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| 1 | CVD growth of fingerprint-like patterned 3D graphene film for an ultrasensitive pressure sensor显示文摘与便携设备的快速的发展,有高敏感和宽可使用的范围的灵活压力传感器高度被需要。在自然,有许多改编得好的结构,通过自然选择开发,它为 biomimetic 材料或设备的设计鼓舞了我们。特别地,在许多表皮的山脉放大外部刺激的地方,人的指尖皮肤可能是一个好例子为高度敏感的传感器模仿。在这个工作,基于唯一的化学蒸汽免职( CVD )种模仿指尖皮肤的形态学的 3D graphene 电影,我们制作了察觉到膜的灵活压力,它同时显示出 110 的高敏感( kPa )为 0-0.2 kPa 和宽可使用的压力范围(多达 75 kPa )的1。从自然叶子塑造的层次结构化的 PDMS 电影为 graphene 电影被用作支持的有弹性的电影,它也贡献压力传感器的优异表演。压力传感器显示出低察觉限制(0.2 Pa ) ,快反应(< 30 ms ) ,并且为超过 10,000 的优秀稳定性装载 / 卸掉周期。把特征基于这些,我们在检测微小的对象,声音,和人的生理的信号演示了它的应用程序,为监视的健康和人 / 机器在便携电子学显示出它的潜力连接。 | Kailun Xia Chunya Wang Muqiang Jian Qi Wang Yingying Zhang | 2018 | Nano Research2018，11，2： | 13 |
| 2 | Superelastic wire-shaped supercapacitor sustaining 850% tensile strain based on carbon nanotube@graphene fiber显示文摘 | Huimin Wang Chunya Wang Muqiang Jian Qi Wang Kailun Xia Zhe Yin Mingchao Zhang Xiaoping Liang Yingying Zhang | 2018 | Nano Research2018，11，5： | 6 |
| 3 | Traditional Chinese Medicine for the treatment of influenza: a systematic review and Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To justify the clinical use of Traditional Chinese Medicine(TCM) in the treatment of influenza.METHODS: MEDLINE, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database and the Cochrane Database of Systematic Reviews were searched from thedate of inception until January 1,2013, for the literature on treatment of influenza with TCM.RESULTS: A total of 7 randomized controlled trials were identified and reviewed. Of these trials, 2 compared a(modified) prescription of TCM with oseltamivir and 5 compared a patent traditional Chinese drug with oseltamivir. Based on the Meta-analysis,compared to oseltamivir, the(modified) prescription had similar effect in defervescence [WMD=5.66, 95% CI(﹣32.02, 43.35), P=0.77] and viral shedding [WMD=﹣ 6.21, 95% CI(﹣84.19, 71.76), P=0.88], and the patent traditional Chinese drug also had similar effect in viral shedding [WMD=﹣ 0.24,95% CI(﹣4.79, 4.31), P=0.92] but more effective in defervescence [WMD=﹣4.65, 95%CI(﹣8.91, ﹣0.38),P=0.03].CONCLUSION: TCM has potential positive effects in the treatment of influenza. | Chunya Wang Hao Wang Xinying Liu Dongping Xu Yiping Tang Ping Luo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 5 |
| 4 | Theoretical and Experimental Research on Error Analysis and Optimization of Tool Path in Fabricating Aspheric Compound Eyes by Precision Micro Milling显示文摘Structure design and fabricating methods of three-dimensional(3D)artificial spherical compound eyes have been researched by many scholars.Micro-nano optical manufacturing is mostly used to process 3D artificial compound eyes.However,spherical optical compound eyes are less at optical performance than the eyes of insects,and it is difficult to further improve the imaging quality of compound eyes by means of micro-nano optical manufacturing.In this research,nonhomogeneous aspheric compound eyes(ACEs)are designed and fabricated.The nonhomogeneous aspheric structure is applied to calibrate the spherical aberration.Micro milling with advantages in processing three-dimensional micro structures is adopted to manufacture ACEs.In order to obtain ACEs with high imaging quality,the tool paths are optimized by analyzing the influence factors consisting of interpolation allowable error,scallop height and tool path pattern.In the experiments,two kinds of ACEs are manufactured by micro-milling with different too path patterns and cutting parameter on the miniature precision five-axis milling machine tool.The experimental results indicate that the ACEs of high surface quality can be achieved by circularly milling small micro-lens individually with changeable cutting depth.A prototype of the aspheric compound eye(ACE)with surface roughness(Ra)below 0.12?m is obtained with good imaging performance.This research ameliorates the imaging quality of 3D artificial compound eyes,and the proposed method of micro-milling can improve surface processing quality of compound eyes. | CHEN Mingjun XIAO Yong TIAN Wenlan WU Chunya CHU Xin | 2014 | Chinese Journal of Mechanical Engineering2014，27，3： | 3 |
