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| 1 | The age of the base of the Paleoproterozoic Hutuo Group in the Wutai Mountains area, North China Craton: SHRIMP zircon U-Pb dating of basaltic andesite显示文摘Basalt and basaltic andesite metamorphosed at greenschist facies occurs with conglomerate layers at the bottom of the Paleoproterozoic Hutuo Group in the Wutai Mountains area, North China Craton. Detailed geological surveying confirms that these volcanic rocks are conformable within the neighboring sedimentary rocks. The SHRIMP results on basaltic andesite are divided into two groups. In one group the 207Pb/206Pb ages are from 2433 to 2558 Ma, which is consistent with the basement crustal age in Fuping and Wutai areas. In the other group, 13 grains yielded a weighted mean 207Pb/206Pb age of 2140±14 Ma. The latter is interpreted as the eruption age of the basaltic andesite, and gives the age of the base of the Hutuo Group. This result further suggests that the Hutuo Group formed in the middle Paleoproterozoic, not the early Palaeoproterozoic or late Archaean, as thought before, and is related to a 2.2-2.1 Ga rifting event in the Central North China Craton. | DU LiLin YANG ChongHui GUO JingHui WANG Wei REN LiuDong WAN YuSheng GENG YuanSheng | 2010 | Chinese Science Bulletin2010，55，17： | 43 |
| 2 | Formation ages and source regions of the Palaeoproterozoic Gaofan, Hutuo and Dongjiao groups in the Wutai and Dongjiao areas of the North China Craton from SHRIMP U-Pb dating of detrital zircons: Resolution of debates over their stratigraphic relationships显示文摘这份报纸在北方中国 Craton 的 Wutai 和 Dongjiao 区域报导 Gaofan, Hutuo 和 Dongjiao 组的元沉积的岩石的由岩屑形成的锆石年龄分布。由岩屑形成的锆石一从 Gaofan 组的 quartzite 主要是在年龄的 2.5 Ga,与大约 2.7 Ga 并且更旧。A 石英岩从 Hutuo 组的基础集团企业的卵石在到 Gaofan 组的 quartzite 的由岩屑形成的锆石年龄分发是类似的。为从 Dongjiao 组的 meta-feldspar-quartz 沙岩,由岩屑形成的锆石的年龄主要在 2.5 Ga 被集中。比 2.6 Ga 旧的锆石都没被识别,但是在年龄与一些是 1.84 Ga 和 2.22.0 Ga。与更早的研究结合了,下列结论能被得出:(1 ) Gaofan 组是在年龄的早 Palaeoproterozoic 并且对迟了的 Neoarchaean Wutai 花岗石绿岩岩层年轻得多、无关,它 unconformably 躺它。因此, Gaofan 组是在诺思中国 Craton 的最旧的 Palaeoproterozoic 元沉积的单位之一。(2 ) Hutuo 组在一个大陆人地下室上在中间的 Palaeoproterozoic (2.14-2.09 Ga ) 被扔,在早 Palaeoproterozoic Gaofan 组后面。(3 ) Dongjiao 组在 1.84 Ga 以后被形成,并且可能属于 Changcheng 系统的更低的部分。(4 ) 从所有三个组的由岩屑形成的锆石显示出 2.5 Ga 的一座明显的年龄山峰,从在北方中国 Craton 在太古代的结束在强烈 tectono-magma-thermal 事件形成的火的岩石被采购。 | WAN YuSheng MIAO PeiSheng LIU DunYi YANG ChongHui WANG Wei WANG HuiChu WANG ZheJiu DONG ChunYan DU LiLin ZHOU HongYing | 2010 | Chinese Science Bulletin2010，55，13： | 32 |
| 3 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 4 | Formation age and tectonic environment of the Gantaohe Group,North China Craton:Geology,geochemistry,SHRIMP zircon geochronology and Hf-Nd isotopic systematics显示文摘The Gantaohe Group is an important early Precambrian unit in the Trans-North China Orogen,North China Craton,and is mainly composed of greenschist-facies metabasalt,meta-sandstone and dolomitic marble.We report whole-rock geochemical compositions and SHRIMP zircon ages as well as LA-ICP-MS Hf-in-zircon isotopeic analyses for metabasalts from the Gantaohe Group.SHRIMP dating yielded a weighted mean 207Pb/206Pb age of 2087±16 Ma(MSWD=1.3) for magmatic zircons,but there are also abundant ca.2.5 Ga inherited zircon xenocrysts.The magmatic zircons shows a large Hf(t) variation in Hf(t) from 7.17 to +0.45,suggesting an isotopically highly heterogeneous source for the metabasalt.Chemically all samples show no distinct Zr or Hf anomalies,and some samples show no Nd or Ta anomalies in a primitive mantle-normalized trace element variation diagram,and their whole-rock Nd(t) values range from 4.0 to 0.8.We suggest that the basalt is formed by partial melting of a depleted