|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus显示文摘Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in clinical treatment because of dysfunction of macrophage polarization and the inflammatory microenvironment in the bone defect region.Three-dimensional(3D)bioprinted scaffolds loaded with live cells and bioactive factors can improve cell viability and the inflammatory microenvironment and further accelerating bone repair.Here,we used modified bioinks comprising gelatin,gelatin methacryloyl(GelMA),and 4-arm poly(ethylene glycol)acrylate(PEG)to fabricate 3D bioprinted scaffolds containing BMSCs,RAW264.7 macrophages,and BMP-4-loaded mesoporous silica nanoparticles(MSNs).Addition of MSNs effectively improved the mechanical strength of GelMA/gelatin/PEG scaffolds.Moreover,MSNs sustainably released BMP-4 for long-term effectiveness.In 3D bioprinted scaffolds,BMP-4 promoted the polarization of RAW264.7 to M2 macrophages,which secrete anti-inflammatory factors and thereby reduce the levels of pro-inflammatory factors.BMP-4 released from MSNs and BMP-2 secreted from M2 macrophages collectively stimulated the osteogenic differentiation of BMSCs in the 3D bioprinted scaffolds.Furthermore,in calvarial critical-size defect models of diabetic rats,3D bioprinted scaffolds loaded with MSNs/BMP-4 induced M2 macrophage polarization and improved the inflammatory microenvironment.And 3D bioprinted scaffolds with MSNs/BMP-4,BMSCs,and RAW264.7 cells significantly accelerated bone repair.In conclusion,our results indicated that implanting 3D bioprinted scaffolds containing MSNs/BMP-4,BMSCs,and RAW264.7 cells in bone defects may be an effective method for improving diabetic bone repair,owing to the direct effects of BMP-4 on promoting osteogenesis of BMSCs and regulating M2 type macrophage polarization to improve the inflammatory microenvironment and secrete BMP-2. | Xin Sun Zhenjiang Ma Xue Zhao Wenjie Jin Chenyu Zhang Jie Ma Lei Qiang Wenhao Wang Qian Deng Han Yang Jinzhong Zhao Qianqian Liang Xiaojun Zhou Tao Li Jinwu Wang | 2021 | Bioactive Materials2021，6，3： | 12 |
| 2 | Non-destructive detection of pigments in oil painting by using terahertz tomography显示文摘Dear Editors,Terahertz technology has been applied in many fields[1–3].The protection and restoration of historical relics and cultural heritage,which is a new application area of terahertz technology,have been attracting much attention recently[4,5]because of its social significance and market prospects.The most important premise is to obtain information of the cultural relics without damaging them again.Therefore the appropriate non-destructively testing methods are | ZHANG ZhenWei WANG KeJia LEI Yong ZHANG ZhuoYong ZHANG ZhenWei WANG KeJia LEI Yong ZHANG ZhuoYong ZHAO YuanMeng LI ChenYu GU An SHI NingChang ZHAO Kun ZHAN HongLei ZHANG CunLin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 8 |
| 3 | Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2显示文摘MicroRNAs (miRNAs ) 是在 posttranscriptional 水平调整目标基因表示的 noncoding RNA 的一个类,导致进一步生物的函数。我们证明了 microvesicles (MV ) 能作为细胞间的通讯的一个新奇方法交付 miRNAs 进目标房间。在中央神经系统, glial 房间释放 MV,这被报导,它处于正常状况调制 neuronal 功能。阐明在疾病的 glial MV 的潜在的角色,我们在压力状况上评估了分泌 astrocytic MV 的效果。我们的结果证明在 Lipopolysaccharide (LPS ) 刺激以后,星形细胞释放了流提高了 dopaminergic 神经原的危险到神经毒素的泡(SV ) 。进一步的调查证明在 SV 的那增加的 astrocytic miR-34a 经由在 dopaminergic 神经原指向 anti-apoptotic 蛋白质 Bcl-2 涉及这进步。我们也发现在 LPS 刺激以后的 astrocytic miR-34a 的抑制能在神经毒素应力下面推迟 dopaminergic 神经原损失。这些数据揭示了在疾病位于星形细胞神经原相互作用下面的新奇机制。 | Susu Mao | 2015 | Protein & Cell2015，6，7： | 7 |
| 4 | Characteristics,timing,and offsets of the middle-southern segment of the western boundary strike-slip fault of the Songliao Basin in Northeast China显示文摘作为 Songliao 盆和 Da Hinggan 山的东方边缘的西方边界差错, Nenjiang-Balihan 差错位于东北中国的中央部分。是一个巨大的深层的 NNE 惹人注目的差错传统地被认为,由一个正常差错或分开差错排水量描绘了。域调查导致了发现可锻砍在 Lingxia 和 Louzidian 区域,中间和差错系统的南部的扇区的地区。作者在这个领域里进行了结构的元素的大小,微结构研究,有限紧张大小,石英的比较喜欢的水晶取向上的研究用电子背决定了散布使变形的岩石的衍射和白云母 40Ar/39Ar 年表在可锻砍地区。变丑 Lingxia 和 Louzidian 展示的结果表演可锻砍地区是类似的,并且他们代表一个连续差错,即, Nenjiang-Balihan 的中间南部的片断指责在早白垩纪(130 妈) 的可锻的砍,它经历了左首的罢工滑倒。由在 Nenjiang-Balihan 差错的双方上测量 Xar 蠢人河缝术和 Wolegen 组的排水量,差错的累积罢工滑倒偏移量是大约 4050 km,这被发现。 | HAN GuoQing LIU YongJiang Franz NEUBAUER Johann GENSER ZOU YunXin LI Wei LIANG ChenYue | 2012 | Science China Earth Sciences2012，55，3： | 7 |
