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| 1 | Future Physics Programme of BESⅢ显示文摘There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESⅢ and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESⅢ, as well as the threshold measurements of charm mesons and charm baryons. We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESⅢ during the remaining operation period of BEPCⅡ. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCⅡ to higher luminosity. | M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht M.Alekseev A.Amoroso F.F.An Q.An Y.Bai O.Bakina R.Baldini Ferroli Y.Ban K.Begzsuren J.V.Bennett N.Berger M.Bertani D.Bettoni F.Bianchi J Biernat J.Bloms I.Boyko R.A.Briere L.Calibbi H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.Chai J.F.Chang W.L.Chang J.Charles G.Chelkov Chen G.Chen H.S.Chen J.C.Chen M.L.Chen S.J.Chen Y.B.Chen H.Y.Cheng W.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai J.P.Dai X.C.Dai A.Dbeyssi D.Dedovich Z.Y.Deng A.Denig Denysenko M.Destefanis S.Descotes-Genon F.De Mori Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong Z.L.Dou S.X.Du S.I.Eidelman J.Z.Fan J.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng M.Fritsch C.D.Fu Y.Fu Q.Gao X.L.Gao Y.Gao Y.Gao Y.G.Gao Z.Gao B.Garillon I.Garzia E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu Y.T.Gu A.Q.Guo F.K.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov S.Han X.Q.Hao F.A.Harris K.L.He F.H.Heinsius T.Held Y.K.Heng Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang J.S.Huang X.T.Huang X.Z.Huang Z.L.Huang N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.L.Jiang X.S.Jiang X.Y.Jiang J.B.Jiao Z.Jiao D.P.Jin S.Jin Y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.Kurth M.G.Kurth W.Kuhn J.S.Lange P.Larin L.Lavezzi H.Leithoff T.Lenz C.Li Cheng Li D.M.Li F.Li F.Y.Li G.Li H.B.Li H.J.Li J.C.Li J.W.Li Ke Li L.K.Li Lei Li P.L.Li P.R.Li Q.Y.Li W.D.Li W.G.Li X.H.Li X.L.Li X.N.Li X.Q.Li Z.B.Li H.Liang H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.Z.Liao J.Libby C.X.Lin D.X.Lin Y.J.Lin B.Liu B.J.Liu C.X.Liu D.Liu D.Y.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.Y.Liu K.Y.Liu Ke Liu Q.Liu S.B.Liu T.Liu X.Liu X.Y.Liu Y.B.Liu Z.A.Liu Zhiqing Liu Y.F.Long X.C.Lou H.J.Lu J.D.Lu J.G.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X.Ma X.Y.Ma Y.M.Ma F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni Y.J.Mao Z.P.Mao S.Marcello Z.X.Meng J.G.Messchendorp G.Mezzadri J.Min T.J.Min R.E.Mitchell X.H.Mo Y.J.Mo C.Morales Morales N.Yu.Muchnoi H.Muramatsu A.Mustafa S.Nakhoul Y.Nefedov F.Nerling I.B.Nikolaev Z.Ning S.Nisar S.L.Niu S.L.Olsen Q.Ouyang S.Pacetti Y.Pan M.Papenbrock P.Patteri M.Pelizaeus H.P.Peng K.Peters A.A.Petrov J.Pettersson J.L.Ping R.G.Ping A.Pitka R.Poling V.Prasad M.Qi T.Y.Qi S.Qian C.F.Qiao N.Qin X.P.Qin X.S.Qin Z.H.Qin J.F.Qiu S.Q.Qu K.H.Rashid C.F.Redmer M.Richter M.Ripka A.Rivetti V.Rodin M.Rolo G.Rong J.L.Rosner Ch.Rosner M.Rump A.Sarantsev M.Savrie K.Schoenning W.Shan X.Y.Shan M.Shao C.P.Shen P.X.Shen X.Y.Shen H.Y.Sheng X.Shi X.D Shi J.J.Song Q.Q.Song X.Y.Song S.Sosio C.Sowa S.Spataro F.F.Sui G.X.Sun J.F.Sun L.Sun S.S.Sun X.H.Sun Y.J.Sun Y.K Sun Y.Z.Sun Z.J.Sun Z.T.Sun Y.T Tan C.J.Tang G.Y.Tang X.Tang V.Thoren B.Tsednee