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| 1 | The age of the base of the Paleoproterozoic Hutuo Group in the Wutai Mountains area, North China Craton: SHRIMP zircon U-Pb dating of basaltic andesite显示文摘Basalt and basaltic andesite metamorphosed at greenschist facies occurs with conglomerate layers at the bottom of the Paleoproterozoic Hutuo Group in the Wutai Mountains area, North China Craton. Detailed geological surveying confirms that these volcanic rocks are conformable within the neighboring sedimentary rocks. The SHRIMP results on basaltic andesite are divided into two groups. In one group the 207Pb/206Pb ages are from 2433 to 2558 Ma, which is consistent with the basement crustal age in Fuping and Wutai areas. In the other group, 13 grains yielded a weighted mean 207Pb/206Pb age of 2140±14 Ma. The latter is interpreted as the eruption age of the basaltic andesite, and gives the age of the base of the Hutuo Group. This result further suggests that the Hutuo Group formed in the middle Paleoproterozoic, not the early Palaeoproterozoic or late Archaean, as thought before, and is related to a 2.2-2.1 Ga rifting event in the Central North China Craton. | DU LiLin YANG ChongHui GUO JingHui WANG Wei REN LiuDong WAN YuSheng GENG YuanSheng | 2010 | Chinese Science Bulletin2010，55，17： | 43 |
| 2 | Formation ages and source regions of the Palaeoproterozoic Gaofan, Hutuo and Dongjiao groups in the Wutai and Dongjiao areas of the North China Craton from SHRIMP U-Pb dating of detrital zircons: Resolution of debates over their stratigraphic relationships显示文摘这份报纸在北方中国 Craton 的 Wutai 和 Dongjiao 区域报导 Gaofan, Hutuo 和 Dongjiao 组的元沉积的岩石的由岩屑形成的锆石年龄分布。由岩屑形成的锆石一从 Gaofan 组的 quartzite 主要是在年龄的 2.5 Ga,与大约 2.7 Ga 并且更旧。A 石英岩从 Hutuo 组的基础集团企业的卵石在到 Gaofan 组的 quartzite 的由岩屑形成的锆石年龄分发是类似的。为从 Dongjiao 组的 meta-feldspar-quartz 沙岩,由岩屑形成的锆石的年龄主要在 2.5 Ga 被集中。比 2.6 Ga 旧的锆石都没被识别,但是在年龄与一些是 1.84 Ga 和 2.22.0 Ga。与更早的研究结合了,下列结论能被得出:(1 ) Gaofan 组是在年龄的早 Palaeoproterozoic 并且对迟了的 Neoarchaean Wutai 花岗石绿岩岩层年轻得多、无关,它 unconformably 躺它。因此, Gaofan 组是在诺思中国 Craton 的最旧的 Palaeoproterozoic 元沉积的单位之一。(2 ) Hutuo 组在一个大陆人地下室上在中间的 Palaeoproterozoic (2.14-2.09 Ga ) 被扔,在早 Palaeoproterozoic Gaofan 组后面。(3 ) Dongjiao 组在 1.84 Ga 以后被形成,并且可能属于 Changcheng 系统的更低的部分。(4 ) 从所有三个组的由岩屑形成的锆石显示出 2.5 Ga 的一座明显的年龄山峰,从在北方中国 Craton 在太古代的结束在强烈 tectono-magma-thermal 事件形成的火的岩石被采购。 | WAN YuSheng MIAO PeiSheng LIU DunYi YANG ChongHui WANG Wei WANG HuiChu WANG ZheJiu DONG ChunYan DU LiLin ZHOU HongYing | 2010 | Chinese Science Bulletin2010，55，13： | 32 |
| 3 | Formation age and tectonic environment of the Gantaohe Group,North China Craton:Geology,geochemistry,SHRIMP zircon geochronology and Hf-Nd isotopic systematics显示文摘The Gantaohe Group is an important early Precambrian unit in the Trans-North China Orogen,North China Craton,and is mainly composed of greenschist-facies metabasalt,meta-sandstone and dolomitic marble.We report whole-rock geochemical compositions and SHRIMP zircon ages as well as LA-ICP-MS Hf-in-zircon isotopeic analyses for metabasalts from the Gantaohe Group.SHRIMP dating yielded a weighted mean 207Pb/206Pb age of 2087±16 Ma(MSWD=1.3) for magmatic zircons,but there are also abundant ca.2.5 Ga inherited zircon xenocrysts.The magmatic zircons shows a large Hf(t) variation in Hf(t) from 7.17 to +0.45,suggesting an isotopically highly heterogeneous source for the metabasalt.Chemically all samples show no distinct Zr or Hf anomalies,and some samples show no Nd or Ta anomalies in a