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| 1 | Western North Pacific Tropical Cyclone Database Created by the China Meteorological Administration显示文摘This paper describes the access to, and the content, characteristics, and potential applications of the tropical cyclone(TC) database that is maintained and actively developed by the China Meteorological Administration, with the aim of facilitating its use in scientific research and operational services. This database records data relating to all TCs that have passed through the western North Pacific(WNP) and South China Sea(SCS) since 1949. TC data collection has expanded over recent decades via continuous TC monitoring using remote sensing and specialized field detection techniques,allowing collation of a multi-source TC database for the WNP and SCS that covers a long period, with wide coverage and many observational elements. This database now comprises a wide variety of information related to TCs, such as historical or real-time locations(i.e., best track and landfall), intensity, dynamic and thermal structures, wind strengths, precipitation amounts, and frequency. This database will support ongoing research into the processes and patterns associated with TC climatic activity and TC forecasting. | Xiaoqin LU Hui YU Ming YING Bingke ZHAO Shuai ZHANG Limin LIN Lina BAI Rijin WAN | 2021 | Advances in Atmospheric Sciences2021，38，4： | 96 |
| 2 | Black carbon aerosols and their radiative properties in the Pearl River Delta region显示文摘The climatic and environmental effects of atmospheric aerosols are a hot topic in global science community, and radiative properties of the aerosols are one of the important parameters in assessing climatic change. Here we studied the black carbon concentration and absorption coefficient measured with aethalometers, scattering coefficient measured with nephelometers, and single scattering albedo derived at an atmospheric composition watch station in Guangzhou from 2004 to 2007. Our main results are as follows. The data of black carbon concentration and absorption coefficients measured with instruments cannot be directly used until they are measured in parallel with internationally accepted instruments for comparison, calibration, and reduction. After evaluation of the data, the result shows that the monthly mean of BC concentration varies 3.1―14.8 μg·m-3 and the concentration decreases by about 1 μg·m-3 in average over the four years; It is higher in the dry season with a multi-year mean of 8.9 μg/m3 and lower in the rainy season with a multi-year mean of 8.0 μg·m-3; The extreme maximum of monthly mean concentration occurred in December 2004 and extreme minimum in July 2007, and a 4-year mean is 8.4 μg·m-3. It is also shown that monthly mean scattering coefficient derived varies 129 -565 Mm-1, monthly mean absorption coefficient 32-139 Mm-1, and monthly mean single scattering albedo 0.71-0.91, with annual mean values of 0.80, 0.82, 0.79 and 0.84 for 2004, 2005, 2006 and 2007, respectively. Three instruments were used to take simultaneous measurements of BC in PM10, PM2.5, and PM1 and the results showed that PM2.5 took up about 90% of PM10 and PM1 accounted for about 68% of PM2.5, and BC aerosols are mainly present in fine particulates. The variability of BC concentrations is quite consistent between the Nancun station (141 m above sea level) and the Panyu station (13 m above sea level), which are 8 km apart from each other. The concentration in higher altitude station (Panyu) is consistently lower than the lower altitude station (Nancun), and the difference of annual mean is about 4 μg·m-3. | WU Dui MAO JieTai DENG XueJiao TIE XueXi ZHANG YuanHang ZENG LiMin LI Fei TAN HaoBo BI XueYan HUANG XiaoYing CHEN Jing DENG Tao | 2009 | Science China Earth Sciences2009，52，8： | 58 |
| 3 | 植被含水量光学遥感估算方法研究进展显示文摘利用光学遥感技术定量估测植被含水量,有助于森林火险评估、农业干旱监测和作物产量估计.本文评述利用光谱反射率、光谱水分指数和辐射传输模型方法反演植被含水量的研究进展,从观测数据和辐射传输模型评估了光谱水分指数估测植被含水量的可靠性.重点针对植被含水量的两个主要定义—可燃物含水量(FMC)和等效水厚度(EWT),分析了植被水分指数对FMC和EWT的反演精度.而且利用观测数据和数据库估算植被含水量,结果表明三类水分指数(WSI,NDII,NDWI1640,WI/NDVI)均与冬小麦冠层FMC有较好的相关性(n=45).最后,本文总结了光学遥感探测植被含水量进一步的发展方向. | 张佳华 许云 姚凤梅 王培娟 郭文娟 李莉 YANG LiMin | 2010 | 中国科学:技术科学2010，40，10： | 40 |
