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| 1 | Genesis of sandstone-type uranium deposits along the northern margin of the Ordos Basin,China显示文摘Sandstone-type U mineral resources are among the important sources for nuclear energy.The U deposits in the Ordos Basin in China form part of the northern segment of the sandstone-hosted Central Asian Uranium MegaProvince.Two types of mineralizations are recognized in this basin:'phreatic permeable type'and'interlayer permeable type',both exhibiting features equivalent to roll-front subtypes.The'interlayer permeable type'is widely accepted as the dominant mineralization type for sandstone-type uranium deposits within large-scale basins,also designated as the'interlayer oxidation zone type',based on the horizontal color zoning model representing changing redox conditions.Here we synthesize data from several drill holes within the Ordos Basin,which suggest that major Mesozoic tectonic movements controlled the evolution of the sedimentary system in the basin.These tectonic movements contributed to the formation of three angular unconformities and four parallel unconformities as inferred from the stratigraphic relationships.In addition,other features such as vertical color zoning,paleo-channel controlled tabular or lentoid ore bodies(without roll-type)and a group interlayer horizontal zoning of altered minerals are also documented.Sequence stratigraphic analysis indicates that the Ordos Basin generally witnessed four cycles of water level variations during Mesozoic.During the variations,three high water level and three low water level events were recorded.Biological characteristics imply that the Ordos Basin went through multiple arid to humid climatic evolutions during Mesozoic.Combining the newly documented features with some novel concepts on the hydrodynamic mechanism for supergene ore-forming fluids,we propose a metallogenic model which invokes the importance of tectonic movements and water level fluctuations to explain the genesis of uranium deposits along the northern margin of the Ordos Basin. | Ruoshi Jin Xueming Teng Xiaoguang Li Qinghong Si Wei Wang | 2020 | Geoscience Frontiers2020，11，1： | 13 |
| 2 | Impact of Accessibility on Housing Prices in Dalian City of China Based on a Geographically Weighted Regression Model显示文摘This paper studies the relationship between accessibility and housing prices in Dalian by using an improved geographically weighted regression model and house prices, traffic, remote sensing images, etc. Multi-source data improves the accuracy of the spatial differentiation that reflects the impact of traffic accessibility on house prices. The results are as follows: first, the average house price is 12 436 yuan(RMB)/m^2, and reveals a declining trend from coastal areas to inland areas. The exception was Guilin Street, which demonstrates a local peak of house prices that decreases from the center of the street to its periphery. Second, the accessibility value is 33 minutes on average, excluding northern and eastern fringe areas, which was over 50 minutes. Third, the significant spatial correlation coefficient between accessibility and house prices is 0.423, and the coefficient increases in the southeastern direction. The strongest impact of accessibility on house prices is in the southeastern coast, and can be seen in the Lehua, Yingke, and Hushan communities, while the weakest impact is in the northwestern fringe, and can be seen in the Yingchengzi, Xixiaomo, and Daheishi community areas. | YANG Jun BAO Yajun ZHANG Yuqing LI Xueming GE Quansheng | 2018 | Chinese Geographical Science2018，28，3： | 10 |
| 3 | Amyloid fibril structure of α-synuclein determined by cryo- electron microscopy显示文摘 | Yaowang Li Chunyu Zhao Feng LUO Zhenying Liu Xinrui Gui Zhipu LUO Xiang Zhang Dan Li Cong Liu Xueming Li | 2018 | Cell Research2018，28，9： | 5 |
