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| 1 | Progress in Global Gas Hydrate Development and Production as a New Energy Resource显示文摘Natural gas hydrates have been hailed as a new and promising unconventional alternative energy,especially as fossil fuels approach depletion,energy consumption soars,and fossil fuel prices rise,owing to their extensive distribution,abundance,and high fuel efficiency.Gas hydrate reservoirs are similar to a storage cupboard in the global carbon cycle,containing most of the world's methane and accounting for a third of Earth's mobile organic carbon.We investigated gas hydrate stability zone burial depths from the viewpoint of conditions associated with stable existence of gas hydrates,such as temperature,pressure,and heat flow,based on related data collected by the global drilling programs.Hydrate-related areas are estimated using various biological,geochemical and geophysical tools.Based on a series of previous investigations,we cover the history and status of gas hydrate exploration in the USA,Japan,South Korea,India,Germany,the polar areas,and China.Then,we review the current techniques for hydrate exploration in a global scale.Additionally,we briefly review existing techniques for recovering methane from gas hydrates,including thermal stimulation,depressurization,chemical injection,and CH4-CO2 exchange,as well as corresponding global field trials in Russia,Japan,United States,Canada and China.In particular,unlike diagenetic gas hydrates in coarse sandy sediments in Japan and gravel sediments in the United States and Canada,most gas hydrates in the northem South China Sea are non-diagenetic and exist in fine-grained sediments with a vein-like morphology.Therefore,especially in terms of the offshore production test in gas hydrate reservoirs in the Shenhu area in the north slope of the South China Sea,Chinese scientists have proposed two unprecedented techniques that have been verified during the field trials:solid fluidization and formation fluid extraction.Herein,we introduce the two production techniques,as well as the so-called'fbur-in-one'environmental monitoring system employed during the Shenhu production test.Methane is not currently commercially produced from gas hydrates anywhere in the world;therefore,the objective of field trials is to prove whether existing techniques could be applied as feasible and economic production methods for gas hydrates in deep-water sediments and permafrost zones.Before achieving commercial methane recovery from gas hydrates,it should be necessary to measure the geologic properties of gas hydrate reservoirs to optimize and improve existing production techniques.Herein,we propose horizontal wells,multilateral wells,and cluster wells improved by the vertical and in dividual wells applied during existing field trials.It is noteworthy that relatively pure gas hydrates occur in seafloor mounds,within near-surface sediments,and in gas migration conduits.Their extensive distribution,high saturation,and easy access mean that these types of gas hydrate may attract considerable attention from academia and industry in the future.Herein,we also review the occurrence and development of concentrated shallow hydrate accumulations and briefly introduce exploration and production techniques.In the closing section,we discuss future research needs,key issues,and major challenges related to gas hydrate exploration and production.We believe this review article provides insight on past,present,and future gas hydrate exploration and production to provide guidelines and stimulate new work into the field of gas hydrates. | LIU Liping SUN Zhilei ZHANG Lei WU Nengyou Yichao Qin JIANG Zuzhou GENG Wei CAO Hong ZHANG Xilin ZHAI Bin XU Cuiling SHEN Zhicong JIA Yonggang | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 13 |