| 5 | Research on the influence of machining introduced sub-surface defects and residue stress upon the mechanical properties of single crystal copper显示文摘Large scale molecular dynamics simulations of nanomachining and stretching of single crystal copper are performed to analyze the machining process’ influence on the material’s mechanical properties. The simulation results show that the machining process will introduce interfacial defects inside the specimen and enhance the compressive stress beneath the surface. Gener- ally speaking, interfacial defects lead to the decrease of the strength limit, while residue compressive stress can enhance the elastic limit and even the strength limit. Various machining parameters are adopted to investigate their influence on the me- chanical behavior of machined specimen. Lower cutting speed and smaller cutting depth lead to less defects and greater residue compressive stress, which brings about better mechanical properties. The elastic limit increases by 36.8% under the cutting depth of 0.73 nm and decreases by 21.1% under the cutting depth of 1.46 nm. The strength limit increases by 7.7% under the cutting speed of 100 m/s and decreases by 28.2% under the cutting speed of 300 m/s. | CHEN MingJun, XIAO GaoBo, CHEN JiaXuan & WU ChunYa Harbin Institute of Technology, Harbin 150001, China | 2010 | Science China(Technological Sciences)2010，53，12： | 3 |
| 6 | Identification of human hnRNP C1/C2 as a dengue virus NS1-interacting protein显示文摘 | Sansanee Noisakran Suchada Sengsai Visith Thongboonkerd Rattiyaporn Kanlaya Supachok Sinchaikul Shui-Tein Chen Chunya Puttikhunt Watchara Kasinrerk Thawornchai Limjindaporn Wiyada Wongwiwat Prida Malasit Pa-thai Yenchitsomanus | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 2 |
| 7 | Comparison of rescue strategies in lamivudine-resistant patients with chronic hepatitis B显示文摘 | Pan Zhao Chunya Wang LiLi Huang Dongping Xu Tanshi Li | 2012 | Antiviral Research2012，，2： | 2 |
| 8 | Utilizing morpholine for purely organic room temperature phosphors显示文摘In this article,morpholine,a non-conjugated heterocycle,is embedded intoπsystem to construct single-component organic room temperature phosphorescence(RTP)luminogens.The effect of morpholine on intermolecular interaction,crystal packing modes,and RTP performance is investigated systematically.The experimental and theoretical calculation results illustrate the versatility of morpholine in promoting the n-π*transition and intensifying the intermolecular interactions,which not only enhances the generation of triplet excitons,but also suppresses the nonradiative decay of triplet excitons.Impressively,TMPh containing three morpholine units shows an ultralong lifetime of 1.03 s and a visible afterglow up to 10 s.The unique dual delayed emission and long afterglow property allow potential application of morpholine derivatives in data encryption,and the time-dependent color change of afterglow emission is realized after removing the excitation source,providing a high-level data security.This article provides a new perspective for the design of purely organic RTP system without utilization of metal,or even any heavy atoms. | Dongyan Jiang Tong Lu Chunya Du Futong Liu Zhenyu Yan Dehua Hu Anqi Shang Lei Gao Ping Lu Yuguang Ma | 2023 | Science China Chemistry2023，66，4： | 1 |
| 9 | Research on the se- mantic-based co -word analysis 显示文摘 | Wang Zhengyi Li Gang Li Chunya | 2012 | Seientometries2012，90，3： | 1 |
| 10 | Development of a parathion sensor based on molecularly imprinted nano-TiO2 self-assembled film electrode 显示文摘 | Li Chunya WangChangfa Wang Chenghang | 2006 | Sensors and Actuators B2006，117，1： | 1 |
| 11 | Resonance light scattering spectral method for the determination of serum albumin with the interaction of neutral red - sodium dodecyl sulfonate 显示文摘 | Guoqing Zhan Lixia Zhang Chunya Li | 2009 | Colloids and Surfaces B: Biointerfaces2009，71，11： | 1 |
