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| 1 | Isolation of the mucilages from Hibiscus rosasinensis linn.and Okra(Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages显示文摘Objective:To isolate and evaluate comparatively the binding efficacy of the mucilages obtained from the plants of Hibiscus rosasinensis and Okra(Abelmoschus esculentus).Methods:Extraction of mucilages from the leaves of Hibiscus and pods of Okra(Ladies finger) was carried out by a cold maceration process.The extracted mucilages were subjected to various physicochemical properties for its suitability as an excipient in the formulation of tablet dosage form.Different concentrations(10,8,5,2 and 1%w/v) of binder solutions of Hibiscus and Okra were used for the formulation of tablets and the formulated tablets were evaluated by studying the standard parameters like diameter,thickness,weight variation,hardness,friability,disintegration and in vitro dissolution.Stability studies of the formulated tablets were conducted for four weeks. Results:The formulated tablets prepared using the mucilages of both Hibiscus and Okra had good appearance.The in vitro drug release profile of the tablets prepared using Okra mucilage had an optimum of 90%at a mucilage concentration of 1%w/v concentration mucilage itself within 4 h.Conclusions:According to the observations,the lower concentration levels of Okra can be used as an alternative binder to starch.The higher concentration levels of Okra mucilage show a slow and sustained release,and can be considered as an alternative natural excipient in the modified drug delivery systems.At the same time,the above natural excipient of Hibiscus mucilage could be used as a platform for prolonged release if its binder concentrations are increased. | Ameena K Dilip C Saraswathi R Krishnan PN Sankar C Simi SP | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 8 |
| 2 | Antimicrobial activity of cotton and silk fabric with herbal extract by micro encapsulation显示文摘Objective:To explore the antimicrobial activity of microcapsules encapsulated with mixture of herbs like neem,tulsi and turmeric,and its application on cellulosic fabric in the form of microcapsules.Methods:The microcapsules were prepared from the mixture of herbs by plain diffusion method,a natural encapsulation technique with yeast and applied on cotton and silk fabric by pad-dry-cure method.The microcapsules were fixed on cotton and silk fabric using the binder UF Silpure FBR-5(PA)B at 120℃.The antimicrobial activities of the finished fabric were assessed by using three types of bacteria including Staphylococcus aureus,Escherichia coli and Pseudomonas.Results:The results of antimicrobial activity from the tests including parallel streak method and disc diffusion method showed that activity of the mixture of herbs was very effective among the three types of bacteria selected,and the antimicrobial activity of prepared microcapsule against Pseudomonas was very good.Conclusions:The herbal microcapsule treated fabric could be applied in the field of medicine.The scanning electron microscope photographs ensure the fixing of the microcapsules firmly in the yarn structure of plain woven cotton and silk fabric. | Saraswathi R Krishnan PN Dilip C | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 3 |
| 3 | Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles显示文摘Objective:To prepare curcumin-piperine(Cu-Pi) nanoparticles by various methods and to study the effect of various manufacturing parameters on Cu-Pi nanoparticles and to identify a suitable method for the preparation of Cu-Pi nanoparticles to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer.Methods:Cu-Pi nanoparticles were prepared by thin film hydration method,solid dispersion method,emulsion polymerization method and Fessi method.Optimization was carried out to study the effect of various manufacturing parameter on the Cu-Pi nanoparticles.Results:Out of four methods,Fessi method produced a minimum average particle size of 85.43 nm with a polydispersity index of 0.183 and zeta potential of 29.7 mV.Change of organic solvent(acetone or ethanol) did not have any significant effect on Cu-Pi nanoparticles.However,increase in sonication time,stirring speed,viscosity,use of 1:10:10 ratio of drag/polymer/surfactant,and use of anionic surfactant or combination of anionic surfactant with cationic polymer or combination of non-ionic surfactant with cationic polymer had a significant effect on Cu-Pi nanoparticles.Conclusions:Cu-Pi nanoparticles coated with PEC containing copolymer produced by Fessi method had a minimum average particle size,excellent polydispersity index and optimal zeta potential which fall within the acceptable limits of the study.This dual nanoparticulate drug delivery system appears to be promising to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer. | C Moorthi Kiran Krishnan R Manavalan K Kathiresan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 3 |