| 2 | Diffusion-tensor imaging as an adjunct to dynamic contrastenhanced MRI for improved accuracy of differential diagnosis between breast ductal carcinoma in situ and invasive breast carcinoma显示文摘Objective:To determine the value of diffusion-tensor imaging(DTI) as an adjunct to dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) for improved accuracy of differential diagnosis between breast ductal carcinoma in situ(DCIS) and invasive breast carcinoma(IBC).Methods:The MRI data of 63 patients pathologically confirmed as breast cancer were analyzed.The conventional MRI analysis metrics included enhancement style,initial enhancement characteristic,maximum slope of increase,time to peak,time signal intensity curve(TIC) pattern,and signal intensity on FST2 WI.The values of apparent diffusion coefficient(ADC),directionally-averaged mean diffusivity(D_(avg)),exponential attenuation(EA),fractional anisotropy(FA),volume ratio(VR) and relative anisotropy(RA)were calculated and compared between DCIS and IBC.Multivariate logistic regression was used to identify independent factors for distinguishing IBC and DCIS.The diagnostic performance of the diagnosis equation was evaluated using the receiver operating characteristic(ROC) curve.The diagnostic efficacies of DCEMRI,DWI and DTI were compared independendy or combined.Results:EA value,lesion enhancement style and TIC pattern were identified as independent factor for differential diagnosis of IBC and DCIS.The combination diagnosis showed higher diagnostic efficacy than a single use of DCE-MRI(P=0.02),and the area of the curve was improved from 0.84(95%CI,0.67-0.99) to0.94(95%CI,0.85-1.00).Conclusions:Quantitative DTI measurement as an adjunct to DCE-MRI could improve the diagnostic performance of differential diagnosis between DCIS and IBC compared to a single use of DCE-MRI. | Yuan Wang Xiaopeng Zhang Kun Cao Yanling Li Xiaoting Li Liping Qi Lei Tang Zhilong Wang Shunyu Gao | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 3 | Incorporating temporal variability to improve geostatistical analysis of satellite-observed CO_2 in China显示文摘Observations of atmospheric carbon dioxide (CO2 ) from satellites offer new data sources to understand global carbon cycling. The correlation structure of satellite-observed CO2 can be analyzed and modeled by geostatistical methods, and CO2 values at unsampled locations can be predicted with a correlation model. Conventional geostatistical analysis only investigates the spatial correlation of CO2 , and does not consider temporal variation in the satellite-observed CO2 data. In this paper, a spatiotemporal geostatistical method that incorporates temporal variability is implemented and assessed for analyzing the spatiotemporal correlation structure and prediction of monthly CO2 in China. The spatiotemporal correlation is estimated and modeled by a product-sum variogram model with a global nugget component. The variogram result indicates a significant degree of temporal correlation within satellite-observed CO2 data sets in China. Prediction of monthly CO2 using the spatiotemporal variogram model and spacetime kriging procedure is implemented. The prediction is compared with a spatial-only geostatistical prediction approach using a cross-validation technique. The spatiotemporal approach gives better results, with higher correlation coefficient (r2 ), and less mean absolute prediction error and root mean square error. Moreover, the monthly mapping result generated from the spatiotemporal approach has less prediction uncertainty and more detailed spatial variation of CO2 than those from the spatial-only approach. | ZENG ZhaoCheng LEI LiPing GUO LiJie ZHANG Li ZHANG Bing | 2013 | Chinese Science Bulletin2013，58，16： | 12 |
