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| 1 | Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism显示文摘 | Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS | 2006 | 中国生物学文摘2006，20，10： | 138 |
| 2 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 3 | Two-stage vs single-stage management for concomitant gallstones and common bile duct stones显示文摘AIM:To evaluate the safety and effectiveness of twostage vs single-stage management for concomitant gallstones and common bile duct stones.METHODS:Four databases,including PubMed,Embase,the Cochrane Central Register of Controlled Trials and the Science Citation Index up to September 2011,were searched to identify all randomized controlled trials(RCTs).Data were extracted from the studies by two independent reviewers.The primary outcomes were stone clearance from the common bile duct,postoperative morbidity and mortality.The secondary outcomes were conversion to other procedures,number of procedures per patient,length of hospital stay,total operative time,hospitalization charges,patient acceptance and quality of life scores.RESULTS:Seven eligible RCTs [five trials(n = 621) comparing preoperative endoscopic retrograde cholangiopancreatography(ERCP)/endoscopic sphincterotomy(EST) + laparoscopic cholecystectomy(LC) with LC + laparoscopic common bile duct exploration(LCBDE);two trials(n = 166) comparing postoperative ERCP/EST + LC with LC + LCBDE],composed of 787 patients in total,were included in the final analysis.The metaanalysis detected no statistically significant difference between the two groups in stone clearance from the common bile duct [risk ratios(RR) =-0.10,95% confidence intervals(CI):-0.24 to 0.04,P = 0.17],postoperative morbidity(RR = 0.79,95% CI:0.58 to 1.10,P = 0.16),mortality(RR = 2.19,95% CI:0.33 to 14.67,P = 0.42),conversion to other procedures(RR = 1.21,95% CI:0.54 to 2.70,P = 0.39),length of hospital stay(MD = 0.99,95% CI:-1.59 to 3.57,P = 0.45),total operative time(MD = 12.14,95% CI:-1.83 to 26.10,P = 0.09).Two-stage(LC + ERCP/EST) management clearly required more procedures per patient than single-stage(LC + LCBDE) management.CONCLUSION:Single-stage management is equivalent to two-stage management but requires fewer procedures.However,patient's condition,operator's expertise and local resources should be taken into account in making treatment decisions. | Jiong Lu Yao Cheng Xian-Ze Xiong Yi-Xin Lin Si-Jia Wu Nan-Sheng Cheng | 2012 | World Journal of Gastroenterology2012，18，24： | 107 |
| 4 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 5 | Entransy dissipation number and its application to heat exchanger performance evaluation显示文摘Based on the concept of the entransy which characterizes heat transfer ability, a new heat exchanger performance evaluation criterion termed the entransy dissipation number is established. Our analysis shows that the decrease of the entransy dissipation number always increases the heat exchanger effectiveness for fixed heat capacity rate ratio. Therefore, the smaller the entransy dissipation number, the better the heat exchanger performance is. The entransy dissipation number in terms of the number of exchanger heat transfer units or heat capacity rate ratio correctly exhibits the global performance of the counter-, cross-and parallel-flow heat exchangers. In comparison with the heat exchanger performance evaluation criteria based on entropy generation, the entransy dissipation number demon-strates some distinct advantages. Furthermore, the entransy dissipation number reflects the degree of irreversibility caused by flow imbalance. | GUO JiangFeng CHENG Lin XU MingTian | 2009 | Chinese Science Bulletin2009，54，15： | 58 |
