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| 1 | Vitamin A administration at birth promotes calf growth and intramuscular fat development in Angus beef cattle显示文摘Background: Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells(adipogenesis). As intramuscular adipogenesis is active during the neonatal stage, we hypothesized that vitamin A administration during the neonatal stage would enhance intramuscular adipogenesis and marbling.Methods: Angus steer calves(n = 30), in a completely randomized design, were randomly allotted to three treatment groups at birth, receiving 0, 150,000, or 300,000 IU of vitamin A at both birth and one month of age.A biopsy of the biceps femoris muscle was collected at two months of age. After weaning at 210 d of age, steers were fed a backgrounding diet in a feedlot until 308 d of age, when they were transitioned to a high concentrate finishing diet and implanted with trenbolone/estradiol/tylosin mixture. Steers were harvested at an average of 438 d of age. All diets were formulated to meet nutrient requirements.Results: Weaning weight and weight during the backgrounding phase were linearly increased(P < 0.05) by vitamin A level, though no difference in body weight was observed at harvest. Intramuscular fat of steers at 308 d of age, measured by ultrasound, quadratically increased(P < 0.05) with vitamin A level from 4.0±0.26 % to 4.9±0.26 %.Similarly, carcass marbling score in the ribeye quadratically increased(P < 0.05).Conclusion: Administration of vitamin A at birth increased weaning weight and enhanced marbling fat development.Thus, vitamin A administration provides a practical method for increasing marbling and early growth of beef cattle. | Corrine L.Harris Bo Wang Jeneane M.Deavila Jan R.Busboom Martin Maquivar Steven M.Parish Brent McCann Mark L.Nelson Min Du | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 7 |
| 2 | Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma显示文摘 | Charles H.Lawrie ShiraGal Heather M.Dunlop BeenaPushkaran Amanda P.Liggins KarenPulford Alison H.Banham FrancescoPezzella JacquelineBoultwood James S.Wainscoat Christian S. R.Hatton Adrian L.Harris | 2008 | British Journal of Haematology2008，，5： | 4 |
| 3 | Identification of microRNAs associated with ileal and colonic Crohn’s disease显示文摘 | FengWu SiminZhang ThemistoclesDassopoulos Mary L.Harris Theodore M.Bayless Stephen J.Meltzer Steven R.Brant John H.Kwon | 2010 | Inflamm Bowel Dis2010，，10： | 2 |
| 4 | Genome‐wide gene expression differences in Crohn’s disease and ulcerative colitis from endoscopic pinch biopsies: Insights into distinctive pathogenesis显示文摘 | FengWu ThemistoclesDassopoulos LeslieCope AnirbanMaitra Steven R.Brant Mary L.Harris Theodore M.Bayless GiovanniParmigiani ShuktiChakravarti | 2007 | Inflamm Bowel Dis2007，，7： | 2 |
| 5 | X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and Ravaz index显示文摘Annual rings from 30 year old vines in a California rootstock trial were measured to determine the effects of 15 different rootstocks on Chardonnay and Cabernet Sauvignon scions.Viticultural traits measuring vegetative growth,yield,berry quality,and nutrient uptake were collected at the beginning(1995 to 1999)and end(2017 to 2020)of the lifetime of a vineyard initially planted in 1991 and removed in 2021.X-ray Computed Tomography(CT)was used to measure ring widths in 103 vines.Ring width was modeled as a function of ring number using a negative exponential model.Early and late wood ring widths,cambium width,and scion trunk radius were correlated with 27 traits.Modeling of annual ring width shows that scions alter the width of the first rings but that rootstocks alter the decay of later rings,consistently shortening ring width throughout the lifetime of the vine.Ravaz index,juice pH,photosynthetic assimilation and transpiration rates,and instantaneous water use efficiency are correlated with scion trunk radius.Ultimately,our research indicates that rootstocks modulate secondary growth over years,altering physiology and agronomic traits.Rootstocks act in similar but distinct ways from climate to modulate ring width,which borrowing techniques from dendrochronology,can be used to monitor both genetic and environmental effects in woody perennial crop species. | ZoëMigicovsky Michelle Y.Quigley Joey Mullins Tahira Ali Joel F.Swift Anita Rose Agasaveeran Joseph D.Dougherty Brendan Michael Grant Ilayda Korkmaz Maneesh Reddy Malpeddi Emily L.McNichol Andrew W.Sharp Jackie L.Harris Danielle R.Hopkins Lindsay M.Jordan Misha T.Kwasniewski R.Keith Striegler Asia L.Dowtin Stephanie Stotts Peter Cousins Daniel H.Chitwood | 2023 | Horticulture Research2023，10，1： | 1 |
