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| 1 | A seamless operation mode transition control strategy for a microgrid based on master-slave control显示文摘This paper proposes a control strategy that can realize seamless microgrid operation mode transition between grid-connected operation and stand-alone operation.The scenario of a microgrid based on master-slave control is considered,where the master distributed generation(DG) unit operates in different control schemes in different microgrid operation modes,while other slave DG units operate with power/current control all the time.The proposed control strategy focuses on the master DG unit,and contains the control state/reference compensation algorithm and separation switch control logic.The proposed method can effectively reduce the impact on the critical loads and DG units caused by microgrid operation mode transitions. | WANG ChengShan LI XiaLin GUO Li LI YunWei | 2012 | Science China(Technological Sciences)2012，55，6： | 45 |
| 2 | Coordinated control for medium voltage DC distribution centers with flexibly interlinked multiple microgrids显示文摘From flexible interconnection among feeders to hybrid alternating current(AC) and direct current(DC)distribution structures of future smart distribution systems medium-voltage DC distribution centers with flexibly interlinked multiple microgrids(MGs) will have wide applications on the demand side. A generic coordinated control framework based on a distributed cooperation scheme is proposed for such DC centers, as opposed to centralized control structures. A novel unified control only using local measurements is proposed for these interlinking converters. During normal power disturbances, automatic coordinated power control and mutual support among sub-systems can be realized, thereby improving DC voltage and AC frequency stability to enable multiple MGs to be treated as a real unified cluster. Moreover, with this method, interlinking converters can realize seamless transition in power dispatching mode, common DC bus voltage control mode, and MG support mode without communication and control system switching. A simplified dynamic model has been developed to verify the proposed control strategy. This work is expected to provide a new solution for flexible interconnection and operational control of large-scale MG clusters. | Lei QIAO Xialin LI Di HUANG Li GUO Yutao XU Zhukui TAN Chengshan WANG | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 9 |
| 3 | Reduced-order Modeling and Dynamic Stability Analysis of MTDC Systems in DC Voltage Control Timescale显示文摘An equivalent source-load MTDC system including DC voltage control units,power control units and interconnected DC lines is considered in this paper,which can be regarded as a generic structure of low-voltage DC microgrids,mediumvoltage DC distribution systems or HVDC transmission systems with a common DC bus.A reduced-order model is proposed with a circuit structure of a resistor,inductor and capacitor in parallel for dynamic stability analysis of the system in DC voltage control timescale.The relationship between control parameters and physical parameters of the equivalent circuit can be found,which provides an intuitive insight into the physical meaning of control parameters.Employing this model,a second-order characteristic equation is further derived to investigate system dynamic stability mechanisms in an analytical approach.As a result,the system oscillation frequency and damping are characterized in a straight forward manner,and the role of electrical and control parameters and different system-level control strategies in system dynamic stability in DC voltage control timescale is defined.The effectiveness of the proposed reduced-order model and the correctness of the theoretical analysis are verified by simulation based on PSCAD/EMTDC and an experiment based on a hardware low-voltage MTDC system platform. | Li Guo Pengfei Li Xialin Li Fei Gao Di Huang Chengshan Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 5 |
| 4 | Entrapping multifunctional dendritic nanoparticles into a hydrogel for local therapeutic delivery and synergetic immunochemotherapy显示文摘Developing multifunctional nanoparticles to support new therapy models is apromising and challenging task to address the current dilemma on antitumortreatment. Herein, we incorporated multifunctional dendritic nanoparticles intoa poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,Lqactide-co-glycolide)(PLGA-PEG-PLGA) triblock copolymers thermosensitive injectable hydrogelmatrix to construct a localized drug delivery system for combining chemotherapyand immunotherapy. The multifunctional dendritic nanoparticles were designedwith following expectations: i, Dendritic scaffolds provide a hydrophobic interiorto load the anticancer drug, doxorubicin (DOX), for chemotherapy; and ii,dendritic scaffolds are used to build arginine-rich molecules to provide theinducible nitric oxide synthase (iNOS) substrate, L-Arg, to M1 macrophages,which can produce the cytotoxic substance nitric oxide (NO) and subsequentlyinduce tumor cell destruction through immunotherapy. It is noteworthy that thedendritic nanoparticles-in-hydrogel delivery system is able to gel at physiologicaltemperature and serves as a warehouse for the sustained release of the drug.Ultimately, this system showed great efficacy in treating 4T1 cells-xenograftedBALB/C mice (86.62% tumor growth inhibition). Therefore, this localized drugdelivery system combining chemotherapy and immunotherapy provides a novelapproach for cancer therapy. | Lei Jiang Yang Ding Xialin Xue Sensen Zhou Cheng Li Xiaoke Zhang Xiqun Jiang | 2018 | Nano Research2018，11，11： | 3 |
