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| 1 | Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections显示文摘唾沫是从患更低的呼吸的道感染的病人收集的最普通的样品,它为这些感染的细菌的鉴定是关键的。在这研究,我们与更低的呼吸的道感染从 101 个病人注册了 101 件唾沫样品。开始,在唾沫包含的细菌的 16S rDNA V3 hypervariable 区域的 pyrosequencing 为 microbiota 分析作为一条文化无关的途径被利用。为比较,用一个文化依赖者的临床的实验室测试为样品也被做的唾沫的一样的队自动化了细菌的鉴定系统。由 pyrosequencing, > 70,000 DNA 碎片在被 Ribosomal 数据库工程(RDP ) 过程分析以后被发现并且分类进 129 个细菌的类。大多数序列属于几个占优势的类,例如链球菌和葡萄球菌,显示这些类起在更低的呼吸的道感染的一个重要作用。另外,属于潜在的原因的代理人的一些序列例如霉浆菌, Haemophilus,和 Moraxella,也被发现,但是这些序列没被临床的实验室测试发现。为两个方法检测的九个类,方法的敏感被比较,结果证明 pyrosequencing 是更敏感的,除了 Klebsiella 和 Mycobacterium。显著地,这个方法揭示了更复杂的细菌的社区,它为细菌的察觉显示出一个有希望的能力。 | Yuhua Zhou Ping Lin Qingtian Li Lizhong Han Huajun Zheng Yanxia Wei Zelin Cui Yuxing Ni Xiaokui Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 8 |
| 2 | Base editing-mediated splicing correction therapy for spinal muscular atrophy显示文摘Dear Editor,Spinal muscular atrophy(SMA)is a devastating autosomal recessive motor neuron disease.1,2 Infants with more severe forms of type I SMA die before the age of 2 if no intervention is provided.1,2 Spinraza and zolgensma have been approved by the FDA as SMA therapeutics for pediatric patients.1,2 However,as an antisense oligonucleotide(ASO)based therapy,spinraza requires four loading doses,followed by three annual maintenance doses.The patients would be subjected to repeated intrathecal injections in the procedure.Zolgensma is a single-dose gene-replacement therapy for SMA,but unfortunately is unreliable in maintaining a high,stable level of gene expression.These issues have limited the therapeutic effects of the two approved drugs for SMA. | Xiang Lin Haizhu Chen Ying-Qian Lu Shunyan Hong Xinde Hu Yanxia Gao Lu-Lu Lai Jin-Jing Li Zishuai Wang Wenqin Ying Lixiang Ma Ning Wang Erwei Zuo Hui Yang Wan-Jin Chen | 2020 | Cell Research2020，30，6： | 5 |
| 3 | Protective electrode/electrolyte interphases for high energy lithium-ion batteries with p-toluenesulfonyl fluoride electrolyte additive显示文摘High energy density lithium-ion batteries using Ni-rich cathode(such as LiNi0.6Co0.2Mn0.2O2) suffer from severe capacity decay.P-toluenesulfonyl fluoride(pTSF) has been investigated as a novel film-forming electrolyte additive to enhance the cycling performances of graphite/LiNi0.6Co0.2Mn0.2O2 pouch cell.In comparison with the baseline electrolyte,a small dose of pTSF can significantly improve the cyclic stability of the cell.Theoretical calculations together with experimental results indicate that pTSF would be oxidized and reduced to construct protective interphase film on the surfaces of LiNi0.6Co0.2Mn0.2O2 cathode and graphite anode,respectively.These S-containing surface films derived from pTSF effectively mitigate the decomposition of electrolyte,reduce the interphasial impedance,as well as prevent the dissolution of transition metal ions from Ni-rich cathode upon cycling at high voltage.This finding is beneficial for the practical application of high energy density graphite/LiNi0.6Co0.2Mn0.2O2 cells. | Yanxia Che Xiuyi Lin Lidan Xing Xiongcong Guan Rude Guo Guangyuan Lan Qinfeng Zheng Wenguang Zhang Weishan Li | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 4 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 5 | Oxaliplatin,Fluorouracil and Leucovorin (FOLFOX) as First-line Chemotherapy for Metastatic or Recurrent Colorectal Cancer Patients显示文摘OBJECTIVE To investigate the efficiency and safety of the oxaliplatin, fluorouracil(5-FU)and leucovorin regimen(FOLFOX)in previously untreated patients with metastatic or recurrent colorectal cancer. METHODS Previously untreated patients with metastatic or recurrent colorectal cancer received 100 mg/m2 of oxaliplatin intravenously(IV)over 2 h on day 1,and IV 400 mg/m2 of leucovorin over 2 h followed by a bolus of 400 mg/m2 of 5-FU.Then 2,600~3,000 mg/m2 of 5-FU was administered by continuous infusion over 46 h. RESULTS An evaluated response rate was determined for 97 of 105 treated patients.The overal response rate was 35.1%,9 patients(9.3%) had a complete response and 25 patients(25.8%)a partial response.Thirty-two patients(33.0%)developed