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| 1 | Relocation of the 10 March 2011 Yingjiang,China,earthquake sequence and its tectonic implications显示文摘An earthquake with MS5.8 occurred on 10 March 2011 in Yingjiang county,western Yunnan,China.This earthquake caused 25 deaths and over 250 injuries.In order to better understand the seismotectonics in the region,we collected the arrival time data from the Yunnan seismic observational bulletins during 1 January to 25 March 2011,and precisely hand-picked the arrival times from high-quality seismograms that were recorded by the temporary seismic stations deployed by our Institute of Crustal Dynamics,China Earthquake Administration.Using these arrival times,we relocated all the earthquakes including the Yingjiang mainshock and its aftershocks using the double-difference relocation algorithm.Our results show that the relocated earthquakes dominantly occurred along the ENE direction and formed an upside-down bow-shaped structure in depth.It is also observed that after the Yingjiang mainshock,some aftershocks extended toward the SSE over about 10 km.These results may indicate that the Yingjiang mainshock ruptured a conjugate fault system consisting of the ENE trending Da Yingjiang fault and a SSE trending blind fault.Such structural features could contribute to severely seismic hazards during the moderate-size Yingjiang earthquake. | Jianshe Lei Guangwei Zhang Furen Xie Yuan Li Youjin Su Lifang Liu Honghu Ma Junwei Zhang | 2012 | Earthquake Science2012，25，1： | 35 |
| 2 | Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth显示文摘 | Yi Yang Chia-Wei Li Li-Chuan Chan Yongkun Wei Jung-Mao Hsu Weiya Xia Jong-Ho Cha Junwei Hou Jennifer L. Hsu Linlin Sun Mien-Chie Hung | 2018 | Cell Research2018，28，8： | 35 |
| 3 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540edspkcxk6qn5fpf6o9c.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540edspkcxk6qn5fpf6o9c.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540edspkcxk6qn5fpf6o9c.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 4 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 5 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 6 | Rice MtN3/saliva/SWEET gene family: Evolution,expression profiling, and sugar transport显示文摘The rice MtN3/saliva/SWEET gene family consists of21 paralogs. However, their functions in physiological processes are largely unknown, although at least three of the 21 paralogs are used by pathogenic bacteria to infect rice.Here, we report the evolutionary features, transcriptional characteristics, and putative functions in sugar transport of this gene family. The wild rice accessions in this study included those with AA, BB, CC, BBCC, CCDD, EE, and GG genomes,which appeared approximately 0.58–14.6 million years ago.The structures, chromosomal locations, phylogenetic relationships, and homologous distribution among the accessions suggest that the number of rice MtN3/saliva/SWEET paralogs gradually increased as the Oryza genus evolved, and one third of the paralogs may have originated recently. These paralogs are differentially expressed in vegetative and reproductive tissues, in the leaf senescence process, and in signaling dependent on gibberellic acid, cytokinin, or 1-naphthalene acetic acid(an analog of auxin), suggesting that they may be associated with multiple physiological processes. Four paral ogs could transport galactose in yeast, which suggests tha they may have a similar function in rice. These results will help to elucidate their roles and biochemical functions in rice development, adaptation to environment, host-pathogen interaction, and so forth. | Meng Yuan Junwei Zhao Renyan Huang Xianghua Li Jinghua Xiao Shiping Wang | 2014 | Journal of Integrative Plant Biology2014，56，6： | 14 |
| 7 | Palmitoylation stabilizes PD-L1 to promote breast tumor growth显示文摘Dear Editor,PD-L1 is a well-known transmembrane protein, which is highly expressed on many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly inhibits T cells activation and activity, and thus plays a pivotal role in driving the escape of tumor cells from immune surveillance.^1. | Yi Yang Jung-Mao Hsu Linlin Sun Li-Chuan Chan Chia-Wei Li Jennifer L. Hsu Yongkun Wei Weiya Xia Junwei Hou Yufan Qiu Mien-Chie Hung | 2019 | Cell Research2019，29，1： | 14 |
