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| 1 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Mesenchymal stem cells in the treatment of spinal cord injuries:A review显示文摘With technological advances in basic research,the intricate mechanism of secondary delayed spinal cord injury(SCI)continues to unravel at a rapid pace.However,despite our deeper understanding of the molecular changes occurring after initial insult to the spinal cord,the cure for paralysis remains elusive.Current treatment of SCI is limited to early administration of high dose steroids to mitigate the harmful effect of cord edema that occurs after SCI and to reduce the cascade of secondary delayed SCI.R ecent evident-based clinical studies have cast doubt on the clinical benefit of steroids in SCI and intense focus on stem cell-based therapy has yielded some encouraging results.An array of mesenchymal stem cells(MSCs)from various sources with novel and promising strategies are being developed to improve function after SCI.In this review,we briefly discuss the pathophysiology of spinal cord injuries and characteristics and the potential sources of MSCs that can be used in the treatment of SCI.We will discuss the progress of MSCs application in research,focusing on the neuroprotective properties of MSCs.Finally,we will discuss the results from preclinical and clinical trials involving stem cell-based therapy in SCI. | Venkata Ramesh Dasari Krishna Kumar Veeravalli Dzung H Dinh | 2014 | World Journal of Stem Cells2014，6，2： | 32 |
| 2 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 3 | WISE USE OF WETLAND FOR SUSTAINABLE LIVELIHOOD THROUGH PARTICIPATORY APPROACH:A CASE OF ADAPTING TO CLIMATE CHANGE显示文摘The facts showed that the number of unemployment people is increasing and a large part of them live in the low-lying areas to be facing the challenge from impacts of climate change. So adaptive capacity of the poverty level for sustainable livelihood in vulnerable wetlands is related to coping with local climate change. This paper focuses on soil-less agriculture (Hydroponics) as an alternative source of livelihood means for the communities having no lands for cultivation. Approximately half of Bangladesh is covered with wetlands. The prospect of enormous productivity lies in the development of wetland resources. The soil-less agriculture is an indigenous practice in the middle of southwestern part of Bangladesh. The people who lives within the wetland ecosystems uses locally available paddy straws, water hyacinths and various invasively aquatic plants for making the floating mat or organic bed on which crops, vegetables and seedlings are grown. The productivity of this farming system is much higher than that of terrestrials agricultural and the system can support fisheries of open water. The compost generated from organic refuse bed is a kind of enriched nutrient and can act as a soil conditioner. It would be a major source of nutrients in aquaculture as well. The system is capable to ensure more agriculture production by restoring wetlands from aquatic invasive plant. In addition, the technology included of the system is friendly to ecosystem of wetlands. | Haq A H M Rezaul Tapan Kumar Ghosal Pritam Ghosh M Aminul Islam | 2005 | 湿地科学2005，3，3： | 4 |
| 4 | MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice显示文摘 | Callis Thomas E Pandya Kumar Seok Hee Young Tang Ru-Hang Tatsuguchi Mariko Huang Zhan-Peng Chen Jian-Fu Deng Zhongliang Gunn Bronwyn Shumate Janelle Willis Monte S Selzman Craig H Wang Da-Zhi | 2009 | Journal of Clinical Investigation2009，，9： | 3 |
| 5 | Genetic determinant s of diabetic nephropathy显示文摘 | Chowdhury T A Dyer P H Kumar S | | 0，，： | 2 |
| 6 | Phytoextraction:the use of plants to remove heavy metals from soils显示文摘 | NADAN KUMAR P B A DUSHENKOV V MOTTO H | 1995 | Environ Sci Technol1995，29，5： | 2 |