| 6 | Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma显示文摘AIM: To determine the number of regulatory T cells (Tregs) in gastric mucosa of patients with gastritis, peptic ulcers and gastric cancer. METHODS: This study was a retrospective analysis of gastric antrum biopsy specimens from healthy controls (n = 22) and patients with gastritis (n = 30), peptic ulcer (n = 83), or gastric cancer (n = 32). Expression of CD4, CD25 and Foxp3 was determined by immunohistochemistry in three consecutive sections per sample.RESULTS: Compared with healthy controls, there was an increased number of CD25+ and Foxp3+ cells in patients with gastritis (P = 0.004 and P = 0.008), peptic ulcer (P < 0.001 and P < 0.001), and gastric cancer (P < 0.001 and P < 0.001). The ratio of CD25+/CD4+ or Foxp3+/CD4+ cells was also significantly higher in all disease groups (P < 0.001, respectively). The number of CD4+, CD25+, and Foxp3+ cells, and the ratio of CD25+/CD4+ and Foxp3+/CD4+ cells, were associated with the histological grade of the specimens, including acute inflammation, chronic inflammation, lymphoid follicle number, and Helicobacter pylori infection. The number of CD4+, CD25+ and Foxp3+ cells, and the ratio of CD25+/CD4+ and Foxp3+/CD4+ cells, were negatively associated with intestinal metaplasia among gastritis (P < 0.001, P < 0.001, P < 0.001, P = 0.002 and P = 0.002) and peptic ulcer groups (P = 0.013, P = 0.004, P < 0.001, P = 0.040 and P = 0.003). | Hsin-Hung Cheng Guan-Ying Tseng Hsiao-Bai Yang Hung-Jung Wang Hwai-Jeng Lin Wen-Ching Wang | 2012 | World Journal of Gastroenterology2012，18，1： | 56 |
| 7 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 8 | 煤中微量元素研究进展显示文摘煤炭是我国的主要能源 ,在煤炭开采、运输、洗选、淋溶 (滤 )、燃烧等其它加工利用过程中 ,煤中的微量元素要发生迁移、析出 ,并入侵到大气、水、土壤和生态环境中 ,最终影响人类生存和生活环境。煤中微量元素十分重要 ,是因为它们与环境问题、动、植物及人类健康密切相关。在研究微量元素时必须考虑微量元素的性质及毒性 ,它们主要依靠其含量、种类、存在形式、pH值、氧化—还原条件及其它因素。在全面综合国内外研究文献的基础上 ,分析了煤中微量元素的发现、分布规律、赋存状态、成因机理及微量元素的应用等方面研究的历史、现状 ,并对今后研究的重点内容和发展方向进行了较为详细的论述和分析 ,并指出在进一步深入研究煤中微量元素地球化学的基础上 ,加强微量元素环境学方面的研究是今后煤中微量元素环境地球化学研究的重要内容。 | 刘桂建 彭子成 王桂梁 杨萍月 Chou Cheng lin | 2002 | 地球科学进展2002，17，1： | 54 |
| 9 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 10 | SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion显示文摘Bone marrow mesenchymal stem cells(MSCs)are considered as a promising cell source to treat the acute myocardial infarction.However,over 90%of the stem cells usually die in the first three days of transplantation.Survival potential,migration ability and paracrine capacity have been considered as the most important three factors for cell transplantation in the ischemic cardiac treatment.We hypothesized that stromal-derived factor-1(SDF-1)/CXCR4 axis plays a critical role in the regulation of these processes.In this study,apoptosis was induced by exposure of MSCs to H2O2 for 2 h.After re-oxygenation,the SDF-1 pretreated MSCs demonstrated a significant increase in survival and proliferation.SDF-1 pretreatment also enhanced the migration and increased the secretion of pro-survival and angiogenic cytokines including basic fibroblast growth factor and vascular endothelial growth factor.Western blot and RT-PCR demonstrated that SDF-1 pretreatment significantly activated the pro-survival Akt and Erk signaling pathways and up-regulated Bcl-2/Bax ratio.These protective effects were partially inhibited by AMD3100,an antagonist of CXCR4.We conclude that the SDF-1/CXCR4 axis is critical for MSC survival,migration and cytokine secretion. | Xiaolei Liu Biyan Duan Zhaokang Cheng Xiaohua Jia Lina Mao Hao Fu Yongzhe Che Lailiang Ou Lin Liu Deling Kong | 2011 | Protein & Cell2011，2，10： | 53 |
