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| 1 | Effect of Huqian Wan on liver-Yin and kidney-Yin deficiency patterns in patients with knee osteoarthritis显示文摘OBJECTIVE: To observe the curative effect of Huqian Wan on liver and kidney-Yin deficiency knee osteoarthritis(KOA).METHODS: One hundred patients were randomly divided into a treatment(50 patients) and control group(50 patients). In the treatment group, patients orally took the Chinese medicine Huqian Wan. Control group patients orally took Votalin, 75 mg, once a day, for 8 weeks. The visual analog scale(VAS), Western Ontario and Mc Master University Osteoarthritis Index(WOMAC), and Medical Outcomes Study Short Form 36-Item Health Survey(SF36) were used to evaluate the curative effect before treatment and after 8 and 16 weeks of treatment.RESULTS: VAS and WOMAC scores significantly decreased and SF 36 scores significantly increased after treatment in both groups compared with before treatment(P < 0.05). There were significant differences in VAS, WOMAC, and SF 36 score changes between the two groups at week 16(P < 0.05).There was a significant increase in VAS and WOMAC scores in the control groups(P < 0.05) between weeks 8 and 16, but no significant difference was found in the treatment group(P > 0.05).CONCLUSION: Huqian Wan could effectively improve the clinical symptoms and quality of life in patients with KOA. It could also have a better and longer lasting curative effect without obvious adverse events compared with Votalin. | Chen Qiqing Jin Hongting He Bin Wang Liang Xiao Luwei Tong Peijian | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 8 |
| 2 | Copper as a single metal atom based photo-,electro-,and photoelectrochemical catalyst decorated on carbon nitride surface for efficient CO_(2) reduction:A review显示文摘The processes of photocatalytic CO_(2) reduction(pCO_(2)R)and electrochemical CO_(2) reduction(ECO_(2)R)have attracted considerable interest owing to their high potential to address many environmental and energy-related issues.In this aspect,a single Cu atom decorated on a carbon nitride(CN)surface(Cu-CN)has gained increasing popularity because of its unique advantages,such as excellent atom utilization and ultrahigh catalytic activity.CN-particularly graphitic CN(g-C_(3)N_(4))-is a photo-and electrocatalyst and used as an important support material for single Cu atom-based catalysts.These key functions of Cu-CN-based catalysts can improve the catalytic performance and stability in the pCO_(2)R and ECO_(2)R during the application process.In this review,we focus on Cu as a single metal atom decorated on CN for efficient photoelectrochemical CO_(2) reduction(pECO_(2)R),where ECO_(2)R increases the electrocatalytic active area and promotes electron transfer,while pCO_(2)R enhances the surface redox reaction by efficiently using photogenerated charges and offering integral activity as well as an active interface between Cu and CN.Interactions of single Cu atom-based photo-,electro-,and photoelectrochemical catalysts with g-C_(3)N_(4) are discussed.Moreover,for a deeper understanding of the history of the development of pCO_(2)R and ECO_(2)R,the basics of CO_(2) reduction,including pCO_(2)R and ECO_(2)R over g-C_(3)N_(4),as well as the structural composition,characterization,unique design,and mechanism of a single atom site are reviewed in detail.Finally,some future prospects and key challenges are discussed. | Lulu Li Israr Masood ul Hasan Farwa Ruinan He Luwei Peng Nengneng Xu Nabeel Khan Niazi Jia-Nan Zhang Jinli Qiao | 2022 | Nano Research Energy2022，1，2： | 7 |
| 3 | Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediatedMAPK signaling显示文摘Background:Colorectal cancer(CRC)is one of the most malignant tumorswith high incidence,yet its molecular mechanism is not fully understood,hindering the development of targeted therapy.Metabolic abnormalities are a hallmark of cancer.Targeting dysregulated metabolic features has become an important direction for modern anticancer therapy.In this study,we aimed to identify a new metabolic enzyme that promotes proliferation of CRC and to examine the related molecular mechanisms.Methods:We performed RNA sequencing and tissue microarray analyses of human CRC samples to identify new genes involved in CRC.Squalene epoxidase(SQLE)was identified to be highly upregulated in CRC patients.The regulatory function of SQLE in CRC progression and the therapeutic effect of SQLE inhibitors were determined by measuring CRC cell viability,colony and organoid formation,intracellular cholesterol concentration and xenograft tumor growth.Themolecularmechanism of SQLE functionwas explored by combining transcriptome and untargeted metabolomics analysis.Western blotting and realtime PCR were used to assess MAPK signaling activation by SQLE.Results:SQLE-related control of cholesterol biosynthesis was highly upregulated in CRC patients and associated with poor prognosis.SQLE promoted CRC growth in vitro and in vivo.Inhibition of SQLE reduced the levels of calcitriol(active form of vitamin D3)and CYP24A1,followed by an increase in intracellular Ca2+concentration.Subsequently,MAPK signaling was suppressed,resulting in the inhibition of CRC cell growth.Consistently,terbinafine,an SQLE inhibitor,suppressed CRC cell proliferation and organoid and xenograft tumor growth.Conclusions:Our findings demonstrate that SQLE promotes CRC through the accumulation of calcitriol and stimulation of CYP24A1-mediated MAPK signaling,highlighting SQLE as a potential therapeutic target for CRC treatment. | Luwei He Huaguang Li Chenyu Pan Yutong Hua Jiayin Peng Zhaocai Zhou Yun Zhao Moubin Lin | 2021 | Cancer Communications2021，41，8： | 4 |
| 4 | Carbon‐based metal‐free catalysts for electrochemical CO2 reduction: Activity, selectivity, and stability显示文摘Zero or negative emissions of carbon dioxide(CO2)is the need of the times,as inexorable rising and alarming levels of CO2 in the atmosphere lead to global warming and severe climate change.The electrochemical CO2 reduction(eCO2R)to value‐added fuels and chemicals by using renewable electricity provides a cleaner and more sustainable route with economic benefits,in which the key is to develop clean and economical electrocatalysts.Carbon‐based catalyst materials possess desirable properties such as high offset potential for H2 evolution and chemical stability at the negative applied potential.Although it is still challenging to achieve highly efficient carbon‐based catalysts,considerable efforts have been devoted to overcoming the low selectivity,activity,and stability.Here,we summarize and discuss the recent progress in carbon‐based metal‐free catalysts including carbon nanotubes,carbon nanofibers,carbon nanoribbons,graphene,carbon nitride,and diamonds with an emphasis on their activity,product selectivity,and stability.In addition,the key challenges and future potential approaches for efficient eCO2R to low carbon‐based fuels are highlighted.For a good understanding of the whole history of the development of eCO2R,the CO2 reduction reactions,principles,and techniques including the role of electrolytes,electrochemical cell design and evaluation,product selectivity,and structural composition are also discussed.The metal/metal oxides decorated with carbon‐based electrocatalysts are also summarized.We aim to provide insights for further development of carbon‐based metal‐free electrocatalysts for CO2 reduction from the perspective of both fundamental understanding and technological applications in the future. | Israr Masood ul Hasan Luwei Peng Jianfeng Mao Ruiman He Yongxia Wang Jing Fu Nengneng Xu Jinli Qiao | 2021 | Carbon Energy2021，3，1： | 2 |
| 5 | Treatment of Chromite Ore Processing Residue by pyrolysis with rice straw显示文摘 | Dalei Zhang Shengbing He Luwei Dai Xiaofang Hu Deyi Wu Kangjin Peng Guanhuan Bu Hao Pang Hainan Kong | 2009 | Chemosphere2009，，8： | 1 |
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