mantle source,followed by significant crustal contamination.Field observations,the presence of abundant inherited zircon,as well as isotope and trace elements geochemistry support formation of the Gantaohe Group on top of a continental basement.These data and the regional geology lead us to conclude that the Trans-North China Orogen constituted an intracontinental rift during the Paleoproterozoic that was connected to the Eastern Block since the end of the Archean. | XIE HangQiang LIU DunYi YIN XiaoYan ZHOU HongYing YANG ChongHui DU LiLin WAN YuSheng | 2012 | Chinese Science Bulletin2012，57，36： | 16 |
| 5 | Intelligent control of mode-locked femtosecond pulses by time-stretch-assisted real-time spectral analysis显示文摘Mode-locked fiber lasers based on nonlinear polarization evolution can generate femtosecond pulses with different pulse widths and rich spectral distributions for versatile applications through polarization tuning.However,a precise and repeatable location of a specific pulsation regime is extremely challenging.Here,by using fast spectral analysis based on a time-stretched dispersion Fourier transform as the spectral discrimination criterion,along with an intelligent polarization search algorithm,for the first time,we achieved real-time control of the spectral width and shape of mode-locked femtosecond pulses;the spectral width can be tuned from 10 to 40 nm with a resolution of ~1.47 nm,and the spectral shape can be programmed to be hyperbolic secant or triangular.Furthermore,we reveal the complex,repeatable transition dynamics of the spectrum broadening of femtosecond pulses,including five middle phases,which provides deep insight into ultrashort pulse formation that cannot be observed with traditional mode-locked lasers. | Guoqing Pu Lilin Yi Li Zhang Chao Luo Zhaohui Li Weisheng Hu | 2020 | Light(Science & Applications)2020，9，1： | 16 |
| 6 | rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study显示文摘Along with the develoipment of high-throughput sequencing technologies,both sample size and SNP number are increasing rapidly in genome-wide association studies(GWAS),and the associated computation is more challenging than ever.Here,we present a memory-efficient,visualization-enhanced,and parallel-accelerated R package called“r MVP”to address the need for improved GWAS computation.r MVP can 1)effectively process large GWAS data,2)rapidly evaluate population structure,3)efficiently estimate variance components by Efficient Mixed-Model Association e Xpedited(EMMAX),Factored Spectrally Transformed Linear Mixed Models(Fa ST-LMM),and Haseman-Elston(HE)regression algorithms,4)implement parallel-accelerated association tests of markers using general linear model(GLM),mixed linear model(MLM),and fixed and random model circulating probability unification(Farm CPU)methods,5)compute fast with a globally efficient design in the GWAS processes,and 6)generate various visualizations of GWASrelated information.Accelerated by block matrix multiplication strategy and multiple threads,the association test methods embedded in r MVP are significantly faster than PLINK,GEMMA,and Farm CPU_pkg.r MVP is freely available at http://gffzz188fe103f8f1460as0u9kw65vqq6x6ow5.ffgz.tsg.suse.edu.cn/xiaolei-lab/r MVP. | Lilin Yin Haohao Zhang Zhenshuang Tang Jingya Xu Dong Yin Zhiwu Zhang Xiaohui Yuan Mengjin Zhu Shuhong Zhao Xinyun Li Xiaolei Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 7 | Quantitative (stereological) study of incomplete spermatogenic suppression induced by testosterone undecanoate injection in rats显示文摘Aim: To evaluate the key lesions in spermatogenesis suppressed partially by testosterone undecanoate(TU) treatment. Methods: Adult male SD rats were