| 7 | Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation显示文摘 | Thomas H. Sanderson Christian A. Reynolds Rita Kumar Karin Przyklenk Maik Hüttemann | 2013 | Molecular Neurobiology2013，，1： | 2 |
| 8 | Mechanical behavior of nanocrystalline metals and alloys 1 1 The Golden Jubilee Issue—Selected topics in Materials Science and Engineering: Past, Present and Future, edited by S. Suresh显示文摘 | K.S Kumar H Van Swygenhoven S Suresh | 2003 | Acta Materialia2003，，19： | 2 |
| 9 | Phytoremediation:The use of plants to remove heavy metals from soils 显示文摘 | Nanda - Kumar P B A Dushenkov V Motto H | 1995 | Environmental Science & Technology1995，29，5： | 2 |
| 10 | Gastric hyperplastic polyps causing upper gastrointestinal hemorrhage in a young adult显示文摘Here, we report a case of a young man who presented with a significant upper gastrointestinal bleed treated by endoscopic removal of multiple hyperplastic polyps. Gastric hyperplastic polyps are a relatively uncommon cause of overt gastrointestinal bleeding. While most hyperplastic gastric polyps are asymptomatic, they may present with abdominal pain, iron def iciency anemia or gastric outlet obstruction. These polyps are associated with conditions such as Helicobacter pylori gastritis and atrophic autoimmune gastritis, which predispose the epithelium to chronic inf lammation and epithelial repair.The patient presented to Northwestern Memorial Hospital in July 2011. The polyps were resected by clip-assisted snare polypectomy. Histopathologic assessment of the resected polyps demonstrated multiple, nonulcerative hyperplastic polyps measuring 1.3-1.8 cm in size, without evidence of dysplasia or malignancy. This case describes a young adult patient with multiple, large gastric polyps causing overt gastrointestinal bleeding. This is a rare presentation in a young individual, as these polyps are typically identifi ed in patients older than 60 years of age and less commonly, pediatric populations. | Brian J Secemsky Kenika R Robinson Kumar Krishnan Kristina A Matkowskyj Barbara H Jung | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 11 | Noor Grafting of sodium carboxymethylcellulose (CMC) with glycidyl methacrylate and development of UV curable coatings from CMC-g-GMA induced by cationic photoinitiators显示文摘 | Lin Ong Hui Kumar R N Rozman H D | 2005 | Carbohydrate Polymers2005，59，1： | 1 |
| 12 | Isolation of arbuscular mycorrhizal fungi and Azotobacter chroococcum from local litchi orchards and evaluation of their activity in the air-layers system显示文摘 | SHARMA S D KUMAR P RAJ H | 2009 | Scientia Hortieulturae2009，123，： | 1 |
| 13 | Effect of the hydrophilic size on the structural phases of aqueous nonionic Gemini surfactant solutions显示文摘 | Nieh M P Kumar S K Fernando R H | 2004 | Langmuir2004，20，21： | 1 |
| 14 | Growth of Shocked C-aseous Interfaces in a Conical Geometry 显示文摘 | Kumar S Hornung H G Sturtevant B | 2003 | Phys Fluids2003，15，10： | 1 |
| 15 | Special issues on sensor networks and applications 显示文摘 | GHARAVI H KUMAR S P | 2003 | Proceedings of the IEEE2003，91，8： | 1 |
| 16 | DNA binding studies and site selective fluorescence sensitization of an anthryl probe显示文摘 | KUMAR C V ASUNCION H E | 1993 | J Am Chem Soc1993，115，： | 1 |
| 17 | Effect of pioglitazone and rosiglitazone on mediators of endothelial dysfunction, markers of angiogenesis and inflammatory cytokines in type 2 diabetes显示文摘 | Vijay SK Mishra M Kumar H | 2009 | Acta Diabetol2009，46，1： | 1 |
| 18 | Mist- CVD Growth of High Quality nnO Thin Films at Low Temperature for Inverted Organic Solar Cells 显示文摘 | Kim K H Shin K S Kumar B | 2010 | Journal of Nanoelectronics and Optoelectronics2010，5，2： | 1 |
| 19 | How far have we reached in tuberculosis vaccine development? 显示文摘 | Kumar H Malhotra D Goswami S | 2003 | Crit Rev Microbiol2003，29，4： | 1 |
| 20 | DNA binding studies and site Selective fluorescence sensatization of an antyryl probe显示文摘 | Kumar C V Asuncion E H | 1993 | J Am Chem Soc1993，115，： | 1 |
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