I.Uman B.Wang B.L.Wang C.W.Wang D.Y.Wang H.H.Wang K.Wang L.L.Wang L.S.Wang M.Wang M.Z.Wang Wang Meng P.L.Wang R.M.Wang W.P.Wang X.Wang X.F.Wang X.L.Wang Y.Wang Y.F.Wang Z.Wang Z.G.Wang Z.Y.Wang Zongyuan Wang T.Weber D.H.Wei P.Weidenkaff H.W.Wen S.P.Wen U.Wiedner G.Wilkinson M.Wolke L.H.Wu L.J.Wu Z.Wu L.Xia Y.Xia S.Y.Xiao Y.J.Xiao Z.J.Xiao Y.G.Xie Y.H.Xie T.Y.Xing X.A.Xiong Q.L.Xiu G.F.Xu L.Xu Q.J.Xu W.Xu X.P.Xu F.Yan L.Yan W.B.Yan W.C.Yan Y.H.Yan H.J.Yang H.X.Yang L.Yang R.X.Yang S.L.Yang Y.H.Yang Y.X.Yang Yifan Yang Z.Q.Yang M.Ye M.H.Ye J.H.Yin Z.Y.You B.X.Yu C.X.Yu J.S.Yu C.Z.Yuan X.Q.Yuan Y.Yuan A.Yuncu A.A.Zafar Y.Zeng B.X.Zhang B.Y.Zhang C.C.Zhang D.H.Zhang H.H.Zhang H.Y.Zhang J.Zhang J.L.Zhang J.Q.Zhang J.W.Zhang J.Y.Zhang J.Z.Zhang K.Zhang L.Zhang S.F.Zhang T.J.Zhang X.Y.Zhang Y.Zhang Y.H.Zhang Y.T.Zhang Yang Zhang Yao Zhang Yi Zhang Yu Zhang Z.H.Zhang Z.P.Zhang Z.Q.Zhang Z.Y.Zhang G.Zhao J.W.Zhao J.Y.Zhao J.Z.Zhao Lei Zhao Ling Zhao M.G.Zhao Q.Zhao S.J.Zhao T.C.Zhao Y.B.Zhao Z.G.Zhao A.Zhemchugov B.Zheng J.P.Zheng Y.Zheng Y.H.Zheng B.Zhong L.Zhou L.P.Zhou Q.Zhou X.Zhou X.K.Zhou Xingyu Zhou Xiaoyu Zhou Xu Zhou A.N.Zhu J.Zhu J.Zhu K.Zhu K.J.Zhu S.H.Zhu W.J.Zhu X.L.Zhu Y.C.Zhu Y.S.Zhu Z.A.Zhu J.Zhuang B.S.Zou J.H.Zou 无 | 2020 | Chinese Physics C2020，44，4： | 517 |
| 2 | 急性下呼吸道感染儿童的维生素D摄入显示文摘目的明确维生素D(Vit D)摄入是否与儿童急性下呼吸道感染(ALRI)相关。方法比较因毛细支气管炎或肺炎入院的5岁以下儿童和非配对、无呼吸道感染的同龄对照组儿童之间Vit D摄入的差别。197例儿童的看护人完成了问卷调查,内容包括人口统计变量、ALRI危险因素和饮食。评估ALRI与Vit D摄入及其他危险因素的相关性。结果 ALRI组儿童的平均Vit D摄入为每日48 IU/kg,对照组为每日60 IU/kg。当控制年龄、民族、社会经济地位、北部地区居住、母乳喂养、免疫接种和接触吸烟等因素时,Vit D每日摄入<80 IU/kg的儿童患ALRI的可能性比每日摄入≥80 IU/kg的儿童高4倍(OR=4.9;95%CI:1.5~16.4)。结论为了避免罹患ALRI等疾病,5岁以下儿童可能需要摄入比现在推荐量更高的Vit D剂量。因毛细支气管炎和肺炎是年幼儿童住院的最常见原因,增加Vit D的补充可能有重要的公共卫生保健意义。 | Karen S Leis J Dayre McNally Matthew R Montgomery Koravangattu Sankaran Chandima Karunanayake Alan M Rosenberg 马丽亚(译) | 2012 | 中国当代儿科杂志2012，14，1： | 25 |
| 3 | Tonoplast calcium sensors CBL2 and CBL3 control plant growth and ion homeostasis through regulating V-ATPase activity in Arabidopsis显示文摘对发展、环境的暗示的植物回答被钙经常调停(被多样的钙传感器播送的 Ca 2+) 信号。calcineurin 象 B 一样(CBL ) 蛋白质家庭代表通过和一组交往 CBL 蛋白质 kinases 的特定的相互作用译码钙信号的钙传感器。我们报导 Arabidopsis CBL2 和 CBL3 的功能的分析,对通过 N 终端指向 tonoplast 的 vacuolar 膜局部性的二个密切相关的 CBL 成员定序。当 cbl2 或 cbl3 单身者异种没从野类型显示出任何 phenotypic 差别时, cbl2 cbl3 两倍异种与叶尖端坏死,不发达的根,更短的 siliques 和更少种子被阻碍。这些缺点在 vha-a2 vha-a3 使人想起那些在 vacuolar H +-ATPase (V-ATPase ) 缺乏的两倍异种。确实, V-ATPase 活动在 cbl2 cbl3 被减少两倍变异的、连接 tonoplast CBL 类型钙传感器到 V-ATPase 的规定。而且, cbl2 cbl3 两倍异种在离子的忍耐和微量元素累积被损害,与在被显示了在离子区分工作的 V-ATPase 活动的缺点一致。我们的结果建议钙传感器 CBL2 和 CBL3 用作在钙发信号和 V-ATPase 之间的分子的连接,细胞内部的离子动态平衡的一个中央管理者。 | Ren-Jie Tang Hua Liu Yang Yang Lei Yang Xiao-Shu Gao Veder J Garcia Sheng Luan Hong-Xia Zhang | 2012 | Cell Research2012，22，12： | 26 |
| 4 | 基于近红外光谱的人参与西洋参的快速鉴别研究显示文摘基于近红外光谱分析技术结合模式判别方法建立了一种人参和西洋参鉴别的新方法。收集根状、根须和粉末状的样品共90份,在有聚乙烯包装袋的情况下直接采集近红外光谱,去除原始光谱中包装袋的显著吸收后进行了MSC与一阶导数处理,然后采用移动窗口偏最小二乘法选择了建模光谱区间,分别建立了PLS-DA,PCA-DA和SVM判别模型,并对3种模型作了对比分析,结果表明SVM判别效果最优,其对预测集的正确判别率为100%。该方法准确、便捷,可实际应用于企业原料药材的质量控制,实现对原料药材的快速筛查。 | 黄亚伟 王加华 李晓云 Jacqueline J Shan Lei Ling 韩东海 | 2010 | 光谱学与光谱分析2010，30，11： | 19 |
