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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Teaching and Assessing Proce- dural Skills Using Simulation: Metres and Methodology显示文摘 | Lammers RL Davenport M Korley F | 2008 | Acad Emerg Med2008，1，： | 1 |
| 3 | Dynamic simulation of dispersed gas-liquid two-phase flow using a discrete bubble model显示文摘 | Delnoij E Lammers F A Kuipers J A M | 1997 | Chem Eng Sci1997，52，9： | 1 |
| 4 | Modeling of complex premixed burner systems by using flamelet-generated manifolds 显示文摘 | VAN OIJEN J A LAMMERS F A DE GOEY I P H | 2001 | Combustion and Flame2001，127，： | 1 |
| 5 | Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress 显示文摘 | Lammers T Kiessling F Hennink WE | 2012 | J Control Release2012，161，： | 1 |
| 6 | Upregulation of skeletal muscle inflammatory genes links inflammation with insulin resistance in women with the metabolic syndrome显示文摘 | Poelkens F Lammers G Pardoel EM | 2013 | Exp Physiol2013，98，10： | 1 |
| 7 | Common dile duct obstruction due to malignancy:treatment with plastic versus metal stents显示文摘 | Lammer J Hausegger KA Fluckiger F | 1996 | Radiology1996，201，1： | 1 |
| 8 | Dieulafoy's disease:endoscopic treatment and follow up显示文摘 | Baettig B Haecki W Lammer F | | 0，，： | 1 |
| 9 | Conjuncti- va-associated lymphoid tissue in avian mucosal immunity显示文摘 | Van Ginkel F W Gulley S L Lammers A | 2012 | Devel Comp Immunol2012，36，2： | 1 |
| 10 | Vulnerability of rabbit atrium to reentry by hypoxia:role of inhomogeneity in conduction and wavelength显示文摘 | Lammers WJ Kirchhof C Bonke F | 1992 | Circulation1992，262，： | 1 |
| 11 | Dieulafoys disease:endoscopic treatment and follow up显示文摘 | Baettig B Haecki w Lammer F | 1993 | Cut1993，34，： | 1 |
| 12 | Investigation of calcium crystals in OA knees显示文摘 | Fuerst M Lammers L Schafer F | 2010 | Rheumatol Int2010，30，5： | 1 |
| 13 | Dieulafoy's disease:treatmen and follow-up显示文摘 | Baettig B Haecki W Lammer F | 1993 | Gut1993，34，： | 1 |
| 14 | Dieulafoy ' s disease: endoscopic treatment and follow up显示文摘 | Baetting B Haecki W Lammer F | 1993 | Gut1993，34，： | 1 |
| 15 | Dynamic simulation of dispersed gas-liquid two-phase flow using a discrete bubble model 显示文摘 | DELNOIJ E LAMMERS F A KUIPERS J A M | 1997 | Chemical Engineering Science1997，52，9： | 1 |
| 16 | Dieulafoy ,s disease:endoscopic treatment and follow up显示文摘 | Baetting B Haecki W Lammer F | 1993 | Gut1993，34，3： | 1 |
| 17 | Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress显示文摘 | LAMMERS T KIESSLING F HENNINK W E | 2012 | Journal of Controlled Release2012，161，2： | 1 |
| 18 | Dynamic simulation of dispersed gas-liquid two-phaseflow using a discrete bubble model 显示文摘 | DELNOU E LAMMERS F A KUIPERS J A M | 1997 | ChemicalEngineering Science1997，52，9： | 1 |
| 19 | Dieulafoy's disease: endoscopic treatment andfollow up显示文摘 | BAETTIG B HAECKI W LAMMER F | 1993 | Gut1993，34，10： | 1 |
| 20 | Dieulafoy's disease:endoscopic treatment and follow up显示文摘 | 9,Bacttig B Haeeki W Lammer F | 1993 | Gut1993，34，10： | 1 |
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