| 5 | Global and regional trends in incidence and mortality of female breast cancer and associated factors at national level in 2000 to 2019显示文摘Background: Female breast cancer (FBC) has become the most prevalent malignancy worldwide. We aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of FBC.Methods: FBC incidence and mortality in 60 selected countries by cancer registry data integrity in 2020 were estimated from the GLOBOCAN database, and their association with the human development index (HDI) was further evaluated. Trends of age-standardized rates of incidence and mortality in 60 countries from 2000 through 2019 were evaluated by joinpoint regression analysis using data of Global Burden of Disease 2019. The association between potential behavioral, metabolic, and socioeconomic risk factor exposure at the nation level retrieved from the World Bank and Global Health Observatory and the incidence and mortality of FBC were evaluated by multivariate linear regression.Results: FBC incidence and mortality varied greatly in the 60 included countries. Higher incidence and mortality rates were typically observed in countries with higher HDIs and vice versa. During 2000 to 2019, significantly increasing trends in incidence and mortality were observed in 26 (average annual percent changes [AAPCs], 0.35-2.96) and nine countries (AAPC, 0.30-1.65), respectively, while significantly decreasing trends in both incidence and mortality were observed in 22 countries, most of which were high-HDI countries. Among the population aged ≥40 years, there were 26 and 11 countries showing significantly increased trends in incidence and mortality, respectively. Ecological analysis showed that countries with higher prevalence rates of high cholesterol and higher health expenditures were more likely to have higher FBC incidence, and countries with higher rates of obesity and poorer universal health coverage were more likely to have higher FBC mortality.Conclusions: Despite decreased or stabilized FBC incidence and mortality rates were observed in some countries with high HDI over the past decades, disease burden became even severer in developing countries, especially for the population aged ≥40 years. Effective targeted preventive programs are strongly encouraged to reduce the FBC disease burden worldwide. | Chenyu Luo Na Li Bin Lu Jie Cai Ming Lu Yuhan Zhang Hongda Chen Min Dai | 2022 | Chinese Medical Journal2022，，1： | 5 |
| 6 | Small molecules in targeted cancer therapy:advances,challenges,and future perspectives显示文摘Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,targeted therapeutic drugs have become mainstream cancer treatments.Since the first tyrosine kinase inhibitor imatinib was approved to enter the market by the US Food and Drug Administration(FDA)in 2001,an increasing number of small-molecule targeted drugs have been developed for the treatment of malignancies.By December 2020,89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration(NMPA)of China.Despite great progress,small-molecule targeted anti-cancer drugs still face many challenges,such as a low response rate and drug resistance.To better promote the development of targeted anti-cancer drugs,we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification.We present all the approved drugs as well as important drug candidates in clinical trials for each target,discuss the current challenges,and provide insights and perspectives for the research and development of anti-cancer drugs. | Lei Zhong Yueshan Li Liang Xiong Wenjing Wang Ming Wu Ting Yuan Wei Yang Chenyu Tian Zhuang Miao Tianqi Wang Shengyong Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 5 |