primitive mantle-normalized trace element variation diagram,and their whole-rock Nd(t) values range from 4.0 to 0.8.We suggest that the basalt is formed by partial melting of a depleted mantle source,followed by significant crustal contamination.Field observations,the presence of abundant inherited zircon,as well as isotope and trace elements geochemistry support formation of the Gantaohe Group on top of a continental basement.These data and the regional geology lead us to conclude that the Trans-North China Orogen constituted an intracontinental rift during the Paleoproterozoic that was connected to the Eastern Block since the end of the Archean. | XIE HangQiang LIU DunYi YIN XiaoYan ZHOU HongYing YANG ChongHui DU LiLin WAN YuSheng | 2012 | Chinese Science Bulletin2012，57，36： | 16 |
| 4 | Provenance of the Paleoproterozoic Hutuo Group basal conglomerates and Neoarchean crustal growth in the Wutai Mountains,North China Craton:Evidence from granite and quartzite pebble zircon U-Pb ages and Hf isotopes显示文摘Zircon U-Pb ages(SHRIMP and LA-ICPMS) and Lu-Hf isotope data(LA-ICPMS) are presented for two granite and two quartzite pebbles from the basal conglomerates of the Sijizhuang Formation in the Hutuo Group from the Wutai Mountains area in the North China Craton.These two granite pebbles give zircon 207 Pb/206 Pb ages of 2513±8 Ma and 2527±8 Ma respectively,which are consistent with the emplacement ages of the Wangjiahui grey granite and Guangmingsi or Shifo granite in the Wutai Mountains.Detrital zircons from those two quartzite pebbles are mostly 2550-2490 Ma old with lesser number of 2800-2550 Ma grains,which is similar to the ages of detrital zircons from quartzites in the Gaofan Subgroup of the Neoarchean Wutai Group.Thus,the pebbles in the Hutuo Group basal conglomerates were derived locally from Wutai Mountains Neoarchean sources.Zircons from the Sijizhuang Formation conglomerate granite and quartzite pebbles mostly have positive ε Hf(t) values,a minority with ε Hf(t) values like model depleted mantle(DM) of the same age,but with most showing DM model ages 200-100 Ma.This indicates that most of the source materials were derived from the mantle within the previous 200 million years,whereas some are derived from 2550-2510 Ma juvenile crustal additions.This additional evidence suggests that in the North China Craton there was important initial polycyclic crustal formation and cratonization in the late Neoarchaean,prior to superimposed Palaeoproterozoic orogenic cycles. | DU LiLin YANG ChongHui WANG Wei REN LiuDong WAN YuSheng SONG HuiXia GAO LinZhi GENG YuanSheng HOU KeJun | 2012 | Science China Earth Sciences2012，55，11： | 8 |
| 5 | Retrorsine Cooperates with Gut Microbiota to Promote Hepatic Sinusoidal Obstruction Syndrome by Disrupting the Gut Barrier显示文摘Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is a life-threatening syndrome,and a cause is exposure to pyrrolizidine alkaloid(PA)-containing products.It is well-established that retrorsine(RTS),a rep-resentative Pas,insults hepatic sinusoidal endothelial cells and ensues congestion of hepatic sinusoids.However,little known about the impact of Pas on gut microbiota and intesti-nal barrier and inflammation in HSOS.Methods:Mice were gavaged with or without nonabsorbable antibiotics(ABX),followed by a single dose of RTS.The gut microbiota was examined by 16S rDNA sequencing.Results:ABX pretreat-ment significantly reversed RTS-induced liver damage.RTS altered gut