| 4 | Nb_2O_5-carbon core-shell nanocomposite as anode material for lithium ion battery显示文摘Mb2O5 -carbon nanocomposite is synthesized through a facile one-step hydrothermal reaction from sucrose as the carbon source,and studied as an anode material for high-performance lithium ion battery.The structural characterizations reveal that the nanocomposite possesses a core-shell structure with a thin layer of carbon shell homogeneously coated on the Nb2O5 nanocrystals.Such a unique structure enables the composite electrode with a long cycle life by preventing the Nb2O5 from volume change and pulverization during the charge-discharge process. In addition,the carbon shell efficiently improves the rate capability.Even at a current density of 500 mA·g-1,the composite electrode still exhibits a specific capacity of~100 mAh·g-1.These results suggest the possibility to utilize the Nb2O5-carbon core-shell composite as a high performance anode material in the practical application of lithium ion battery. | Ge Li Xiaolei Wang Xueming Ma | 2013 | Journal of Energy Chemistry2013，22，3： | 5 |
| 5 | Architecture of type VI secretion system membrane core complex显示文摘Dear Editor, Type VI secreti on system (T6SS) adopts a con tact-dependent secretion mechanism to deliver various lethal effectors into prokaryotic or eukaryotic cells.1,2 Due to its antibacterial and anti-eukaryotic activity, T6SS provides a powerful weapon for bacteria to kill their competitors and attackers.2 T6SS has been show n to resemble a bacteriophage tail-like nano machine of more than 13 components. | Meng Yin Zhaofeng Yan Xueming Li | 2019 | Cell Research2019，29，3： | 5 |
| 6 | miR-155 aggravates impaired autophagy of pancreatic acinar cells through targeting Rictor显示文摘The aim of this study was to investigate the role and mechanism of miR-155 in regulating autophagy in a caerulein-induced acute pancreatitis(AP)cellular model.GFP-LC3 immunofluo-rescence assay was performed to detect autophagy vesicle formation in pancreatic acinar cell line AR42J.AR42J cells were transfected with miR-155 mimic,inhibitor,and corresponding controls to explore the effect of miR-155 on autophagy.The protein levels of LC3-I,LC3-11,Beclin-1,and p62 were analyzed by western blot analysis.Dual-luciferase reporter assay was performed to verify the interaction between miR-155 and Rictor(RPTOR independent companion of MTOR complex 2).The results showed that caerulein treatment induced impaired autophagy as evi-denced by an increase in the accumulation of p62 together with LC3-11 in AR42J cells,accompanied by miR-155 upregulation.Furthermore,miR-155 overexpression aggravated,whereas miR-155 silencing reduced the caerulein-induced impairment of autophagy.Mechanistically,Rictor was confirmed to be a direct target of miR-155,which could rescue the miR-155 overexpression-mediated aggravation of im paired autophagy.Collectively,these findings indicate that miR-155 aggravates impaired autophagy in caerulein-treated pancreatic acinar cells by targeting Rictor. | Xueming Zhang Jiangtao Chu Haijun Sun Dali Zhao Biao Ma Dongbo Xue Weihui Zhang Zhituo Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 4 |
| 7 | Investigation of Amorphization of Nb-Si Alloys by Mechanical Alloying显示文摘Amorphous Nb_(62.5)Si_(37.5) and Nb_(75)Si_(25) alloys were produced from mixtures of elemental Nb and Si powders by mechanical alloying(MA).The structural changes of mechanically alloyed powders were monitored by x-ray diffraction.It was found that NbSi_(2),intermetallic compound was formed in the initial stage of MA of or Nb_(62.5)Si_(37.5) or Nb_(75)Si_(25) powders.With continued milling,the mixtures of intermetallic NbSi_(2) and elemental Nb transformed into amorphous Nb-Si alloys(Nb_(62.5)Si_(37.5) or Nb_(75)Si_(25)).The slow interdiffusion of Nb and Si and the slower diffusion of silicon atoms to niobium matrix than that of niobium atoms to silicon matrix were suggested to be responsible for the formation of intermetallic NbSi_(2).The amorphization of 3NbSi_(2)+7Nb mixtures(or NbSi_(2)+5Nb mixtures)is believed to be controlled by material transfer,which moves composition of line intermetallic NbSi2 off stoichiometry,and causes the matrix of elemental Nb deformed. | LI Bing MA Xueming LIU Lin QI Zhenzhong DONG Yuanda | 1994 | Chinese Physics Letters1994，11，11： | 4 |
