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| 1 | Peritoneal carcinomatosis of colorectal origin:Incidence,prognosis and treatment options显示文摘Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the histori-cal prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients withCRC. Risk factors for developing PC have been identi-fied:right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemother-apeutical and surgical treatments have achieved prom-ising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hy-perthermic intraperitoneal chemotherapy. This edito-rial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC. | Yvonne LB Klaver Valery EPP Lemmens Simon W Nienhuijs Misha DP Luyer Ignace HJT de Hingh | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 2 | Differences in outcomes of oesophageal and gastric cancer surgery across Europe显示文摘 | J. L. Dikken J. W. van Sandick W. H. Allum J. Johansson L. S. Jensen H. Putter V. H. Coupland M. W. J. M. Wouters V. E. P. Lemmens C. J. H. van de Velde | 2012 | Br J Surg2012，，1： | 4 |
| 3 | Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration显示文摘Matrix metalloproteinases(MMPs)are members of the metzincin superfamily named after the zinc ion and the conserved methionine residue at the active site.In addition to their role in extracellular matrix(ECM)remodeling,these proteinases(in)activate many signaling molecules such as growth factors,adhesion molecules and cytokines;and even exert some intra- | Kim Lemmens Inge Van Hove Lieve Moons | 2016 | Neural Regeneration Research2016，11，5： | 3 |
| 4 | In-Situ Hydrothermal Synthesis of Bi–Bi2O2CO3 Heterojunction Photocatalyst with Enhanced Visible Light Photocatalytic Activity显示文摘Bismuth containing nanomaterials recently received increasing attention with respect to environmental applications because of their low cost, high stability and nontoxicity. In this work, Bi–Bi_2O_2CO_3 heterojunctions were fabricated by in-situ decoration of Bi nanoparticles on Bi_2O_2CO_3 nanosheets via a simple hydrothermal synthesis approach. X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM) and high-resolution TEM(HRTEM) were used to confirm the morphology of the nanosheet-like heterostructure of the Bi–Bi_2O_2CO_3 composite. Detailed ultrafast electronic spectroscopy reveals that the in-situ decoration of Bi nanoparticles on Bi_2O_2CO_3 nanosheets exhibit a dramatically enhanced electron-hole pair separation rate, which results in an extraordinarily high photocatalytic activity for the degradation of a model organic dye, methylene blue(MB) under visible light illumination. Cycling experiments revealed a good photochemical stability of the Bi–Bi_2O_2CO_3 heterojunction under repeated irradiation. Photocurrent measurements further indicated that the heterojunction incredibly enhanced the charge generation and suppressed the charge recombination of photogenerated electron-hole pairs. | Prasenjit Kar Tuhin Kumar Maji Ramesh Nandi Peter Lemmens Samir Kumar Pal | 2017 | Nano-Micro Letters2017，9，2： | 3 |
| 5 | Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands显示文摘 | A.E. Dassen V.E.P.P. Lemmens L.V. van de Poll-Franse G.J. Creemers S.J. Brenninkmeijer D.J. Lips A.A.M. vd Wurff K. Bosscha J.W.W. Coebergh | 2010 | European Journal of Cancer2010，，6： | 2 |