| 4 | (E)-Nerolidol is a volatile signal that induces defenses against insects and pathogens in tea plants显示文摘Plants release large amounts of volatile organic compounds(VOCs)in response to attackers.Several VOCs can serve as volatile signals to elicit defense responses in undamaged tissues and neighboring plants,but many questions about the ecological functions of VOCs remain unanswered.Tea plants are impacted by two harmful invaders,the piercing herbivore Empoasca(Matsumurasca)onukii Matsuda and the pathogen Colletotrichum fructicola.To determine the VOC signals in tea,we confirmed CsOPR3 as a marker gene and set up a rapid screening method based on a 1.51 kb CsOPR3 promoter fused with aβ-glucuronidase(GUS)reporter construct(OPR3p::GUS)in Arabidopsis.Using this screening system,a terpenoid volatile(E)-nerolidol was identified as a potent signal that elicits plant defenses.The early responses triggered by(E)-nerolidol included the activation of a mitogen-activated protein kinase and WRKY,an H2O2 burst,and the induction of jasmonic acid and abscisic acid signaling.The induced plants accumulated high levels of defenserelated chemicals,which possessed broad-spectrum anti-herbivore or anti-pathogen properties,and ultimately triggered resistance against Empoasca onukii and Colletotrichum fructicola in tea.We propose that these findings can supply an environmentally friendly management strategy for controlling an insect pest and a disease of tea plants. | Shenglong Chen Liping Zhang Xiaoming Cai Xin Li Lei Bian Zongxiu Luo Zhaoqun Li Zongmao Chen Zhaojun Xin | 2020 | Horticulture Research2020，7，1： | 12 |
| 5 | Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather:a review and perspective显示文摘Correct understanding of the land-surface processes and cloud-precipitation processes in the Tibetan Plateau(TP)is an important prerequisite for the study and forecast of the downstream activities of weather systems and one of the key points for understanding the global atmospheric movement.In order to show the achievements that have been made,this paper reviews the progress on the observations for the atmospheric boundary layer,land-surface heat fluxes,cloud-precipitation distributions and vertical structures by using ground-and space-based multiplatform,multisensor instruments and the effect of the cloud system in the TP on the downstream weather.The results show that the form drag related to the topography,land-atmosphere momentum and scalar fluxes is an important part of the parameterization process.The sensible heat flux decreased especially in the central and northern TP caused by the decrease in wind speeds and the differences in the ground-air temperatures.Observations show that the cloud and precipitation over the TP have a strong diurnal variation.Studies also show the compressed-air column in the troposphere by the higher-altitude terrain of the TP makes particles inside clouds vary at a shorter distance in the vertical direction than those in the non-plateau area so that precipitation intensity over the TP is usually small with short duration,and the vertical structure of the convective precipitation over the TP is obviously different from that in other regions.In addition,the influence of the TP on severe weather downstream is preliminarily understood from the mechanism.It is necessary to use model simulations and observation techniques to reveal the difference between cloud precipitation in the TP and non-plateau areas in order to understand the cloud microphysical parameters over the TP and the processes of the land boundary layer affecting cloud,precipitation and weather in the downstream regions. | Yunfei Fu Yaoming Ma Lei Zhong Yuanjian Yang Xueliang Guo Chenghai Wang Xiaofeng Xu Kun Yang Xiangde Xu Liping Liu Guangzhou Fan Yueqing Li Donghai Wang | 2020 | National Science Review2020，7，3： | 10 |
| 6 | Crop Classification Using MODIS NDVI Data Denoised by Wavelet: A Case Study in Hebei Plain, China显示文摘Time-series Moderate Resolution Imaging Spectroradiometer (MODIS) Normalized Difference Vegetation Index (NDVI) data have been widely used for large area crop mapping.However,the temporal crop signatures generated from these data were always accompanied by noise.In this study,a denoising method combined with Time series Inverse Distance Weighted (T-IDW) interpolating and Discrete Wavelet Transform (DWT) was presented.The detail crop planting patterns in Hebei Plain,China were classified using denoised time-series MODIS NDVI data at 250 m resolution.The denoising approach improved original MODIS NDVI