| 11 | Principle of equipartition of entransy dissipation for heat exchanger design显示文摘In the present work,a principle of equipartition of entransy dissipation(EoED) for heat exchanger design is established,which says that for a heat exchanger design with given heat duty and heat transfer area,the total entransy dissipation rate reaches the minimum when the local entransy dissipation rate is uniformly distributed along the heat exchanger.When the heat transfer coefficient is unfixed,the total entransy dissipation obtained by the EoED principle is less than that obtained by the principle of equipartition of temperature difference(EoTD).Furthermore,the exchanger effectiveness obtained by the EoED principle is larger than that obtained by the EoTD principle.When the heat transfer coefficient is fixed,the EoED principle is equivalent to the EoTD principle.We show that the equipartition of entropy production(EoEP) and EoED principles give rise to difference in entropy generation and entransy dissipation for a heat exchanger optimization design.The discrepancies are caused by distinct features of entropy production minimization and entransy dissipation minimization principles,the former is to optimize the design of heat exchanger by making the lost available work minimum,while the latter is not involved with heat-work conversion.It is found that the entropy generation number is not suitable for evaluating heat exchanger performance,since it directly depends on the inlet and outlet temperatures of working fluids.On the contrary,the entransy dissipation number is not directly related to the inlet and outlet temperatures of working fluids.Therefore,the entransy dissipation number is more suitable for serving as a criterion to evaluate heat exchanger performance. | GUO JiangFeng,XU MingTian & CHENG Lin Institute of Thermal Science and Technology,Shandong University,Jinan 250061,China | 2010 | Science China(Technological Sciences)2010，53，5： | 46 |
| 12 | Effects of sediment dredging on water quality and zooplankton community structure in a shallow of eutrophic lake显示文摘Effects of suction dredging on water quality and zooplankton community structure in a shallow of eutrophic lake,were evaluated.The results showed that a decreasing trend for levels of phosphorus,organic matter,total suspended solids,Chlorophyll a and Secchi transparency in the water column was found,while levels of water depth,electrical conductivity,total dissolved solids and NO 3--N concentration increased markedly post-dredging.The effects of dredging on dissolved oxygen,pH value and temperature were almost negligible.The zooplankton community structure responded rapidly to the environmental changes caused mainly by dredging.As a result,the abundance of rotifers decreased,while the density of zooplanktonic crustaceans increased markedly.The representative taxa were Brachionus angularis,B.budapestinensis,B.diversicornis,Synchaeta spp.and Neodiaptomus schmackeri.A distinct relationship between zooplankton taxa composition and their environment,unraveled by a redundancy analysis,indicating that the measured environment contributed to the variations in the zooplankton community structure to some extent.The first four synthetic environmental variables explained 51.7% of the taxonomic structure.Therefore,with the reduction of internal nutrient load and a shift in dominance by less eutrophic species,it inferred that dredging might be one of effective measures for environmental improvements of such lakes. | Shiyang Zhang Qiaohong Zhou Dong Xu Jidong Lin Shuiping Cheng Zhenbin Wu | 2010 | Journal of Environmental Sciences2010，22，2： | 41 |