| 7 | Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer显示文摘To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy. | Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou | 2021 | Bioactive Materials2021，6，2： | 5 |
| 8 | Spatial artificial neural network model for subgrid-scale stress and heat flux of compressible turbulence显示文摘The subgrid-scale(SGS)stress and SGS heat flux are modeled by using an artificial neural network(ANN)for large eddy simulation(LES)of compressible turbulence.The input features of ANN model are based on the first-order and second-order derivatives of filtered velocity and temperature at different spatial locations.The proposed spatial artificial neural network(SANN)model gives much larger correlation coefficients and much smaller relative errors than the gradient model in an a priori analysis.In an a posteriori analysis,the SANN model performs better than the dynamic mixed model(DMM)in the prediction of spectra and statistical properties of velocity and temperature,and the instantaneous flow structures. | Chenyue Xie Jianchun Wang Hui Li Minping Wan Shiyi Chen | 2020 | Theoretical & Applied Mechanics Letters2020，10，1： | 5 |
| 9 | Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediatedMAPK signaling显示文摘Background:Colorectal cancer(CRC)is one of the most malignant tumorswith high incidence,yet its molecular mechanism is not fully understood,hindering the development of targeted therapy.Metabolic abnormalities are a hallmark of cancer.Targeting dysregulated metabolic features has become an important direction for modern anticancer therapy.In this study,we aimed to identify a new metabolic enzyme that promotes proliferation of CRC and to examine the related molecular mechanisms.Methods:We performed RNA sequencing and tissue microarray analyses of human CRC samples to identify new genes involved in CRC.Squalene epoxidase(SQLE)was identified to be highly upregulated in CRC patients.The regulatory function of SQLE in CRC progression and the therapeutic effect of SQLE inhibitors were determined by measuring CRC cell viability,colony and organoid formation,intracellular cholesterol concentration and xenograft tumor growth.Themolecularmechanism of SQLE functionwas explored by combining transcriptome and untargeted metabolomics analysis.Western blotting and realtime PCR were used to assess MAPK signaling activation by SQLE.Results:SQLE-related control of cholesterol biosynthesis was highly upregulated in CRC patients and associated with poor prognosis.SQLE promoted CRC growth in vitro and in vivo.Inhibition of SQLE reduced the levels of calcitriol(active form of vitamin D3)and CYP24A1,followed by an increase in intracellular Ca2+concentration.Subsequently,MAPK signaling was suppressed,resulting in the inhibition of CRC cell growth.Consistently,terbinafine,an SQLE inhibitor,suppressed CRC cell proliferation and organoid and xenograft tumor growth.Conclusions:Our findings demonstrate that SQLE promotes CRC through the accumulation of calcitriol and stimulation of CYP24A1-mediated MAPK signaling,highlighting SQLE as a potential therapeutic target for CRC treatment. | Luwei He Huaguang Li Chenyu Pan Yutong Hua Jiayin Peng Zhaocai Zhou Yun Zhao Moubin Lin | 2021 | Cancer Communications2021，41，8： | 4 |
| 10 | Analysis of Malware Application Based on Massive Network Traffic显示文摘Security and privacy issues are magnified by velocity, volume, and variety of big data. User's privacy is an even more sensitive topic attracting most people's attention. While XcodeGhost, a malware of i OS emerging in late 2015, leads to the privacy-leakage of a large number of users, only a few studies have examined XcodeGhost based on its source code. In this paper we describe observations by monitoring the network activities for more than 2.59 million i Phone users in a provincial area across 232 days. Our analysis reveals a number of interesting points. For example, we propose a decay model for the prevalence rate of Xcode Ghost and we find that the ratio of the infected devices is more than 60%; that a lot of popular applications, such as Wechat, railway 12306, didi taxi, Youku video are also infected; and that the duration as well as the traffic volume of most Xcode Ghost-related HTTP-requests is similar with usual HTTP-request which makes it difficult to be found. Besides, we propose a heuristic model based on fingerprint and its web-knowledge to identify the infected applications. The identifying result shows the efficiency of this model. | Xiaolin Gui Jun Liu Mucong Chi Chenyu Li Zhenming Lei | 2016 | China Communications2016，13，8： | 4 |