microbiota composition,increasing Gram-nega-tive bacteria and resulting in a sharp elevation of circulating lipopolysaccharides(LPS)in HSOS mice.Gut decontamina-tion with ABX alleviated RTS-induced intestine inflamma-tion,protected against disruption of the intestinal epithelial barrier and gut vascular barrier(GVB),and suppressed he-patic LPS-NF-κB pathway activation in RTS-induced HSOS.Importantly,the LPS level was positively correlated with MELD score in patients with HSOS.Elevated LPS in patients with HSOS confirmed that Gram-negative bacteria were in-volved in the pathogenesis of HSOS.Conclusions:RTS,a PA,cooperated with gut dysbiosis to cause intestinal inflam-mation and gut barrier compromise that increased transport of gut-derived LPS into the liver through the portal vein,which contributed to the pathology of HSOS.Modulating the gut microbiota,protecting the intestinal barrier,and sup-pressing intestinal inflammation with prebiotics or antibiot-ics might be a useful pharmacologic intervention in HSOS. | Li Xiao Lilin Hu Huikuan Chu Liuying Chen Jingjing Yan Weijun Wang Xiaoqian Yang Qingjing Zhu Fan Du Yuhu Song Peng Chen Xiaohua Hou Ling Yang | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 2 |
| 6 | Ca. 1.7 Ga Magmatism on Southwestern Margin of the Yangtze Block: Response to the Breakup of Columbia显示文摘This paper presents some data of the Jiaopingdu gabbro and Caiyuanzi granite at the southwestern margin of the Yangtze Block,on the geochemical compositions,zircon LA-ICP-MS U-Pb ages and Hf isotopic data.The Jiaopingdu gabbro gives the age of 1721±5 Ma,the Caiyuanzi granite 1732±6 Ma and 1735±4 Ma,and the Wenjiacun porphyry granite 1713±4 Ma,suggesting nearly contemporaneous formation time of the gabbro and granite.The bimodal feature is demonstrated by the gabbro Si O2 content of 44.64-46.87 wt%and granite 73.81-77.03 wt%.In addition,the granite has high content of Si O2 and Na2 O+K2 O,low content of Al2 O3 and Ca O,enriched in REEs(except Eu)and Zr,Nb,Ga and Y,depleted in Sr,implying it belongs to A-type granite geochemistry and origin of within-plate environment.The zirconε(Hf)(t)of the granite and gabbro is at the range of 2-6,which is near the 2.0 Ga evolution line of the crust,implying the parent magma of the gabbro being derived from the depleted mantle and a small amount of crustal material,and the parent magma of the granite from partial melting of the juvenile crust and some ancient crustal material at the same time.Compared with 1.8-1.7 Ga magmatism during breakup of other cratons in the world,we can deduce that the Columbia has initially broken since ca.1.8 Ga,and some continental marginal or intra-continental rifts occurred at ca.1.73 Ga. | GENG Yuansheng DU Lilin KUANG Hongwei LIU Yongqing | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 1 |
| 7 | Lipase--catalyzed trans- esterifieation of rapeseed oils for biodiesel production with a novel or ganic solvent as the reaction medium 显示文摘 | Lilin Li Wei Du Dehua Liu | 2006 | Journal of Molecular Catalysis B : Enzymatic2006，43，： | 1 |
| 8 | Lipase-catalyzed transesterification of rapeseed oils for biodiesel production with a novel organic solvent as the reaction medium显示文摘 | Lilin Li Wei Du Dehua Liu Li Wang | 2006 | Journal of Molecular Catalysis B: Enzymatic2006，，43： | 1 |
| 9 | Multisitage lateNeoarchaean crustal evolution of the North China Craton, easternHebei显示文摘 | Nutman Allen P Wan Yusheng Du Lilin | 2011 | Precambrian Reseach2011，189，： | 1 |