| 4 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 5 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 6 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 7 | Tree-ring precipitation records from Baiyinaobao, Inner Mongolia since A.D. 1838显示文摘Correlation function analysis shows that total precipitation from April to early July (to July 10) in growing season limits the ring width of Picea Koraiensis significantly in Baiyinaobao, Xilinhot, Inner Mongolia. Thus a transfer function is designed to reconstruct the total precipitation from April to early July over the region for the last 160 years. The explained variance of the reconstruction is 49.3% (and 45.7% when adjusted for loss of degrees of freedom, N = 31, r = 0.702, F = 13.608, p < 0.0001). There are three relatively wet periods in the reconstruction which are: 1869—1875, 18861921 and 19431968, and four relatively dry periods: 1851—1868, 1876—1885, 1922—1943 and 1969—1999. Among them, the wet periods of 1886—1921 and 1943—1968, and the dry period of 1922—1943 appeared almost at the same time with those in Mt. Qilian region. Meanwhile, the dry period of 1922—1943 corresponds to high temperature and low rainfall during the 1920s and thereafter, and wetness of 1943—1968 corresponds very well to low temperature and more precipitation after the 1940s in Northwest, Northern China and the Changjiang River drainage basin. Calculation shows that the reconstruction series is significantly correlated with local dry-wet index (r = -0.234, p < 0.007, N = 143). Wavelet analysis indicates that there is a 22-a cycle in the precipitation of April to early July during 18381920, and an 11-a cycle during 1920—1952. No more cycles that reach 95% confidence limits are identified after 1953. The precipitation from April to early July quickly dropped into low during the 1920s. After 1950, precipitation shows a declining trend, but the reconstruction shows a tendency of increase in the late of 1990s. | LIU Yu CAI Qiufang Park Won-Kyu AN Zhisheng MA Limin | 2003 | Chinese Science Bulletin2003，48，11： | 29 |
| 8 | Hygroscopic growth of aerosol scattering coefficient:A comparative analysis between urban and suburban sites at winter in Beijing显示文摘A humidity controlled inlet system was developed to measure the hygroscopic growth of aerosol scattering coefficient in conjunction with nephelometry at an urban site of Chinese Academy of Meteorological Sciences (CAMS) in Beijing and a rural site at Shangdianzi Regional Background Air Pollution Monitoring Station (SDZ) outside Beijing during winter, from December 2005 to January 2006. Measurements were carried out at a wavelength of 525 nm with an Ecotech M9003 nephelometer. The hygroscopic growth function (or factor) of the aerosol scattering coefficient f(RH) increased continuously with increasing relative humidity (RH) and showed no obvious 'step-like' deliquescent behavior at both sites during the experiment. The average growth factor f(RH) at the SDZ site could reach 1.5 when RH increased from less than 40% to 92%, and to 2.1 at the CAMS site when RH increased from less than 40% to 93%. The average hygroscopic growth factor at a relative humidity of 80%, f(RH = 80 ± 1%), was found to be about 1.26 ± 0.15 at CAMS and 1.24 ± 0.11 at SDZ. Further analysis indicated that under relatively polluted conditions, the average hygroscopic growth factor was higher at the CAMS site than that at the SDZ site. However, under relatively clean air conditions, the difference between the two sites was small, showing a hygroscopic growth behavior similar to those of burning biomass or blowing dust. These results reflected the different characteristics of aerosol types at the two sites. | Peng Yan Xiaole Pan Jie Tang Xiuji Zhou Renjian Zhang Limin Zeng | 2009 | Particuology2009，7，1： | 30 |