| 8 | Urban Green Space, Uneven Development and Accessibility: A Case of Dalian′s Xigang District显示文摘This study examines the socio-spatial context of uneven development and the residential accessibility of green space in Dalian of Liaoning Province, China. The social fairness was analyzed with a community scale as the basis. We combined social scientific methods with a GIS method using a behavior accessibility model from the perspectives of fairness of urban green space allocation based on social geography, geographic information science, management science and many other related discipline theories. The results show that: 1) Most of the urban green space distribution presents an unbalanced phenomenon, and it does not match with the population distribution; 2) We found some differences in the accessibility of the population with different attributes and opportunities to use and enjoy the urban green spaces, mainly due to: the dual social and spatial attributes of the residents and the serious stratum differentiation generated were the internal causes; the residential space differentiation and the pursuit of economic and real estate development were the direct causes; and unreasonable planning, in regard to the fact that government policies did not give consideration to efficiency and fairness, was also an important factor. | YANG Jun LI Chuang LI Yuechen XI Jianhao GE Quansheng LI Xueming | 2015 | Chinese Geographical Science2015，25，5： | 3 |
| 9 | Elucidating the various multi-phosphorylation statuses of protein functional regions by 193-nm ultraviolet photodissociation显示文摘Ultraviolet photodissociation is a high-energy fast excitation method in mass spectrometry and has been successfully applied for the elucidation of sequences and structures of biomolecules. However, its ability to distinguish the phosphorylation sites isomers of multi-phosphopeptides has been not systematically investigated until now. A 193-nm ultraviolet laser dissociation mass spectrometry system was established in this study and applied to elucidate the complex multi-phosphorylation statuses mimicking the functional regions of Sic1, Gli3 and Tau. The numbers of matched fragment ions and phosphorylation site-determining ions were improved on average 123% and 104%, respectively, by utilizing the ultraviolet photodissociation strategy, comparing to the typically utilized collision induced dissociation strategy.Finally, 94% phosphorylation sites within various statuses were unambiguously elucidated. | Zheyi Liu You Jiang Chunlei Xiao Xingchuang Xiong Tao Wang Jinan Li Fangjun Wang Xiang Fang Xueming Yang | 2018 | Chinese Chemical Letters2018，29，5： | 3 |
| 10 | THE FEATURE SUBSET SELECTION ALGORITHM显示文摘The motivation of data mining is how to extract effective information from huge data in very large database. However, some redundant and irrelevant attributes, which result in low performance and high computing complexity, are included in the very large database in general.So, Feature Subset Selection (FSS) becomes one important issue in the field of data mining. In this letter, an FSS model based on the filter approach is built, which uses the simulated annealing genetic algorithm. Experimental results show that convergence and stability of this algorithm are adequately achieved. | Liu Yongguo Li Xueming Wu Zhongfu (Department of Computer Science and Engineering, Chongqing University, Chongqing 400044) | 2003 | Journal of Electronics(China)2003，20，1： | 3 |
| 11 | An Ontology Reasoning Architecture for Data Mining Knowledge Management显示文摘In order to realize the intelligent management of data mining (DM) domain knowledge, this paper presents an architec-ture for DM knowledge management based on ontology. Using ontology database, this architecture can realize intelligent knowl-edge retrieval and automatic accomplishment of DM tasks by means of ontology services. Its key features include: ① Describ-ing DM ontology and meta-data using ontology based on Web ontology language (OWL). ② Ontology reasoning function. Based on the existing concepts and relations, the hidden knowledge in ontology can be obtained using the reasoning engine. This paper mainly focuses on the construction of DM ontology and the rea-soning of DM ontology based on OWL DL(s). | ZHENG Liang LI Xueming | 2008 | Wuhan University Journal of Natural Sciences2008，13，4： | 3 |