| 8 | An Integrated Cyber-Physical Simulation Environment for Smart Grid Applications显示文摘The concept of Cyber-Physical Systems(CPSs),which combine computation,networking,and physical processes,is considered to be beneficial to smart grid applications. This study presents an integrated simulation environment to provide a unified platform for the investigation of smart grid applications involving power grid monitoring,communication,and control. In contrast to the existing approaches,this environment allows the network simulator to operate independently,importing its results to the power system simulation. This resolves conflicts between discrete event simulation and continuous simulation. In addition,several data compensation methods are proposed and investigated under different network delay conditions. A case study of wide-area monitoring and control is provided,and the efficiency of the proposed simulation framework has been evaluated based on the experimental results. | Yuxin Wan Junwei Cao Shuqing Zhang Guoyu Tu Chao Lu Xingtao Xu Keqin Li | 2014 | Tsinghua Science and Technology2014，19，2： | 13 |
| 9 | Phenotypic variation in Phoebe bournei populations preserved in the primary distribution area显示文摘Phoebe bournei(Hemsl.) Yang is a rare and protected plant in China. This study was conducted to determine the phenotypic variation in this species and to document phenotypic variation within and among populations of P. bournei. Nested analysis of variance, coefficient of variation, multiple comparisons, principal component analysis(PCA) and correlation analysis were used to analyze ten phenotypic traits in ten natural populations of P.bournei from both the northeastern and the primary region of the range of this species. Significant differences among and within populations were observed in leaf and seed phenotypic traits. Variation among populations(34.92%)was greater than that within populations(26.19%). The mean phenotypic differentiation coefficient was 53.77%among populations, indicating that variation among populations comprised the majority of the phenotypic variation of P. bournei. The coefficient of variance(CV) of ten traits varied from 6.44 to 18.45%, with an average of 12.03%.The CV of leaf traits among populations(15.64%) was higher than that of seed traits(8.60%), indicating that seed traits were more stable. The results from CV and PCA indicated that leaf area, leaf length and thousand seed weight were the main factors accounting for the observed phenotypic variations. Significant or highly significant correlations were observed among most leaf and/or in seed phenotypic traits, whereas no significant correlations were observed between phenotypic traits and geographic factors.Based on cluster analysis, the ten populations can be divided into three clusters. These clusters were not a result of geographic distances. | Yingang Li Xinhong Liu Junwei Ma Xiaomian Zhang Li-an Xu | 2018 | Journal of Forestry Research2018，29，1： | 13 |
| 10 | Quantitative prediction of mining subsidence and its impact on the environment显示文摘This study is focused on the prediction of mining subsidence and its impact on the environment in the Hongqi mining area. The study was carried out by means of a probability integral model based, in first instance based on field surveys and the analysis of data collected from this area. Isolines of mining subsidence were then drawn and the impact caused by mining subsidence on the environment was analyzed quantitatively by spatial analysis with Geographic Information System (GIS). The results indicate that the subsidence area of the first working-mine can be as large as 2.54 km 2 , the maximum subsidence is 3440 mm which will cause 1524 houses to be relocated. The entire subsidence area of the mine can reach 8.09 km 2 , with a maximum subsidence of 3590 mm. Under these circumstances the value of the loss of ecosystem services will reach 5.371 million Yuan and the cost of relocating buildings will increase to 6.858 million Yuan. | Jianjun Song Chunjian Han Ping Li Junwei Zhang Deyuan Liu Minde Jiang Lin Zheng Jingkai Zhang Jianying Song | 2012 | International Journal of Mining Science and Technology2012，22，1： | 13 |