| 9 | Geological characteristics and mineralization setting of the Zhuxi tungsten(copper) polymetallic deposit in the Eastern Jiangnan Orogen显示文摘The Zhuxi ore deposit is a super-large scheelite(copper) polymetallic deposit discovered in recent years. It grew above copper/tungsten-rich Neoproterozoic argilloarenaceous basement rocks and was formed in the contact zone between Yanshanian granites and Carboniferous-Permian limestone. Granites related to this mineralization mainly include equigranular, middle- to coarse-grained granites and granitic porphyries. There are two mineralization types: skarn scheelite(copper) and granite scheelite mineralization. The former is large scale and has a high content of scheelite, whereas the latter is small scale and has a low content of scheelite. In the Taqian-Fuchun Basin, its NW boundary is a thrust fault, and the SE boundary is an angular unconformity with Proterozoic basement. In Carboniferous-Permian rock assemblages, the tungsten and copper contents in the limestone are both very high. The contents of major elements in granitoids do not differ largely between the periphery and the inside of the Zhuxi ore deposit. In both areas, the values of the aluminum saturation index are A/CNK>1.1, and the rocks are classified as potassium-rich strongly peraluminous granites. In terms of trace elements, compared to granites on the periphery of the Zhuxi ore deposit, the granites inside the Zhuxi ore deposit have smaller d Eu values, exhibit a significantly more negative Eu anomaly, are richer in Rb, U, Ta, Pb and Hf, and are more depleted in Ba, Ce, Sr, La and Ti, which indicates that they are highly differentiated S-type granites with a high degree of evolution. Under the influence of fluids, mineralization of sulfides is evident within massive rock formations inside the Zhuxi ore deposit, and the mean SO_3 content is 0.2%. Compared to peripheral rocks, the d Eu and total rare earth element(REE) content of granites inside the Zhuxi ore deposit are both lower, indicating a certain evolutionary inheritance relationship between the granites on the periphery and the granites inside the Zhuxi ore deposit. For peripheral and ore district plutons, U-Pb zircon dating shows an age range of 152–148 Ma. In situ Lu-Hf isotope analysis of zircon in the granites reveals that the calculated e_(Hf)(t) values are all negative, and the majority range from -6 to -9. The T_(DM2) values are concentrated in the range of 1.50–1.88 Ga(peak at 1.75 Ga), suggesting that the granitic magmas are derived from partial melting of ancient crust. This paper also discusses the metallogenic conditions and ore-controlling conditions of the ore district from the perspectives of mineral contents, hydrothermal alteration, and ore-controlling structures in the strata and the ore-bearing rocks. It is proposed that the Zhuxi ore deposit went through a multistage evolution, including oblique intrusion of granitic magmas, skarn mineralization, cooling and alteration, and precipitation of metal sulfides. The mineralization pattern can be summarized as 'copper in the east and tungsten in the west, copper at shallow-middle depths and tungsten at deep depths, tungsten in the early stage and copper in the late stage'. | CHEN GuoHua SHU LiangShu SHU LiMin ZHANG Cheng OUYANG YongPeng | 2016 | Science China Earth Sciences2016，59，4： | 25 |
| 10 | Exploration of the formation mechanism and source attribution of ambient ozone in Chongqing with an observation-based model显示文摘An intensive field campaign was conducted in Chongqing during the summer of 2015 to explore the formation mechanisms of ozone pollution. The sources of ozone, the local production rates, and the controlling factors, as well as key species of volatile organic compounds(VOCs), were quantified by integrating a local ozone budget analysis, calculations of the relative incremental reactivity, and an empirical kinetic model approach. It was found that the potential for rapid local ozone formation exists in Chongqing. During ozone pollution episodes, the ozone production rates were found to be high at the upwind station Nan Quan, the urban station Chao Zhan, and the downwind station Jin-Yun Shan. The average local ozone production rate was 30×10^(-9) V/V h^(-1) and the daily integration of the produced ozone was greater than 180×10^(-9) V/V. High ozone concentrations were associated with urban and downwind air masses. At most sites, the local ozone production was VOC-limited and the key species were aromatics and alkene, which originated mainly from vehicles and solvent usage. In addition, the air masses at the northwestern rural sites were NO_x-limited and the local ozone production rates were significantly higher during the pollution episodes due to the increased NOx concentrations. In summary, the ozone abatement strategies of Chongqing should be focused on the mitigation of VOCs. Nevertheless, a reduction in NO_x is also beneficial for reducing the regional ozone peak values in Chongqing and the surrounding areas. | SU Rong LU KeDing YU JiaYan TAN ZhaoFeng JIANG MeiQing LI Jing XIE ShaoDong WU YuSheng ZENG LiMin ZHAI ChongZhi ZHANG YuanHang | 2018 | Science China Earth Sciences2018，61，1： | 24 |