| 10 | Mechanism exploration during lipase - mediated methanolysis of renewable oils for biodiesel production in a tert - butanol system显示文摘 | DU Wei LIU Dehua LI Lilin | 2007 | Biotechnol Prog2007，23，： | 1 |
| 11 | Lipase-catalyzed transesterification of rapeseed oils for biodiesel production with a novel organic solvent as the reaction medium显示文摘 | Lilin Li Wei Du Dehua Liu Li Wang Zebo Li | 2006 | Journal of Molecular Catalysis B Enzymatic2006，，1： | 1 |
| 12 | Lipase-catalyzed transesterification of rapeseed oils for biodiesel production with a novel organic solvent as the reaction medium显示文摘 | Du Wei Liu Dehua | 2006 | Journal of Molecular Catalysis B:Enzymatic2006，43，： | 1 |
| 13 | Lipase-catalyzed transesterification of rapeseed oils for biodiesel production with a novel organic solvent as the reaction medium显示文摘 | Li Lilin Du Wei Liu Dehua | 2006 | Journal of Molecular Catalysis B:Enzymatic2006，43，1234： | 1 |
| 14 | Fabrication of catalytically active Au/Pt/Pd trimetallic nanoparticles by rapid injection of NaBH4显示文摘 | Haijun Zhang Lilin Lu Yingnan Cao Shuang Du Zhong Cheng Shaowei Zhang | 2014 | Materials Research Bulletin2014，49，1： | 1 |
| 15 | Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics显示文摘核苷酸绑定充满白氨酸的重复(NLR ) 蛋白质在植物和动物用作有免疫力的受体。为了识别部件,为调停 NLR 的免疫要求了,我们设计了并且执行了一幅化学遗传屏幕寻找能在 Arabidopsis thaliana 改变有免疫力的回答的小分子。从 13 600 混合物,我们识别了能明确地压制 chs3-2D 的严重自体免疫的显型的 Ro 8-4304 (寒心敏感 3, 2D ) ,包括逮捕生长形态学和提高的 PR (联系的致病) 基因表示。进一步,六 Ro 8-4304 感觉迟钝的异种从 Ro 8-4304-insensitive 异种(边界) 被揭开用一张 mutagenized chs3-2D 人口的屏幕。位置的克隆表明 rim1 编码 AtICln 的等位基因(我,水流;Cl,氯化物;n,核苷酸) 。基因、生物化学的分析证明 AtICln 在有 methylosome 部件的一样的蛋白质建筑群小原子 ribonucleoprotein D3b (SmD3b ) 和蛋白质精氨酸 methyltransferase 5 (PRMT5 ) ,它为涉及拼接的 mRNA 的小原子 ribonucleoproteins (snRNPs ) 的生物的续生说被要求。两倍变异的分析表明 SmD3b 也涉及敏感到 Ro 8-4304,和 prmt5-1 chs3-2D 两倍异种致命。AtICln, SmD3b,或 PRMT5 功能的损失对剧毒的 oomycete 病原体 Hyaloperonospora arabidopsidis Noco2 导致提高的疾病电阻,建议拼接的 mRNA 起在植物免疫的一个以前未知的否定作用。一幅高产量的化学基因屏幕的成功的实现和影响植物免疫的小分子的混合物的鉴定显示化学遗传是一个强大的工具学习整个有机体的植物防卫小径。 | Shuai Huang Aruna Balgi Yaping Pan Meng Li Xiaoran Zhang Lilin Du Ming Zhou Michel Roberge Xin Li | 2016 | Molecular Plant2016，9，12： | 1 |
| 16 | Lipase-catalyzed transesteritication of rapeseed oils for biodiesel production with a novel organic solvent as the reaction medium显示文摘 | Li Lilin Du Wei Liu Dehua | 2006 | Journal of Molecular Catalysis B: Enzymatic2006，43，： | 1 |
| 17 | Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment显示文摘Although DNA mutation drives stem cell aging,how mutation-accumulated stem cells obtain clonal advantage during aging remains poorly understood.Here,using a mouse model of irradiation-induced premature aging and middle-aged mice,we show that DNA mutation accumulation in hematopoietic stem cells(HSCs)during aging upregulates their surface expression of major histocompatibility complex class II(MHCII).MHCII upregulation increases the chance for recognition by bone marrow(BM)-resident regulatory T cells(Tregs),resulting in their clonal expansion and accumulation in the HSC niche.On the basis of the establishment of connexin 43(Cx43)-mediated gap junctions,BM Tregs transfer cyclic adenosine monophosphate(cAMP)to aged HSCs to diminish apoptotic priming and promote their survival via activation of protein kinase A(PKA)signaling.Importantly,targeting the HSC–Treg interaction or depleting Tregs effectively prevents the premature/physiological aging of HSCs.These findings show that aged HSCs use an active