product significantly in several periods,which may affect the accuracy of classification.The MODIS NDVI-derived crop map of the Hebei Plain achieved satisfactory classification accuracies through validation with field observation,statistical data and high resolution image.The field investigation accuracy was 85% at pixel level.At county-level,for winter wheat,there is relatively more significant correlation between the estimated area derived from satellite data with noise reduction and the statistical area (R2 = 0.814,p < 0.01).Moreover,the MODIS-derived crop patterns were highly consistent with the map generated by high resolution Landsat image in the same period.The overall accuracy achieved 91.01%.The results indicate that the method combining T-IDW and DWT can provide a gain in time-series MODIS NDVI data noise reduction and crop classification. | ZHANG Shengwei LEI Yuping WANG Liping LI Hongjun ZHAO Hongbin | 2011 | Chinese Geographical Science2011，21，3： | 9 |
| 7 | A critical review on the application of biochar in environmental pollution remediation:Role of persistent free radicals(PFRs)显示文摘Biochar as an emerging carbonaceous material has exhibited a great potential in environmental application for its perfect adsorption ability.However,there are abundant persistent free radicals(PFRs)in biochar,so the direct and indirect PFRs-mediated removal of organic and inorganic contaminants by biochar was widely reported.In order to comprehend deeply the formation of PFRs in biochar and their interactions with contaminants,this paper reviews the formation mechanisms of PFRs in biochar and the PFRs-mediated environmental applications of biochar in recent years.Finally,future challenges in this field are also proposed.This review provides a more comprehensive understanding on the emerging applications of biochar from the viewpoint of the catalytic role of PFRs. | Kun Luo Ya Pang Dongbo Wang Xue Li Liping Wang Min Lei Qi Huang Qi Yang | 2021 | Journal of Environmental Sciences2021，33，10： | 8 |
| 8 | Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery显示文摘癌症化疗被它的副作用和 multidrug 抵抗(MDR ) 限制了。因此,指向了能围绕 MDR 的药交货系统被需要。这里,我们向 chemosensitive 和在白血病和乳癌房间模型围绕了 MDR 的 MDR 癌症房间为指向的药交货汇报多功能的 DNA nanoflowers (NF ) 。NF 经由卷圆复制, NF 为特定的癌症房间识别,为 bioimaging 的 fluorophores,和 doxorubicin (纪录影片) 用 aptamers 在期间被合并产生的 DNA 和镁焦磷酸盐的潜在的一起沉淀是自我装配的为药交货的有约束力的 DNA。NF 尺寸是悦耳的(在直径击倒 nm 到 200 ) ,并且浓密地包装的药绑定主题和多孔的 intrastructures 赋予 NF 以一个高装载药的能力(71.4% , wt/wt ) 。尽管 Doxloaded NF (NF 纪录影片) 在生理的 pH 是稳定的,药版本在酸或基本的条件下面被便于。NF 交付纪录影片进目标 chemosensitive 和 MDR 癌症房间,阻止药流出并且提高在 MDR 房间的药保留。NF 纪录影片在两个目标 chemosensitive 房间和 MDR 房间,然而并非在 nontarget 房间导致有势力 cytotoxicity,并发地因此围绕 MDR 并且减少副作用。总的来说,这些 NF 为在指向的癌症治疗围绕 MDR 正在答应工具。 | Lei Mei Guizhi Zhu Liping Qiu Cuichen Wu Huapei Chen Hao Liang Sena Cansiz Yifan Lv Xiaobing Zhang Weihong Tan | 2015 | Nano Research2015，8，11： | 8 |
| 9 | Ablation of C/SiC-HfC composite prepared by precursor infiltration and pyrolysis in plasma wind tunnel显示文摘Carbon fiber reinforced silicon carbide-hafnium carbide(C/SiC-HfC)composite was prepared by precursor infiltration and pyrolysis process.Then,ablation behavior of C/SiC-HfC was evaluated in plasma wind tunnel.It was found that oxide layer formed during ablation significantly influenced the surface temperature.Formation of dense HfO2 SiO2 layer under low heat flux led to stable surface temperature.Silica(SiO2)on the surface was gradually consumed when heat flux increased,resulting in conversion of HfO2-SiO2 on the surface to HfO2.Converted HfO2 with high catalytic cofficient absorbed more energy,causing gradual increase in the surface temperature.Formed oxide layer was destroyed at high heat flux and high stagnation point pressure.After carbon fiber lost the protection of HfO2-SiO2 layer,it burned immediately,leading to surface temperature jump. | Liuyang DUAN Lei LUO Liping LIU Yiguang WANG | 2020 | Journal of Advanced Ceramics2020，9，3： | 7 |