| 11 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddhpkcxk6qn5fpf6o9c.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3hpkcxk6qn5fpf6o9c.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 12 | Two-dimensional heterostructure promoted infrared photodetection devices显示文摘It is a rapidly developed subject in expanding the fundamental properties and application of two-dimensional(2D)materials.The weak van der Waals interaction in 2D materials inspired researchers to explore 2D heterostructures(2DHs)based broadband photodetectors in the far-infrared(IR)and middle-IR regions with high response and high detectivity.This review focuses on the strategy and motivation of designing 2DHs based high-performance IR photodetectors,which provides a wide view of this field and new expectation for advanced photodetectors.First,the photocarriers'generation mechanism and frequently employed device structures are presented.Then,the 2DHs are divided into semimetal/semiconductor 2DHs,semiconductor/semiconductor 2DHs,and multidimensional semi-2DHs;the advantages,motivation,mechanism,recent progress,and outlook are discussed.Finally,the challenges for next-generation photodetectors are described for this rapidly developing field. | Gaofeng Rao Xuepeng Wang Yang Wang Peihua Wangyang Chaoyi Yan Junwei Chu Lanxin Xue Chuanhui Gong Jianwen Huang Jie Xiong Yanrong Li | 2019 | InfoMat2019，1，3： | 12 |
| 13 | Early Permian–Late Triassic Magmatism in the Tuotuohe Region of the Qinghai–Tibet Plateau: Constraints on the Tectonic evolution of the Western Segment of the Jinshajiang Suture显示文摘In this paper we present new zircon U–Pb ages, whole-rock major and trace element analyses, and zircon Hf isotopic data for magmatic rocks in the Tuotuohe region of the western segment of the Jinshajiang suture. Our aim is to constrain the Early Permian–Late Triassic tectonic evolution of the region. Zircons from the magmatic rocks of the Tuotuohe region are euhedral–subhedral in shape and display fine-scale oscillatory zoning as well as high Th/U ratios(0.4–4.6), indicating a magmatic origin. The zircon U–Pb ages obtained using LA–ICP–MS are 281 ± 1 Ma, 258 ± 1 Ma, 244 ± 1 Ma, and 216 ± 1 Ma, which indicate magmatism in the Early Permian–Late Triassic. A diorite from Bashihubei(BSHN) has SiO2 = 57.18–59.97 wt%, Al2O3 = 15.70–16.53 wt%, and total alkalis(Na2O + K2O) = 4.46–6.34 wt%, typical of calc-alkaline and metaluminous series. A gabbro from Bashibadaoban(BSBDB) belongs to the alkaline series, and is poor in SiO2(45.46–54.03 wt%) but rich in Al2O3(16.19–17.39 wt%) and total alkalis(Na2O + K2O = 5.48–6.26 wt%). The BSHN diorite and the BSBDB gabbro both display an enrichment of LREEs and LILEs and depletion of HFSEs, and they have no obvious Eu anomaly; they have relatively low MgO contents(2.54–4.93 wt%), Mg# values of 43 to 52, and low Cr and Ni contents(8.07–33.6 ppm and 4.41–14.2 ppm, respectively), indicating they differentiated from primitive mantle magmas. They have low Nb/U, Ta/U, and Ce/Pb ratios(1.3–9.6, 0.2–0.8, and 0.1–18.1, respectively), and their initial Hf isotopic ratios range from +9.6 to +16.9(BSHN diorite) and +6.5 to +12.6(BSBDB gabbro), suggesting their primary magmas were derived mainly from the partial melting of a mantle wedge that had been metasomatized by subduction fluids. Taking all the new data together, we conclude that the western and eastern segment of the Jinshajiang suture regions underwent identical processes of evolution in the Early Permian–Late Triassic: oceanic crust subduction before the Early Permian, continental collision during the Early–Middle Triassic, and post-collisional extension from the Late Triassic. | QIAN Ye SUN Fengyue LI Bile LI Shijin ZHAO Junwei | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 12 |
| 14 | Adaptive inverse control of random vibration based on the filtered-X LMS algorithm显示文摘随机的颤动控制针对复制力量光谱在指定控制的密度(PSD ) 指。古典频率光谱均等算法需要计算多重频率反应函数(FRF ) 的一般水准,它变长在均等进程的控制循环时间。同样,反馈控制算法让很慢的集中由于反馈获得参数的小价值评价保证系统的稳定性。克服这些限制,随机的颤动的适应反的控制基于 filtered-X 最不吝啬平方(LMS ) 算法被建议。根据描述和频率领域的随机的颤动测试的重复特征,而且,频率领域 LMS 算法被采用精制 FRF 的反的特征而不是传统的时间领域 LMS 算法。这个反的特征,在控制下面被称为系统的阻抗函数,被用来直接更新驱动器 PSD。测试结果显示除了成功地避免发生在重复过程期间的不稳定性问题,适应控制策略最小化需要获得一个短控制环并且完成均等的时间的数量。关键词随机的颤动 - 力量光谱密度 - 频率反应功能 - 适应反的控制 - filtered-X LMS 算法旁边支持了:不在资助下面在大学里为新世纪优秀才能编程序。 | Yang Zhidong,Huang Qitao~(++),Han Junwei~§and Li Hongren~§National Key Laboratory of Robots Technique and System,Harbin Institute of Technology,Harbin 150080,China PhD Candidate ~++ PhD ~§Professor | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 10 |