treated with vehicle or TU (19 mg/kg) injection (i.m.) every 15 days for 130 days. The numbers of all types of cells (nuclei) in the seminiferous tubules and the interstitial tissue were estimated using a contemporary stereological tool, the optical disector. Results: In response to TU treatment, the numbers of non-type B spermatogonia, type B sperrnatogonia and late elongated spermatids per testis were reduced to 51%, 66% and 14% of the controls, respectively. The conversion ratios from type B spermatogonia to early spermatocytes and pachytene spermatocytes were not significantly affected and the ratios to the later germ cell types fell to 51%-65% of the controls. Less than 1.0 % of immature round spermatids were seen sloughing into the tubule lumen, 4.0% of elongated spermatids retained in the seminiferous epithelium, and about half of the elongated spermatid nuclei appreciably malformed. Leydig cells were atrophied but their number and the peritubular myoid cell number per testis were unchanged. Conclusion: Double inhibition of spermatogenesis (i.e. inhibition at spermiation and spermatogonial conversion to type B spermatogonia), a scenario seen in the monkey and human following gonadotrophin withdrawal, was not sufficiently effective for a complete spermatogenic suppression in the rat after TU treatment, probably due to ineffective inhibition of the Leydig cell population and therefore the intra-testicular test-osterone levels. (Asian J Androl 2004 Dec; 6: 291-297) | Zheng-WeiYang YangGuo LiLin Xing-HaiWang Jian-SunTong Gui-YuanZhang | 2004 | Asian Journal of Andrology2004，6，4： | 9 |
| 8 | Mercury adsorption characteristics of HBr-modified fly ash in an entrained-flow reactor显示文摘In this study, the mercury adsorption characteristics of HBr-modified fly ash in an entrained-flow reactor were investigated through thermal decomposition methods. The results show that the mercury adsorption performance of the HBr-modified fly ash was enhanced significantly. The mercury species adsorbed by unmodified fly ash were Hg Cl2,Hg S and Hg O. The mercury adsorbed by HBr-modified fly ash, in the entrained-flow reactor,existed in two forms, Hg Br2 and Hg O, and the HBr was the dominant factor promoting oxidation of elemental mercury in the entrained-flow reactor. In the current study, the concentration of Hg Br2 and Hg O in ash from the fine ash vessel was 4.6 times greater than for ash from the coarse ash vessel. The fine ash had better mercury adsorption performance than coarse ash, which is most likely due to the higher specific surface area and longer residence time. | Yongsheng Zhang Lilin Zhao Ruitao Guo Na Song Jiawei Wang Yan Cao William Orndorff Wei-ping Pan | 2015 | Journal of Environmental Sciences2015，27，7： | 9 |
| 9 | Provenance of the Paleoproterozoic Hutuo Group basal conglomerates and Neoarchean crustal growth in the Wutai Mountains,North China Craton:Evidence from granite and quartzite pebble zircon U-Pb ages and Hf isotopes显示文摘Zircon U-Pb ages(SHRIMP and LA-ICPMS) and Lu-Hf isotope data(LA-ICPMS) are presented for two granite and two quartzite pebbles from the basal conglomerates of the Sijizhuang Formation in the Hutuo Group from the Wutai Mountains area in the North China Craton.These two granite pebbles give zircon 207 Pb/206 Pb ages of 2513±8 Ma and 2527±8 Ma respectively,which are consistent with the emplacement ages of the Wangjiahui grey granite and Guangmingsi or Shifo granite in the Wutai Mountains.Detrital zircons from those two quartzite pebbles are mostly 2550-2490 Ma old with lesser number of 2800-2550 Ma grains,which is similar to the ages of detrital zircons from quartzites in the Gaofan Subgroup of the Neoarchean Wutai Group.Thus,the