| 11 | Third-order point contact approach for five-axis sculptured surface machining using non-ball-end tools(II): Tool positioning strategy显示文摘Based on the mathematical model describing the third-order approximation of the cutter envelope surface according to one given cutter location(CL),a tool positioning strategy is proposed for efficiently machining free-form surfaces with non-ball-end cutters.The optimal CL is obtained by adjusting the inclination and tilt angles of the cutter until its envelope surface and the design surface have the third-order contact at the cutter contact(CC)point,which results in a wide machining strip.The strategy can handle the constraints of machine joint angle limits,global collision avoidance and tool path smoothness in a nature way,and can be applied to general rotary cutters and complex surfaces.Numerical examples demonstrate that the third-order point contact approach can improve the machining strip width greatly as compared with the recently reported second-order one. | ZHU LiMin 1 ,DING Han 2 &XIONG YouLun 2 1State Key Laboratory of Mechanical System and Vibration,Shanghai Jiao Tong University,Shanghai 200240,China 2State Key Laboratory of Digital Manufacturing Equipment and Technology,Huazhong University of Science and Technology,Wuhan 430074, China | 2010 | Science China(Technological Sciences)2010，53，8： | 23 |
| 12 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system显示文摘MicroRNAs (miRNAs ) 是内长的 noncoding RNA (~ 22 nt ) 在细胞质在 post-transcriptional 水平调整目标基因表示。在房间原子核的要求功能的 argonaute 家庭蛋白质提示了我们假设那 miRNAs 的 miRNAs 和 miRNA 的存在的最近的发现可以也在房间原子核有规章的功能。在这研究,我们证明老鼠 miR-709 主要位于各种各样的房间类型的原子核并且它的原子本地化模式很快在 apoptotic 刺激之上变化。在房间原子核, miR-709 直接在 pri-miR-15a/16-1 上绑在一个 19-nt miR-709 识别元素并且阻止它处理成 pre-miR-15a/16-1,导致 miR-15a/16-1 成熟的抑制。而且,原子 miR-709 通过 miR-15a/16-1 小径参予房间 apoptosis 的规定。在摘要,现在的学习提供一 miRNA 能由直接在原子核指向他们的主要抄本控制另外的 miRNAs 的生物的续生说的第一条证据。 | Rui Tang Limin Li Dihan Zhu Dongxia Hou Ting Cao Hongwei Gu Jing Zhang Junyuan Chen Chen-Yu Zhang Ke Zen | 2012 | Cell Research2012，22，3： | 23 |
| 13 | Rural land use spatial allocation in the semiarid loess hilly area in China:Using a Particle Swarm Optimization model equipped with multi-objective optimization techniques显示文摘Semiarid loess hilly areas in China are enduring a series of environmental conflicts between urban expansion,cultivated land conservation,soil erosion and water shortage,and require land use allocation to reconcile these environmental conflicts.We argue that the optimized spatial allocation of rural land use can be achieved by a Particle Swarm Optimization (PSO) model in conjunction with multi-objective optimization techniques.Our study focuses on Yuzhong County of Gangsu Province in China,a typical catchment on the Loess Plateau,and proposes a land use spatial optimization model.The model maximizes land use suitability and spatial compactness based on a variety of constraints,e.g.optimal land use structure and restrictive areas,and employs an improved PSO algorithm equipped with a determinant initialization method and a dynamic weighted aggregation (DWA) method to obtain the optimized land use spatial pattern.The results suggest that (1) approximately 4% of land use should be reallocated and these changes would alleviate the environmental conflicts in the study area;(2) the major reshuffling is slope farmland and newly added construction and cultivated land,whereas the unchanged areas are largely forests and basic farmland;and (3) the PSO is capable of optimizing rural land use allocation,and the determinant initialization method and DWA can improve the performance of the PSO. | LIU YaoLin LIU DianFeng LIU YanFang HE JianHua JIAO LiMin CHEN YiYun HONG XiaoFeng | 2012 | Science China Earth Sciences2012，55，7： | 23 |