| 5 | 基于主根横断面近红外光谱的西洋参和人参鉴别研究显示文摘为了快速准确进行西洋参和人参的品种鉴别,从主根横断面入手,采集其横断面的近红外光谱,分别从物理结构因素和化学因素方面对光谱进行了分析,选定特定波段进行物理因素主导建模、化学因素主导建模、理化因素综合建模,并对三种建模结果进行比较分析,发现三种模型判别率都在96%以上,都能很好的满足批量原材料快速检测的需求。物理因素模型运算简单,但判别率相对低。化学因素判别率较高,但运算量大。理化因素综合模型判别率最高为100%,无需预处理,运算量小,效果最理想,该结果说明近红外定性判别中物理结构因素有时也发挥重要作用。横断面鉴别法准确、便捷,可实际应用于企业原料药材的质量控制,实现对原料药材的快速筛查。 | 王灵灵 黄亚伟 戚淑叶 Jacqueline J SHAN Lei LING 韩东海 | 2012 | 光谱学与光谱分析2012，32，4： | 17 |
| 6 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 7 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 8 | An implementation assessment of China's Environmental Information Disclosure Decree显示文摘China's 2007 Open Government Information Regulations is widely considered as a milestone in the country's information policy history and is praised as a'sunshine program'.The Environmental Information Disclosure Decree was the first to operationalize these general regulations into a sectoral information disclosure system on environment.This study assessed the implementation of the environmental information disclosure system about six months after the Decree took eect on May 1,2008.Through reviewing the websites of all 31 provincial Environmental Protection Bureaus and the Ministry of Environmental Protection,conducting an experiment with actual information disclosure request,and through interviews with all provincial Environmental Protection Bureaus,this article concluded that the implementation of the environmental information disclosure system still falls short.Future improvements should focus on further publicity of the regulations and decree to enhance public participation,the establishment of an independent evaluation and supervision system for information disclosure,the exchange of experiences and best practices among provincial Environmental Protection Bureaus,and on strengthening the legal status of environmental information disclosure. | Lei Zhang Arthur E J Mol Guizhen He Yonglong Lu | 2010 | Journal of Environmental Sciences2010，22，10： | 9 |
| 9 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 10 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 11 | Boosting third-harmonic generation by a mirror-enhanced anapole resonator显示文摘We demonstrate that a dielectric anapole resonator on a metallic mirror can enhance the third harmonic emission by two orders of magnitude compared to a typical anapole resonator on an insulator substrate.By employing a gold mirror under a silicon nanodisk,we introduce a novel characteristic of the anapole mode through the spatial overlap of resonantly excited Cartesian electric and toroidal dipole modes.This is a remarkable improvement on the early demonstrations of the anapole mode in which the electric and toroidal modes interfere off-resonantly.Therefore,our system produces a significant near-field enhancement,facilitating the nonlinear process.Moreover,the mirror surface boosts the nonlinear emission via the free-charge oscillations within the interface,equivalent to producing a mirror image of the nonlinear source and the pump beneath the interface.We found that these improvements result in an extremely high experimentally obtained efficiency of 0.01%. | Lei Xu Mohsen Rahmani Khosro Zangeneh Kamali Aristeidis Lamprianidis Lavinia Ghirardini Jürgen Sautter Rocio Camacho-Morales Haitao Chen Matthew Parry Isabelle Staude Guoquan Zhang Dragomir Neshev Andrey E.Miroshnichenko | 2018 | Light(Science & Applications)2018，7，1： | 5 |