pebbles in the Hutuo Group basal conglomerates were derived locally from Wutai Mountains Neoarchean sources.Zircons from the Sijizhuang Formation conglomerate granite and quartzite pebbles mostly have positive ε Hf(t) values,a minority with ε Hf(t) values like model depleted mantle(DM) of the same age,but with most showing DM model ages 200-100 Ma.This indicates that most of the source materials were derived from the mantle within the previous 200 million years,whereas some are derived from 2550-2510 Ma juvenile crustal additions.This additional evidence suggests that in the North China Craton there was important initial polycyclic crustal formation and cratonization in the late Neoarchaean,prior to superimposed Palaeoproterozoic orogenic cycles. | DU LiLin YANG ChongHui WANG Wei REN LiuDong WAN YuSheng SONG HuiXia GAO LinZhi GENG YuanSheng HOU KeJun | 2012 | Science China Earth Sciences2012，55，11： | 8 |
| 10 | Porcine Immunoglobulin Fc Fused P30/P54 Protein of African Swine Fever Virus Displaying on Surface of S. cerevisiae Elicit Strong Antibody Production in Swine显示文摘African swine fever virus(ASFV)infects domestic pigs and European wild boars with strong,hemorrhagic and high mortality.The primary cellular targets of ASFV is the porcine macrophages.Up to now,no commercial vaccine or effective treatment available to control the disease.In this study,three recombinant Saccharomyces cerevisiae(S.cerevisiae)strains expressing fused ASFV proteins-porcine Ig heavy chains were constructed and the immunogenicity of the S.cerevisiae-vectored cocktail ASFV feeding vaccine was further evaluated.To be specific,the P30-Fcγand P54-Fcαfusion proteins displaying on surface of S.cerevisiae cells were produced by fusing the Fc fragment of porcine immunoglobulin IgG1 or IgA1 with p30 or p54 gene of ASFV respectively.The recombinant P30-Fcγand P54-Fcαfusion proteins expressed by S.cerevisiae were verified by Western blotting,flow cytometry and immunofluorescence assay.Porcine immunoglobulin Fc fragment fused P30/P54 proteins elicited P30/P54-specific antibody production and induced higher mucosal immunity in swine.The absorption and phagocytosis of recombinant S.cerevisiae strains in IPEC-J2 cells or porcine alveolar macrophage(PAM)cells were significantly enhanced,too.Here,we introduce a kind of cheap and safe oral S.cerevisiae-vectored vaccine,which could activate the specific mucosal immunity for controlling ASFV infection. | Chen Chen Deping Hua Jingxuan Shi Zheng Tan Min Zhu Kun Tan Lilin Zhang Jinhai Huang | 2021 | Virologica Sinica2021，36，2： | 7 |
| 11 | Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer显示文摘Clusterin/apolipoprotein J (Clu ) 是在几个生理的过程被含有的无所不在地表示的分泌 heterodimeric glycoprotein。这被报导了分泌 clusterin (sClu ) 的提高的水平蛋白质在乳癌病人与差的幸存被联系并且能在啮齿类动物模型导致转移。在这研究,我们在 vitro 并且在 vivo 在细胞活动性,侵略,和生长上与小介入 RNA (siRNAs ) 调查了 sClu 抑制的效果。MDA-MB-231 房间是有 pSuper-siRNA/sClu 的 transfected。房间幸存和增长被 3-(4,5-dimethyl-thiazol-2yl ) 检验 -5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium 和 clonogenic 幸存试金。结果证明 sClu silencing 显著地禁止了 MDA-MB-231 房间的增长。侵略和迁居能力戏剧性地也被减少,它被 matrigel 试金检测。染色的 TUNEL 和 caspase-3 活动试金证明 sClu silencing 能也增加房间的 apoptosis 率,导致房间生长的抑制。我们也在一个 orthotopic 乳癌模型在肿瘤生长和变形前进上决定了 sClu silencing 的效果。结果比肿瘤源于父母 MDA-MB-231 或 MDA-MB-231/pSuper 的证明主要肿瘤从 MDA-MB-231/pSuper sClu siRNA 房间导出的 orthotopic 变得显著地慢爬 siRNA 房间,并且少些转移到肺。这些数据建议能分泌的 clusterin 在肿瘤生长和变形前进起一个重要作用。敲门下面 sClu 基因表示可以为乳癌治疗提供一个珍贵方法。 | Zhaohe Niu Xinhui Li Bin Hu Rong Li Ligang Wang Lilin Wu Xingang Wang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，12： | 6 |