| 13 | Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4显示文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing(180±20)g,wererandomized into five groups(control group,modelgroup,and three losartan treated groups),inwhich all rats were given the subcutaneousinjection of 40% CCl4(every 3 days for 6 weeks)except for rats of control group.Rats of losartan-treated groups were treated with losartan(20 mg/kg,10 mg/kg,5 mg/kg,daily gavage),After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid(HA),procollagen typeⅢ(PCⅢ)were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta(TGF-β),and alpha-smooth muscle actin(a-SMA)inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced(t=4.20,P<0.01 and t=4.57,P<0.01).Serum HAand PCⅢalso had significant differences(t=3.53,P<0.01 and t=2.20,P<0.05).Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors. | Hong Shan Wei Ding Guo Li Han Ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing Zhang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，4： | 42 |
| 14 | Analysis of Paraquat Intoxication Epidemic (2002-2011) within China显示文摘Paraquat, is a Bipy herbicide have been widely used in last decade in China. Because of its high human toxicity and mortality characteristics, paraquat has been gained considerable attention in recent years. In order to evaluate the epidemic status of paraquat harm to human health in China, | YIN Yu GUO Xiang ZHANG Shou Lin SUN Cheng Ye | 2013 | Biomedical and Environmental Sciences2013，26，6： | 43 |
| 15 | Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line显示文摘背景 MicroRNAs (miRNAs ) 是调停的 18-25 核苷酸(nt ) 的高度保存的小非编码的 RNA post-transcriptional 基因规定。肝炎 B 病毒(HBV ) 能引起尖锐或长期的肝炎 B,并且是为肝肝硬化和 hepatocellular 癌的一个高风险因素。一些哺乳动物的病毒被显示了调制表示招待细胞的 miRNAs。然而,在 HBV 之间的相互作用和主人细胞的 miRNAs 大部分是未知的。方法 miRNA microarray 和北弄污分析被用来比较稳定的表示 HBV 房间行 HepG2.2.15 和它的父母房间行 HepG2 的细胞的 miRNAs 的表示侧面。mRNA microarray 试金和人权保护的节目被用来预言 miRNA 目标。流动 cytometric 试金进一步被用来调查人的白血球的表示抗原(HLA ) A。结果十八 miRNAs 是在二房间行之间表示的差别。在他们之中,十一是起来调整的,七在 HepG2.2.15 房间是下面调整的。北弄污分析证实 miR-181a, miR-181b, miR-200b 和 miR-146a 的表示是起来调整的, miR-15a 的表示是下面调整的,它在与 microarray 分析的结果一致。而且,一些通常认为的 miRNA 目标被预言并且验证了与 mRNA 表示被连接。HLA 的 3'-UTR -- 基因为 miR-181a 和 miR-181a 力量下面调整有一个部分互补的地点 HLA 的表示 -- 一。结论 HBV 复制调制表达式招待细胞的 miRNAs,它可以在 HBV 相关的肝疾病的致病起一个作用。 | LIU Yan ZHAO Jian-Jun WANG Chun-mei LI Mian-yang HAN Ping WANG Lin CHENG Yong-qian Fabien Zoulim MA Xu XU Dong-ping | 2009 | Chinese Medical Journal2009，，1： | 38 |
| 16 | Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells显示文摘瞄准:最近的试验性、人的研究证明了 hyperuricemia 与高血压和心血管的疾病被联系。endothelin-1 (ET-1 ) 的提高的层次被认为是心血管的疾病的最强大的独立预言者之一。为调查尿导致酸的脉管的疾病是否与 ET-1 有关,在人的大动脉的光滑的肌肉房间(HASMC ) 的尿导致酸的 ET-1 表示被检验。方法:与尿酸,房间增长和 ET-1 表示对待的有教养的 HASMC 被检验。尿导致酸的细胞外的调整信号的家族 ases (英皇家空军之阶级最低之兵) 上的抗氧化剂预告的处理 phosphorylation 被执行阐明在增长和 ET-1 基因表示的氧化还原作用敏感的小径。结果:尿酸被发现增加 HASMC 增长, ET-1 表示和反应的氧种类生产。N-acetylcysteine 和 apo-cynin 的能力(l-[4-hydroxy-3-methoxyphenyl ] ethanone,一个 NADPH oxidase 禁止者) 建议了细胞内部的氧化还原作用小径的参与禁止尿导致酸的 ET-1 分泌物和房间增长。而且, apocynin,和 p47 phox 击倒的禁止的 ET-1 分泌物和房间增长由尿酸导致了的小介入 RNA。由 U0126 的英皇家空军之阶级最低之兵的抑制(1,4-diamino-2,3-dicyano-1,4-bis [2-aminophenylthio ] 丁二烯) 显著地压制的尿导致酸的 ET-1 表示,含有在对尿酸的反应的这条小径。另外,尿酸增加了抄写因素使活跃之物 protein-1 (AP-1 ) 调停的记者活动,以及 ERK phosphorylation。ET-1 基因倡导者的 Mutational 分析证明 AP-1 有约束力的地点是在尿导致酸的 ET-1 基因表示的重要 cis 元素。结论:这是由在 HASMC 的尿酸的 ET-1 规定的第一观察,它含有在脉管的变化的尿酸的重要角色与高血压和脉管的疾病联系了。 | Hung-hsing CHAO Ju-chi LIU Jia-wei LIN Cheng-hsien CHEN Cheng-hsi WU Tzu-hurng CHENG | 2008 | Acta Pharmacologica Sinica2008，29，11： | 31 |