| 12 | Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China显示文摘Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been recognised.Methods: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli complex.Results: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler L.montis and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed morphologically.Conclusions: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou provinces.The taxonomic status of the other allopatric populations is less clear. However, as they differ to a degree comparable with that of the sympatric L. mandelli and the new species, we elevate L. idonea to species status, and retain L. seebohmi and L. montis as separate species, the latter with timorensis as a subspecies. Further research should focus on different populations of L. montis and the Mt Victoria population of L. mandelli. | Per Alstrom Canwei Xia Pamela C Rasmussen Urban Olsson Bo Dai Jian Zhao Paul J Leader Geoff J Carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei | 2015 | Chinese Birds2015，，2： | 4 |
| 13 | Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks显示文摘Antibacterial dimethylaminododecyl methacrylate(DMADDM) was recently synthesized. The objectives of this study were to:(1)investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans impregnated into dentin blocks for the first time, and(2) compare the antibacterial efficacy of DMADDM with a previous quaternary ammonium dimethacrylate(QADM).Scotchbond Multi-Purpose(SBMP) bonding agent was used. DMADDM and QADM were mixed into SBMP primer. Six primers were tested: SBMP control primer P, P+2.5% DMADDM, P+5% DMADDM, P+7.5% DMADDM, P+10% DMADDM, and P+10% QADM.S. mutans were impregnated into human dentin blocks, and each primer was applied to dentin to test its ability to kill bacteria in dentinal tubules. Bacteria in dentin were collected via a sonication method, and the colony-forming units(CFU) and inhibition zones were measured. The bacterial inhibition zone of P+10% DMADDM was 10 times that of control primer(Po0.05). CFU in dentin with P+10% DMADDM was reduced by three orders of magnitude, compared with control. DMADDM had a much stronger antibacterial effect than QADM, and antibacterial efficacy increased with increasing DMADDM concentration. Dentin shear bond strengths were similar among all groups(P40.1). In conclusion, antibacterial DMADDM-containing primer was validated to kill bacteria inside dentin blocks, possessing a much stronger antibacterial potency than the previous QADM. DMADDM-containing bonding agent was effective in eradicating bacteria in dentin, and its efficacy was directly proportional to DMADDM mass fraction. Therefore, DMADDM may be promising for use in bonding agents as well as in other restorative and preventive materials to inhibit bacteria. | Chen Chen Lei Cheng Michael D Weir Nancy J Lin Sheng Lin-Gibson Xue-Dong Zhou Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，4： | 4 |