| 15 | Thermally conductive polyvinyl alcohol composite films via introducing hetero-structured MXene@silver fillers显示文摘Ag nanoparticles were in-situ grown on the surface of MXene nanosheets to prepare thermally conductive hetero-structured MXene@Ag fillers.With polyvinyl alcohol(PVA)as the polymer matrix,thermally conductive MXene@Ag/PVA composite films were fabricated by the processes of solution blending,pouring,evaporative self-assembly.With the same mass fraction,MXene@Ag-III(MXene/Ag,2:1,w/w)presents more significant improvement in thermal conductivity coefficient(λ)than MXene@Ag,single MXene,Ag,simply blending MXene/Ag.MXene@Ag-III/PVA composite films show dual functions of excellent thermal conductivity and electromagnetic interference(EMI)shielding.When the mass fraction of MXene@Ag-III is 60 wt.%,the in-planeλ(λ_(∥)),through-planeλ(λ_(⊥)),EMI shielding effectiveness(EMI SE)are 3.72 and 0.41 W/(m∙K),32 dB,which are increased by 3.1,1.3,105.7 times than those of pure PVA film(0.91 and 0.18 W/(m∙K),0.3 dB),respectively.The 60 wt.%MXene@Ag-III/PVA composite film also has satisfying mechanical and thermal properties,with Young’s modulus,glass transition temperature,heat resistance index of 3.8 GPa,58.5 and 175.3℃,respectively. | Mukun Li Yuyao Sun Dianying Feng Kunpeng Ruan Xia Liu Junwei Gu | 2023 | Nano Research2023，16，5： | 10 |
| 16 | Edible Peanut Worm(Sipunculus nudus) in the Beibu Gulf: Resource, Aquaculture, Ecological Impact and Counterplan显示文摘Sipunculus nudus is an important economic species because of its high nutritional and medicinal values. The exploitation and utilization of S. nudus primarily occur in the coastal regions of the Beibu Gulf. However, wild resource of S. nudus is rapidly decreasing because of the overexploitation, which has led to considerable developments of artificial breeding techniques. The cultivation scale of S. nudus has increased in response to successful artificial breeding; however, methods for culturing S. nudus in tidal flats or ponds require further study. Most studies have focused on the breeding, nutrition, medical value and ecological impact of these worms. Studies on the distribution, sediment requirements, nutrition characteristics, breeding techniques and aquaculture ecology of this species are summarized in this paper to promote the development of the aquaculture industry for S. nudus. The high biomass of S. nudus in the Beibu Gulf is positively correlated with the sediment characteristics and water quality of the region. The production of peanut worm has improved to some extent through culturing; however, the nutrient value and ecological environment problems have been observed, which reflect the over exploitation of trace elements and the sediment. These problems will worsen unless they are resolved, and the release of organic materials, nitrogen and phosphorus during harvesting impacts the coastal environment. Moreover, genetic erosion is a potential risk for larvae in artificial breeding programs in tidal flats. Therefore, culturing and collecting methods should be improved and the wild resource conservation should be implemented to promote the sustainable development of the peanut worm. | LI Junwei XIE Xiaoyong ZHU Changbo GUO Yongjian CHEN Suwen | 2017 | Journal of Ocean University of China2017，16，5： | 10 |
| 17 | Hierarchical construction of CNT networks in aramid papers for high-efficiency microwave absorption显示文摘Carbon nanotubes(CNTs)incorporated polymeric composites have been extensively investigated for microwave absorption at target frequencies to meet the requirement of radar cross-section reduction.In this work,a strategy of efficient utilization of CNT in producing CNT incorporated aramid papers is demonstrated.The layer-by-layer self-assembly technique is used to coat the surfaces of meta-aramid fibers and fibrils with CNT,providing novel raw materials available for the large-scale papermaking.The hierarchical construction of CNT networks resolves the dilemma of increasing CNT content and avoiding the agglomeration of CNT,which is a frequent challenge for CNT incorporated polymeric composites.The composite paper,which contains abundant heterogeneous interfaces and long-range conductive networks,is capable of reaching a high permittivity and dielectric loss tangent at a low CNT loading,its complex permittivity is,so far,adjustable in the range of(1.20−j0.05)to(25.17−j18.89)at 10 GHz.Some papers with optimal matching thicknesses achieve a high-efficiency microwave absorption with a reflection loss lower than−10 dB in the entire X-band. | You Wu Li Chen Yixuan Han Panbo Liu Haihong Xu Guanze Yu Yingying Wang Tao Wen Wenbo Ju Junwei Gu | 2023 | Nano Research2023，16，5： | 9 |