self-protective mechanism by entrapping local Tregs to construct a prosurvival niche and obtain a clonal advantage. | Weinian Liao Chaonan Liu Ke Yang Jun Chen Yiding Wu Shuzhen Zhang Kuan Yu Lisha Wang Li Ran Mo Chen Fang Chen Yang Xu Song Wang Fengchao Wang Qian Zhang Jinghong Zhao Lilin Ye Changhong Du Junping Wang | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 18 | miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1- containing AMPA receptors in a mouse model of Alzheimer’s disease显示文摘Alzheimer ’s disease(AD) is a leading cause of dementia in the elderly.Mitogen-activated protein kinase phosphatase 1(MKP-1) plays a neuroprotective role in AD.However,the molecular mechanisms underlying the effects of MKP-1 on AD have not been extensively studied.MicroRNAs(miRNAs) regulate gene expression at the post-transcriptional level,thereby repressing mRNA translation.Here,we reported that the microRNA-429-3p(miR-429-3p) was significantly increased in the brain of APP23/PS45 AD model mice and N2AAPPAD model cells.We further found that miR-429-3p could downregulate MKP-1 expression by directly binding to its 3’-untranslated region(3’ UTR).Inhibition of miR-429-3p by its antagomir(A-miR-429) restored the expression of MKP-1 to a control level and consequently reduced the amyloidogenic processing of APP and Aβ accumulation.More importantly,intranasal administration of A-miR-429 successfully ameliorated the deficits of hippocampal CA1 long-term potentiation and spatial learning and memory in AD model mice by suppressing extracellular signal-regulated kinase(ERK1/2)-mediated GluAl hyperphosphorylation at Ser831 site,thereby increasing the surface expression of GluAl-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors(AMPARs).Together,these results demonstrate that inhibiting miR-429-3p to upregulate MKP-1 effectively improves cognitive and synaptic functions in AD model mice,suggesting that miR-429/MKP-1 pathway may be a novel therapeutic target for AD treatment. | Man Luo Yayan Pang Junjie Li Lilin Yi Bin Wu Qiuyun Tian Yan He Maoju Wang Lei Xia Guiqiong He Weihong Song Yehong Du Zhifang Dong | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 19 | DAPK1(death associated protein kinase 1)mediates mTORC1 activation and antiviral activities in CD8^(+)T cells显示文摘Mechanistic target of rapamycin complex 1(mTORCt)regulates CD8^(+)T-cell differentiation and function.Despite the links between PI3K-AKT and mTORCI activation in CD8^(+)T cells,the molecular mechanism underlying mTORCI activation remains undear.Here,we show that both the kinase activity and the death domain of DAPK1 are required for maximal mTOR activation and CD8^(+)T-cell function.We found that TCR-induced activation of calcineurin activates DAPK1,which subsequently interacts with TSC2 via its death domain and phosphorylates TSC2 to mediate mTORCI activation.Furthermore,both the kinase domain and death domain of DAPK1 are required for CD8^(+)T-cell antiviral responses in an LCMV infection model.Together,our data reveal a novel mechanism of mTORCI activation that mediates optimal CD8^(+)T-cell function and antiviral activity. | Zhengping Wei Pingfei Li Ran He Huicheng Liu Na Liu Yu Xia Guoyu Bi Qiuyang Du Minghui Xia Lei Pei Jing Wang Guihua Wang Zhao-Hui Tang Xiang Cheng Huabin Li Zhuoya Li Lilin Ye Arian Laurence Youming Lu Xiang-Ping Yang | 2021 | Cellular & Molecular Immunology2021，18，1： | 0 |
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