stable disease and 32.0%of the patients progressed.The median time to progression(TTP)was 7.7 months and the median overal survival 20.5 months.One and 2-year survival rates were 68%and 32%.Toxic effects based on the National Cancer Institute-Common Toxicity Criteria(NCI-CTC),reaching grade 3/4 were:neutropenia 12.3%, anemia 11.3%,vomiting 4.1%and diarrhea 7.2%.Grade 3 neuropathy was 5.1%.The overall survival rate of patients who had received a radical resection was superior to the patients who had not received a operation,or had received a pal iative resection(P=0.0658).The serum levels of CEA,ALP and LDH had no relationship with survival(P>0.05). CONCLUSION The FOLFOX regimen containing oxaliplatin,5-FU plus leucovorin was an efficacious regimen with good tolerability in previously untreated metastatic or recurrent colorectal cancer patients. | Bing Han Ruihua Xu Yanxia Shi Huiyan Luo Xiaojuan Xiang Yuhong Li Li Zhang Tongyu Lin Youjian He | 2007 | Chinese Journal of Clinical Oncology2007，4，6： | 2 |
| 6 | Preparation of highly dispersed Pt-SnO x nanoparticles supported on multi-walled carbon nanotubes for methanol oxidation显示文摘 | Chuangang Hu Yanxia Cao Lin Yang Zhengyu Bai Yuming Guo Kui Wang Pengle Xu Jianguo zhou | 2011 | Applied Surface Science2011，，18： | 1 |
| 7 | Loss protection in pairs trading through minimum profit bounds:A cointegration approach显示文摘 | LIN Yanxia McCrae M Gulati C | 2006 | Journal of Applied Mathematics and Decision Sciences2006，，： | 1 |
| 8 | Copper content in animal manures and potential risk of soil copper pollution with animal manure use in agriculture显示文摘 | Xiong Xiong Li Yanxia Li Wei Lin Chunye Han Wei Yang Ming | 2010 | Resources, Conservation & Recycling2010，，11： | 1 |
| 9 | Content, enrichment, and regional geochemical baseline of antimony in the estuarine sediment of the Daliao river system in China显示文摘 | Chunye Lin Mengchang He Yanxia Li Shaoqing Liu | 2012 | Chemie der Erde - Geochemistry - Interdisciplinary Journal for Chemical Problems of the Geosciences and Geoecology2012，，： | 1 |
| 10 | Phosphorus sorption and fraction characteristics in the upper, middle and low reach sediments of the Daliao river systems, China 显示文摘 | Lin Chunye Wang Zhigang He Mengchang Li Yanxia Liu Ruimin Yang Zhifeng | 2009 | J Hazard Mater2009，170，1： | 1 |
| 11 | Copper content in animal manures and potential risk of soil copper pollution with animal manure use in agriculture显示文摘 | Xiong Xiong Li Yanxia Li Wei Lin Chunye Han Wei Yang Ming | 2010 | Resources Conservation & Recycling2010，，11： | 1 |
| 12 | Phosphorus sorption and fraction characteristics in the upper, middle and low reach sediments of the Daliao river systems, China显示文摘 | Chunye Lin Zhigang Wang Mengchang He Yanxia Li Ruimin Liu Zhifeng Yang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 13 | Loss protection in pairs trading through minimum profit bounds: A coin- tegration approach 显示文摘 | Lin Yanxia McCRAE M Gulati C | 2006 | Journal of Applied Mathemat- ics and Decision Sciences2006，，： | 1 |
| 14 | Toward practical gas sensing with rapid recovery semiconducting carbon nanotube film sensors显示文摘Nanomaterials have been considered as promising materials to construct highly sensitive and miniaturized gas sensors due to their high ratio of surface to volume,but almost all of the reported nanomaterials based resistive gas sensors are difficult to use in the practical system mainly owing to the long recovery time and non-equilibrium state at room temperature.Here,we demonstrate a gate assistant technology to realize the rapid recovery to an equilibrium state in semiconducting carbon nanotube(CNT)thin-film gas sensors and promote the CNT-based gas sensors to reach the practical application level.Specifically,we construct highly uniform gas sensors based on semiconducting solution-derived CNT film and accelerate the gas molecules desorption by applying a voltage on the back gate(substrate),which is named gate-assistant recovery technology.By combining the gate-assistant recovery technology and a modified concentration calculation method,highly reproducible detection systems have