| 10 | A comparison of atmospheric CO_2 concentration GOSAT-based observations and model simulations显示文摘Satellite observations of atmospheric CO2 are able to truly capture the variation of global and regional CO2 concentration.The model simulations based on atmospheric transport models can also assess variations of atmospheric CO2 concentrations in a continuous space and time,which is one of approaches for qualitatively and quantitatively studying the atmospheric transport mechanism and spatio-temporal variation of atmospheric CO2 in a global scale.Satellite observations and model simulations of CO2 offer us two different approaches to understand the atmospheric CO2.However,the difference between them has not been comprehensively compared and assessed for revealing the global and regional features of atmospheric CO2.In this study,we compared and assessed the spatio-temporal variation of atmospheric CO2 using two datasets of the column-averaged dry air mole fractions of atmospheric CO2(XCO2)in a year from June 2009 to May 2010,respectively from GOSAT retrievals(V02.xx)and from Goddard Earth Observing System-Chemistry(GEOS-Chem),which is a global 3-D chemistry transport model.In addition to the global comparison,we further compared and analyzed the difference of CO2 between the China land region and the United States(US)land region from two datasets,and demonstrated the reasonability and uncertainty of satellite observations and model simulations.The results show that the XCO2 retrieved from GOSAT is globally lower than GEOS-Chem model simulation by 2 ppm on average,which is close to the validation conclusion for GOSAT by ground measures.This difference of XCO2 between the two datasets,however,changes with the different regions.In China land region,the difference is large,from 0.6 to 5.6 ppm,whereas it is 1.6 to 3.7 ppm in the global land region and 1.4 to 2.7 ppm in the US land region.The goodness of fit test between the two datasets is 0.81 in the US land region,which is higher than that in the global land region(0.67)and China land region(0.68).The analysis results further indicate that the inconsistency of CO2concentration between satellite observations and model simulations in China is larger than that in the US and the globe.This inconsistency is related to the GOSAT retrieval error of CO2 caused by the interference among input parameters of satellite retrieval algorithm,and the uncertainty of driving parameters in GEOS-Chem model. | LEI LiPing GUAN XianHua ZENG ZhaoCheng ZHANG Bing RU Fei BU Ran | 2014 | Science China Earth Sciences2014，57，6： | 6 |
| 11 | Construction of biomimetic smart nanochannels for confined water显示文摘In this review,we focus on the conined water that exists in one-dimensional micro/nano composite structures,particularly inside biological nanochannels.Using these nanochannels as inspiration,we discuss a strategy for the design and construction of biomimetic smart nanochannels.Unique features of the inner surfaces of a nanochannel’s wall have similar properties to living systems.Importantly,the abiotic analogs have potential applications in,for example,sensing,energy conversion and iltering. | Liping Wen Lei Jiang | 2014 | National Science Review2014，1，1： | 6 |
| 12 | Diversity and distribution of bacterial community in the coastal sediments of Bohai Bay,China显示文摘In order to understand the diversity and distribution of the bacterial community in the coastal sediment of the Bohai Bay,China,high-throughput barcoded pyrosequencing of the 16 S r RNA gene was used.Metagenomic DNA was extracted from the sediment samples,and was sequenced using a 454 GS FLX Titanium system.At 97%similarity,the sequences were assigned to 22 884 operational taxonomic units(OTUs) which belonged to 41 phyla,84 classes,268 genera and 789 species.At the different taxonomic levels,both the dominants and their distribution varied significantly among the six coastal sediments.Proteobacteria was the first dominant phylum across all the six coastal sediments,representing 57.52%,60.66%,45.10%,60.92%,56.63% and 56.59%,respectively.Bacteroidetes was the second dominant phylum at Stas S1,S2 and S4,while Chloroflexi was the second