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| 1 | Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediatedMAPK signaling显示文摘Background:Colorectal cancer(CRC)is one of the most malignant tumorswith high incidence,yet its molecular mechanism is not fully understood,hindering the development of targeted therapy.Metabolic abnormalities are a hallmark of cancer.Targeting dysregulated metabolic features has become an important direction for modern anticancer therapy.In this study,we aimed to identify a new metabolic enzyme that promotes proliferation of CRC and to examine the related molecular mechanisms.Methods:We performed RNA sequencing and tissue microarray analyses of human CRC samples to identify new genes involved in CRC.Squalene epoxidase(SQLE)was identified to be highly upregulated in CRC patients.The regulatory function of SQLE in CRC progression and the therapeutic effect of SQLE inhibitors were determined by measuring CRC cell viability,colony and organoid formation,intracellular cholesterol concentration and xenograft tumor growth.Themolecularmechanism of SQLE functionwas explored by combining transcriptome and untargeted metabolomics analysis.Western blotting and realtime PCR were used to assess MAPK signaling activation by SQLE.Results:SQLE-related control of cholesterol biosynthesis was highly upregulated in CRC patients and associated with poor prognosis.SQLE promoted CRC growth in vitro and in vivo.Inhibition of SQLE reduced the levels of calcitriol(active form of vitamin D3)and CYP24A1,followed by an increase in intracellular Ca2+concentration.Subsequently,MAPK signaling was suppressed,resulting in the inhibition of CRC cell growth.Consistently,terbinafine,an SQLE inhibitor,suppressed CRC cell proliferation and organoid and xenograft tumor growth.Conclusions:Our findings demonstrate that SQLE promotes CRC through the accumulation of calcitriol and stimulation of CYP24A1-mediated MAPK signaling,highlighting SQLE as a potential therapeutic target for CRC treatment. | Luwei He Huaguang Li Chenyu Pan Yutong Hua Jiayin Peng Zhaocai Zhou Yun Zhao Moubin Lin | 2021 | Cancer Communications2021，41，8： | 4 |
| 2 | Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila显示文摘 | Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin Fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao | 2018 | Journal of Molecular Cell Biology2018，10，5： | 3 |
| 3 | Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci)显示文摘表明小径的刺猬(Hh ) 在胚胎的开发和成年织物动态平衡起重要作用。如此的生物功能被抄写因素肘脉 interruptus (Ci ) 调停。然而,受动器 Ci 本身的 transcriptional 规定糟糕被调查。通过一幅基于 RNAi 的基因屏幕,我们识别了那女性无菌(1 ) homeotic (Fsh ) ,抄写激活剂,直接激活 Ci 抄写。生物化学试金在 Fsh 之中表明了物理相互作用,性梳子额外(Sce ) ,并且 Polycomb (Pc ) 。功能的试金进一步证明 Pc 和 Sce 为 Ci 被要求表示,没被 Engrailed 的 derepression 多半调停,) , Ci 的一个抑压者,在 Pc 或 Sce 异种房间。最后,我们提供证明 Pc/Sce 在 Ci 地点便于 Fsh 的绑定并且在 Fsh 和 Pc 之间的物理相互作用为调停 Fsh 的 Ci 抄写是必要的证据。一起拿,我们不仅揭开那 Ci 被复杂的 Fsh-Pc-Sce transcriptionally 调整而且在 transcriptional 为在 Fsh 和 PcG 蛋白质之间的协作提供证据规定。 | Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin Fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao | 2018 | Journal of Molecular Cell Biology2018，10，5： | 2 |
| 4 | Spirobifluorene-Based Three-Dimensional Covalent Organic Frameworks with Rigid Topological Channels as Efficient Heterogeneous Catalyst显示文摘Although the past decade has witnessed tremendous progress in the development of covalent organic frameworks(COFs),three-dimensional(3D)COFs fabrications and characterizations are still much less studied compared with two-dimensional(2D)COFs,due to their complicated topology structures caused by interpenetration and limited choices of node-building blocks.In this work,we constructed a novel 3D COF(SP-3D-COF-BPY)successfully using orthogonal dual-planar spirobifluorene and bipyridine as building blocks.Also,we demonstrated the application of 3D COF-supported