| 4 | Gastric hyperplastic polyps causing upper gastrointestinal hemorrhage in a young adult显示文摘Here, we report a case of a young man who presented with a significant upper gastrointestinal bleed treated by endoscopic removal of multiple hyperplastic polyps. Gastric hyperplastic polyps are a relatively uncommon cause of overt gastrointestinal bleeding. While most hyperplastic gastric polyps are asymptomatic, they may present with abdominal pain, iron def iciency anemia or gastric outlet obstruction. These polyps are associated with conditions such as Helicobacter pylori gastritis and atrophic autoimmune gastritis, which predispose the epithelium to chronic inf lammation and epithelial repair.The patient presented to Northwestern Memorial Hospital in July 2011. The polyps were resected by clip-assisted snare polypectomy. Histopathologic assessment of the resected polyps demonstrated multiple, nonulcerative hyperplastic polyps measuring 1.3-1.8 cm in size, without evidence of dysplasia or malignancy. This case describes a young adult patient with multiple, large gastric polyps causing overt gastrointestinal bleeding. This is a rare presentation in a young individual, as these polyps are typically identifi ed in patients older than 60 years of age and less commonly, pediatric populations. | Brian J Secemsky Kenika R Robinson Kumar Krishnan Kristina A Matkowskyj Barbara H Jung | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 5 | Fracture toughness of a soft sandstone 显示文摘 | Krishnan G R Zhao X L Zaman M | 1998 | Int J Rock Mech1998，35，6： | 1 |
| 6 | Using Advertising Alliances for New Product Introduction:Interactions between Product Complementarity and promotional Strategies显示文摘 | SAMU S H KRISHNAN S SMITH R E | 1999 | Journal of Marketing1999，63，1： | 1 |
| 7 | Anodic electrosynthesis of cadmium selenide thin films-characterization and comparison with the passive/transpassive behavior of the CdX(X=S,Te) counterparts 显示文摘 | Kamal K Krishnan R | 1991 | J Electrchem Soc1991，138，1： | 1 |
| 8 | Feature mapping of the HLA class I region: localization of the POUSF1 and TCF19 genes显示文摘 | Krishnan B R Jamry I Chaplin D D | 1995 | Genomics1995，30，： | 1 |
| 9 | International Journal of Powder Metallurgy显示文摘 | Joshi P B Krishnan P S Patel R H | 1998 | 34(4):63-741998，34，4： | 1 |
| 10 | Coordinating Contracts for Decentralized Supply Chains with Retailer Promotional Effort显示文摘 | Krishnan H Kapuscinski R Butz D A | 2004 | Management Science2004，50，1： | 1 |
| 11 | Mechanisms of urokinase plasminogen activator ( uPA)-mediated atheroselerosis: role of the uPA receptor and S100A8/A9 proteins显示文摘 | Farris SD Hu JH Krishnan R | 2011 | J Biol Chem2011，286，22： | 1 |
| 12 | Precipitation hardening in a PH 13-8 Mo stainless steel显示文摘 | Seetharaman V Sundararaman M Krishnan R | 1981 | Materials Science and Engineering1981，47，1： | 1 |
| 13 | Mechanisms of urokinase plasminogen activator-mediated atherosclerosis:role of the uPA receptor and S100A8/A9 proteins显示文摘 | Farris SD Hu JH Krishnan R | | 0，，： | 1 |
| 14 | Modeling, Simulation and Anal-ysis of Permanent-Magnet Motor Drives, Part II : TheBrusldess DC Motor Drive 显示文摘 | Pithy P Krishnan R | 1989 | IEEE Transactions &Industry Application1989，25，2： | 1 |
| 15 | Metal distribution in electroplating of nickel and chro- mium显示文摘 | JAYAKRISHNAN S DHAYANAND K KRISHNAN R M | 1998 | Transactions of the Institute of'' Metal Finishing1998，76，3： | 1 |
| 16 | Modeling of permanent magnet mo-tor drives 显示文摘 | Pillay P Krishnan R | 1988 | IEEE Transactions on Industrial Electron-ics1988，35，4： | 1 |
| 17 | Microfabricated reaction and separation systems显示文摘 | Krishnan M Namasivayam V Lin R | 2001 | Analytical Biotechonlogy2001，12，1： | 1 |
| 18 | When does trust matter to alliance performance?显示文摘 | Krishnan R Martin X Noorderhaven N G | 2006 | Academy of Management Journal2006，49，5： | 1 |
| 19 | On Evaluating In- formation Revelation Policies in Procurement Auctions:A Markov Decision Process Approach 显示文摘 | GREENWALD A KANNAN K KRISHNAN'R | 2010 | Information Systems Research2010，21，1： | 1 |
| 20 | Analysis of exhaust waste heat recovery from a dual fuel low temperature combustion engine using an organic Rankine cycle 显示文摘 | Srinivasan K K Mago P J Krishnan S R | 2010 | Energy2010，35，6： | 1 |
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