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| 1 | Temporal and regional variations of China's fertilizer consumption by crops during 1998-2008显示文摘The agricultural and land policies in China are always focused on protecting its food supply and security because of the country's large population and improved diets.The crop production guide 'Take Grain as the Key Link' prompted peasants to plant grain on most of the agricultural land,leading to the majority of fertilizer being used in grain crops for many years in China.This situation has changed dramatically in recent years.Based on data pertaining to provincial crops sown area and fertilizer use per unit area in 1998 and 2008,the temporal and spatial variations of China's fertilizer consumption by crops were analyzed at the provincial level,and the results are presented here.(1) Fertilizer consumption in China grew strongly in the last decade,while the growth was mainly attributable to the increase of fertilizer con-sumption by horticultural crops.The fertilizer consumption of grain crops dropped from 71.0% in 1998 to 57.8% in 2008.Thus,it is concluded that the emphasis of fertilizer consumption is shifting toward horticultural crops.(2) There were marked differences in the growth rates of fertilizer consumption from the regional point of view.The national average growth rate of fertilizer consumption was 31.9% during 1998-2008.The western and northeastern parts of the country came close to the national average,while the eastern part was lower,with an average of 13.0%,and central China was much higher(50.8%).The increase of fertilizer consumption in central and west China was higher than the other zones,which already ac-counted for 77.9% of the national total.Thus,it is concluded that the consumption emphasis of chemical fertilizer shifts toward the central and western regions.(3) The decline of fertilizer consumption by grain crops was largely due to the decrease in sown area compared with the increase by vegetable crops attributable to the enlarging sown area;the increase by orchard crops was affected by both expanding the sown area and fertilizer use per unit area. | XIN Liangjie LI Xiubin TAN Minghong | 2012 | Journal of Geographical Sciences2012，22，4： | 49 |
| 2 | Activation of gibberellin 2-oxidase 6 decreases active gibberellin levels and creates a dominant semi-dwarf phenotype in rice (Oryza sativa L.)显示文摘Gibberellin (GA) 2-oxidase plays a key role in the GA catabolic pathway through 2β-hydroxylation.In the present study,we isolated a CaMV 35S-enhancer activation tagged mutant,H032.This mutant exhibited a dominant dwarf and GA-deficient phenotype,with a final stature that was less than half of its wild-type counterpart.The endogenous bioactive GAs are markedly decreased in the H032 mutant,and application of bioactive GAs (GA3 or GA4) can reverse the dwarf phenotype.The integrated T-DNA was detected 12.8 kb upstream of the OsGA2ox6 in the H032 genome by TAIL-PCR.An increased level of OsGA2ox6 mRNA was detected at a high level in the H032 mutant,which might be due to the enhancer role of the CaMV 35S promoter.RNAi and ectopic expression analysis of OsGA2ox6 indicated that the dwarf trait and the decreased levels of bioactive GAs in the H032 mutant were a result of the up-regulation of the OsGA2ox6 gene.BLASTP analysis revealed that OsGA2ox6 belongs to the class III of GA 2-oxidases,which is a novel type of GA2ox that uses C20-GAs (GA12 and/or GA53) as the substrates.Interestingly,we found that a GA biosynthesis inhibitor,paclobutrazol,positively regulated the OsGA2ox6 gene.Unlike the over-expression of OsGA2ox1,which led to a high rate of seed abortion,the H032 mutant retained normal flowering and seed production.These results indicate that OsGA2ox6 mainly affects plant stature,and the dominant dwarf trait of the H032 mutant can be used as an efficient dwarf resource in rice breeding. | Jian Huang Ding Tang Yi Shen Baoxiang Qin Lilan Hong Aiqing You Ming Li Xin Wang Hengxiu Yu Minghong Gu Zhukuan Cheng | 2010 | Journal of Genetics and Genomics2010，37，1： | 36 |