| 12 | MicroRNA expression profile of gastric cancer stem cells in the MKN-45 cancer cell line显示文摘MicroRNAs (miRNAs ) 玩在目标送信人 RNA 的 post-transcriptional 基因 silencing 的重要角色,它几乎涉及所有生物过程。以前,我们证明了从 MKN-45 癌症房间的形成身体的房间衬里的球状体拥有了胃的癌症干细胞(CSC ) 性质。在这研究,我们试图决定胃的 CSC 的 miRNA 侧面并且在胃的 CSC 探索 miRNAs 的角色。人的 miRNA microarrays,它包含为 1887 人的 miRNAs 特定的探针被用来决定胃的 CSC 的表示侧面。有一个超过 2 褶层变化的 182 miRNAs 的一个总数被识别是在球状体之间表示的差别形成身体的房间和父母房间。这些 miRNAs, 9 miRNAs 在球状体是过去表示的形成身体的房间当另外的 173 miRNAs 都是下面表示的时,显示在人的胃的 CSC 的大多数 miRNAs 的角色可以是肿瘤 suppressors。microarray 分析的结果被量的即时聚合酶链反应验证,并且坚固性率是 70%(7 从 10 ) 。为验证 miRNAs 的目标基因被使用三个联机软件程序预言,人权保护, PicTar,和 TargetScan。大多数 miRNAs 的潜在的目标与在癌症的肌动朊细胞骨架,焦点的粘附,细胞外的 matrixreceptor 相互作用,和小径的规定相关。特别,几基因与干细胞基因的一些枢轴的发信号小径被联系。评估胃的 CSC 的典型 miRNAs 可以是为学习胃的癌症并且开发治疗学的策略的一个新方法,它在胃的癌症在根除瞄准了 CSC 的 subpopulation。 | Jianming Liu Lilin Ma Zhiwei Wang Lei Wang Chun Liu Ruixin Chen Jianguo Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 6 |
| 13 | Preliminary Studies on the Intergeneric Hybridization Between Brassica napus with OguCMS and Orychophragmus violaceus显示文摘In the cross between B. napus with OguCMSOrychophragmus violaceus, pre-fertilizatiocompatibility was observed. An intergeneric hybrid was successfully obtained by usinovary culture. The hybrid status was confirmed by cytology, morphology, fertilityisozyme and miosis analysis. The seed setting rate was 0.0072%. An amphidiploid of thhybrid was also produced by the use of chromosome-doubling method with 0.1% colchicinetreatment. Obtaining this hybrid and its amphidiploid has important theoretical anutilization value. | WUJun LIXu-feng QINJin-hong LILin WUShu-hui TANGKe-xuan | 2004 | Agricultural Sciences in China2004，3，4： | 6 |
| 14 | Complex interplay between formation routes and natural organic matter modification controls capabilities of C_(60)nanoparticles(nC_(60)) to accumulate organic contaminants显示文摘Accumulation of organic contaminants on fullerene nanoparticles(nC_(60)) may significantly affect the risks of C_(60) in the environment.The objective of this study was to further understand how the interplay of nC_(60) formation routes and humic acid modification affects contaminant adsorption of nC_(60).Specifically,adsorption of 1,2,4,5-tetrachlorobenzene(a model nonionic,hydrophobic organic contaminant) on nC_(60) was greatly affected by nC_(60)formation route- the formation route significantly affected the aggregation properties of nC_(60),thus affecting the available surface area and the extent of adsorption via the pore-filling mechanism.Depending on whether nC_(60) was formed via the 'top-down' route(i.e.,sonicating C_(60) powder in aqueous solution) or 'bottom-up' route(i.e.,phase transfer from an organic solvent) and the type of solvent involved(toluene versus tetrahydrofuran),modification of nC_(60) with Suwannee River humic acid(SRHA) could either enhance or inhibit the adsorption affinity of nC_(60).The net effect depended on the specific way in which SRHA interacted with C_(60) monomers and/or C_(60) aggregates of different sizes and morphology,which determined the relative importance of enhanced adsorption from SRHA modification via preventing C_(60) aggregation and inhibited adsorption through blocking available adsorption sites.The findings further demonstrate the complex mechanisms controlling interactions between nC_(60) and organic contaminants,and may have significant implications for the life-cycle analysis and risk assessment of C_(60). | Lei Hou John D.Fortner Ximeng Wang Chengdong Zhang Lilin Wang Wei Chen | 2017 | Journal of Environmental Sciences2017，29，1： | 5 |
| 15 | Coating thick MgB_(2) layer on stainless steel substrate显示文摘 | CHENChinping FENGQingrong GANZizhao XlONGGuangcheng XUJun LIUYufei KONGLingwen LILin JIAZhang GUOJingpu ZHUANGChenggang DINGLili CHENLiping LIFen ZHANGKaicheng | 2005 | Chinese Science Bulletin2005，50，7： | 5 |