| 6 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 7 | Estimation of water pollution sources in Lake Victoria, East Africa: Application and elaboration of the rapid assessment methodology显示文摘 | P.A.G.M Scheren H.A Zanting A.M.C Lemmens | 2000 | Journal of Environmental Management2000，，4： | 2 |
| 8 | 老龄小鼠模型内皮细胞衰老导致射血分数保留的心力衰竭显示文摘由于全球老龄化,射血分数保留的心力衰竭(heart failure with preserved ejection fraction,HFpEF)发生率持续上升。虽然HFpEF的病理生理机制仍然不完全清楚,但通常认为内皮炎症发挥了核心作用。细胞衰老是一种与老化和炎症有关的细胞生长停滞过程。Gevaert等使用加速老化的小鼠(senescence-accelerated mice,SAM)模型探究细胞衰老在HFpEF发生发展中的作用。 | 刘莉 叶鹏 Gevaert AB Shakeri H Leloup AJ Van Hove CE De Meyer GRY Vrints CJ Lemmens K Van Craenenbroeck EM | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 9 | Anti-tumor necrosis factor treatment restores the gut barrier in Crohn’s disease显示文摘 | Peter Suenaert Veerle Bulteel Liesbeth Lemmens Maja Noman Benny Geypens Gert Van Assche Karel Geboes Jan L Ceuppens Paul Rutgeerts | 2002 | The American Journal of Gastroenterology2002，，8： | 2 |
| 10 | Outcomes of colorectal cancer patients with peritoneal carcinomatosis treated with chemotherapy with and without targeted therapy显示文摘 | Y.L.B. Klaver L.H.J. Simkens V.E.P.P. Lemmens M. Koopman S. Teerenstra R.P. Bleichrodt I.H.J.T. de Hingh C.J.A. Punt | 2012 | European Journal of Surgical Oncology2012，，7： | 2 |
| 11 | 国际卒中遗传学联盟的推荐意见(第2部分):生物样本的采集和储存显示文摘在2003年人类基因组测序以及全基因组基因分型技术发展的共同促进下,人类遗传学的进步已使我们识别出2000多个与性状相关的基因突变。由于这些突变大多数对疾病风险仅有微小的独立影响,因此成功的遗传学研究需要很大的样本量(包含数以千计、万计或者十万计的病例和对照)才能达到足够的研究效能。如此大的样本量积累需要依赖在人类遗传学研究乃至在临床研究中史无前例的大规模国际协作。现在已有许多常见疾病的专病联盟将大量独立机构和合作者联合起来。每个联盟均面临至少2个基本问题:如何整合具有足够数量、同质性和表型质量高的研究样本以及如何储存和分析来自入组受试者的生物样本,有时可能需要在数年间反复进行。 | Thomas W.K.Battey Valerie Valant Sylvia Baedorf Kassis Christina Kourkoulis Chaeyoung Lee Christopher D. Anderson Guido J. Falcone Jordi Jimenez-Conde Israel Fernandez-Cadenas Guillaume Pare Tatjana Rundek Michael L. James Robin Lemmens Tsong-Hai Lee Turgut Tatlisumak Steven J. Kittner Arne Lindgren Farrah J. Mateen Aaron L. Berkowitz Elizabeth G. Holliday Jennifer Majersik 李海峰 姜平 岳耀先 | 2015 | 国际脑血管病杂志2015，23，9： | 2 |
| 12 | The pharmacokinetics of the new short acting opioid remifentanil in healthy adult male volunteer显示文摘 | Egan TD Lemmens HJM Fiset P | 1993 | Aneesthesiology1993，79，5： | 1 |
| 13 | The pharmacokinetics of the new short-acting opioid remifentanil (G187084B) in healthy adult male volunteer显示文摘 | Egan TD Lemmens HJ Fisel P | 1993 | Anesthesiology1993，79，7： | 1 |
| 14 | Iron status in rats fed on diets containing marginal amounts of vitamin A显示文摘 | Sijtsma KW Van Den Berg GJ Lemmens AG | 1993 | Br J Nutr1993，70，： | 1 |
| 15 | AHTN and HHCB show weak estrogenic-butno uterotrophic activity显示文摘 | Willem Seinen Josephine G Lemmen Raymond H HPieters et a1 | 1999 | Toxicology Letters1999，111，： | 1 |
| 16 | Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta显示文摘 | Kuiper GGJM Lemmen JG Carlsson B | 1998 | Endocrinology1998，139，： | 1 |
| 17 | CD4^+ T-cell help controls CD8^+ T-cell memory via TRAIL-mediated activation-induced cell death显示文摘 | Janssen EM Droin NM Lemmens EE | 2005 | Nature2005，434，7029： | 1 |
| 18 | Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta显示文摘 | Kuiper GG Lemmen JG Carlsson B | 1998 | Endocr-inology1998，139，10： | 1 |
| 19 | Changes in fl-carotene bioaccessibility and concentration during processing of carrot puree显示文摘 | Knockaert G Lemmens L Van Buggenhout S | 2012 | Food Chemistry2012，133，1： | 1 |
| 20 | Left double-lumen tubes:clinical experience with 1 170 patients显示文摘 | BRODSKY J B LEMMENS H J | | 0，，03： | 1 |
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