Pd(II)catalyst in heterogeneous catalysis.A sevenfold interpenetrated dia structure was revealed for SP-3DCOF-BPY by powder X-ray diffraction(PXRD)in conjunction with structural simulation and Pawley refinement.The bipyridine-linked frameworks bear one-dimensional(1D)unobstructed rigid channels and offer a high density of discrete coordination sites for chelating Pd(II)species.Very high loading of Pd(II)(∼15 wt%)was achieved in the asymmetric(as)-prepared Pd(II)@3D-COF-BYP.The generated highly ordered porous channels and easily accessible catalytic sites,such as COF-supported Pd(II)complex,serves as a highly active and stable microporous heterogeneous catalyst in Suzuki–Miyaura coupling reactions.The observed catalytic efficiency was high and the catalyst could be conveniently reused multiple times without any noticeable decay in catalytic performance. | Yamei Liu Chenyu Wu Qingzhu Sun Fan Hu Qingyan Pan Jing Sun Yinghua Jin Zhibo Li Wei Zhang Yingjie Zhao | 2021 | CCS Chemistry2021，3，4： | 1 |
| 5 | An Intelligent Fuzzy Agent for Meeting Scheduling Decision Support System 显示文摘 | Lee Changshing Pan Chenyu | 2009 | Environmental Modeling and Software2009，19，9： | 1 |
| 6 | Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis显示文摘The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines has stimulated intensive efforts to expand nanoparticle strategies to treat various diseases.Numerous synthetic nanoparticles have been developed for pharmaceutical delivery and cancer treatment.However,only a limited number of nanotherapies have enter clinical trials or are clinically approved.Systemically administered nanotherapies are likely to be sequestered by host mononuclear phagocyte system(MPS),resulting in suboptimal pharmacokinetics and insufficient drug concentrations in tumors.Bioinspired drug-delivery formulations have emerged as an alternative approach to evade the MPS and show potential to improve drug therapeutic efficacy.Here we developed a biodegradable polymer-conjugated camptothecin prodrug encapsulated in the plasma membrane of lipopolysaccharide-stimulated macrophages.Polymer conjugation revived the parent camptothecin agent(e.g.,7-ethyl-10-hydroxy-camptothecin),enabling lipid nanoparticle encapsulation.Furthermore,macrophage membrane cloaking transformed the nonadhesive lipid nanoparticles into bioadhesive nanocamptothecin,increasing the cellular uptake and tumor-tropic effects of this biomimetic therapy.When tested in a preclinical murine model of breast cancer,macrophage-camouflaged nanocamptothecin exhibited a higher level of tumor accumulation than uncoated nanoparticles.Furthermore,intravenous administration of the therapy effectively suppressed tumor growth and the metastatic burden without causing systematic toxicity.Our study describes a combinatorial strategy that uses polymeric prodrug design and cell membrane cloaking to achieve therapeutics with high efficacy and low toxicity.This approach might also be generally applicable to formulate other therapeutic candidates that are not compatible or miscible with biomimetic delivery carriers. | Kangkang Ying Yifeng Zhu Jianqin Wan Chenyue Zhan Yuchen Wang Binbin Xie Peirong Xu Hongming Pan Hangxiang Wang | 2023 | Bioactive Materials2023，，2： | 1 |
