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| 1 | Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats显示文摘Objective:To evaluate the hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatic damage in rats.Methods:The plant material was shade dried, powdered and extracted with ethanol.Liv 52 and silymarin were used as standard drugs and 2%gum acacia as a control(vehicle).Alteration in the levels of biochemical markers of hepatic damage like AST,ALT,ALP and lipid peroxides were tested,and phytochemical tests were also performed.Results:Paracetamol(2 g/kg) increased the serum levels of alanine aminotransfer (ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP) and the lipid peroxides. Treatment of Liv 52,silymarin and ethanolic extract of Terminalia paniculata(200 mg/kg) altered levels of biochemical marker and showed significant hepatoprotective activity.Ethanolic extract revealed the presence of phenolic compound and flavanoids.Our findings suggested that ethanolic bark extract of Terminalia paniculata possessed hepatoprotective activity in a dose dependent manner.Conclusions:Terminalia paniculata possesses hepatoprotective activity.It could be an effective and promising preventive agent against PCT induced hepatotoxicity. | Eesha BR Mohanbabu Amberkar V Meena Kumari K Sarath babu Vijay M Lalit M Rajput R | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 5 |
| 2 | QSAR,docking studies and pharmacophore identification of phenylmethyl phenoxy propyl amino propanoic acid derivatives as leukotriene A_4 hydrolase inhibitors显示文摘The enzyme leukotriene A4 (LTA4) plays an important role as precursor of slow reactive substances as LTC4, LTD4, and LTE4. It is an attractive target for molecular modeling and QSAR study. Our effort is mainly focused on exploring the SAR for inhibitors of the LTA4 hydrolase through docking study, pharmacophore modeling and molecular descriptor study. The binding of these small molecules on LTA4 hydrolase enzyme was described by the models developed on 2D molecular descriptors, with good predictive power (39 compounds, 6 descriptors, r2 0.98, SEE 0.167, F-value 268.53, q2 0.90, r2adj 0.97, P-value < 0.0001, SD of residuals 0.15). Docking studies were employed to presume the probable binding conformation of these analogues and exploring the SAR for the compounds. The novel pharmacophore represents the ligand features that are involved in interactions with the target protein, as well as the space around the ligand occupied by the protein. The efforts are aimed to discover the SAR for the inhibitors of LTA4 hydrolase through techniques of QSAR, docking and pharmacophore. | SONAWANE Lalit V BARI Sanjaykumar B | 2010 | 药学学报2010，45，5： | 1 |
| 3 | Surgical dislocation of the hip for reduction of acetabular fracture and evaluation of chondral damage显示文摘 | Maini Lalit Batra Sahil Arora Sumit Singh Shailendra Kumar Santosh Gautam V K | 2014 | Journal of Orthopaedic Surgery2014，22，1： | 1 |
| 4 | Effect of various pretreatment methods on anaerobic mixed microflora to enhance biohydrogen production utilizing dairy wastewater as substrate显示文摘 | S Venkata Mohan V Lalit Babu P N Sarma | 2008 | Bioresource Technology2008，99，1： | 1 |
| 5 | Influence of recirculation on the performance of anaerobic sequencing batch biofilm reactor (AnSBBR) treating hypersaline composite chemical wastewater显示文摘 | Mohan S V Lalit B V Vijaya B Y | 2007 | Bioresour Technol2007，98，7： | 1 |
| 6 | Radiation synthesis of superabsorbent poly( acrytic acid) - carrageenan hydrogels显示文摘 | SANJU F MANMOHAN K LALIT V | 2004 | Radiation Physics and Chemistry2004，69，： | 1 |
| 7 | Radiation synthesis of superabsorbent poly ( acrylic acid ) - carrageenan hydrogels 显示文摘 | SANJU F MANMOHAN K LALIT V | 2004 | Radiation Physics and Chemistry2004，69，： | 1 |
| 8 | Optimizing efficiency-robustness trade-offs in supply chain design under uncertainty due to disruptions 显示文摘 | Shukla A Lalit V A Venkatasubramanian V | 2011 | International Journal of Physical Distribution & Logistics Management2011，41，6： | 1 |
| 9 | Anaerobic bio-hydrogen production from dairy wastewater treatment insequencing batch reactor (AnSBR) : Effect of organic loading rate 显示文摘 | Venkata Mohan S Lalit Babu V Sarma P N | 2007 | Enzyme and Microbial Technology2007，41，： | 1 |
| 10 | Effect of various pretreatment methods on anaerobic mixed microflora to enhance biohydrogen production utilizing dairy wastewater as substrate显示文摘 | Venkata Mohan S Lalit Babu V Sanna P N | 2008 | Bioresource Technology2008，99，： | 1 |
| 11 | The Ilizarov method in infected nonunion of fractures显示文摘 | LALIT M MANISH C JASHAN V | 2000 | Injury Int J Care Injured2000，31，： | 1 |
| 12 | Radiation synthesis of superabsorbent poly(acrylic acid)-carrageenan hydrogels 显示文摘 | SANJU F MANMOHAN K LALIT V | 2004 | Radiation Physics and Chemistry2004，69，： | 1 |
| 13 | Influ-ence of recireulation on the performance of anaerobic se- quencing batch biofilm reactor (AnSBBR) treating hy- persaline composite chemical wastewater 显示文摘 | Mohan S V Lalit Babu V Vijaya Bhaskar Y | 2007 | Bioresour Technol2007，98，7： | 1 |
| 14 | Anaerobic biohydrogen production from dairy wastewater treatment in sequencing batch reactor (AnSBR): Effect of organic loading rate 显示文摘 | S Venkata Mohan V Lalit Babu P N Sarma | 2007 | Enzyme and Microbial Technology2007，41，： | 1 |
| 15 | Effect of various pretreatment methods on anaerobic mixed micro- flora to enhance biohydrogen production utilizing dairy wastewater as substrate 显示文摘 | Venkata Mohan S Lalit Babu V Sarna P N | 2008 | Bioresource Technology2008，99，： | 1 |
| 16 | Chemotherapy in recurrent and advanced cervical cancer显示文摘 | Lalit K and Bhargara V | 2008 | Gynecol Oncol2008，40，： | 1 |
| 17 | Modeling of microwave assisted drying of osmotically pretreated red sweet pepper (Capsicum annum L)显示文摘 | SWAIN S SAMUEL D V K LALIT M B | 2012 | Food Science and Biotechnology2012，21，4： | 1 |
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