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| 1 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 2 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 3 | 放牧绵羊瘤胃液挥发性脂肪酸的变化规律及其受蠕虫感染的影响显示文摘选用敖汉细毛羊的育成母羊和成年母羊进行了3年试验。第1年试验在同一饲养水平下设对照组、常规驱虫组和缓释胶囊驱虫组;第2年和第3年又在常规饲养和改进饲养2种饲养方案下进行驱虫试验。所有试验羊在以披碱草、羊草和冰草为主的同类草场上放牧,每年进行3次驱虫处理。试验表明:放牧绵羊瘤胃液中挥发性脂肪酸(VFA)浓度随季节呈动态变化。其挥发性脂肪酸总量(TVFA)在青草期内较高;在枯草期内较低。放牧绵羊瘤胃发酵水平较低,特别在冬春季节内瘤胃发酵处于最低水平,发酵质量不高。另外,绵羊瘤胃液pH值随季节变动幅度较小。但发现在枯草期内的瘤胃液pH值高于青草期,特别在冬春季节内较高。蠕虫感染严重的时期内,蠕虫会影响绵羊瘤胃发酵水平,使瘤胃液VFA浓度降低;但常规驱虫法与缓释胶囊驱虫法间差异不显著。改进饲养与常规饲养方案对绵羊瘤胃液挥发性脂肪酸总量无显著影响。 | 王洪荣 冯宗慈 卢德勋 王晓冬 任家琨 李志明 李恒荣 王庆基 张富 D B Purser D W Peter J Lindsay | 2010 | 畜牧与饲料科学2010，31，6： | 3 |
| 4 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Volatile compounds characterizing the aroma of fresh Atlantic and Pacific oysters显示文摘 | JOSEPHSON D B LINDSAY R C STUIBER D A | 1987 | J Food Sci1987，50，： | 1 |
| 7 | Cognitive approaches to insomnia显示文摘 | Allison GH Nicole KY Lindsay B | 2005 | Clin Psychol Rev2005，25，5： | 1 |
| 8 | High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes显示文摘 | VOZAROVA B WEYER C LINDSAY R S | 2002 | Diabetes2002，51，： | 1 |
| 9 | Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions:a meta-analysis update显示文摘 | Smith JS Lindsay L Hoots B | 2007 | Int J Cancer2007，121，3： | 1 |
| 10 | A thermodynamic viscous interface theory and associated stability problems显示文摘 | Lindsay K A Straughan B | 1979 | Arch Rational Mech Anal1979，71，： | 1 |
| 11 | Auger re- combination in long-wavelength infrared InNxSbl-x alloys 显示文摘 | Murdin B N Kamal-Saadi M Lindsay A | 2001 | Applied Physics Letters2001，78，11： | 1 |
| 12 | Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update显示文摘 | Smith JS Lindsay L Hoots B | 2007 | IntJ Cancer2007，121，3： | 1 |
| 13 | A study of electrochemically treated PAN-based carbon fibres by IGC and XPS 显示文摘 | LINDSAY B ABEL M WATTS J F | 2007 | Carbon2007，25，12： | 1 |
| 14 | High blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes显示文摘 | Vozarova B Weyer C Lindsay RS | 2002 | Diabetes2002，51，2： | 1 |
| 15 | Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions:a meta-analysis update显示文摘 | SMITH J S LINDSAY L HOOTS B | 2007 | Int J Cancer2007，121，3： | 1 |
| 16 | A study of electrochemically treated PAN based carbon fibers by IGC and XPS显示文摘 | Lindsay B Abel M L Watts J F | 2007 | Carbon2007，45，12： | 1 |
| 17 | Human papillomavirus type distribution in invasive cervical cancer and high grade cervical lesions:a meta-analysis update显示文摘 | Smith JS Lindsay L Hoots B | 2007 | Int J Cancer2007，121，3： | 1 |
| 18 | Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions:a meta-analysis update显示文摘 | Smith JS Lindsay L Hoots B | 2007 | Int J Cancer2007，121，3： | 1 |
| 19 | Use of the Tobit model in contingent valuation: Experimental evidence from the Pemige- wasset Wilderness Area显示文摘 | Halstead J M Lindsay B E Brown C M | 1991 | Journal of Environmental Manage- ment1991，33，1： | 1 |
| 20 | Pacermaker- implantation complication rates: an analysis of some contributing factors 显示文摘 | Parsonnet V Bernstein A Lindsay B | 1989 | J Am Coll Cardiol1989，13，4： | 1 |
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