targeting. The results showed that branching changed the behavior of polymeric self-assembly in solution, thereby changing the size and surface anti-fouling performance of the polymeric micelles. Moreover, star-branched copolymer micelles with a higher branching degree allowed their payload to persist better in blood(half-time prolonged from 7.1, 8.6 to 13.8 h) and for a 1.72-fold higher content at the tumor site. These studies suggest that raising the branching degree of amphiphilic copolymer potentially offers a promising strategy for the design of carriers capable of enhanced circulation and targeting in vivo. | LONG LiXia CHENG LinJie HOU JingJing WANG LiMei WANG Xu HE LiGang LI SiDi ZHAO Jin HOU Xin KANG ChunSheng YUAN XuBo | 2021 | Science China(Technological Sciences)2021，64，1： | 0 |
| 10 | Few-layered hexagonal boron nitride nanosheets stabilized Pt NPs for oxidation promoted adsorptive desulfurization of fuel oil显示文摘A few-layered hexagonal boron nitride nanosheets stabilized platinum nanoparticles(Pt/h-BNNS)is engineered for oxidation-promoted adsorptive desulfurization(OPADS)of fuel oil.It was found that the few-layered structure and the defective sites of h-BNNS not only are beneficial to the stabilization of Pt NPs but also favor the adsorption of aromatic sulfides.By employing Pt/h-BNNS with a Pt loading amount of 1.19 wt%as the active adsorbent and air as an oxidant,a 98.0%sulfur removal over dibenzothiophene(DBT)is achieved along with a total conversion of the DBT to the corresponding sulfones(DBTO_(2)).Detailed experiments show that the excellent desulfurization activity originates from the few-layered structure of h-BNNS and the high catalytic activity of Pt NPs.In addition,the OPADS system with Pt/h-BNNS as the active adsorbent shows remarkable stability in desulfurization performance with the existence of different interferents such as olefin,and aromatic hydrocarbons.Besides,the Pt/h-BNNS can be recycled 12 times without a significant decrease in desulfurization performance.Also,a process flow diagram is proposed for deep desulfurization of fuel oil and recovery of high value-added products,which would promote the industrial application of such OPADS strategy. | Peiwen Wu Xin Song Linlin Chen Lianwen He Yingcheng Wu Duanjian Tao Jing He Chang Deng Linjie Lu Yanhong Chao Mingqing Hua Wenshuai Zhu | 2024 | Green Energy & Environment2024，9，3： | 0 |
| 11 | Silicon mode-loop Mach-Zehnder modulator with L-shaped PN junction for 0.37 V·cm V_(π)L high-efficiency modulation显示文摘Optical signaling without a high voltage driver for electric-optic modulation is in high demand to reduce power consumption,packaging complexity,and cost.In this work,we propose and experimentally demonstrate a silicon mode-loop Mach–Zehnder modulator(ML-MZM) with record-high modulation efficiency.We used a mode-loop structure to recycle light twice in the phase shifter.With an L-shaped PN junction,a comparably large overlap between the PN junction and optical modes of both TE0 and TE1 was achieved to lower the driving voltage or decrease the photonic device size.Proof-of-concept high-efficiency modulation with low VπL of 0.37 V · cm was obtained.Subvoltage Vπcan be realized with a millimeter’s length phase shifter by this scheme,which makes the realization of CMOS-compatible driverless modulation highly possible.40 Gb/s signaling with a bit error rate below the 7% forward-error-correction threshold was then demonstrated with the fabricated ML-MZM,indicating great potential for high-speed optical communication. | JIACHENG LIU GANGQIANG ZHOU JIANGBING DU WEIHONG SHEN LINJIE ZHOU ZUYUAN HE | 2022 | Photonics Research2022，10，1： | 0 |
| 12 | In-situ composite microstructure formation of immiscible alloy solidified in space显示文摘About one-third of alloys show a phase diagram with a miscibility gap in the liquid state.The solidifications of these alloys proceed with a liquid-liquid decomposition and have great potential in the development of high-performance in-situ particulate composites,and composites with a core/shell structure. | Jiuzhou Zhao Hao Sun Lili Zhang Hongxiang Jiang Linjie Yang Jie He | 2023 | National Science Review2023，10，2： | 0 |
| 13 | Engineering 3D-printed aqueous colloidal ceramic slurry for direct ink writing显示文摘The construction of rapid prototyping for structured ceramics has a promoting effect on potential applications.In this work,engineering slurry with different formulations were used to develop aqueous colloidal ceramic slurry for direct ink writing(DIW).Optimized slurry of Formulation 5 possessed good printing effect for DIW with stable mechanical properties.Related characteristics,including shrinkage,compressive strength,rheological behavior,and chemical property,were also examined.DIW ceramics prepared from optimized slurry can be preliminarily applied to adsorption of Rhodamine B and chlortetracycline,and possessed the advantages of easy separation and operation compared with powder adsorbents.This work provides a strategy for the design of 3D-printed kaolin ceramic slurry,and also extends to potential application in adsorption. | Jie Zhu Jiangtao Yu Yingcheng Wu Yanhong Chao Peiwen Wu Linjie Lu Linlin Chen Jing He Wenshuai Zhu | 2023 | Green Chemical Engineering2023，4，1： | 0 |