| 11 | Analysis and Prediction of Content Popularity for Online Video Service:A Youku Case Study显示文摘Understanding the characteristics and predicting the popularity of the newly published online videos can provide direct implications in various contexts such as service design, advertisement planning, network management and etc. In this paper, we collect a real-world large-scale dataset from a leading online video service provider in China, namely Youku. We first analyze the dynamics of content publication and content popularity for the online video service. Then, we propose a rich set of features and exploit various effective classification methods to estimate the future popularity level of an individual video in various scenarios. We show that the future popularity level of a video can be predicted even before the video's release, and by introducing the historical popularity information the prediction performance can be improved dramatically. In addition, we investigate the importance of each feature group and each feature in the popularity prediction, and further reveal the factors that may impact the video popularity. We also discuss how the early monitoring period influences the popularity level prediction. Our work provides an insight into the popularity of the newly published online videos, and demonstrates promising practical applications for content publishers,service providers, online advisers and network operators. | Chenyu Li Jun Liu Shuxin Ouyang | 2016 | China Communications2016，13，12： | 3 |
| 12 | PtNi-W/C with Atomically Dispersed Tungsten Sites Toward Boosted ORR in Proton Exchange Membrane Fuel Cell Devices显示文摘The performance of proton exchange membrane fuel cells is heavily dependent on the microstructure of electrode catalyst especially at low catalyst loadings.This work shows a hybrid electrocatalyst consisting of PtNi-W alloy nanocrystals loaded on carbon surface with atomically dispersed W sites by a two-step straightforward method.Single-atomic W can be found on the carbon surface,which can form protonic acid sites and establish an extended proton transport network at the catalyst surface.When implemented in membrane electrode assembly as cathode at ultra-low loading of 0.05 mgPt cm^(−2),the peak power density of the cell is enhanced by 64.4%compared to that with the commercial Pt/C catalyst.The theoretical calculation suggests that the single-atomic W possesses a favorable energetics toward the formation of*OOH whereby the intermediates can be efficiently converted and further reduced to water,revealing a interfacial cascade catalysis facilitated by the single-atomic W.This work highlights a novel functional hybrid electrocatalyst design from the atomic level that enables to solve the bottle-neck issues at device level. | Huawei Wang Jialong Gao Changli Chen Wei Zhao Zihou Zhang Dong Li Ying Chen Chenyue Wang Cheng Zhu Xiaoxing Ke Jiajing Pei Juncai Dong Qi Chen Haibo Jin Maorong Chai Yujing Li | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 13 | Mechanical microenvironments as key cellular regulator in the liver显示文摘Tissue stiffness, shear stress, and interstitial pressure make up major factors of liver mechanical microenvironment, which play the key regulatory role to control cell behaviors in the liver and progress of liver diseases. In this review, we focus on the characteristics of liver mechanical microenvironments and summarize cellular responses to mechanobiological changes during liver pathogenesis, especially in hepatic fibrosis and cirrhosis. A better understanding of the indispensable contributions of mechanical cues to liver homeostasis and pathogenesis is significant to identify new therapeutic targets for liver diseases such as hepatic fibrosis or cirrhosis. | Zhifeng You Lyu Zhou Wenjing Li Chenyu Huang Yanan Du | 2019 | Acta Mechanica Sinica2019，35，2： | 3 |