| 14 | Structural insights into Ca^2+-activated long-range allosteric channel gating of RyR1显示文摘Ryanodine 受体(RyRs ) 是有分子的质量的巨大的离子隧道的一个班超过 2.2 大 -- 道尔顿。这些隧道调停钙在许多房间发信号。因为超过 80% RyR 蛋白质被合拢进细胞质的集会,留下的残余形成 transmembrane 领域, RyR 隧道的激活和规定发生通过,这被假设了一迄今为止 uncharacterized 远程的 allosteric 机制。这里,我们报导 Ca 2+-activated 的描述由 cryo 电子的开状态的 RyR1 结构显微镜学。结构有 4.9 Å 的一个全面决定;并且 4.2 Å 的一个决定;为核心区域。与以前坚定的 apo/closed-state 结构比较,我们在 Ca 2+ 激活之上观察了隧道的远程的 allosteric gating。深入的结构的分析阐明了新奇隧道门机制和 RyR1 的新奇离子选择机制。我们的工作不仅提供结构的卓见进隧道 gating 和 RyRs 的规定的分子的机制,而且为 six-transmembrane-helix 阳离子隧道家庭为隧道门和离子选择机制使结构的基础清楚些。 | Risheng Wei Xue Wang Yan Zhang Saptarshi Mukherjee Lei Zhang Qiang Chen Xinrui Huang Shan Jing Congcong Liu Shuang Li Guangyu Wang Yaofang Xu Sujie Zhu Alan J Williams Fei Sun Chang-Cheng Yin | 2016 | Cell Research2016，26，9： | 3 |
| 15 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 16 | MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development显示文摘轴突开发从细胞内部的供应要求膜增加,它被显示了被 Rab10 积极的 plasmalemmal 先锋泡(PPV ) 调停。然而,位于 PPV 的膜 trafficking 过程下面的分子的机制仍然保持不清楚。这里,我们显示出那 myristoylated 充满丙氨酸的 C-kinase 底层(MARCKS ) 调停膜指向 Rab10 积极的 PPV,和这条规定为轴突开发是批评的。我们发现 Rab10 的锁 GTP 的活跃形式绑在联系膜的 MARCKS,其亲密关系取决于 MARCKS 受动器领域的 phosphorylation 地位。MARCKS 的或基因的 silencing 或它和 Rab10 的相互作用的混乱禁止了外皮的神经原的轴突生长,停靠损害并且有血浆膜的 Rab10 泡的熔化,并且因而引起了对细胞外的轴突生长因素应答的 axonal 受体的膜插入的损失。因此,这研究在调停识别了 MARCKS 的新奇功能在轴突开发期间 PPV 指向的膜。 | Xiao-Hui Xu Cai-Yun Deng Yang Liu Miao He Jian Peng Tong Wang Lei Yuan Zhi-Sheng Zheng Perry J Blackshear Zhen-Ge Luo | 2014 | Cell Research2014，24，5： | 2 |
| 17 | 激素对乳腺上皮细胞亮氨酸代谢的调控作用显示文摘在泌乳期,乳腺上皮细胞能主动摄取和分解支链氨基酸(BCAA)用于合成谷氨酸、谷氨酰胺和天冬氨酸。有证据表明,泌乳的发动与皮质醇、催乳素、胰高血糖素循环水平的升高及胰岛素、生长激素水平的降低有关。本试验旨在研究上述激素的浓度对奶牛乳腺上皮细胞亮氨酸(一种具有代表性的支链氨基酸)代谢的影响。细胞在克雷布斯缓冲液中37℃培养2h,缓冲液含有3mmol/LD-葡萄糖、O.5mmol/LL一亮氨酸(或L[1—14C]亮氨酸、L-Eu-14C]亮氨酸)和0-50IU/mL胰岛素(或0~20ng/mL生长激素、0-200ng/mL催乳素、0-150nmol/L皮质醇、0~300Pg/mL胰高血糖素)。增加细胞外胰岛素浓度对亮氨酸的转氨基作用和氧化脱羧作用无影响,但可降低亮氨酸2-6号碳原子的氧化率。生长激素水平的升高可抑制亮氨酸的分解代谢、酮异己酸(KIC)的产生及谷氨酸、谷氨酰胺的总合成量,且具有剂量依赖性。相反,皮质醇和胰高血糖素的升高能增加亮氨酸的转氨基作用和氧化脱羧作用,促进KIC的产生和亮氨酸2-6号碳原子的氧化,提高谷氨酸和谷氨酰胺的总合成量。在乳腺上皮细胞中,催乳素对亮氨酸的分解代谢没有影响。亮氨酸的降解与大量支链氨基酸转氨酶活性和支链酮酸脱氢酶的磷酸化水平呈正相关。在泌乳过程中,胰岛素和生长激素水平的降低,皮质醇和胰高血糖素水平的升高,均可促进支链氨基酸的分解,进而合成谷氨酸和谷氨酰胺。这些激素的相互协调作用可能促进泌乳期哺乳动物的产奶。 | Lei J 田雯 | 2014 | 中国畜牧兽医2014，41，2： | 2 |
| 18 | A review on MBE-grown HgCdSe infrared materials on GaSb(211)B substrates显示文摘We review our recent efforts on developing HgCdSe infrared materials on Ga Sb substrates via molecular beam epitaxy(MBE) for fabricating next generation infrared detectors with features of lower production cost and larger focal plane array format size. In order to achieve high-quality HgCdSe epilayers, ZnTe buffer layers are grown before growing HgCdSe, and the study of misfit strain in ZnTe buffer layers shows that the thickness of ZnTe buffer layer needs to be below 300 nm in order to minimize the generation of misfit dislocations. The cut-off wavelength/alloy composition of HgCdSe materials can be varied in a wide range by varying the ratio of Se/Cd beam equivalent pressure during the HgCdSe growth.Growth temperature presents significant impact on the material quality of HgCdSe, and lower growth temperature leads to higher material quality for HgCdSe. Typically, long-wave infrared HgCdSe(x = 0.18, cut-off wavelength of 10.4 μm at 80 K) presents an electron mobility as high as 1.3×10~5cm^2·V^(-1)·s^(-1), a background electron concentration as low as 1.6×10^(16)cm^(-3), and a minority carrier lifetime