| 3 | Urban land expansion and arable land loss of the major cities in China in the 1990s显示文摘Based on the land-use data in 1990 and 2000, determined by interpreting Landsat Thematic Mapper (TM) imagery, this paper defines the extent of urban construction land, and extracts patches of urban construction land of 145 cities with the largest areas in 1990 and arable land patches around these cities. With these data, this paper analyzes the characteristics of ur- ban construction land expansion and the consequent arable land loss in East, Middle and West China, and further identifies the social, economic and spatial factors of the urban land use changes, using GIS (Geographical Information System) and multivariate regression approaches. The results show that total urban land of the 145 cities expanded by 39.8%, with about 70% of the new urban land converted from arable land in the 1990s. The urban land expansion varied among the three regions, with a value of 43.0% in the East, 33.1% in the West (33.1%) and 17.8% in the Middle. Moreover, mean urban construction land per capita increased by10.7% in the East, but it decreased by 7.7% in the Middle, 1.4% in the West. Statistical analysis indicated that total wages of staff and workers could best explain the differences of urban land expansion. | TAN Minghong LI Xiubin LU Changhe | 2005 | Science China Earth Sciences2005，48，9： | 32 |
| 4 | Wx^lv、the Ancestral Allele of Rice Waxy Gene显示文摘In rice grains,the Waxy (Wx) gene is responsible for the synthesis of amylose,the most important determinant for eating and cooking quality.The effects of several Wx alleles on amylose content and the taste of cooked rice have been elucidated.However,the relationship between artificial selection and the evolution of various Wx alleles as well as their distribution remain unclear.Here we report the identification of an ancestral allele,Wx^lv,which dramatically affects the mouthfeel of rice grains by modulating the size of amylose molecules.We demonstrated that WF originated directly from wild rice,and the three major Wx alleles in cultivated rice (Wx^b,Wx^a,and Wx^in) differentiated after the substitution of one base pair at the functional sites.These data indicate that the Wx^lv allele played an important role in artificial selection and domestication.The findings also shed light on the evolution of various Wx alleles,which have greatly contributed to improving the eating and cooking quality of rice. | Changquan Zhang Jihui Zhu Shengjie Chen Xiaolei Fan Qianfeng Li Yan Lu Min Wang Hengxiu Yu Chuandeng Yi Shuzhu Tang Minghong Gu Qiaoquan Liu | 2019 | Molecular Plant2019，12，8： | 22 |
| 5 | Introgression of qPE9-1 allele,conferring the panicle erectness,leads to the decrease of grain yield per plant in japonica rice(Oryza sativa L.)显示文摘圆锥花序建筑学是仔细与产量有关形成。qPE9-1 基因被证明了广泛地在产量很高的米饭栽培变种开发被过去常,授与在装饰用的梨树米饭的直立的圆锥花序特性。最近, qPE9-1 成功地被克隆;然而,谷物产量上的基因效果还每直立的圆锥花序等位基因 qPE9-1 的植物是争论的。在现在的学习,低垂的圆锥花序父母 Nongken 57,带 qpe9-1 等位基因,被用作周期性父母到连续地回交到从双 haploid (DH ) 的一根典型直立的圆锥花序线人口(Wuyunjing 8/Nongken 57 ) ,它以前被显示带 qPE9-1 等位基因。因此,一双 near-isogenic 线(无) 被开发。在无之间的农学的特点的比较证明当 qpe9-1 被 qPE9-1 代替时,圆锥花序建筑学从低垂树立被改变;而且,圆锥花序长度,植物高度, 1000 谷物重量和 tillers 显著地被减少,因而在 30% 每植物导致谷物产量的戏剧的减少。因此,我们断定 qPE9-1 是控制圆锥花序建筑学的一个主要因素,并且 qPE9-1 有多种的自然,与每植物的谷物产量上的否定效果。这结果强烈建议直立的圆锥花序等位基因 qPE9-1 应该在产量很高的繁殖实践和另外的有利基因被使用。另外,吃并且煮质量上的 qPE9-1 的效果也在现在的学习被讨论。 | Xiuhua Yi Zujian Zhang Shengyuan Zeng Chunyan Tian Juncheng Peng Min Li Yue Lu Qingcai Meng Minghong Gu Changjie Yan | 2011 | Journal of Genetics and Genomics2011，38，5： | 20 |
| 6 | China’s Potential of Grain Production Due to Changes in Agricultural Land Utilization in Recent Years显示文摘The changes in utilization of agricultural land have gradually grown into one of the major factors impacting grain output in China. This study explores the various components of agricultural production in China from the land utilization perspective, involving changes in grain production per unit area, multi-cropping index, and adjustment of agricultural structure. Compared with the record values, different research methodologies are used to analyze the po- tential of above three components. The results indicate that grain production potential of 65.68×109kg was unexploited in 2006, in which 45.8×109kg came from the restructuring in agriculture. So we can infer that the reduction of grain production in China could be primarily attributed to agricultural restructuring in recent years. So the productive poten- tial can be fully restored by increasing agricultural investment, or recovering agricultural structure in favorable condi- tions. So we can say that China’s current condition of food security is good. | XIN Liangjie LI Xiubin ZHU Huiyi TAN Minghong | 2009 | Chinese Geographical Science2009，19，2： | 19 |