| 14 | A Malvaceae-specific miRNA targeting the newly duplicated GaZIP1L to regulate Zn^(2+)ion transporter capacity in cotton ovules显示文摘MicroRNAs(miRNAs)play critical roles in regulating gene expression in plants,yet their functions underlying cultivated diploid Gossypium arboreum cotton ovule development are largely unknown.Here,we acquired small RNA profiles from G.arboreum ovules and fibers collected at different growth stages,and identified 46 novel miRNAs that accounted for 23.7%of all miRNAs in G.arboreum reported in the latest plant sRNA database.Through analysis of 84(including 38 conserved)differentially expressed G.arboreum miRNAs,we detected 215 putative protein-coding genes in 26 biological processes as their potential targets.A Malvaceae-specific novel miRNA named gar-miRN44 was found to likely regulate cotton ovule growth by targeting to a newly duplicated Zn^(2+)ion transporter gene GaZIP1L.During cotton ovule development,gar-miRN44 transcript level decreased sharply after 10 to 15 days post-anthesis(DPA),while that of the GaZIP1L increased significantly,with a concomitant increase of Zn^(2+)ion concentration in late ovule developmental stages.Molecular dynamics simulation and ion absorption analysis showed that GaZIP1L has stronger Zn2+ion binding ability than the original GaZIP1,indicating that the newly evolved GaZIP1L may be more suitable for maintaining high Zn2+ion transport capacity that is likely required for cotton ovule growth via enhanced cellulose synthase activities.Our systematic miRNA profiling in G.arboreum and characterization of gar-miRN44 not only contribute to the understanding of miRNA function in cotton,but also provide potential targets for plant breeding. | Xingpeng Wen Gai Huang Chenyu Li Yuxian Zhu | 2021 | Science China(Life Sciences)2021，64，3： | 3 |
| 15 | Analysis of TM/TE mode enhancement and droop reduction by a nanoporous n-AIGaN underlayer in a 290 nm UV-LED显示文摘A full structure 290 nm ultraviolet light emitting diode(UV-LED)with a nanoporous n-AlGaN underlayer was fabricated by top via hole formation followed by high-voltage electrochemical etching.The 20 to 120 nm nanopores were prepared in regular doped n-AlGaN by adjusting the etching voltage.The comparison between the Raman spectrum and the photoluminescence wavelength shows that the biaxial stress in the nanoporous material is obviously relaxed.The photoluminescence enhancement was found to be highly dependent on the size of the pores.It not only improves the extraction efficiency of top-emitting transverse-electric(TE)-mode photons but also greatly improves the efficiency of side emitting tran sverse-magnetic(TM)-mode photons.This leads to the polarization change of the side-emitting light from-0.08 to-0.242.The intensity of the electroluminescence was increased by 36.5%at 100 mA,and the efficiency droop at high current was found to decrease from 61%to 31%. | YUFENG LI CHENYU WANG YE ZHANG PENG HU SHENGNAN ZHANG MENGQI DU XILIN SU QIANG LI FENG YUN | 2020 | Photonics Research2020，8，6： | 2 |
| 16 | MicroRNA-29a modulates axon branching by targeting doublecortin in primary neurons显示文摘MicroRNAs (miRNAs ) 内长地被表示调整蛋白质表示的小、非编码的抄本。实质的证据建议 miRNAs 在中央神经系统被充实,在他们被假设在神经开发期间起枢轴的作用的地方。在现在的学习,我们在在不同发展阶段和发现 miR-29a 的服的外皮和马头鱼尾的怪兽在出生后的阶段戏剧性地增加了的老鼠分析了 miRNAs 表示。另外,我们提供了 miR-29a 在 vitro 并且在 vivo 在成熟神经原被充实的充分证据。进一步的调查证明 glutamate 受体的激活在主要神经原导致了内长的 miR-29a 水平。而且,我们证明 miR-29a 直接调整了它的目标蛋白质 Doublecortin (DCX ) 表示,它进一步调制的轴突在主要文化分叉。一起,我们的结果建议 miR-29a 在鼠标的 neuronal 开发起一个重要作用大脑。 | Hanqin Li Susu Mao Haitao Wang Ke Zen Chenyu Zhang Liang Li | 2014 | Protein & Cell2014，5，2： | 2 |