| 12 | Spatio-temporal Differentiation of Residential Land for Coastal Town: A Case Study of Dalian Jinshitan显示文摘Based on SPOT5 satellite remote sensing images and land use data in five time phases covering the period 1988–2012, the distribution characteristics, spatial differentiation processes, and driving mechanisms affecting the residential land of the Jinshitan Tourist Resort were studied. The work included a combination of GIS technology, adoption of the differentiation index D, and the multi-group differentiation-measure model D(m). The results provided a basis for the following conclusions: 1) From 1988 to 2012, the degree of differentiation of the rural residential land first decreased, and then increased. The general residential, commercial residential and garden-house land-types all showed declining trends, of which the garden-house type presented the most intense volatility. 2) The overall background of the traditional residential land type was gradually replaced by a new residential land type, and the total area of residential land increased year by year, significantly improving the overall residential conditions. The areas of the new residential land type showed growth, and were increasingly widely distributed in the coastal tourist resorts, transportation corridors, and scenic areas. 3) Government policy, social differentiation, market mechanisms, and individual choices(along with other factors) were mutually promoted, although still restrained. However, all of these factors interacted to constrain the developmental direction and the processes affecting tourism real estate in the Dalian Jinshitan Tourist Resort. | YANG Jun SUN Jing ZHAO Hongdan XI Jianchao LI Xueming | 2016 | Chinese Geographical Science2016，26，4： | 3 |
| 13 | Plasticity of language pathways in patients with low-grade glioma A diffusion tensor imaging study显示文摘Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively. | Gang Zheng Xiaolei Chen Bainan Xu Jiashu Zhang Xueming Lv Jinjiang Li Fangye Li Shen Hu Ting Zhang Ye Li | 2013 | Neural Regeneration Research2013，8，7： | 3 |
| 14 | The 2012 Flash Drought Threatened US Midwest Agroecosystems显示文摘In the summer of 2012, the US Midwest, the most productive agricultural region in the world, experienced the most intense and widespread drought on record for the past hundred years. The 2012 drought, characterized as ‘flash drought’, developed in May with a rapid intensification afterwards, and peaked in mid-July. ~76% of crop region and 60% of grassland and pasture regions have been under moderate to severe dry conditions. This study used multiple lines of evidences, i.e., in-situ AmeriFlux measurements, spatial satellite observations, and scaled ecosystem modeling, to provide independent and complementary analysis on the impact of 2012 flash drought on the US Midwest vegetation greenness and photosynthesis carbon uptake. Three datasets consistently showed that 1) phenological activities of all biomes advanced 1–2 weeks earlier in 2012 compared to the other years of 2010–2014;2) the drought had a more severe impact on agroecosystems(crop and grassland) than on forests;3) the growth of crop and grassland was suppressed from June with significant reduction of vegetation index, sun-induced fluorescence(SIF) and gross primary production(GPP), and did not recover until the end of growing season. The modeling results showed that regional total GPP in 2012 was the lowest(1.76 Pg C/yr) during 2010–2014, and decreased by 63 Tg C compared with the other-year mean. Agroecosystems, accounting for 84% of regional GPP assimilation, were the most impacted by 2012 drought with total GPP reduction of 9%, 7%, 6%, and 29% for maize, soybean, cropland, and grassland, respectively. The frequency and severity of droughts have been predicted to increase in future. The results imply the importance to investigate the influences of flash droughts on vegetation productivity and terrestrial carbon cycling. | JIN Cui LUO Xue XIAO Xiangming DONG Jinwei LI Xueming YANG Jun ZHAO Deyu | 2019 | Chinese Geographical Science2019，29，5： | 2 |
| 15 | Cryo-EM structure of SNAP-SNARE assembly in 20S particle显示文摘N-ethylmaleimide-sensitive 因素(NSF ) 和 α可溶的 NSF 附件蛋白质(α -SNAPs) 在一个 20S 粒子以内一起工作拆卸并且再循环 SNAP 受体(圈套) 在细胞内部的膜熔化以后复杂。由 NSF 和 α 理解 SNARE 建筑群的拆卸机制; -SNAP, 我们执行了 20S 粒子的单个粒子的 cryo 电子显微镜学分析并且决定了 α 的结构;在 7.35 Å 的分辨率的 -SNAP-SNARE 汇编部分;。结构说明那四 α脆裂声在一个 20S 粒子以内作为一个右手的圆柱的集会在单个左手的圈套螺旋状的捆附近包。连接 helices 的一个保存恐水病的补丁 9 各个和 10 α脆裂声形成耸出进 SNARE 四螺旋的捆的沟的一个楔子。生物化学的研究证明这个结构的元素为圈套复杂拆卸是批评的。我们的学习建议怎么四 α脆裂声可以与 NSF 协调把 SNARE 建筑群撕成单个蛋白质。 | Qiang Zhou Xuan Huang Shan Sun Xueming Li Hong-Wei Wang Sen-Fang Sui | 2015 | Cell Research2015，25，5： | 2 |
| 16 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 17 | Mechanism of chromatin remodeling revealed by the Snf2-nucleosome structure显示文摘Subject Code:C05With the support from the National Natural Science Foundation of China,a collaborative study by the research teams led by Chen Zhucheng(陈柱成)and Li Xueming(李雪明)at the School of Life Sciences,Tsinghua University,recently reported their work,titled“Mechanism of chromatin remodeling revealed | Chen Zhucheng (陈柱成) Li Xueming (李雪明) | 2017 | Science Foundation in China2017，25，3： | 2 |