as long as 2.2 μs. These values of electron mobility and minority carrier lifetime represent a significant improvement on previous studies of MBE-grown HgCdSe reported in the open literatures,and are comparable to those of counterpart HgCdTe materials grown on lattice-matched CdZnTe substrates. These results indicate that HgCdSe grown at the University of Western Australia, especially long-wave infrared can meet the basic material quality requirements for making high performance infrared detectors although further effort is required to control the background electron concentration to below 10^(15)cm^(-3). More importantly, even higher quality HgCdSe materials on GaSb are expected by further optimizing the growth conditions, using higher purity Se source material, and implementing postgrowth thermal annealing and defect/impurity gettering/filtering. Our results demonstrate the great potential of HgCdSe infrared materials grown on GaSb substrates for fabricating next generation infrared detectors with features of lower cost and larger array format size. | Z K Zhang W W Pan J L Liu W Lei | 2019 | Chinese Physics B2019，28，1： | 2 |
| 19 | Central role of myeloid MCPIP1 in protecting against LPSinduced inflammation and lung injury显示文摘Although systemic inflammatory responses attributable to infection may lead to significant lung injury,the precise molecular mechanisms leading to lung damage are poorly understood and therapeutic options remain limited.Here,we show that myeloid monocyte chemotactic protein-inducible protein 1(MCPIP1)plays a central role in protecting against LPS-induced inflammation and lung injury.Myeloid-specific MCPIP1 knockout mice developed spontaneous inflammatory syndromes,but at a late age compared to global MCPIP1 knockout mice.Moreover,mice with a myeloid-specific deletion of MCPIP1 were extremely sensitive to LPS-induced lung injury due to overproduction of proinflammatory cytokines and chemokines.We identified C/EBPβand C/EBPδ,two critical transcriptional factors that drive cytokine production and lung injury,as targets of MCPIP1 RNase.LPS administration caused MCPIP1 protein degradation in the lungs.Pharmacological inhibition of MALT1,a paracaspase that cleaves MCPIP1,by MI-2 selectively increased the MCPIP1 protein levels in macrophages and in the lungs.Meanwhile,administration of MI-2 protected mice from LPS-induced inflammation,lung injury and death.Collectively,these results indicate that myeloid MCPIP1 is central in controlling LPS-induced inflammation and lung injury.Pharmacological inhibition of MALT1 protease activity may be a good strategy to treat inflammatory diseases by enhancing MCPIP1 expression in myeloid cells. | Yong Li Xuan Huang Shengping Huang Hui He Tianhua Lei Fatma Saaoud Xiao-Qiang Yu Ari Melnick Anil Kumar Christopher J Papasian Daping Fan Mingui Fu | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 20 | 溶液环境中工作的扫描近场光学/荧光光谱显微术显示文摘我们采用双压电陶瓷片发展了一种切变力非光学检测探针-样品间距控制方法。基于这种方法,研制成能与倒置光学显微镜联合使用的扫描近场光学 荧光光谱显微系统,实现了在溶液环境中探针-样品间距的可靠控制和成像,获得了人体乳腺癌细胞内的近场荧光光谱。本文简要介绍该系统的工作原理以及利用该系统得到的实验结果。 | 商广义 朱传凤 王琛 万立骏 白春礼 Lei F H M Troyon H Morjani J F Angiboust M Manfait | 2003 | 电子显微学报2003，22，5： | 2 |
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