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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Clinical and organizational content of clinical pathways for digestive surgery: a systematic review显示文摘 | Lemmens L van Zelm R Borel Rinkes I | 2009 | Dig Surg2009，26，2： | 1 |
| 3 | Matrix metalloproteinase-2 and-9 as promising benefactors in development,plasticity and repair of the nervous system显示文摘 | Verslegers M Lemmens K Van Hove I | 2013 | Prog Neurobiol2013，105，： | 1 |
| 4 | Identification of the multiple endocrine neoplasia type 1 ( MEN1 ) gene 显示文摘 | Lemmens I Van de Ven W J Kas K | 1997 | Hum Mol Genet1997，6，7： | 1 |
| 5 | Tavernier mammalian two-hybrids come of age 显示文摘 | LIEVENS S LEMMENS I TAVERNIER J | 2009 | Trends Biochem Sci2009，34，11： | 1 |
| 6 | Kinetic markers of human embryo quality using time-lapse rocordings of IVF/ICSI-fertilized ocytes显示文摘 | Lemmen JC Agerholm I Ziebe S | 2008 | Reprod Biomed Online2008，17，3： | 1 |
| 7 | Recent trends of cancer in Europe:a combined approach of incidence,survival and mortality for 17 cancer sites since the 1990s显示文摘 | Karim-Kos H E de Vries E Soerjomataram I Lemmens V Siesling S Coebergh J W | | 0，，： | 1 |
| 8 | MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling 显示文摘 | Ulrichts P Lemmens I Lavens D | 2009 | Methods Mol Biol2009，517，： | 1 |
| 9 | Incidence, prognosis, and treatment options for patients with synchronous peritoneal carcinomatosis and liver metastases from colorectal origin 显示文摘 | Thomassen I van Gestel YR Lemmens VE | 2013 | Dis Colon Rectum2013，56，12： | 1 |
| 10 | Towards a better understanding of the relationship between the β- carotene in vitro bio-accessibility and pectin structural changes: a case study on carrots显示文摘 | Lemmens L Van Buggenhout S Oey I | 2009 | Food Res Intl2009，42，9： | 1 |
| 11 | Kinetic markers of humanembryo quality using time-lapse recordings of IVF/ICSI-fertilizedoocytes显示文摘 | Lemmen JG Agerholm I Ziebe S | 2008 | Reprod Biomed Online2008，17，3： | 1 |
| 12 | Recombinant soluble p55 receptor in duces remission,is non-immunogenic and well tolerated in active Crohn's disease:results of a randomized pilot trial显示文摘 | Rutgeerts P Lemmens L Van Assche G Noman M Borghini-fuher I Goedkoop R | 2001 | Gastroenterology2001，120，： | 1 |
| 13 | Pregnane X receptor upregulates ABC - transporter Abcg2 and Abebl at the blood - bar- tier显示文摘 | Lemmen J I Tozakidis IE Galla H J | 2013 | Brain Research2013，49，： | 1 |
| 14 | High-quality binary protein interaction map of the yeast interactome network显示文摘 | Yu HY Braun P Yildirim MA Lemmens I Venkatesan K Sahalie J Hirozane-Kishikawa T Gebreab F Li N Simonis N Hao T Rual JF Dricot A Vazquez A Murray RR Simon C Tardivo L Tam S Svrzikapa N Fan CY de Smet AS Motyl A Hudson ME Park J Xin XF Cusick ME Moore T Boo | | 0，，5898： | 1 |
| 15 | Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes显示文摘 | Lemmen JG Agerholm I Ziebe S | | 0，，3： | 1 |
| 16 | Processing tomato pulp in the presence of lipids : The impact on lycopene bioaccessibility显示文摘 | Colle I J P Lemmens L Van Buggenhout S | 2013 | Food Research International2013，51，： | 1 |
| 17 | Intravenous cyclosporine versus ntravenous corticosteroids as single therapy for severe attacks of ulcerative colitis显示文摘 | D' Haens G Lemmens I G eboes K | 2001 | Gastroenterology2001，120，： | 1 |
| 18 | Carotenoid bioaccessibility in fruit-and vegetable based food products as affected by product (micro) structural characteristics and the presence of lipids-A review 显示文摘 | Lemmens L Colle I Buggenhout VS | 2014 | Trends in Food Science & Technology2014，38，： | 1 |
| 19 | Flavonol glycosides from the leaves of Embelia keniensis 显示文摘 | Manguro LOA Ugi I Lemmen P | 2005 | Journal of the Chinese Chemical Society2005，52，1： | 1 |
| 20 | Clinical and organizational content of clinical pathways for digestive surgery:a systematic review显示文摘 | Lemmens L van Zelm R Borel Rinkes I | 2009 | Dig Surg2009，26，2： | 1 |
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