| 7 | GRB 220408B:A Three-episode Burst from a Precessing Jet显示文摘Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B by examining both its temporal and spectral consistency with the predictions of the model.As one of the recently confirmed GRBs observed by our GRID CubeSat mission,GRB 220408B is noteworthy as it exhibits three apparently similar emission episodes.Furthermore,the similarities are reinforced by their strong temporal correlations and similar features in terms of spectral evolution and spectral lags.Our analysis demonstrates that these features can be well explained by the modulated emission of a Fast-Rise-Exponential-Decay(FRED)shape light curve intrinsically produced by a precessing jet with a precession period of 18.4_(-0.2)~(+0.2)s,a nutation period of11.1_(-0.2)~(+0.2)s and viewed off-axis.This study provides a straightforward explanation for the complex yet similar multiepisode GRB light curves. | Zijian Zhang Yi-Han Iris Yin Chenyu Wang Xiangyu Ivy Wang Jun Yang Yan-Zhi Meng Zi-Ke Liu Guo-Yin Chen Xiaoping Fu Huaizhong Gao Sihao Li Yihui Liu Xiangyun Long Yong-Chang Ma Xiaofan Pan Yuanze Sun Wei Wu Zirui Yang Zhizhen Ye Xiaoyu Yu Shuheng Zhao Xutao Zheng Tao Zhou Qing-Wen Tang Qiurong Yan Rong Zhou Zhonghai Wang Hua Feng Ming Zeng Bin-Bin Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，11： | 0 |
| 8 | 共担与赋能:有温度的社区与住房显示文摘Introduction On Apr.15-16,2023,the 2022 Annual Conference of the Housing and Community Planning Committee of the Urban Planning Society of China(UPSC)was successfully held at the Chongqing Planning Exhibition Gallery,Chongqing.The conference was hosted by the Housing and Community Planning Committee of the UPSC. | 尹稚 王宇 江维 Yu Ying Liu Jiayan Yao Nan Wang Chenghui Fang Xiaotao Wang Ying Xi Wenqin Pan Chenyue Mou Yanchuan Wei Wei Li Yun Xiao Xiao Chen Yulin Zhao Di Liu Wei Zhang Jiuhe Deng Yi | 2023 | China City Planning Review2023，32，4： | 0 |
| 9 | Direct Synthesis of Crystalline Graphtetrayne-A New Graphyne Allotrope显示文摘We report a bottom-up synthesis of a new graphyne allotrope-graphtetrayne(GTTY),which features four acetylene linkages between the adjacent benzene on the surface of copper under low temperature.The as-prepared GTTY exhibited nanosheet morphology with an average thickness of 4.5 nm.Structural analysis based on high-resolution transmission electron microscopy(HR-TEM)/selected area electron diffraction(SAED)characterizations revealed high crystallinity formed with a ninefold stacking structure.The GTTY displayed excellent semiconductor properties bearing a band gap of 1.3 eV and a conductivity of 0.285 S m^(−1)at room temperature.Moreover,by the space-charge-limited current(SCLC)method,the measured hole and electron mobilities of the GTTY films reached up to 1.47×10^(3) cm^(2) V^(−1)S^(−1)and 2.98×10^(3)cm^(2)V^(−1)S^(−1),respectively. | Qingyan Pan Siqi Chen Chenyu Wu Feng Shao Jing Sun Lishui Sun Zhaohui Zhang Yixiao Man Zhibo Li Lixia He Yingjie Zhao | 2021 | CCS Chemistry2021，3，4： | 0 |
| 10 | A positive role for polycomb in transcriptional regulation via H4K20mel显示文摘 | Xiangdong Lv Zhijun Han Hao Chen Bo Yang Xiaofeng Yang Yuanxin Xia Chenyu Pan Lin Fu Shuo Zhang Hui Han Min Wu Zhaocai Zhou Lei Zhang Lin Li Gang Wei Yun Zhao | 2016 | Cell Research2016，26，5： | 0 |
| 11 | Hedgehog in the Drosophila testis niche:what does it do there?显示文摘Stem cell niche is a specialized microenvironment crucial to self-renewal.The testis in Drosophila contains two dif-ferent types of stem cells,the germline stem cells and the somatic cyst stem cells that are sustained by their respec-tive niche signals,thus is a good system for studying the interaction between the stem cells and their hosting niche.The JAK-STAT and BMP pathways are known to play critical roles in the self-renewal of different kinds of stem cells,but the roles of several other pathways have emerged recently in a complex signaling network in the testis niche.Reports of independent observations from three research groups have uncovered an important role of Hedgehog(Hh)in the Drosophila testis niche.In this review,we summarize these recent fi ndings and discuss the interplay between the Hh signaling mechanisms and those of the JAK-STAT and BMP pathways.We also dis-cuss directions for further investigation. | Zhao Zhan Chenyu Pan Yun Zhao | 2013 | Protein & Cell2013，4，9： | 0 |
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