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| 1 | Isolation of the mucilages from Hibiscus rosasinensis linn.and Okra(Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages显示文摘Objective:To isolate and evaluate comparatively the binding efficacy of the mucilages obtained from the plants of Hibiscus rosasinensis and Okra(Abelmoschus esculentus).Methods:Extraction of mucilages from the leaves of Hibiscus and pods of Okra(Ladies finger) was carried out by a cold maceration process.The extracted mucilages were subjected to various physicochemical properties for its suitability as an excipient in the formulation of tablet dosage form.Different concentrations(10,8,5,2 and 1%w/v) of binder solutions of Hibiscus and Okra were used for the formulation of tablets and the formulated tablets were evaluated by studying the standard parameters like diameter,thickness,weight variation,hardness,friability,disintegration and in vitro dissolution.Stability studies of the formulated tablets were conducted for four weeks. Results:The formulated tablets prepared using the mucilages of both Hibiscus and Okra had good appearance.The in vitro drug release profile of the tablets prepared using Okra mucilage had an optimum of 90%at a mucilage concentration of 1%w/v concentration mucilage itself within 4 h.Conclusions:According to the observations,the lower concentration levels of Okra can be used as an alternative binder to starch.The higher concentration levels of Okra mucilage show a slow and sustained release,and can be considered as an alternative natural excipient in the modified drug delivery systems.At the same time,the above natural excipient of Hibiscus mucilage could be used as a platform for prolonged release if its binder concentrations are increased. | Ameena K Dilip C Saraswathi R Krishnan PN Sankar C Simi SP | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 8 |
| 2 | Colonic adenocarcinoma,mucosa associated lymphoid tissue lymphoma and tuberculosis in a segment of colon:A case report显示文摘Synchronous occurrence of adenocarcinoma and mucosa associated lymphoid tissue(MALT) lymphoma of colon is rare,and its presence with coexisting tuberculosis is still rarer.To our knowledge,this may be the first case report.In the present report,we describe a 43-year-old female who presented with a history of abdominal pain,fever,loss of weight and loss of appetite.Colonoscopy showed a large ulceroproliferative mass arising from the caecum,biopsy of which showed it to be adenocarcinoma of the colon.A right hemicolectomy was performed and microscopic study of the colon revealed tuberculosis and synchronous adenocarcinoma with lymphoma.Eight of sixteen lymph nodes showed tuberculosis and three of sixteenpericoloniclymphnodes showed metastatic deposits.Immunostains further confirmed the tumour to be adenocarcinoma with MALT lymphoma.We would like to highlight the diagnostic challenges arising from the multi-faceted presentations of these three conditions. | Ambedkar Raj Kulandai Velu Banushree C Srinivasamurthy Krishnan Nagarajan Ilavarasi Sinduja | 2014 | World Journal of Gastrointestinal Oncology2014，6，9： | 3 |
| 3 | Antimicrobial activity of cotton and silk fabric with herbal extract by micro encapsulation显示文摘Objective:To explore the antimicrobial activity of microcapsules encapsulated with mixture of herbs like neem,tulsi and turmeric,and its application on cellulosic fabric in the form of microcapsules.Methods:The microcapsules were prepared from the mixture of herbs by plain diffusion method,a natural encapsulation technique with yeast and applied on cotton and silk fabric by pad-dry-cure method.The microcapsules were fixed on cotton and silk fabric using the binder UF Silpure FBR-5(PA)B at 120℃.The antimicrobial activities of the finished fabric were assessed by using three types of bacteria including Staphylococcus aureus,Escherichia coli and Pseudomonas.Results:The results of antimicrobial activity from the tests including parallel streak method and disc diffusion method showed that activity of the mixture of herbs was very effective among the three types of bacteria selected,and the antimicrobial activity of prepared microcapsule against Pseudomonas was very good.Conclusions:The herbal microcapsule treated fabric could be applied in the field of medicine.The scanning electron microscope photographs ensure the fixing of the microcapsules firmly in the yarn structure of plain woven cotton and silk fabric. | Saraswathi R Krishnan PN Dilip C | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 3 |