| 16 | Research on the magnetic material of Sm-Fe matrix nitrides显示文摘In this paper,the types of Sm-Fe matrix compounds and their correlations are introduced,and progress of research on the magnetic materials of Sm-Fe matrix nitrides is also reviewed.Possible research trends of future permanent magnetic materials of Sm-Fe matrix nitrides are briefly predicted. | CUIChunxiang SUNJibing ZHANGYing WANGRu LILin LIANGZhimei | 2005 | Progress in Natural Science:Materials International2005，15，3： | 5 |
| 17 | Solidification Microstructure of Laser Additive Manufactured Ti—6Al—2Zr—2Sn—3Mo—1.5Cr—2Nb Titanium Alloy显示文摘Solidification microstructure of powder fed laser additive manufactured Ti—6Al—2Zr—2Sn—3Mo—1.5Cr—2Nb titanium alloy was investigated.The results showed that by deliberately increasing the powder feed rate,partially melted powders were retained at the top of the molten pool,which can promote heterogeneous nucleus.Thus,each cladding layer is composed of two regions:(i)randomly orientated cellular structure region caused by partially melted powders at the top of each cladding layer;and(ii)epitaxial cellular structure region adjacent to the fusion line.Usually,randomly orientated cellular structure region was totally remelted for a wide range of process conditions.The remelting effect ensures the continuity of epitaxial growth of cellular structure and leads to the formation of columnarβgrains.In order to obtain equiaxed grains the scanning velocity and powder feed rate should be carefully selected to enlarge the randomly orientated cellular structure region. | Qiang Zhang Jing Chen Lilin Wang Hua Tan Xin Lin Weidong Huang | 2016 | Journal of Materials Science & Technology2016，32，4： | 4 |
| 18 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 19 | Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion显示文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy. | Huanmin Niu Lilin Qian Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 4 |
| 20 | Gene Identification and Expression Analysis of 86,136 Expressed Sequence Tags(EST)from the Rice Genome显示文摘Expressed Sequence Tag(EST)analysis has pioneered genome-wide gene discovery and expression profiling.In order to establish a gene expression index in the rice cultivar indica,we sequenced and analyzed 86,136 ESTs from nine rice cDNA libraries from the super hybrid cultivar LYP9 and its parental cultivars.We assembled these ESTs into 13,232 contigs and leave 8,976 singletons.Overall,7,497 sequences were found similar to the existing sequences in GenBank and 14,711 are novel.These sequences are classified by molecular function,biological process and pathways according to the Gene Ontology.We compared our sequenced ESTs with the publicly available 95,000 ESTs from japonica,and found little sequence variation,despite the large difference between genome sequences,We then assembled the combined 173,000 rice ESTs for further analysis.Using the pooled ESTs,we compared gene expression in metabolism pathway between rice and Arabidopsis according to KEGG.We further profiled gene expression patterns in different tissues,developmental stages,and in a conditional sterile mutant,after checking the libraries are comparable by means of sequence coverage.We also identified some possible library specific genes and a number of enzymes and transcription factors that contribute to rice development. | YanZhou JiabinTang MichaelG.Walker XiuqingZhang JunWang SongnianHu HuayongXu SigiLiu HuanmingYang JunYu JianWang YajunDeng JianhaiDong LinYe LiLin JunLi XuegangWang HaoHu YibinPan WeiLin WeiTian JingLiu LipingWei | 2003 | Genomics, Proteomics & Bioinformatics2003，1，1： | 4 |
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