| 14 | Monitoring lake changes of Qinghai-Tibetan Plateau over the past 30 years using satellite remote sensing data显示文摘During the years 2006–2009,lakes in the Qinghai-Tibetan Plateau(QTP)were investigated using satellite remote sensing strategies.We report the results of this investigation as well as follow-up research and expanded work.For the investigation,we mainly focused on lakes whose areas are more than 1 km2.The remote sensing data that we used included 408 scenes of CBERS CCD images and 5 scenes of Landsat ETM?images in Qinghai Province and Tibet Autonomous Region.All these data were acquired around years 2005–2006.Besides remote sensing images,we also collected 1,259 topographic maps.Numbers and areas of lakes were analyzed statistically,which were then compared with those coming from the first lake investigation(implemented between the1960s and 1980s).According to our investigation,up to and around year 2005–2006,the total number of lakes in the QTP was 1,055(222 in Qinghai and 833 in Tibet),accounting for more than 30%of that of China.Thirty newborn lakes with area[1 km2were found,and 5 dead lakes with initial area[1 km2were also found.Among those 13 big lakes([500 km2),Yamzhog Yumco had seriously shrunk,and it has continued to shrink in recent years;Qinghai Lake had shrunk during the period,but some new researches indicated that it has been expanding since the year 2004;Siling Co,Nam Co,and Chibuzhang Co had expanded in the period.We divided the newborn lakes into six categories according to their forming reasons,including river expansion,wetland conversion,etc.The changes of natural conditions led to the death of four lakes,and human exploitation was the main reason for the death of Dalianhai Lake in Qinghai.We picked out three regions which were sensitive to the change of climate and ecological environment:Nagqu Region,Kekexili Region,and the source area of the Yellow River(SAYR).Lakes in both Nagqu and Kekexili have been expanded;meanwhile,most lakes in the SAYR have obviously been shrunk.These regional patterns of lake changes were highly related to variations of temperature,glacier,precipitation,and evaporation.Our investigation and analysis will provide references for researches related to lake changes in the QTP and the response to climate fluctuations. | Wei Wan Pengfeng Xiao Xuezhi Feng Hui Li Ronghua Ma Hongtao Duan Limin Zhao | 2014 | Chinese Science Bulletin2014，59，10： | 22 |
| 15 | Role of secondary aerosols in haze formation in summer in the Megacity Beijing显示文摘A field experiment from 18 August to 8 September 2006 in Beijing, China, was carried out. A hazy day was defined as visibility < 10 km and RH(relative humidity) < 90%. Four haze episodes, which accounted for ~ 60% of the time during the whole campaign, were characterized by increases of SNA(sulfate, nitrate, and ammonium) and SOA(secondary organic aerosol) concentrations. The average values with standard deviation of SO2-+4, NO-3, NH4 and SOA were 49.8(± 31.6), 31.4(±22.3), 25.8(±16.6) and 8.9(±4.1) μg/m3, respectively, during the haze episodes, which were 4.3, 3.4, 4.1, and 1.7 times those in the non-haze days. The SO2-4,NO-3, NH+4, and SOA accounted for 15.8%, 8.8%, 7.3%, and 6.0% of the total mass concentration of PM10 during the non-haze days. The respective contributions of SNA species to PM10 rose to about27.2%, 15.9%, and 13.9% during the haze days, while the contributions of SOA maintained the same level with a slight decrease to about 4.9%. The observed mass concentrations of SNA and SOA increased with the increase of PM10 mass concentration, however, the rate of increase of SNA was much faster than that of the SOA. The SOR(sulfur oxidation ratio) and NOR(nitrogen oxidation ratio) increased from non-haze days to hazy days, and increased with the increase of RH. High concentrations of aerosols and water vapor favored the conversion of SO2 to SO2-4and NO2 to NO-3, which accelerated the accumulation of the aerosols and resulted in the formation of haze in Beijing. | Tingting Han Xingang Liu Yuanhang Zhang Yu Qu Limin Zeng Min Hu Tong Zhu | 2015 | Journal of Environmental Sciences2015，27，5： | 22 |