| 4 | Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles显示文摘Objective:To prepare curcumin-piperine(Cu-Pi) nanoparticles by various methods and to study the effect of various manufacturing parameters on Cu-Pi nanoparticles and to identify a suitable method for the preparation of Cu-Pi nanoparticles to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer.Methods:Cu-Pi nanoparticles were prepared by thin film hydration method,solid dispersion method,emulsion polymerization method and Fessi method.Optimization was carried out to study the effect of various manufacturing parameter on the Cu-Pi nanoparticles.Results:Out of four methods,Fessi method produced a minimum average particle size of 85.43 nm with a polydispersity index of 0.183 and zeta potential of 29.7 mV.Change of organic solvent(acetone or ethanol) did not have any significant effect on Cu-Pi nanoparticles.However,increase in sonication time,stirring speed,viscosity,use of 1:10:10 ratio of drag/polymer/surfactant,and use of anionic surfactant or combination of anionic surfactant with cationic polymer or combination of non-ionic surfactant with cationic polymer had a significant effect on Cu-Pi nanoparticles.Conclusions:Cu-Pi nanoparticles coated with PEC containing copolymer produced by Fessi method had a minimum average particle size,excellent polydispersity index and optimal zeta potential which fall within the acceptable limits of the study.This dual nanoparticulate drug delivery system appears to be promising to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer. | C Moorthi Kiran Krishnan R Manavalan K Kathiresan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 3 |
| 5 | Hyperuricemia and Incidence of Hypertension Among Men Without Metabolic Syndrome显示文摘 | Eswar Krishnan C Kent Kwoh H Ralph Schumacher Lewis Kuller | 2007 | Hypertension2007，，2： | 2 |
| 6 | A new type of secondary radiation显示文摘 | Raman C V Krishnan K S | 1928 | Nature1928，121，3048： | 1 |
| 7 | Effect of coherent to incoherent structural transition on magnetic anisotropy in Co/Pt muhilayers 显示文摘 | Chowdhury P Kulkkarni P D Krishnan M Barshilia H C Sagdeo A Rai S K Lodha G S Rao D V S | 2012 | Journal of Applied Physics2012，112，02： | 1 |
| 8 | Alkylation of phenol with tertiary butyl alcohol over zeolite显示文摘 | Krishnan A V OjhaK Pradhan N C | 2002 | Org Proc Res Dev2002，6，： | 1 |
| 9 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 10 | Dose effects of oxaliplatin on persistent and transient Na+ conductances and the development of neurotoxicity显示文摘 | Park S B Lin C S Krishnan A V | 2011 | PlosOne2011，6，18： | 1 |
| 11 | GSK- 3β phosphorylation and alteration of β-catenin in hepatoeellular carcinoma显示文摘 | BAN K C SINGH H KRISHNAN R | 2003 | Cancer Lett2003，199，： | 1 |
| 12 | XRD analysis and leachability of solidified phenol-cement mixtures显示文摘 | VIPULANNADAN C KRISHNAN S | 1993 | Cement and Concrete Research1993，23，4： | 1 |
| 13 | Axonal growth of embryon- ic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats显示文摘 | Harper JM Krishnan C Darman JS | 2004 | Proc Natl Acad Sci USA2004，101，18： | 1 |
| 14 | Cognitive Radio:Spectrum Sensing Problems in Signal Processing显示文摘 | Christopher C J Krishnan K V Bagubali A | 2012 | International Journal of Computer Appli-cations2012，40，16： | 1 |
| 15 | Time and streak surfaces for flow visualization in large time-varying data sets 显示文摘 | Krishnan H Garth C Joy K I | 2009 | IEEE Transactions on Visualization and Computer Graphics (S1077-2626)2009，15，6： | 1 |
| 16 | Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats显示文摘 | Harper JM Krishnan C Darman JS | 2004 | Proc Natl Acad Sci USA2004，101，18： | 1 |
| 17 | Neuroglial activation and neuroinflammation in the brain of patients with autism 显示文摘 | Vargas DL Nascimbene C Krishnan C | 2005 | Annals of Neurology2005，57，： | 1 |
| 18 | HIF1alpha and HIF2alpha independently activate SRC to promote melanoma metastases显示文摘 | HANNA S C KRISHNAN B BAILEY S T | | 0，，05： | 1 |
| 19 | Clinical presentation and ura- chal remnant pathology: implications for treatment 显示文摘 | Copp HL Wong Y Krishnan C | 2009 | J Urol2009，182，4： | 1 |
| 20 | Hybrid segmen- tation, characterization and classification of basal cell nuclei from histopathological images of normal oral mucosa and oral submucous fibrosis显示文摘 | Krishnan MMR Chakraborty C Paul RR | 2012 | Expert Systems with Application2012，39，1： | 1 |
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