| 5 | The Averaged-value Model of a Flexible Power Electronics Based Substation in Hybrid AC/DC Distribution Systems显示文摘The concept of a flexible power electronics substation(FPES)was first applied in the Zhangbei DC distribution network demonstration project.As a multi-port power electronics transformer(PET)with different AC and DC voltage levels,the FPES has adopted a novel topology integrating modular multilevel converter(MMC)and four-winding medium frequency transformer(FWMFT)based multiport DC-DC converter,which can significantly reduce capacitance in each sub-module(SM)of a MMC and also save space and cost.In this paper,in order to accelerate speed of electromagnetic transient(EMT)simulations of FPES based hybrid AC/DC distribution systems,an averaged-value model(AVM)is proposed for efficient and accurate representation of FPES.Assume that all SM capacitor voltages are perfectly balanced in the MMC,then the MMC behavior can be modeled using controlled voltage sources based on modulation voltages from control systems.In terms of the averaged current transfer characteristics among the windings of the FWMFT,we consider that all multiport DC-DC converters are controlled with the same dynamics,a lumped averaged model using controlled current and voltage sources has been developed for these four-port DC-DC converters connected to the upper or lower arms of the MMC.The presented FPES AVM model has been tested and validated by comparison with a detailed IGBT-based EMT model.Results show that the AVM is significantly more efficient while maintaining its accuracy in an EMT simulation. | Hong Liu Zhanfeng Deng Xialin Li Li Guo Di Huang Shouqiang Fu Xiangyu Chen Chengshan Wang | 2022 | CSEE Journal of Power and Energy Systems2022，8，2： | 2 |
| 6 | PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib显示文摘Skeletal interoception regulates bone homeostasis through the prostaglandin E2(PGE2)concentration in bone.Vertebral endplates undergo ossification and become highly porous during intervertebral disc degeneration and aging.We found that the PGE2 concentration was elevated in porous endplates to generate spinal pain.Importantly,treatment with a high-dose cyclooxygenase 2 inhibitor(celecoxib,80 mg·kg−1 per day)decreased the prostaglandin E2 concentration and attenuated spinal pain in mice with lumbar spine instability.However,this treatment impaired bone formation in porous endplates,and spinal pain recurred after discontinuing the treatment.Interestingly,low-dose celecoxib(20 mg·kg−1 per day,which is equivalent to one-quarter of the clinical maximum dosage)induced a latent inhibition of spinal pain at 3 weeks post-treatment,which persisted even after discontinuing treatment.Furthermore,when the prostaglandin E2 concentration was maintained at the physiological level with low-dose celecoxib,endplate porosity was reduced significantly,which was associated with decreased sensory nerve innervation and spinal pain.These findings suggest that low-dose celecoxib may help to maintain skeletal interoception and decrease vertebral endplate porosity,thereby reducing sensory innervation and spinal pain in mice. | Peng Xue Shenyu Wang Xiao Lyu Mei Wan Xialin Li Lei Ma Neil CFord Yukun Li Yun Guan Wenyuan Ding Xu Cao | 2021 | Bone Research2021，9，3： | 2 |
| 7 | Training Hidden Markov Models with multiple observation--A combinatorial method显示文摘 | LI Xialin PARIZEAU M PLAMONDON R | 2000 | IEEE Trans on Pattern Analysis and Machine Intelligence2000，22，4： | 1 |
| 8 | A Nonlinear Disturbance Observer Based DC Bus Voltage Control for a Hybrid AC/DC Microgrid显示文摘 | Chengshan Wang Xialin Li Guo Li | 2014 | IEEE Trans on Power Electronics2014，29，11： | 1 |
| 9 | Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases显示文摘 | Ping Wu Xialin Zuo Houliang Deng Xiaoxia Liu Li Liu Aimin Ji | 2013 | Brain Research Bulletin2013，，： | 1 |
| 10 | Stability Analysis of a DC Microgrid with Master-Slave Control Structure显示文摘 | Li Guo Yibin F Xialin Li | 2014 | IEEE Energy Conversion Congress and Exposition (ECCE)2014，，： | 1 |
| 11 | Endothelial progenitorcells (EPCs) mobilized and activated by neurotrophic factors may contribute to pathologic neovascularization in diabetic retinopathy 显示文摘 | Liu Xialin Li Yongjun Liu Yizhi | 2010 | AJP2010，176，1： | 1 |
| 12 | Stability analysis of a DC microgrid with master-slave control strucan'e显示文摘 | Li Guo Yibin F Xialin Li | 2014 | IEEE Energy Conversion Congress and Exposition (ECCE)2014，，： | 1 |
| 13 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 14 | Displacement and development characteristics of fire flooding of vertical wells in old heavy oil areas显示文摘As the vertical-well fire flooding technology is industrially applied in the steam-injection old heavy oil areas of Xinjiang and Liaohe oilfields,its enhanced oil recovery potential is gradually clear.According to laboratory experiment,field test and reservoir engineering,the displacement characteristics of verticalwell fire flooding in the steam-injection old heavy oil areas are systematically investigated.Laboratory experiments and core data show that the vertical-well fire flooding has significantly high flooding ef-ficiency,no residual oil are remained in the firing front sweeping zone,and the lateral sweep efficiency and ultimate recovery can be achieved.The vertical-well fire flooding is a strategic replacement technology to enhance the recovery greatly.Development characteristics and advantages of areal and linear fire flooding are well investigated,and research results are applied in the design