| 7 | A rare Waxy allele coordinately improves rice eating and cooking quality and grain transparency显示文摘In rice(Oryza sativa), amylose content(AC) is the major factor that determines eating and cooking quality(ECQ). The diversity in AC is largely attributed to natural allelic variation at the Waxy(Wx)locus. Here we identified a rare Wx allele, Wx^(mw) ,which combines a favorable AC, improved ECQ and grain transparency. Based on a phylogenetic analysis of Wx genomic sequences from 370 rice accessions, we speculated that Wx^(mw) may have derived from recombination between two important natural Wx alleles, Wx^(in) and Wx^(b). We validated the effects of Wx^(mw) on rice grain quality using both transgenic lines and near-isogenic lines(NILs). When introgressed into the japonica Nipponbare(NIP) background, Wx^(mw) resulted in a moderate AC that was intermediate between that of NILs carrying the Wx^(b)allele and NILs with the Wx^(mp) allele. Notably, mature grains of NILs fixed for Wx^(mw) had an improved transparent endosperm relative to soft rice. Further, we introduced Wx^(mw) into a high-yielding japonica cultivar via molecular marker-assisted selection: the introgressed lines exhibited clear improvements in ECQ and endosperm transparency. Our results suggest that Wx^(mw) is a promising allele to improve grain quality, especially ECQ and grain transparency of high-yielding japonica cultivars, in rice breeding programs. | Changquan Zhang Yong Yang Shengjie Chen Xueju Liu Jihui Zhu Lihui Zhou Yan Lu Qianfeng Li Xiaolei Fan Shuzhu Tang Minghong Gu Qiaoquan Liu | 2021 | Journal of Integrative Plant Biology2021，63，5： | 18 |
| 8 | Diurnal variations of polycyclic aromatic hydrocarbons associated with PM_(2.5) in Shanghai, China显示文摘Forty-eight daily time interval PM2.5 samples were collected from December 2006 to January 2008 in an urban site in Shanghai, China. Concentrations and compositions of polycyclic aromatic hydrocarbons (PAHs) were analyzed with GC-MS to study the diurnal and seasonal variations and to identify the main emitting sources. The diurnal variation of the PAHs concentrations was greater in the late autumn and winter sampling days, and was greatly influenced by meteorological conditions such as wind speed and ambient temperature. The concentration of PAHs in the mornings (6:30-10:00) increased distinctly, and was high in the late autumn and winter sampling days, indicating the contribution from vehicle emissions during rush hours. The diurnal variation of the high molecular weight PAHs did not seem to be controlled by the shift of gas-particle partitioning due to temperature variation, instead, it could be indicative of the variation in the source. Statistical analyses showed that the concentrations of PAHs were negatively correlated with temperature and wind speed, and positively correlated with relative humidity. Diagnostic ratios of PAHs suggested mixed emission sources of petroleum and coal/biomass combustion for PAHs in the PM2.5 in Shanghai. | Zeping Gu Jialiang Feng Wenliang Han Li Li Minghong Wu Jiamo Fu Guoying Sheng | 2010 | Journal of Environmental Sciences2010，22，3： | 13 |