| 17 | Final Closure Time of the Paleo-Asian Ocean: Implication from the Provenance Transformation from the Yangjiagou Formation to Lujiatun Formation in the Jiutai Area, NE China显示文摘The Jiutai area is tectonically situated at the eastern segment of the Central Asian Orogenic Belt(CAOB) and is close to the North China Craton(NCC) to the south, serving as an ideal place to investigations of the closure of the PaleoAsian Ocean(PAO). Sandstone samples collected from the Yangjiagou Formation and the Lujiatun Formation in this area have been studied in detail in terms of petrology, geochronology and geochemistry. The maximum depositional time of the Yangjiagou and Lujiatun formations has been constrained to early Middle Triassic(ca. 245 Ma) and middle Late Triassic(ca. 219 Ma), respectively. The Yangjiagou Formation, with a major provenance of dissected island arcs, is dominantly composed of Phanerozoic sediments from Northeastern China(NE China) massifs. The Lujiatun Formation, with major sediments from active continental margins, has a relatively larger proportion of Precambrian sediments, in which the ~1.85 Ga and ~2.5 Ga sediments are typical of the crystalline basements of the NCC and NE China massifs, which were uplifted and eroded during the closure of the PAO. Besides, both formations show the enrichment in LREEs and the depletion in HREEs, the common Eu negative anomalies, and trace element contents similar to that of the upper continental crust. Based on the provenance analysis of these two formations, the final closure time of the PAO in this area is constrained as from the early Middle Triassic(ca. 245 Ma) to the middle Late Triassic(ca. 219 Ma). | ZHANG Qian LIANG Chenyue LIU Yongjiang ZHENG Changqing LI Weimin | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 2 |
| 18 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 19 | Spectrin:Structure, function and disease显示文摘Spectrin is a large,cytoskeletal,and heterodimeric protein composed of modular structure of and subunits,it typically contains 106 contiguous amino acid sequence motifs called'spectrin repeats'.Spectrin is crucial for maintaining the stability and structure of the cell membrane and the shape of a cell.Moreover,it contributes to diverse cell functions such as cell adhesion,cell spreading,and the cell cycle.Mutations of spectrin lead to various human diseases such as hereditary hemolytic anemia,type 5 spinocerebellar ataxia,cancer,as well as others.This review focuses on recent advances in determining the structure and function of spectrin as well as its role in disease. | ZHANG Rui ZHANG ChenYu ZHAO Qi LI DongHai | 2013 | Science China(Life Sciences)2013，56，12： | 2 |
| 20 | The diameter factor of aligned membranes facilitates wound healing by promoting epithelialization in an immune way显示文摘Topographical properties,such as pattern and diameter,of biomaterials play important roles in influencing cell activities and manipulating the related immune response during wound healing.We prepared aligned electrospinning membranes with different fiber diameters,including 319±100 nm(A300),588±132 nm(A600),and 1048±130 nm(A1000),by adjusting the distance from the tip to the collector,the injection rate,and the concentration of the solution.The A300 membranes significantly improved cell proliferation and spreading and facilitated wound healing(epithelization and vascularization)with the regeneration of immature hair follicles compared to the other membranes.Transcriptomics revealed the underlying molecular mechanism that A300 could promote immune-related processes towards a pro-healing direction,significantly promoting keratinocyte migration and skin wound healing.All the results indicated that wound healing requires the active participation of the immune process,and that A300 was a potential candidate for guided skin regeneration applications. | Chenbing Wang Chenyu Chu Xiwen Zhao Yang Yang Chen Hu Li Liu Jidong Li Yili Qu Yi Man | 2022 | Bioactive Materials2022，7，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员