| 6 | The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications显示文摘 | Elias Campo Steven H.Swerdlow Nancy L.Harris | | 0，，19： | 1 |
| 7 | Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma显示文摘 | Charles H.Lawrie ShiraGal Heather M.Dunlop BeenaPushkaran Amanda P.Liggins KarenPulford Alison H.Banham FrancescoPezzella JacquelineBoultwood James S.Wainscoat Christian S. R.Hatton Adrian L.Harris | 2008 | British Journal of Haematology2008，，5： | 1 |
| 8 | Floor dust erosion during early stages of coal dust explosion development显示文摘An ignition of methane and air can generate enough air flow to raise mixtures of combustible coal and rock dust.The expanding high temperature combustion products ignite the suspended dust mixture and will continue to propagate following the available combustible fuel supply.If the concentration of the dispersed rock dust is sufficient,the flame will stop propagating.Large-scale explosion tests were conducted within the National Institute for Occupational Safety and Health(NIOSH)Lake Lynn Experimental Mine(LLEM)to measure the dynamic pressure history and the post-explosion dust scour depth.The aim of this effort is to provide quantitative data on depth of dust removal during the early stages of explosion development and its relationship to the depth of floor dust collected for assessing the incombustible content most likely to participate in the combustion process.This experimental work on dust removal on is not only important for coal mine safety but also for industrial dust explosions. | Marcia L.Harris Michael J.Sapko | 2019 | International Journal of Mining Science and Technology2019，29，6： | 1 |
| 9 | Non-linear survival analysis using neural networks显示文摘 | Ruth M.Ripley Adrian L.Harris Lionel Tarassenko | | 0，，05： | 1 |
| 10 | Identification of microRNAs associated with ileal and colonic Crohn’s disease显示文摘 | FengWu SiminZhang ThemistoclesDassopoulos Mary L.Harris Theodore M.Bayless Stephen J.Meltzer Steven R.Brant John H.Kwon | 2010 | Inflamm Bowel Dis2010，，10： | 1 |
| 11 | Estimating the components of the bid/ask spread显示文摘 | Glosten L L.Harris | | 0，，21： | 1 |
| 12 | Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma显示文摘 | Charles H.Lawrie ShiraGal Heather M.Dunlop BeenaPushkaran Amanda P.Liggins KarenPulford Alison H.Banham FrancescoPezzella JacquelineBoultwood James S.Wainscoat Christian S. R.Hatton Adrian L.Harris | 2008 | British Journal of Haematology2008，，5： | 1 |
| 13 | Seismic damage and fragility analysis of structures with tuned mass dampers based on plastic energy显示文摘 | Kevin K. F.Wong John L.Harris | 2012 | Struct Design Tall Spec Build2012，，4： | 1 |
| 14 | The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: A report from the glucosamine/chondroitin arthritis intervention trial显示文摘 | Allen D.Sawitzke HelenShi Martha F.Finco Dorothy D.Dunlop Clifton O.Bingham Crystal L.Harris Nora G.Singer John D.Bradley DavidSilver Christopher G.Jackson Nancy E.Lane Chester V.Oddis FredWolfe JeffreyLisse Daniel E.Furst Domenic J.Reda Roland W.Moskowit | 2008 | Arthritis & Rheumatism2008，，10： | 1 |
| 15 | WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects显示文摘 | GünterBurg WernerKempf AntonioCozzio JosefFeit ReinWillemze ElaineS. Jaffe ReinhardDummer EmilioBerti LorenzoCerroni SergioChimenti José L.Diaz‐Perez FlorentGrange Nancy L.Harris Dmitry V.Kazakov HelmutKerl MichaelKurrer RobertKnobler Chris J.L.M.Meijer N | 2005 | Journal of Cutaneous Pathology2005，，10： | 1 |
| 16 | SNP analysis of AMY2 and CTSL genes in Litopenaeus vannamei and Penaeus monodon shrimp显示文摘 | K. L.Glenn L.Grapes T.Suwanasopee D. L.Harris Y.Li K.Wilson M. F.Rothschild | 2005 | Animal Genetics2005，，3： | 1 |