| 9 | Urban spatial development and land use in Beijing: Implications from London's experiences显示文摘Beijing is facing a huge challenge to manage the growth of its built-up area whilst also retaining both productive arable land and land for conservation purposes in order to simultaneously realize the three aims of economic development,protecting arable land and generating environmental improvements. Meanwhile,London,as a world city with more than 200 years of industrialization and urbanization,has accumulated rich theoretical and practical experiences for land use planning in a major urban area,such as the creation of Garden Cities,a designated Green Belt and New Towns. This paper firstly analyzes the main characteristics of the spatial distribution of the built-up area,arable land and conservation land in Beijing. Then,some of the key aspects of urban fringe planning in the London region are examined. Lastly,several implications from the experience of London are provided with respect to land-use planning for Beijing,concentrating on a re-appraisal of land-use functions around Beijing,measures to improve the green belt,the development of small towns to house rural-urban migrants and urban overspill,and effective implementation of land-use planning. | TAN Minghong GUY M. Robinson LI Xiubin | 2011 | Journal of Geographical Sciences2011，21，1： | 13 |
| 10 | Development of gene-tagged molecular markers for starch synthesis-related genes in rice显示文摘Improving grain quality is an important goal in breeding new elite rice varieties,requiring effective tools for the identification of target genotypes.Molecular marker-aided selection(MAS),combined with conventional breeding approaches,enables us to pre-cisely identify the individual genotypes that are associated with different grain quality features,which can dramatically improve the breeding efficiency.However,to date,the number of molecular markers used in MAS for grain quality improvement is still somewhat limited.In this study,based on our previous study that rice grain quality is strongly associated with starch synthesis in the endosperm,we developed 51 gene-tagged molecular markers according to sequence variations in 18 starch synthesis-related genes from 16 typical rice cultivars.These markers can discriminate the different alleles among rice germplasms.These novel markers will provide effective tools in improving grain quality via the breeding new elite rice varieties. | TIAN ZhiXi YAN ChangJie QIAN Qian YAN Song XIE HuiLan WANG Fang XU JieFen LIU GuiFu WANG YongHong LIU QiaoQuan TANG ShuZhu LI JiaYang GU MingHong | 2010 | Chinese Science Bulletin2010，55，33： | 12 |
| 11 | ELE restrains empty glumes from developing into lemmas显示文摘Although there is evident homology among reproductive organs when comparing Poaceae (grass) and eudicots, the identity of grass specific organs, such as lodicules, palea, lemma, and glumes has been the subject of a vast and largely inconclusive discussion. Here we provide some direct evidence to support the idea that the empty glumes of rice (Oryza sativa) are counterparts of lemmas. We show that the development of empty glumes is regulated by ELE (elongated empty glume), which belongs to a plant specific novel gene family. Mutations at the ELE locus cause elongated empty glumes, which mimic the lemmas and have the epidermal morphology of lemmas with four or five vascular bundles. As a nuclear-localized gene, ELE is specifically expressed at the empty glumes of immature spikelets, and its ectopic expression causes many floral development defects, including lemma-like palea, extra palea-like structures, elongated lodicules, extra stamens and stigmas. Our result suggests that empty glumes are lemmas of the sterile florets located at the lateral side of the rice spikelet, and ELE acts as a regulator restraining its growth to maintain its small size in wild-type plants. | Lilan Hong Qian Qian Keming Zhu Ding Tang Zejun Huang Ling Gao Ming Li Minghong Gu Zhukuan Cheng | 2010 | Journal of Genetics and Genomics2010，37，2： | 11 |
| 12 | Spatial and Temporal Variability of Farm Size in China in Context of Rapid Urbanization显示文摘During the last 30 years,China has witnessed rapid economic growth and dramatic urbanization,with about 1.2 × 107rural people migrating annually into urban areas.Meanwhile,especially since 1995,the rural population has been declining,which is closely linked to land circulation and the increase in farm size in many villages.Increasing scale of farming operations is often regarded as a key to avoiding the abandonment of farmland and to increasing the income of rural farmers.However,until now,there has been little research on the spatial and temporal variability of farm size at the national level in China.Using