| 16 | Chemically exfoliated metallic MoS2 nanosheets: A promising supporting co-catalyst for enhancing the photocatalytic performance of TiO2 nanocrystals显示文摘电子洞分离是到完成有效光催化,合作催化剂的使用向成为了广泛地使用的策略的关键步。当设计划算的、高效的混合光催化剂时,尽管有巨大的努力和高贵金属合作催化剂的表明的功能,寻求高贵没有金属的合作催化剂将总是是目标。在这个工作,我们证明瞬间 < 潜水艇 class= “ a-plus-plus ” > 有 1T 阶段的 2 nanosheets (即,八面的阶段) 能与多重优点作为合作催化剂工作:(1 ) Noble-metal-free;(2 ) 为充电的高活动性运输;(3 ) 为 H 的活跃地点的高密度 < 潜水艇 class= “ a-plus-plus ” > 基础飞机上的 2 进化;(4 ) 好表演稳定性;(5 ) 高点亮透明性。是在两 photocatalytic 氢生产和玫瑰精 B 降级示威了,有 TiO 的发达混合结构<潜水艇class=“ a-plus-plus ”> 2 展出优秀性能,在到赤裸的 TiO 的鲜明对比<潜水艇class=“ a-plus-plus ”>有2H瞬间的 2 和混合对应物<潜水艇class=“ a-plus-plus ”> 2 。 | Song Bai Limin Wang Xiaoyi Chen Junteng Du Yujie Xiong | 2015 | Nano Research2015，8，1： | 19 |
| 17 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 18 | Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook显示文摘Traditional Chinese medicine (TCM) is a medical system that has collected and summarized abundant clinical experience over its long history of more than 2000 years. However, the frequent occurrence of TCM-induced adverse reactions has hindered the modernization and internationalization of TCM, while attracting increasing attention from around the world. Unlike chemical drugs and biological agents, the difficulties involved in research on the toxicity and safety of TCM mainly include the complexity of its components and the unpredictability of drug–body interactions. Much of TCM, which has overall therapeutic effects, has the typical mechanisms of multiple components, multiple pathways, and multiple targets. While considering the gradualness and unpredictability of TCM toxicity, the ambiguity of toxicants and safe dosage, and individual differences during long-term TCM administration, we have systematically established key techniques for the toxicity assessment of TCM. These techniques mainly include TCM toxicity discovery in an early phase, based on a combination of drug toxicology genomics and metabolomics;methods to identify dose–toxicity relationships in TCM;and integrated techniques for the exploration of TCM interactions, such as fast-screening tests based on drug-metabolizing enzymes and receptor pathways. In particular, we have developed a new technical system for TCM safety evaluation using molecular toxicology, which has been validated well in research on TCM compatibility contraindication, quality control, and allergen discovery. The application of this key technical platform is introduced here in detail. This application includes model organisms, toxicant biomarkers, a magnetic suspension technique, and the application of network toxicology and computational toxicology in research on the toxicity of Fructus toosendan, Semen cassiae, Polygonum multiflorum, and Fructus psoraleae. | Yue Gao Aihua Liang Xiaohui Fan Limin Hu Feiran Hao Yubo Li | 2019 | Engineering2019，5，1： | 19 |
| 19 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 20 | The influence of land use change on the spatial–temporal variability of habitat quality between 1990 and 2010 in Northeast China显示文摘Land use changes are a direct consequence of interactions between humans and nature.Analysing the spatial and temporal changes in habitat quality brought about by land use change can provide a scientific basis for ecological protection and land planning.Based on the analysis of land use change from 1990 to 2010 in Northeast China,we used the InVEST(integrated valuation of ecosystem services and trade-offs)module to evaluate habitat quality based on watershed subdivision.The results show that:(1)the main land use changes from 1990 to 2010 were the transition from grasslands and forest lands to agricultural lands,which led to a decrease in connectivity of landscape and an increase in fragmentation;(2)areas of high habitat quality were distributed north of the Greater Khingan Mountains,the region of the Lesser Khingan Mountains and east of the Changbai Mountains,while the central plain had low habitat quality;(3)agricultural lands had the largest effect on habitat degradation among all habitat threats.During these 2 decades,the contribution of agricultural lands to habitat degradation were 43.4%in 1990,44.6%in 2000 and 43.9%in 2010;and,(4)at a landscape scale,patch density and splitting index present noticeable negative correlations with habitat quality index.Habitat quality was significantly affected by landscape fragmentation and decreased connectivity. | Limin Dai Shanlin Li Bernard J.Lewis Jian Wu Dapao Yu Wangming Zhou Li Zhou Shengnan Wu | 2019 | Journal of Forestry Research2019，30，6： | 18 |
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