| 18 | Warming moxibustion attenuates inflammation and cartilage degradation in experimental rabbit knee osteoarthritis显示文摘OBJECTIVE:To explore the molecular mechanism of warming moxibustion(WM)in knee osteoarthritis(KOA).METHODS:The knee joints of 40 New Zealand rabbits were placed in a plaster cast in an extended position to establish a KOA model.The animals were randomly divided into four groups:the control group,model group,WM group,and diclofenac(DF)group.Hematoxylin-eosin staining and the modified Mankin score were applied to evaluate the histopathological changes.Chondrocyte apoptosis was determined by the terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay.Western blotting and real-time quantitative polymerase chain reaction were performed to measure the expression of interleukin-1β(IL-1β),prostaglandin E receptor 3(PTGER3),a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-5(ADAMTS-5),matrix metalloproteinase-13(MMP-13),and C-terminal telopeptides of collagen typeⅡ(CTX-Ⅱ)in cartilage tissues of the different groups.The concentrations of IL-1β,PTGER3,and CTX-Ⅱin serum were detected by the enzyme-linked immunosorbent assay.RESULTS:Rabbits with KOA in the WM and DF groups showed significantly reduced cartilage erosion and Mankin scores,compared with the untreated rabbits.The number of TUNEL-positive cells observed in the WM group was much fewer than that in the model group.The expression of PTGER3,MMP-13,CTX-Ⅱ,IL-1β,and ADAMTS-5 in cartilage tissues was remarkably downregulated following therapy with WM and DF.Moreover,a marked reduction was observed in the serum levels of IL-1β,PTGER3,and CTX-Ⅱin the WM and DF groups.CONCLUSION:WM exerts favorable therapeutic effects on articular injuries of KOA by regulating the expression of inflammatory and cartilage degradation-related cytokines. | LIU Di WU Yongli LI Chun WANG Minglei MA Xiaoxiu LIU Junwei ZHANG Yanling YANG Lei | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 9 |
| 19 | Efficient spectral regulation in Ce:Lu_(3)(Al,Cr)_(5)O_(12) and Ce:Lu_(3)(Al,Cr)_(5)O_(12)/Ce:Y_(3)Al_(5)O_(12) transparent ceramics with high color rendering index for high-power white LEDs/LDs显示文摘Realizing a high color rendering index(CRI)in Ce:LuAG transparent ceramics(TCs)with desired thermal stability is essential to their applications in white LEDs/LDs as color converters.In this study,based on the scheme of configuring the red component by Cr^(3+) doping,an efficient spectral regulation was realized in Ce,Cr:LuAG TCs.A unilateral shift phenomenon could be observed in both photoluminescence(PL)and photoluminescence excitation(PLE)spectra of TCs.By constructing TC-based white LED/LD devices in a remote excitation mode,luminescence properties of Ce,Cr:LuAG TCs were systematically investigated.The CRI values of Ce:LuAG TC based white LEDs could be increased by a magnitude of 46.2%.Particularly,by combining the as fabricated Ce,Cr:LuAG TCs with a 0.5 at% Ce:YAG TC,surprising CRI values of 88 and 85.5 were obtained in TC based white LEDs and LDs,respectively.Therefore,Ce,Cr:LuAG TC is a highly promising color convertor for high-power white LEDs/LDs applied in general lighting and displaying. | Tianyuan ZHOU Chen HOU Le ZHANG Yuelong MA Jian KANG Tao LI Rui WANG Jin HUANG Junwei LI Haidong REN Zhenxiao FU Farida ASELIM Ming LI Hao CHEN | 2021 | Journal of Advanced Ceramics2021，10，5： | 7 |
| 20 | A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes显示文摘细胞毒素的 T 房间(CTL ) 在肝炎 B 的控制起一个关键作用病毒(HBV ) 感染和病毒的清理。然而,大多数识别 CTL epitopes 从遗传型 A 和 D 的 HBV 被导出,并且很少在在亚洲更流行的遗传型 B 和 C 的病毒被定义。因为 HBV 核心蛋白质(HBc ) 是最保守、产生免疫性的部件,在这研究,我们使用了盖住 HBc 屏蔽并且识别特定的 CTL epitopes 的一个重叠 9-mer 肽水池。异乎寻常的 HLA-A2-restricted epitope HBc141149 被结晶化分析发现,在结构上描绘了。immunogenicity 和 anti-HBV 活动进一步在 HBV 和 HLA-A2 被决定转基因的老鼠。最后,我们证明在 HBc141149 epitope 的变化与病毒的参数被联系,在 HBV 的疾病前进感染了病人。我们的数据因此提供卓见进这异乎寻常的 epitope 绑定的结构特征给 MHC-I 分子,以及 epitope 特定的 CTL 活动在 HBV 安排 T 房间反应和有免疫力的避免感染的病人。 | Lu Sun Yu Zhang Bao Zhao Mengmeng Deng Jun Liu Xin Li Junwei Hou Mingming Gui Shuijun Zhang Xiaodong Li George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，4： | 7 |
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