data from the national agricultural census and rural household surveys,this study examines the characteristics of land use circulation and the consequent changes in the area of farmland per household.The results show that: 1) 12.2% of rural households were involved in land circulation at the national level.The highest amounts of land circulation have occurred in those provinces where the farmland per capita is more than 0.2 ha or less than 0.1 ha;2) over 80% of households operate less than 0.6 ha of farmland;3) the proportion of mid-sized farms(between 0.2 ha and 0.6 ha per household) has decreased while the smallest and the largest farms have increased.This bears some similarity with the phenomenon known as the ′disappearing middle′,referring to the changes in farm size.This study establishes a framework for interpreting the factors affecting the changes in farm size in China,which include two promoting factors(urbanization and agriculture) and four hindering factors(agricultual land system,household registration,stable clan system,and farmland loss). | TAN Minghong Guy M ROBINSON LI Xiubin XIN Liangjie | 2013 | Chinese Geographical Science2013，23，5： | 8 |
| 13 | Soil phosphorus availability and rice phosphorus uptake in paddy fields under various agronomic practices显示文摘Agronomic practices affect soil phosphorus(P) availability, P uptake by plants, and subsequently the efficiency of P use. A field experiment was carried out to investigate the effects of various agronomic practices(straw incorporation, paddy water management, nitrogen(N) fertilizer dose, manure application,and biochar addition) on soil P availability(e.g., soil total P(STP), soil available P(SAP), soil microbial biomass P(SMBP), and rice P uptake as well as P use efficiency(PUE)) over four cropping seasons in a rice-rice cropping system, in subtropical central China. Compared to the non-straw treatment(control,using full dose of chemical N fertilizer), straw incorporation increased SAP and SMBP by 9.3%–18.5% and 15.5%–35.4%, respectively;substituting half the chemical N fertilizer dose with pig manure and the biochar application increased STP, SAP, and SMBP by 10.5%–48.3%, 30.2%–236.0%, and 19.8%–72.4%,respectively, mainly owing to increased soil P and organic carbon inputs;adding a half dose of N and no N input(reduced N treatments) increased STP and SAP by 2.6%–7.5% and 19.8%–33.7%, respectively, due to decreased soil P outputs. Thus, soil P availability was greatly affected by soil P input and use. The continuous flooding water regime without straw addition significantly decreased SMBP by 11.4% compared to corresponding treatments under a mid-season drainage water regime. Total P uptake by rice grains and straws at the harvest stage increased under straw incorporation and under pig manure application, but decreased under the reduced N treatments and under biochar application at a rate of 48 t ha-1, compared to the control. Rice P uptake was significantly positively correlated with rice biomass, and both were positively correlated with N fertilizer application rates, SAP, SMBP, and STP. Phosphorus use efficiency generally increased under straw incorporation but decreased under the reduced N treatments and under the manure application(with excessive P input), compared to the control. These results showed that straw incorporation can be used to increase soil P availability and PUE while decreasing the use of chemical P fertilizers. When substituting chemical fertilizers with pig manure, excess P inputs should be avoided in order to reduce P accumulation in the soil as well as the environmental risks from non-point source pollution. | Bingshen JIANG Jianlin SHEN Minghong SUN Yajun HU Wenqian JIANG Juan WANG Yong LI Jinshui WU | 2021 | Pedosphere2021，31，1： | 6 |