| 14 | Quantum entangled connectivity and functional connectivity of human brain显示文摘Quantum process may conduce to brain function.Particularly,it was proposed that the Posner molecules,Cag(PO4)6,can serve as neural qubits,which can maintain quantum entanglement between phosphorus nuclei for quite a long time.We study the process from entangled Posner molecules to the synchronized activities of brain.A diffusion model of Posner molecules with appropriate boundary conditions and the mean first arriving time of Posner molecules from one area of brain to another are obtained.We establish linkages between the quantum entangled connectivity of brain and the remaining time of entangled Posner molecules before decoherence.Based on these results,we find direct correlations between entangled Posner molecules and the functional connectivity of human brain.Furthermore,we discover that the quantum entangled connectivity depends on age. | You Zhai Linjie Qiu Chenxiang He Lina Wang Jian Zhai | 2023 | International Journal of Biomathematics2023，16，8： | 0 |
| 15 | High-speed silicon microring modulator at the 2μm waveband with analysis and observation of optical bistability显示文摘Recently,significantly raised interests have emerged for the 2μm waveband as an extended new window for fiber optic communication.Much research progress has been made on the photonic integrated circuits for the 2μm waveband,especially on the CMOS-compatible silicon-on-insulator wafer.In this work,a silicon integrated microring modulator(MRM)with record high-speed performances at the 2μm waveband was demonstrated.An L-shaped PN junction was specially designed for 2μm to achieve a high modulation efficiency with V_(π)L of 0.85V·cm.The measured 3 dB bandwidth is 18 GHz,supporting up to 50 Gbps signaling at 2μm.Additionally,optical bistability induced by the thermo-optical effect and nonlinear effects was analyzed theoretically and observed experimentally in the 2μm MRM for the first time to our knowledge.Nonlinear coupled mode theory and the Runge-Kutta method were used to simulate the behaviors of bistability in the 2μm MRM.The simulation and experimental results indicate that,when the MRM is launched by a high optical power,the distorted resonant spectrum under an optical bistable state deteriorates the modulation efficiency and signal performances.This work breaks the record of high-speed silicon MRM at 2μm,drawing a promising prospect for the silicon photonic integration and high-speed interconnection at the 2μm waveband,and it provides the referenceable analysis of optical bistability,which guides the design and experimental investigation of 2μm MRM. | Weihong Shen Gangqiang Zhou Jiangbing Du Linjie Zhou Ke Xu Zuyuan He | 2022 | Photonics Research2022，10，3： | 0 |
| 16 | Stable Au nanoparticles confined in boron nitride shells for optimizing oxidative desulfurization显示文摘Supported gold(Au)nanocatalysts have long played an important role in numerous heterogeneous catalysis.However,the dominant difficulty of poor thermodynamic stability hampers its practical application.Herein,a core–shell structured Au nanocatalyst with Au nanoparticles(NPs)confined in boron nitride(BN)shells is proposed for enhanced thermodynamic stability.The two-dimensional porous structure of BN not only functions as a physical separator for the sintering resistance of Au NPs,but also provides a microchannel for catalytic reaction substrates.Besides,owing to the confinement effect,a strengthened interaction between well-designed Au NPs and the BN can be expected,which further boosts the stability and catalytic activity.Detailed experiments show that a proper BN shell thickness is important to maintain the balance between the sintering resistance and catalytic activity.A significantly boosted performance of 97.2%conversion in oxidative desulfurization(ODS)was obtained with a proper number of BN coating layers,outperforming the one with a thicker BN shell.Moreover,the recyclability of the prepared catalyst was investigated with no obvious decrease in catalytic performance after 10 runs,greatly higher than that without a BN shell,suggesting excellent durability. | Linjie Lu Jing He Peiwen Wu Yang Sun Mingqing Hua Peng Cui Wenshuai Zhu Huaming Li Zhichang Liu Chunming Xu | 2023 | Nano Research2023，16，10： | 0 |
| 17 | Contamination and Remediation of Heavy Metals in Soils near E-waste Recycling Area显示文摘In order to assess heavy metals pollution in agricultural soil after renovation in typical e-waste recycling areas,212 soil samples were collected and the mass fractions of 7 kinds of heavy metals(Cd,Cr,Cu,Hg,Ni,Pb and Zn)were analyzed.The results indicated that heavy metals pollution in agricultural soil was commonly existed in the study areas,and the soil was slightly contaminated by Pb but was moderately or critically polluted by Cd and Cu.However,the carcinogenic risk and non-carcinogenic risk status by heavy metals pollution were beyond acceptable levels,and soil remediation was quite necessary.After some investigations of bioremediation,we found that saponin as washing agent could highly strengthen the behavior of heavy metals desorption from soil,which had a good prospect of engineering practice. | Chen Haitang He Huayan Zhou Dandan Lou Linjie Hu Qingnian | 2015 | Meteorological and Environmental Research2015，6，4： | 0 |
| 18 | Crowd Psychology and the Complexity of the Security Market显示文摘 | Fenghua Wen Linjie He Xiaoyong Zhang Chaoqun Ma | 2005 | China-USA Business Review2005，4，3： | 0 |
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