dominant phylum at Stas S3,S5 and S6.At class level,γ-Proteobacteria was the first dominant class at Stas S1,S2,S4 and S6,while δ-Proteobacteria became the first dominant class at Stas S3 and S5.In addition,a large proportion of unclassified representatives have distributed at the different taxonomic levels.Canonical correspondence analysis(CCA) results indicated that the sediment texture,water depth(D),dissolved oxygen(DO),total nitrogen(TN) and nine EPA priority control polycyclic aromatic hydrocarbons(PAHs) including naphthalene,acenaphthylene,acenaphthene,fluorine,phenanthrene,fluoranthene,pyrene,benzo[a]anthracene and indeno[1,2,3-cd]pyrene were the important factors in regulating the bacterial community composition.Those results are very important to further understand the roles of bacterial community in the coastal biogeochemical cycles. | WANG Liping ZHENG Binghui LEI Kun | 2015 | Acta Oceanologica Sinica2015，34，10： | 6 |
| 13 | China's sizeable and uncertain carbon sink: a perspective from GOSAT显示文摘Despite the agreement that China’s terrestrial ecosystems can provide a carbon sink and offset carbon dioxide(CO2)emissions from fossil fuels,the magnitude and spatial distribution of the sink remain uncertain.Accurate quantification of the carbon sequestration capacity of China’s terrestrial ecosystems has profound scientific and policy implications.Here,we report on the magnitude and patterns of China’s terrestrial carbon sink using the global monthly CO2flux data product from the Greenhouse gases Observing SATellite(GOSAT),the world’s first satellite dedicated to global greenhouse gas observation.We use the first year’s data from GOSAT(June 2009–May2010)that are currently available to assess China’s biospheric carbon fluxes.Our results show that China’s terrestrial ecosystems provide a carbon sink of-0.21 Pg C a-1.The consumption of fossil fuels in China leads to carbon dioxide emissions of 1.90 Pg C a-1into the atmosphere,approximately 11.1%of which is offset by China’s terrestrial ecosystems.China’s terrestrial ecosystems play a significant role in offsetting fossil fuel emissions and slowing down the buildup of CO2in the atmosphere.Our analysis based on GOSAT data offers a new perspective on the magnitude and distribution of China’s carbon sink.Our results show that China’s terrestrial ecosystems provide a sizeable and uncertain carbon sink,and further research is needed to reduce the uncertainty in its magnitude and distribution. | Li Zhang Jingfeng Xiao Li Li Liping Lei Jing Li | 2014 | Chinese Science Bulletin2014，59，14： | 5 |
| 14 | Research on global change scientific satellites显示文摘Global change now poses a severe threat to the survival and development of mankind.Large-scale,real-time,highly accurate Earth observation from space has become a key technology used to observe global change.China is one of the most influential countries affecting and being affected by global change,yet it has no scientific satellite for global change research so far.Developing global change scientific satellites not only would meet an important demand of China,but also would be a valuable contribution to the world.By analyzing the mechanisms of space-based observation of variables sensitive to global change,this paper explores the concept of global change scientific satellites,and proposes a series of global change scientific satellites to establish a scientific observation system for global environmental change monitoring from space. | GUO HuaDong FU WenXue LI XinWu CHEN Pei LIU Guang LI Zhen WANG Cheng DONG Qing LEI LiPing BAI LinYan LIU QingJie | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 15 | Dynamic analysis of the Wenchuan Earthquake disaster and reconstruction with 3-year remote sensing data显示文摘Earth observation is an effective technique that plays an important role in earthquake damage reduction and reconstruction.This paper introduces the results of dynamic analysis on monitoring and assessing heavily impacted areas affected by the Wenchuan Earthquake using remote sensing data acquired