| 18 | Direct experimental detection of hydrogen radicals in non-oxidative methane catalytic reaction显示文摘Non-oxidative conversion of methane to olefins,aromatics and hydrogen(MTOAH) has been reported recently over metal single sites such as iron and platinum.The reaction was proposed to involve catalytic activation of methane followed by gas phase C-C coupling of methyl radicals.This study using H atom Rydberg Tagging time-of-flight technique provides direct experimental evidence for the formation of hydrogen radicals during MTOAH reaction over a catalytic quartz wall reactor containing embedded iron species(denoted as Fe-reactor).Fe-reactor gives 7.3% methane conversion at 1273 K with 41.2% selectivity toward C2(ethane,ethylene and acetylene) and 31.8% toward BTX(benzene,toluene and xylene),respectively.The enhancing effects of hydrogen radicals on overall MTOAH performance are validated by cofeeding hydrogen donor benzene,which provides an additional route of methane activation apart from catalytic activation. | Jianqi Hao Pierre Schwach Lulu Li Xiaoguang Guo Junben Weng Hailei Zhang Hao Shen Guangzong Fang Xin Huang Xiulian Pan Chunlei Xiao Xueming Yang Xinhe Bao | 2021 | Journal of Energy Chemistry2021，30，1： | 2 |
| 19 | Intraoperative diffusion tensor imaging predicts the recovery of motor dysfunction after insular lesions显示文摘Insular lesions remain surgically challenging because of the need to balance aggressive resection and functional protection. Motor function deficits due to corticospinal tract injury are a common complication of surgery for lesions adjacent to the internal capsule and it is therefore essential to evaluate the corticospinal tract adjacent to the lesion. We used diffusion tensor imaging to evaluate the corticospinal tract in 89 patients with insular lobe lesions who underwent surgery in Chinese PLA General Hospital from February 2009 to May 2011. Postoperative motor function evaluation revealed that 57 patients had no changes in motor function, and 32 patients suffered motor dysfunction or aggravated motor dysfunction. Of the affected patients, 20 recovered motor function during the 6-12-month follow-up, and an additional 12 patients did not recover over more than 12 months of follow-up. Following reconstruction of the corticospinal tract, fractional anisotropy comparison demonstrated that preoperative, intraoperative and follow-up normalized fractional anisotropy in the stable group was higher than in the transient deficits group or the long-term deficits group. Compared with the transient deficits group, intraoperative normalized fractional anisotropy significantly decreased in the long-term deficits group. We conclude that intraoperative fractional anisotropy values of the corticospinal tracts can be used as a prognostic indicator of motor function outcome. | Jinjiang Li Xiaolei Chen Jiashu Zhang Gang Zheng Xueming Lv Fangye Li Shen Hu Ting Zhang Bainan Xu | 2013 | Neural Regeneration Research2013，8，15： | 2 |
| 20 | Identification of EGF as an Important Regulator for Promoting CYP3A4 Expression in Human Embryonic Stem Cell-Derived Hepatocytes Using TALEN-Based Gene Targeting显示文摘Functional human hepatocytes are one of the most significant tools for studying drug absorption,distribution,metabolism and excretion/toxicity (ADME/Tox),especially for applications in preclinical drug development (Sahi et al.,2010;Godoy et al.,2013).They provide the closest in vitro model to the human liver and the only model that mimics the drug metabolic profiles found in vivo.However,these cells lose their metabolic function rapidly and dramatically during the in vitro culture process,which largely hinders their wider application in drug development (Sahi et al.,2010;Godoy et al.,2013).To overcome this obstacle,it is important to regulate the activities of key genes which are responsible for the detoxification metabolic function of human hepatocytes. | Ming YinaCollege of Veterinary Medicine Jilin University Huan Yang Xiaohua Su Ziyi Li Zhanpeng Yue Xueming Zhang Da Sun Yan Shi Dexue Li | 2014 | Journal of Genetics and Genomics2014，41，6： | 2 |
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