of industrial test plan of fire flooding in the Hongqian block,Xinjiang.The research shows that the linear well pattern has advantages of easy construction of ground facilities and management,less well of stage management,simple matching technology and easy achievement of purposeful control for fire front;the areal well pattern has advantages in reducing the air/oil ratio during the fire flooding period,increasing the total recovery rate of reservoirs and reducing the geological and reservoir management risks.To select well patterns of fire flooding,some factors such as geology,reservoir,fluid properties,oil price,and reservoir development degree should be mainly considered.In the Hongqian block,an improved linear well pattern with a combination of new wells and old wells is applied,this not only absorb experiences of linear well pattern pilot test,but also use advantages of areal well pattern. | Wenlong Guan Xialin Zhang Changfeng Xi Xiaochun Wang Fengxiang Yang Xiaorong Shi Qiu Li | 2018 | Petroleum Research2018，3，2： | 0 |
| 15 | A Unified Control of Super-capacitor System Based on Bi-directional DC-DC Converter for Power Smoothing in DC Microgrid显示文摘To improve the equivalent inertia of DC microgrids(DCMGs),a unified control is proposed for the first time for a bi-directional DC-DC converter based super-capacitor(SC)system,whereby power smoothing and SC terminal voltage regulation can be achieved in a DCMG simultaneously.The proposed control displays good plug-and-play features using only local measurements.For quantitative analysis and effective design of the critical parameter of unified control,two indices,equivalent power supporting time and inertia contributed by the unified controlled SC system,are introduced firstly.Then,with a simple but effective reduced-order model of a DCMG,analytical solutions are obtained for the two indices.In addition,a systematic design method is presented for the proposed unified control.Finally,to verify the proposed unified control,a switching model is developed for a typical DCMG in PSCAD/EMTDC,and theoretical analyses are conducted for different operating conditions. | Xialin Li Pengfei Li Leijiao Ge Xunyang Wang Zhiwang Li Lin Zhu Li Guo Chengshan Wang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 0 |
| 16 | Data-driven Based Uncertainty Set Modeling Method for Microgrid Robust Optimization with Correlated Wind Power显示文摘Microgrid is considered an important part of the future zero carbon energy systems.However,the uncertainty caused by renewable energy source brings huge challenges to the scheduling of MG and restricts its ability of carbon emission reduction.In this paper,a novel improved multi-ellipsoidal uncertainty set modeling method is proposed to better depict the uncertainty of wind power and reduce the conservativeness of traditional robust optimization.Probabilistic information from historical data is utilized to capture the temporal correlation of forecast error of wind power,as well as the conditional correlation of forecast error with forecast value,making the uncertainty set more data-adaptive to variation of forecast results and more accurate for uncertainty description.A two-stage robust optimization model of a grid-connected microgrid is established based on the proposed uncertainty set and solved by column and constraint generation algorithm.Simulation results based on actual data illustrate the average unbalanced power of microgrid between day-ahead trading and real-time power exchange with utility grid is dropped by nearly 11.16%compared with a deterministic optimization method,11.86%with traditional box uncertainty set-based robust optimization method,and 2.89%with stochastic optimization method. | Xinchen Li Yixin Liu Li Guo Xialin Li Chengshan Wang | 2023 | CSEE Journal of Power and Energy Systems2023，9，2： | 0 |
| 17 | Novel organoid model in drug screening: Past, present, and future显示文摘Advances in the field of stem cells have led to the development of a technology called organoids.Organoids are cell cluster structures formed by the cultivation of stem cells in a three-dimensional environment in vitro,and they can simulate the living environment of cells in vivo.Organoids play an important role in the screening of drugs for tumor therapy.Compared with traditional drug screening models,tumor organoid models derived from patient tumors have higher sensitivity,heterogeneity,and stability and can restore the real situation of tumors more effectively.Researchers have conducted a number of researches on the feasibility of using organoid technology in drug screening.By testing and comparing the effects of antitumor drugs in organoids and primary tumors,we can select the most appropriate treatment drugs for patients.In the past ten years,organoids from dozens of tissues and biological sample banks from several main organs have been established,and a large number of anticancer drugs have been screened out.This article summarizes the advantages and disadvantages of traditional drug screening models,discusses the development history of organoid technology,and reviews the research results on organoids from tumor drug screening.In addition,the combination of organoid technology and other modern biotechnologies is put forward to further promote the role of organoid technology in the medical field.Finally,this article reviews the history,progress,and prospect on organoids from the view of antitumor drug screening. | Xialin Nie Zhixing Liang Kun Li Haoyuan Yu Yuhan Huang Linsen Ye Yang Yang | 2021 | Liver Research2021，5，2： | 0 |
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