| 17 | Thawing and freezing processes of active layer in Wudaoliang region of Tibetan Plateau显示文摘The interaction between permafrost and atmosphere is accomplished through transfer of heat and moisture in the overlay active layer. Thus, the research on the thermal and hydrodynamics of active layer during the thawing and freezing processes was considered a key to revealing the heat and moisture exchanges between permafrost and atmosphere. The monitoring and research on active layer were conducted because permafrost occupies about two thirds of the total area of the Tibetan Plateau. Based on the analysis of the ground temperature data and soil moisture data of monitoring near the Wudaoliang region of the Tibetan Plateau, the thawing and freezing processes of active layer were divided into four stages, i.e. summer thawing stage (ST), autumn freezing stage (AF), winter cooling stage (WC) and spring warming stage (SW). Coupled heat and water flow is much more complicated in ST and AF, and more amount of water is migrating in these two stages. Heat is transferred mainly via conductive heat flow in the | Lin Zhao Guodong Cheng Shuxun Li Xinmin Zhao Shaoling Wang | 2000 | Chinese Science Bulletin2000，45，23： | 31 |
| 18 | Generation of neural progenitor cells by chemical cocktails and hypoxia显示文摘神经祖先房间(NPC ) 能被定义因素从体的房间导致。这里,我们报导 NPC 能从老鼠被产生由化学鸡尾酒的胚胎的成纤维细胞,也就是 VCR (V, VPA, HDAC 的一个禁止者;C, CHIR99021, GSK-3 kinases 和 R 的一个禁止者, Repsox, TGF-β 的一个禁止者;小径) ,在一个生理的 hypoxic 条件下面。这些导致化学药品的 NPC (ciNPCs ) 类似于鼠标关于他们为在 vitro 并且在 vivo 的不同 neuroectodermal 系的 proliferative 和自我更新的能力,基因表达式侧面,和 multipotency 的导出大脑的 NPC。进一步的实验揭示那种选择有 histone deacetylation,肝糖 synthase kinase,和 TGF-β 的禁止者的鸡尾酒;小径为 ciNPC 正式就职显示出类似的功效。而且, ciNPCs 能也与一样的化学鸡尾酒 VCR 从老鼠尾巴尖端成纤维细胞和人的尿房间被导致。因此,我们的学习证明没有介绍外长的因素,到 NPC 的体的房间的那系特定的变换能被化学鸡尾酒完成。 | Lin Cheng Wenxlang Hu Binlong Qiu Jian Zhao Yongchun Yu Wuqiang Guan Min Wang Wuzhou Yang Gang Pei | 2014 | Cell Research2014，24，6： | 32 |
| 19 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 20 | Draining Tangjiashan Barrier Lake after Wenchuan Earthquake and the flood propagation after the dam break显示文摘Tangjiashan Barrier Lake is one of the largest barrier lakes caused by the Wenchuan Earthquake. Its risk analysis, emergency plan and effect of the emergency plan are introduced in this paper. The dam height of Tangjiashan Barrier Dam is about 105 m, and the reservoir storage capacity is 3.2×108 m3. When the dam broke the flood peak were estimated to be larger than 48000 m3/s, which might cause a enormous disaster to the downstream cities and residents. A discharge channel with 13 m deep and 8 m wide was drug, so that the water may flow out of the lake before the dam breaks. As a result, the drainage and risk mitigation project are successful. During the drainage process, the flood peak was about 6500 m3/s, and about 1.6×108 m3 of water was drained off and the residual reservoir capacity was only 8.97×107 m3. A new channel with average width 100 m was formed, which can bear floods of 200 years frequency. The successful experience and the collected data can be used to deal with the similar natural disasters in future. | LIU Ning1, ZHANG JianXin2, LIN Wei3, CHENG WuYI4 & CHEN ZuYu5 1 Ministry of Water Resources of the People’s Republic of China, Beijing 100053, China 2 Bureau of Hydrology of the Ministry of Water Resources of the People’s Republic of China, Beijing 100053, China 3 Sichuan Hydrographic and Water Resources Survey Bureau Chengdu 610031, China 4 HydroChina Chengdu Engineering Corporation, Chengdu 610072, China 5 China Institute of Water Resources and Hydropower Research, Beijing 100044, China | 2009 | Science China(Technological Sciences)2009，52，4： | 29 |
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