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| 1 | Diabetes mellitus:An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity显示文摘Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge numlier of population in the world.It is mainly characterized by chronic hyperglycemia,resulting from defects in insulin secretion or insulin action.It is predicated that the number of diabetes person in the world could reach upto 366 million by the year 2030.Even though the cases of diabetes are increasing day by day,except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far.Thus,the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic disorder.The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used nowadays.Alloxan and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular drug.This review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat model.From the available data in the literature,it was found that plant having antidiabetic activity is mainly due to the presence of the secondary metabolite.Thus,the information provided in this review will help the researchers for the development of an alternative methods rather than insidin and oral hypoglycemic agents for the treatment of diabetes niellitus,which will minimize the complication associated with the diabetes and related disorder. | Patel DK Kumar R Laloo D Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 17 |
| 2 | Antioxidant and cytotoxic effects of hexane extract of Morinda pubescens leaves in human liver cancer cell line显示文摘Objective:To evaluate the antioxidant and cytotoxic effects of hexane extract of Morinda pubescens leaves and to find the primary bioactive compound responsible for antioxidant and cytotoxic activities.Methods:The individual compounds were isolated using column chromatography and were characterized by spectroscopic techniques.The antioxidant activity was evaluated for all individual isolated compounds by DPPH method using L-Ascorbic acid as standard and cytotoxicity was assessed for the extract and the hyoscyamine by MTT assay, caspase test and RT-PCR study.Results:The antioxidant activity of the isolated compounds and the extract increased as the concentration increased.One of the isolated compound hyoscyamine showed the high antioxidant activity.The extract and the hyoscyamine dose-dependently decreased the cell viability in HepG2 cells.Hyoscyamine induced caspase-3 mediated apoptosis. Up regulation of p53 gene expression provides cue for apoptotic activity of hyoscyamine. Conclusions:The results indicate that hexane extract possessed potent antioxidant and cytotoxic activity and hyoscyamine is the principal bioactive compound in hexane extract. | Jaya Kumar D Jaya Santhi R | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，5： | 4 |
| 3 | 米糠油同时脱胶脱蜡物理精炼新技术显示文摘对米糠油同时脱胶脱蜡物理精炼新工艺进行了小试研究,并在此基础上进行了生产试验。毛米糠油与氯化钙水溶液混合,在低温下结晶(20℃)使水化磷脂和非水化磷脂与蜡一起沉析分离,随后进行脱色和冬化(20℃)处理,进一步将磷脂含量降到5mg/kg以下,再经物理精炼,即可使成品精炼米糠油满足市售商品对其色泽(10~12罗维朋值,25.4mm槽)、游离脂肪酸含量(〈0.25%)和浊点(4~5℃)的要求;且中性油损失少。米糠油含有多种生物活性物质,如谷维素,VE和甾醇。本工艺可在最终产品中保留80%以上的生物活性物质。 | Rajam L Soban Kumar D R Sundaresan A Arumughan C 武丽荣(译) | 2006 | 中国油脂2006，31，7： | 3 |
| 4 | 焊接参数对搅拌摩擦焊接AA2219-T87材料韧性、洋葱圆环的断裂行为的影响(英文)显示文摘与熔焊相比,搅拌摩擦焊可以更好地保持材料的韧性和塑性,提高焊接的抗裂稳定性。本研究旨在提高焊接接头的延性和强度。刀具廓形在保持延性、分析金属流动行为和确定断裂起始点等方面起着重要作用。分析了洋葱圆环不同区域的微观结构,得出了洋葱圆环强度与金属流型的关系。结果表明,洋葱圆环强化了焊缝熔核。肩部和锥形螺纹型线刀具具有优异的力学性能。显微硬度数据表明,断口经过热影响区和热机械影响区等低硬度区。扫描电镜图像显示了细长的晶粒和韧窝,证实了断裂为韧性断裂。 | Dinesh KUMAR R S MUTHUKUMARAN Vincent XAVIER T VENKATESWARAN D SIVAKUMAR | 2019 | Journal of Central South University2019，26，9： | 2 |
| 5 | Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects显示文摘 | DK Patel R Kumar D Laloo S Hemalatha | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 2 |
