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| 1 | Antioxidant activities of Indigofera cassioides Rottl.Ex.DC.using various in vitro assay models显示文摘Objective:To evaluate the antioxidant potential of methanolic leaf extract of Indigofera cassioides(MEIC) using various in vilro antioxidant assay systems.Methods:Antioxidant and free radical scavenging activity of MEIC was assayed by using different in vitro models like ABTS, DPPH,nitric oxide,superoxide,hydrogen peroxide and hydroxyl radical.Reductive ability of the extract was tested by the complex formation with potassium ferricyanide.Further total phenol and flavonoid contents of the crude extract were also determined.Rutin and ascorbic acid were used as standards.Results:MEIC exhibited potent and concentration dependent free radical scavenging activity in all the tested models.Reductive ability was also found to increase with increase in MEIC concentration.Total phenol and flavonoid content determination showed that the extract is rich in phenols and flavonoids.Conclusions:All the results of the in vitro antioxidant assays reveal potent antioxidant and free radical scavenging activity of the leaves of Indigofera cassioides,equivalent to that of standard ascorbic acid and rutin.This potent antioxidant activity may be attributed to its high phenolic and flavonoid contents. | R Senthil Kumar B Rajkapoor P Perumal | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 15 |
| 2 | Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals:From experimental models to clinical trials显示文摘Chemoprevention is one of the cancer prevention approaches wherein natural/synthetic agent(s) are prescribed with the aim to delay or disrupt multiple pathways and processes involved at multiple steps, i.e., initiation, promotion, and progression of cancer. Amongst environmental chemopreventive compounds, diet/beverage-derived components are under evaluation, because of their long history of exposure to humans, high tolerability, low toxicity, and reported biological activities. This compilation briefly covers and compares the available evidence on chemopreventive efficacy and probable mechanism of chemoprevention by selected dietary phytochemicals(capsaicin, curcumin, diallyl sulphide, genistein, green/black tea polyphenols, indoles, lycopene, phenethyl isocyanate, resveratrol, retinoids and tocopherols) in experimental systems and clinical trials. All the dietary phytochemicals covered in this review have demonstrated chemopreventive efficacy against spontaneous or carcinogen-induced experimental tumors and/or associated biomarkers and processes in rodents at several organ sites. The observed anti-initiating, anti-promoting and anti-progression activity of dietary phytochemicals in carcinogen-induced experimental models involve phytochemical-mediated redox changes, modulation of enzymes and signaling kinases resulting to effects on multiple genes and cell signaling pathways. Results from clinical trials using these compounds have not shown them to be chemopreventive. This may be due to our:(1) inability to reproduce the exposure conditions, i.e., levels, complexity, other host and lifestyle factors; and(2) lack of understanding about the mechanisms of action and agent-mediated toxicity in several organs and physiological processes in the host. Current research efforts in addressing the issues of exposure conditions, bioavailability, toxicity and the mode of action of dietary phytochemicals may help address the reason for observed mismatch that may ultimately lead to identification of new chemopreventive agents for protection against broad spectrum of exposures. | Girish B Maru Rasika R Hudlikar Gaurav Kumar Khushboo Gandhi Manoj B Mahimkar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 3 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 4 | Remote sensing and GIS for land use/cover mapping and integrated land management: case from the middle Ganga plain显示文摘在印度,陆地资源由于很快成长的人口到达了一个批评阶段。这挑战向利用陆地资源要求一条综合途径,当考虑脆弱的环境条件时。遥感和地理信息系统(GIS ) 基于技术可以被用于一个区域以便产生最佳地被适合到地面并且到本地资源的生产潜力的一个持续开发计划。现在的学习区域是中间的 Ganga 平原的部分,作为 Son-Karamnasa 河间地知道,在印度。其他的陆地使用系统和有农业系统的家畜企业的集成为陆地资源管理被建议了。这份报纸的目的是准备一个陆地资源发展计划以便为持续开发增加土地的生产率。现在的学习将贡献必要输入让政策制造者改进这个区域的社会经济、环境的条件[出版摘要] | R B SINGH Dilip KUMAR | 2012 | Frontiers of Earth Science2012，6，2： | 2 |