| 14 | Genetic analysis and gene fine mapping of a rolling leaf mutant (rl_(11(t))) in rice (Oryza sativa L.)显示文摘The exploration of new genes controlling rice leaf shape is an important foundation for rice functional genomics and plant architecture improvement. In the present study, we identified a rolling leaf mutant from indica variety Yuefeng B, named rl11(t), which exhibited reduced plant height, rolling and narrow leaves. Leaves in rl11(t) mutant showed abnormal number and morphology of veins compared with those in wild type plants. In addition, rl11(t) mutant was less sensitive to the inhibitory effect of auxin than the wild type. Genetic analysis suggested that the mutant was controlled by a single recessive gene. Gene Rl11(t) was initially mapped between SSR markers RM6089 and RM124 on chromosome 4. Thirty-two new STS markers around the Rl11(t) region were developed for fine mapping. A physical map encompassing the Rl11(t) locus was constructed and the target gene was finally delimited to a 31.6 kb window between STS4-25 and STS4-26 on BAC AL606645. This provides useful information for cloning of Rl11(t) gene. | ZHOU Yong FANG YunXia ZHU JinYan LI ShengQiang GU Fei GU MingHong LIANG GuoHua | 2010 | Chinese Science Bulletin2010，55，17： | 5 |
| 15 | Agricultural land use intensity study in Taibus Banner, and its determinants: a case Inner Mongolia, China显示文摘 | Haiguang HAO Xiubin LI Minghong TAN Jiping ZHANG Huiyuan ZHANG | 2015 | Frontiers of Earth Science2015，9，2： | 5 |
| 16 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 17 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 18 | FBG Arrays for Quasi-Distributed Sensing: A Review显示文摘Fiber Bragg grating (FBG) array is a powerful technique for quasi-distributed sensing along the entire length of sensing fiber with fast response and high precision. It has been widely used for temperature, strain, and vibration monitoring. In this review work, an overview on the recent advances of FBG arrays is conducted. Firstly, the fabrication methods of FBG array are reviewed, which include femtosecond laser system and online writing technique. Then, the demodulation techniques for FBG arrays are presented and discussed. Distributed static sensing can be performed by demodulating wavelength shift of each FBG, while phase demodulation techniques with low noise are employed for dynamic vibration sensing. Simultaneous distributed dynamic and static sensing system based on FBG array is also outlined. Finally, possible future directions are discussed and concluded. It is believed that the FBG array has great development potential and application prospect. | Chengli LI Jianguan TANG Cheng CHENG Longbao CAI Minghong YANG | 2021 | Photonic Sensors2021，11，1： | 4 |
| 19 | Fine mapping and cloning of MT1,a novel allele of D10显示文摘瑞斯是为谷物生产的一个重要决定因素到 ering 为止。调查机制到 ering 为止,我们描绘了一到从装饰用的梨树变化识别的 ering 异种(mt1 ) 为止多重, Zhonghua 11,与他们对待。展览推进了到 ering 开发为止并且与野类型的植物相比相形见绌的这异种。印射的基因分析和好基因显示 mt1 异种被后退的基因控制,住在染色体 1 的 AP003376 上的一扇 29-kb 窗户上。在这个区域的一通常认为的基因,编码类胡萝卜素劈开 dioxygenase 8 (CCD8 ) ,对 D10 突变而产生之遗传。mt1 异种显型被野类型的 MT1 的介绍补充,并且在模仿的野类型的米饭的 MT1 击倒变异的显型。实时 PCR 分析显示 MT1 基因在腋的芽,圆锥花序,叶子,和根在茎并且在底层高度被表示。另外, MT1 表示清楚地在反馈规定下面。 | Yong Zhou Jinyan Zhu Zhengyi Li Fei Gu Honggen Zhang Shuzhu Tang Minghong Gu Guohua Liang | 2009 | Progress in Natural Science:Materials International2009，19，12： | 3 |
| 20 | 2D and 3D Shape Sensing Based on 7-Core Fiber Bragg Gratings显示文摘A fiber-optic shape sensing based on 7-core fiber Bragg gratings(FBGs)is proposed and experimentally demonstrated.The investigations are presented for two-dimensional(2D)and three-dimensional(3D)shape reconstruction by distinguishing bending and twisting of 7-core optical fiber with FBGs.The curvature and bending orientation can be calculated by acquiring FBG wavelengths from any two side cores among the six outer cores.And the shape sensing in 3D space is computed by analytic geometry theory.The experiments corresponding of 2D and 3D shape sensing are demonstrated and conducted to verify the theoretical principles.The resolution of curvature is about 0.1 m^(-1) for 2D measuring.The error of angle in shape reconstruction is about 1.89°for 3D measuring.The proposed sensing technique based on 7-core FBGs is promising of high feasibility,stability,and repeatability,especially for the distinguishing ability on the bending orientation due to the six symmetrical cores on the cross-section. | Tianting LAI Pu CHENG Congliao YAN Chi LI Wenbin HU Minghong YANG | 2020 | Photonic Sensors2020，10，4： | 2 |
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