been realized by using a custom-built printed circuit board(PCB)based data acquisition circuits to execute a real-time rapid detection of H_(2) in the air at room temperature,and especially exhibits a record response time of 9 s and recovery time of 50 s under a resolution of 10 ppm,which outperformed previous low dimensional nanomaterials based portable H2 detection systems.The gate-assistant rapid recovery and related concentration calculation technologies are helpful to promote the nanomaterials-based gas sensors to practical application for highly sensitive online gas detection. | Fangfang LIU Mengmeng XIAO Yongkai NING Shaoyuan ZHOU Jianping HE Yanxia LIN Zhiyong ZHANG | 2022 | Science China(Information Sciences)2022，65，6： | 1 |
| 15 | Floating-Point FPGA Gaussian Elimination in Reconfigurable Computing System显示文摘 | ZHANG Bowei GU Guochang SUN Lin WU Yanxia | 2011 | Chinese Journal of Electronics2011，20，1： | 1 |
| 16 | Aryl hydrocarbon receptor activation drives polymorphonuclear myeloid-derived suppressor cell response and efficiently attenuates experimental Sjögren’s syndrome显示文摘Myeloid-derived suppressor cells(MDSCs)comprise heterogeneous myeloid cell populations with immunosuppressive capacity that contribute to immune regulation and tolerance induction.We previously reported impaired MDSC function in patients with primary Sjögren’s syndrome(pSS)and mice with experimental SS(ESS).However,the molecular mechanisms underlying MDSC dysfunction remain largely unclear.In this study,we first found that aryl hydrocarbon receptor(AhR)was highly expressed by human and murine polymorphonuclear MDSCs(PMN-MDSCs).Indole-3-propionic acid(IPA),a natural AhR ligand produced from dietary tryptophan,significantly promoted PMN-MDSC differentiation and suppressive function on CD4^(+)T cells.In contrast,feeding a tryptophan-free diet resulted in a decreased PMN-MDSC response,a phenotype that could be reversed by IPA supplementation.The functional importance of PMN-MDSCs was demonstrated in ESS mice by using a cell-depletion approach.Notably,AhR expression was reduced in PMN-MDSCs during ESS development,while AhR antagonism resulted in exacerbated ESS pathology and dysregulated T effector cells,which could be phenocopied by a tryptophan-free diet.Interferon regulatory factor 4(IRF4),a repressive transcription factor,was upregulated in PMN-MDSCs during ESS progression.Chromatin immunoprecipitation analysis revealed that IRF4 could bind to the promoter region of AhR,while IRF4 deficiency markedly enhanced AhR-mediated PMN-MDSC responses.Furthermore,dietary supplementation with IPA markedly ameliorated salivary glandular pathology in ESS mice with restored MDSC immunosuppressive function.Together,our results identify a novel function of AhR in modulating the PMN-MDSC response and demonstrate the therapeutic potential of targeting AhR for the treatment of pSS. | Yanxia Wei Na Peng Chong Deng Futao Zhao Jie Tian Yuan Tang Sulan Yu Yacun Chen Yu Xue Fan Xiao Yingbo Zhou Xiaomei Li Hejian Zou Ke Rui Xiang Lin Liwei Lu | 2022 | Cellular & Molecular Immunology2022，19，12： | 1 |
| 17 | Contribution of streptomyces in sediment to earthy odor in the overlying water in Xionghe Reservoir, China 显示文摘 | ZUO Yanxia LI Lin ZHANG Ting | 2010 | Water Research2010，44，20： | 1 |
| 18 | Classical CMF regimen as adjuvant chemotherapy for triple-negative breast cancer may be more effective compared with anthracycline or taxane-based regimens显示文摘 | Shusen Wang Yanxia Shi Zhongyu Yuan Xi Wang Donggen Liu Roujun Peng Xiaoyu Teng Tao Qin Jiewen Peng Guinan Lin Xiaomei Jiang | 2012 | Medical Oncology2012，，2： | 1 |
| 19 | Cadmium in animal production and its potential hazard on Beijing and Fuxin farmlands 显示文摘 | LI Yanxia XIONG Xiong LIN Chunye | 2010 | J Hazard Mater2010，177，123： | 1 |
| 20 | Nuclear PKM2 expression predicts poor prognosis in patients with esophageal squamous cell carcinoma显示文摘 | Xuelin Zhang Chengzhi He Chunya He Baofu Chen Yanxia Liu Min Kong Chunguo Wang Lizhong Lin Yan Dong Haihui Sheng | 2013 | Pathology - Research and Practice2013，，： | 1 |
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