| 12 | Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer显示文摘Background:Immune checkpoint inhibitors(ICIs)targeting programmed cell death protein 1(PD-1)and programmed death-ligand 1(PD-L1)have shown a moderate response in colorectal cancer(CRC)with deficient mismatch repair(dMMR)functions and poor response in patients with proficientMMR(pMMR).pMMRtumors are generally immunogenically“cold”,emphasizing combination strategies to turn the“cold”tumor“hot”to enhance the efficacy of ICIs.ATR inhibitors(ATRi)have been proven to cooperate with radiation to promote antitumor immunity,but it is unclear whether ATRi could facilitate the efficacy of IR and ICI combinations in CRCs.This study aimed to investigate the efficacy of combining ATRi,irradiation(IR),and anti-PD-L1 antibodies in CRC mouse models with different microsatellite statuses.Methods:The efficacy of combining ATRi,IR,and anti-PD-L1 antibodies was evaluated in CRC tumors.The tumor microenvironment and transcriptome signatures were investigated under different treatment regimens.The mechanisms were explored via cell viability assay,flow cytometry,immunofluorescence,immunoblotting,co-immunoprecipitation,and real-time quantitative PCR in multiple murine and human CRC cell lines.Results:Combining ATRi berzosertib and IR enhanced CD8+T cell infiltration and enhanced the efficacy of anti-PD-L1 therapy in mouse CRC models with different microsatellite statuses.The mechanistic study demonstrated that IR+ATRi could activate both the canonical cGAS-STING-pTBK1/pIRF3 axis by increasing cytosolic double-stranded DNA levels and the non-canonical STING signaling by attenuating SHP1-mediated inhibition of the TRAF6-STINGp65 axis,via promoting SUMOylation of SHP1 at lysine 127.By boosting the STING signaling,IR+ATRi induced type I interferon-related gene expression and strong innate immune activation and reinvigorated the cold tumor microenvironment,thus facilitating immunotherapy.Conclusions:The combination of ATRi and IR could facilitate anti-PD-L1 therapy by promoting STING signaling in CRC models with different microsatellite statuses.The new combination strategy raised by our study isworth investigating in the management of CRC. | Chaofan Liu Xi Wang Wan Qin Jingyao Tu Chunya Li Weiheng Zhao Li Ma Bo Liu Hong Qiu Xianglin Yuan | 2023 | Cancer Communications2023，43，4： | 1 |
| 13 | Electrocatalytic oxidation of nitric oxide at nano-TiO2/Nafion composite film modified glassy carbon electrode显示文摘 | WANG Yazhen LI Chunya HU Shengshui | 2006 | J Solid State Electrochem2006，10，6： | 1 |
| 14 | Research on the semantic- based co-word analysis 显示文摘 | Wang Zhongyi Li Gang Li Chunya | 2012 | Scientometrics2012，90，3： | 1 |
| 15 | Basis mechanism of MIC poly-Si thin film material dynamic gettered technology and its applications显示文摘 | Li Yang Meng Zhiguo Wu Chunya | 2007 | Chinese Journal of Semiconductors2007，28，10： | 1 |
| 16 | Novel anti-dengue monoclonal antibody recognizing conformational structure of the prM-E heterodimeric complex of dengue virus显示文摘 | Chunya P Poonsook K Nuanpan K | | 0，，01： | 1 |
| 17 | Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis显示文摘 | Janjuree N Sansanee N Chunya P | | 0，，02： | 1 |
| 18 | Covalent Modification of Glassy Carbon Electrode with L-Cysteine for the Determination of Acetaminophen 显示文摘 | Chenghang Wang Chunya Li Fang Wang | 2006 | Microchim Acta2006，，： | 1 |
| 19 | The development of a novel serotyping-NS1-ELISA to identify serotypes of dengue virus显示文摘 | Chunya P Tanapan P Nathaporn U | | 0，，04： | 1 |
| 20 | Electrochemical sensor for the determination of parathion based on p-tert-butylcalix arene-1,4-crown-4 sol-gel film and its characterization by electrochemical methods 显示文摘 | Li Chunya Wang Changfa Zhang Yangyang | 2005 | Sensors and Actuators B2005，107，1： | 1 |
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