| 5 | Laparoscopic esophagomyotomy for achalasia in children:Areview显示文摘Esophageal achalasia in children is rare but ultimately requires endoscopic or surgical treatment. Historically, Heller esophagomyotomy has been recommended as the treatment of choice. The refinement of minimally invasive techniques has shifted the trend of treatment toward laparoscopic Heller myotomy(LHM) in adults and children with achalasia. A review of the available literature on LHM performed in patients < 18 years of age was conducted. The pediatric LHM experience is limited to one multiinstitutional and several single-institutional retrospective studies. Available data suggest that LHM is safe and effective. There is a paucity of evidence on the need for and superiority of concurrent antireflux procedures. In addition, a more complete portrayal of complications and long-term(> 5 years) outcomes is needed. Due to the infrequency of achalasia in children, these characteristics are unlikely to be defined without collaboration between multiple pediatric surgery centers. The introduction of peroral endoscopic myotomy and single-incision techniques, continue the trend of innovative approaches that may eventually become the standard of care. | T Kumar Pandian Nimesh D Naik Aodhnait S Fahy Arman Arghami David R Farley Michael B Ishitani Christopher R Moir | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 6 | Co-immobilization of cholesterol oxidase and horseradish peroxidase in a sol-gel film显示文摘 | KUMAR A MALHOTRA R MALHOTRA B D | 2000 | Anal Chim Acta2000，414，： | 1 |
| 7 | Fabrication and characterization of a boehmite nanoparticle impregnated electrospun fiber membrane for removal of metal ions 显示文摘 | Garudadhwaj Hota B R Kumar Ramakrishna Wjns | 2008 | Journal of Materials Science2008，302，12： | 1 |
| 8 | Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro显示文摘 | Kumar R D McMahon S B | 1999 | Eur J Neurosci1999，11，： | 1 |
| 9 | Graft copolymerization of acrylonitrilc onto Cassia tora gum with eerie ammonium nitrate - nitricaeid as a redox initiator显示文摘 | Sharma B R Kumar V Soni P L | 2003 | Journal of Applied Polymer Science2003，，1： | 1 |
| 10 | Efficient and convenient polyethylene glyeol(PEG)-mediated synthesis of spiro-oxindoles显示文摘 | Meshram H M Kumar D A Prasad B R V | 2010 | Helvetica Chimica ACTA2010，93，4： | 1 |
| 11 | Solvent extraction of Hf(IV) from acidic chloride solutions using Cyanex 302显示文摘 | REDDY B R KUMAR J R RAJA K P REDDY A V | 2004 | Minerals Engineering2004，17，： | 1 |
| 12 | Staged pulmonary and hepatic metaststomy in colorectal cancer:is it worth it显示文摘 | Reddy RH Kumar B Shah R | | 0，，： | 1 |
| 13 | Application of liquid/sol- id fluidization technique in beneficiation of fines 显示文摘 | Mukherjee A K Mishra B K Kumar R V | 2009 | International Journal of Mineral Processing2009，92，12： | 1 |
| 14 | Parkinson's disease, depression, and quality-of-life显示文摘 | Menon B Nayar R Kumar S | 2015 | Indian J Psychol Med2015，37，2： | 1 |
| 15 | Rigid nasal en- doscopy in the diagnosis and treatment of epistaxis 显示文摘 | Kumar M V V Prasad K U R Gowda P R B | 2013 | J Clin Diagn Res2013，7，5： | 1 |
| 16 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 17 | Characterisation and expression of a PP1serine/threonine protein phosphatase(PfPP1) from the malaria parasite, Plasmodiumfalciparum:demonstration of its essential role using RNA interference 显示文摘 | Kumar R Adams B Oldenburg A | 2002 | Malar J2002，1，1： | 1 |
| 18 | Agroforestry as sequestration 显示文摘 | Nair P K R Kumar B M a strategyfor carbon Nair V D | 2009 | Journal of Plant Nutrition and Soil Science2009，172，： | 1 |
| 19 | Porosity, Pore Size Distribution and In-situ Strength of Concrete显示文摘 | R Kumar B Bhattacharjee | 2003 | Cement Concrete Research2003，33，1： | 1 |
| 20 | Mapping the effcacy of new designs for large scale sonochemical reactors显示文摘 | Kumar A Gogate P R Pandit A B | 2007 | Ultrasonics Sonoshemistry2007，14，： | 1 |
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