| 17 | Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5显示文摘Proper regulation of Wnt signaling is critical for normal bone development and homeostasis.Mutations in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass in human subjects and mouse models.Increased bone mass is often accompanied by severe headaches from increased intracranial pressure,which can lead to fatality and loss of vision or hearing due to the entrapment of cranial nerves.In addition,progressive forehead bossing and mandibular overgrowth occur in almost all subjects.Treatments that would provide symptomatic relief in these subjects are limited.Porcupine-mediated palmitoylation is necessary for Wnt secretion and binding to the frizzled receptor.Chemical inhibition of porcupine is a highly selective method of Wnt signaling inhibition.We treated three different mouse models of high bone mass caused by aberrant Wnt signaling,including homozygosity for loss-of-function in Sost,which models sclerosteosis,and two strains of mice carrying different point mutations in Lrp5(equivalent to human G171V and A214V),at 3 months of age with porcupine inhibitors for 5–6 weeks.Treatment significantly reduced both trabecular and cortical bone mass in all three models.This demonstrates that porcupine inhibition is potentially therapeutic for symptomatic relief in subjects who suffer from these disorders and further establishes that the continued production of Wnts is necessary for sustaining high bone mass in these models. | Cassandra R.Diegel Ina Kramer Charles Moes Gabrielle E.Foxa Mitchell J.McDonald Zachary B.Madaj Sabine Guth Jun Liu Jennifer L.Harris Michaela Kneissel Bart O.Williams | 2023 | Bone Research2023，11，3： | 0 |
| 18 | Why some tumours trigger neovascularisation and others don't:the story thus far显示文摘Background:Angiogenesis is not essential for tumours to develop and expand,as cancer can also grow in a nonangiogenic fashion,but why this type of growth occurs is unknown.Surprisingly,our data from mRNA transcription profiling did not show any differences in the classical angiogenic pathways,but differences were observed in mitochondrial metabolic pathways,suggesting a key role for metabolic reprogramming.We then validated these results with mRNA profiling by investigating differential protein expression via immunohistochemistry in angiogenic and non-angiogenic non-small cell lung cancers(NSCLCs).Methods:Immunohistochemical staining for 35 angiogenesis- and hypoxia-related biomarkers were performed on a collection of 194 angiogenic and 73 non-angiogenic NSCLCs arranged on tissue microarrays.Sequencing of P53 was performed with frozen tissue samples of NSCLC.Results:The non-angiogenic tumours were distinguished from the angiogenic ones by having higher levels of proteins associated with ephrin pathways,mitochondria,cell biogenesis,and hypoxia-inducible factor 1(HIF1) regulation by oxygen and transcription of HIF-controlled genes but lower levels of proteins involved in the stroma,cell-cell signaling and adhesion,integrins,and Delta-Notch and epidermal growth factor(EGF)-related signaling.However,proteins classically associated with angiogenesis were present in both types of tumours at very comparable levels.Cytoplasmic expression of P53 was strongly associated with non-angiogenic tumours.A pilot investigation showed that P53 mutations were observed in 32.0%of angiogenic cases but in 71.4%of non-angiogenic tumours.Conclusions:Our observations thus far indicate that both angiogenic and non-angiogenic tumours experience hypoxia/HIF and vascular endothelial growth factor(VEGF) pathway protein expression in a comparable fashion.However,angiogenesis does not ensue in the non-angiogenic tumours.Surprisingly,metabolic reprogramming seems to distinguish these two types of neoplastic growth.On the basis of these results,we raise the hypothesis that in some,but not in all cases,initial tissue remodeling and/or inflammation could be one of the secondary steps necessary to trigger angiogenesis.In the non-angiogenic tumours,in which neovascularisation fails to occur,HIF pathway activation could be the driving force toward metabolic reprogramming. | Omanma Adighibe Russell D.Leek Marta Fernandez-Mercado Jiangting Hu Cameron Snell Kevin C.Gatter Adrian L.Harris Francesco Pezzella | 2016 | Chinese Journal of Cancer2016，35，2： | 0 |
| 19 | 酒店监控实例研究显示文摘Caribe希尔顿酒店位于波多黎各的首府圣胡安市,坐落在一个幽静的小岛上,每年都有许多来自不同国家的人士在这里旅游或者从事商业活动.相比这个国家的其他地区而言,这里的犯罪率要低的多,即便如此,加强该酒店的安全措施也是非常必要的. | Joanne L.Harris 于岚 | 2003 | 安防科技2003，，8： | 0 |
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