in the past 3 years from 2008 to 2010.Immediately after the disaster on 12 May 2008,the Chinese Academy of Sciences launched a project entitled‘Wenchuan Earthquake Disasters Monitoring and Assessment Using Remote Sensing Technology.’More than 400 images from 17 satellites and 20.2TB airborne remote sensing data were acquired to facilitate quick monitoring and evaluation of severely damaged areas in 14 counties.Results of the image analyses were forwarded on a timely basis to assist with consultative service and decisionmaking support.In subsequent years,in order to monitor the process of environmental restoration and reconstruction,airborne optical remote sensing images covering most of the severely damaged areas were again acquired in May 2009 and April 2010.These images were analyzed and compared along with images from 2008.Results were useful in support of further work on environmental protection and reconstruction in earthquake-damaged areas.Three typical areas were selected for illustrative purposes including Tangjiashan Barrier Lake,Beichuan County,and counties of Yingxiu and the new Beichuan.These results well demonstrate the importance and effectiveness of the utility of earth observation for disaster mitigation and reconstruction. | Huadong Guo Liangyun Liu Liping Lei Yanhong Wu Liwei Li Bing Zhang Zhengli Zuo Zhen Li | 2010 | International Journal of Digital Earth2010，3，4： | 5 |
| 16 | Preparation of YSZ solid electrolyte by slip casting and its properties显示文摘Fully stabilized YSZ solid electrolyte was prepared by slip casting. The density was measured according to the Archimedes principle and the linear shrinkage was calculated from measuring the sizes of samples before and after sintering. XRD analysis was conducted to verify the phase structure of both the starting YSZ powder and the prepared YSZ electrolyte. The microstructure of fracture surface and the electrical properties of the samples sintered at different temperatures were investigated via SEM and a complex impedance method, respectively. By comparison of the properties and features among the samples, a slip casting method was established to be a simple way to manufacture high-quality YSZ electrolyte at the sintering temperature of 1550°C for 3 h, which provides a new approach for YSZ electrolyte with complex shapes and mass production. | DOU Jinga LI Heping XU Liping ZHANG Lei WANG Guangwei | 2009 | Rare Metals2009，28，4： | 5 |
| 17 | Chemical probing reveals insights into the signaling mechanism of inflammasome activation显示文摘Caspase-1-mediated IL-1 尾生产被二条小径通常控制。像使用费的受体(TLR ) 认出导出病原体的产品并且导致 NF-魏 B 依赖者 pro-IL-1 尾抄写;像点头的受体(NLR ) 装配察觉到细菌的产品 / 危险信号的 caspase-1-activating inflammasome 建筑群。通过一幅指向的化学屏幕,我们识别 bromoxone,一个海洋的自然产品,一特定并且 caspase-1 小径的有势力禁止者。Bromoxone 在包括加 ATP/nigericin, cytosolic DNA, flagellin 和杆菌 anthracis 的 TLR ligands 的多样的煽动性的刺激上是有效的致命的毒素。Bromoxone 高效地也压制激活由细菌的感染的几种类型触发了的 caspase-1。在上游的 Bromoxone 行为或在以一种抄写无关的方式的 inflammasome 的水平。Bromoxone 也由在 TLR-NF-魏 B 小径指向 IKK 在上游的部件禁止 pro-IL-1 尾表示。bromoxone 的唯一的双活动被明确地堵住 Nalp3 inflammasome 激活的已知的 TAK1 禁止者分享。提示了从机械学并且 bromoxone 的药理学性质,我们进一步发现几个已知的 NF-魏 B 禁止者 IKK 在上游的那行为,然而并非下游地指向 IKK 或 IKK 的那些,是不同调停 NLRs 的 caspase-1 激活的有势力 blockers。我们的学习揭开可能的 non-transcriptional 在 NLR (Nalp3 ) 之间的分子的连接调停了 inflammasome 小径和 TLR-NF-魏 B 发信号,并且建议潜在的策略开发新反煽动性的药。 | Yi-Nan Gong Xiaoming Wang Jiayi Wang Zhenxiao Yang Shan Li Jieling Yang Liping Liu Xiaoguang Lei Feng Shao | 2010 | Cell Research2010，20，12： | 5 |
| 18 | Spatial distribution and inducement of collapsed buildings in Yushu earthquake based on remote sensing analysis显示文摘At 7:49 a.m. on April 14th, 2010, an earthquake of 7.1 on the Richter scale occurred in Yushu County, Yushu Tibetan Autonomous Prefecture in Qinghai Province. There was great loss of property and life. | HuaDong Guo Bing Zhang LiPing Lei Li Zhang Yu Chen | 2010 | Science China Earth Sciences2010，53，6： | 5 |
| 19 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 20 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
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