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61篇 您的检索式：作者名="R Manavalan"

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	题名	作者	年代	出处	被引量
1	Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles显示文摘Objective:To prepare curcumin-piperine(Cu-Pi) nanoparticles by various methods and to study the effect of various manufacturing parameters on Cu-Pi nanoparticles and to identify a suitable method for the preparation of Cu-Pi nanoparticles to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer.Methods:Cu-Pi nanoparticles were prepared by thin film hydration method,solid dispersion method,emulsion polymerization method and Fessi method.Optimization was carried out to study the effect of various manufacturing parameter on the Cu-Pi nanoparticles.Results:Out of four methods,Fessi method produced a minimum average particle size of 85.43 nm with a polydispersity index of 0.183 and zeta potential of 29.7 mV.Change of organic solvent(acetone or ethanol) did not have any significant effect on Cu-Pi nanoparticles.However,increase in sonication time,stirring speed,viscosity,use of 1:10:10 ratio of drag/polymer/surfactant,and use of anionic surfactant or combination of anionic surfactant with cationic polymer or combination of non-ionic surfactant with cationic polymer had a significant effect on Cu-Pi nanoparticles.Conclusions:Cu-Pi nanoparticles coated with PEC containing copolymer produced by Fessi method had a minimum average particle size,excellent polydispersity index and optimal zeta potential which fall within the acceptable limits of the study.This dual nanoparticulate drug delivery system appears to be promising to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer.	C Moorthi Kiran Krishnan R Manavalan K Kathiresan	2012	Asian Pacific Journal of Tropical Biomedicine2012，2，11：	3
2	Antibacterial activity of the leaf and stem bark extracts of a mangrove Rhizophora mucronata 显示文摘	Akalanka D Somaasundaram S T Manavalan R	2002	Seshaiyana2002，10，2：	1
3	Multicriteria decision making approach and experimental design as chemometric tools to optimize HPLC separation of domperidone and pantoprazole 显示文摘	Sivakumar T Manavalan R Muralidharan C	2007	J Pharm Biomed Anal2007，43，5：	1
4	Tolerization of dendritic cells by Ts cells:the crucial role of inhibitory receptors ILT3 and ILT4显示文摘	CHANG C C CIUBOTARIU R MANAVALAN J S	2002	Nat Immunol2002，3，：	1
5	Nanotherapeu- tics to overcome conventional cancer chemo therapy limit ations 显示文摘	Chidambararn M Manavalan R Kathiresan K	2011	J Pharm Pharmaceut Sci2011，14，1：	1
6	Generation and function of antigen-specific suppressor and regulatory T cells显示文摘	SUCIU-FOCA N MANAVALAN J S CORTESINI R	2003	Transpl Immunol2003，11，34：	1
7	An improvement HPLC method with the aid of a chemometric protocol: Simultaneous analysis of Amlodipine and Atorvastatin in pharmaceutical formulations 显示文摘	SIVAKUMAR T MANAVALAN R MURALIDHARAN C	2007	J Sep Sci2007，30，：	1
8	Tolerization of den- dritic cells by T ( S ) cells : the crucial role of inhibitory receptors ILT3 and ILT4 显示文摘	Chang CC Ciubotariu R Manavalan JS	2002	Nat Immuno12002，3，3：	1
9	显示文摘	Chang CC Ciubotariu R Manavalan JS	2001	Nat Immunol2001，3，3：	1
10	Reduced immunosuppression in pediatric liver-intestine transplant recipienTs with CD8^+ CD28^- T-suppressor cells显示文摘	SINDHI R MANAVALAN J S MAGILL A	2005	Hum Immunol2005，66，3：	1
11	Amino acids composition and thermal stability of proteins 显示文摘	Ponnuswamy P K Muthusamy R Manavalan P	1982	Int J Biol Macromol1982，，4：	1
12	Tolerization of dendritic cells by T(S) cells: The crucial role of inhibitory recep- tors ILT3 and ILT4 显示文摘	Chang CC Ciubotariu R Manavalan JS	2002	Nat Irnmunol2002，3，3：	1
13	Hepatoprotective and antioxidant effects of Commiphora berryi (Am) Engl bark extract against CCh-induced oxidative damage in rats显示文摘	NLGowri Shankar R Manavalan DVenkappayya	2008	Food Chem Toxicol2008，46，：	1
14	In silico approach to inhibition of signaling pathways of toll-like recep- tors 2 and 4 by ST2L显示文摘	Chinese BASITH S MANAVALAN B GOVINDARAJ R	2011	PLoS One2011，6，23：	1
15	Tolerization of dendritic cells by T(S) cells:the crucial role of inhibitory receptors ILT3 and ILT4显示文摘	Chang CC Ciubotariu R Manavalan JS	2002	Nat Immunol2002，3，3：	1
16	Tolerization of dendritic cells by T(S) cells; the crutial role of inhibitory receptors ILT3 and ILT4显示文摘	Chang C C Ciubotariu R Manavalan J S	2002	Nat Immunol2002，3，3：	1
17	Allospecific T regulatory and T suppressor cells in transplantation显示文摘	Cortesini R Manavalan JS Galluzzo S	2004	Transplantation2004，78，2：	1
18	Comparative analysis of speckle filtering techniques 显示文摘	Aroquiaraj I L Thangavel K Manavalan R	2009	International Journal of Recent Trends in Engineering2009，2，2：	1
19	Generation and function of antigen-specific suppressor and regulatory T cells显示文摘	Suciu FN Manavalan JS Cortesini R	2003	Transpl Immunol2003，11，34：	1
20	Tolerization of dendritic cells by T(S) cells:the crucial role of inhibitory receptors ILT3 and ILT4显示文摘	Chang CC Ciubotariu R Manavalan JS	2002	Nat Immunol2002，3，3：	1

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