| 6 | Laparoscopic esophagomyotomy for achalasia in children:Areview显示文摘Esophageal achalasia in children is rare but ultimately requires endoscopic or surgical treatment. Historically, Heller esophagomyotomy has been recommended as the treatment of choice. The refinement of minimally invasive techniques has shifted the trend of treatment toward laparoscopic Heller myotomy(LHM) in adults and children with achalasia. A review of the available literature on LHM performed in patients < 18 years of age was conducted. The pediatric LHM experience is limited to one multiinstitutional and several single-institutional retrospective studies. Available data suggest that LHM is safe and effective. There is a paucity of evidence on the need for and superiority of concurrent antireflux procedures. In addition, a more complete portrayal of complications and long-term(> 5 years) outcomes is needed. Due to the infrequency of achalasia in children, these characteristics are unlikely to be defined without collaboration between multiple pediatric surgery centers. The introduction of peroral endoscopic myotomy and single-incision techniques, continue the trend of innovative approaches that may eventually become the standard of care. | T Kumar Pandian Nimesh D Naik Aodhnait S Fahy Arman Arghami David R Farley Michael B Ishitani Christopher R Moir | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 7 | A comparison of seven soil P tests for plant species with different external P requirements grown on soils containing rock phosphate and superphosphate residues 显示文摘 | KUMAR V GILKES R J BOLLAND M D A | 1993 | Fertiliser Research1993，33，： | 1 |
| 8 | Noor Grafting of sodium carboxymethylcellulose (CMC) with glycidyl methacrylate and development of UV curable coatings from CMC-g-GMA induced by cationic photoinitiators显示文摘 | Lin Ong Hui Kumar R N Rozman H D | 2005 | Carbohydrate Polymers2005，59，1： | 1 |
| 9 | Co-immobilization of cholesterol oxidase and horseradish peroxidase in a sol-gel film显示文摘 | KUMAR A MALHOTRA R MALHOTRA B D | 2000 | Anal Chim Acta2000，414，： | 1 |
| 10 | Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro显示文摘 | Kumar R D McMahon S B | 1999 | Eur J Neurosci1999，11，： | 1 |
| 11 | Experimental and finite element modeling studies on single-layer and multi-layer 1-3 piezocomposite transducers显示文摘 | RAMESH R PRASAD C D VINOD KUMAR T K | 2006 | Ultrasonics2006，44，2006： | 1 |
| 12 | Endobronchial tu- berculosis presenting as tumorous mass 显示文摘 | Singla R Kumar A Chauhan D | 2007 | Indian J Chest Dis Allied Sci2007，49，1： | 1 |
| 13 | Efficient and convenient polyethylene glyeol(PEG)-mediated synthesis of spiro-oxindoles显示文摘 | Meshram H M Kumar D A Prasad B R V | 2010 | Helvetica Chimica ACTA2010，93，4： | 1 |
| 14 | Effects of micro- structure variability on intrinsic fatigue resistance of nickel-base superalloys-a computational micromechan ics approach显示文摘 | Kumar R Wang A Mcdowell D | 2006 | International Journal of Fracture2006，137，： | 1 |
| 15 | Role of FDG-PET/CT in detection of recurrent disease in colorectal cancer 显示文摘 | Shamim SA Kumar R Halanaik D | 2010 | Nucl Med Commum2010，31，6： | 1 |
| 16 | Controlling band gap and refractive index in dopant-freeα-Fe2O3Films显示文摘 | KUMAR P RAWAT N HANG D R | 2015 | Electronic Materials Letters2015，11，13： | 1 |
| 17 | High diversity andwidespread occurrence of mitotic spore mats in ectomycorrhizalPezizales显示文摘 | Healy R A Smith M E Bonito G M Pfister D H Ge Z W Guevara G G ’ Williams G Stafford K Kumar L Lee T HobartC Trappe J Vilgalys R McLaughlin D J | 2013 | Molecular Ecology2013，22，： | 1 |
| 18 | High-performance liquid chromatographic analysis of ampho-tericin B in rat plasma using α-naphthol as an internal standard显示文摘 | ITALIA J L SINGH D KUMAR M N V R | 2009 | Anal Chim Acta2009，634，1： | 1 |
| 19 | Ectopic expression ot Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumininduced apoptosis 显示文摘 | Rashmi R Kumar S Karunagaran D | 2004 | Carcinogenesis2004，25，2： | 1 |
| 20 | Characterization of tensile properties of tailor welded IF steel sheets and their formability in stretch forming显示文摘 | PANDA S K KUMAR D R KUMAR H | 2007 | Journal of Materials Processing Technology2007，183，： | 1 |
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