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| 1 | Neoadjuvant chemoradiotherapy followed by D2 gastrectomy in locally advanced gastric cancer显示文摘AIM:To investigate the efficacy of neoadjuvant chemoradiotherapy(NACRT) for resectability of locally advanced gastric cancer(LAGC).METHODS:Between November 2007 and January 2014,29 patients with LAGC(clinically T3 with distal esophagus invasion/T4 or bulky regional node metastasis) that were treated with NACRT followed by D2 gastrectomy were included in this study.Resectability was evaluated with radiologic and endoscopic exams before and after NACRT.Using threedimensional conformal radiotherapy,patients received 45 Gy,with a daily dose of 1.8 Gy.The entire tumor extent and the regional metastatic lymph nodes were included in the gross tumor volume.Patients presenting with a resectable tumor after NACRT received a total or subtotal gastrectomy with D2 dissection.The pathologic tumor response was evaluated using Japanese Gastric Cancer Association histologic evaluation criteria.Postoperative morbidity was evaluated using the National Cancer Institute-Common Terminology Criteria for Adverse Events version 4.0.Overall survival(OS) and progression-free survival(PFS) rates were estimated using a Kaplan-Meier analysis and compared using the log-rank test.RESULTS:All patients were assessed as unresectable cases.Twenty-four patients(24/29; 82.8%) showed LAGC on positron emission tomography-computed tomography(CT) and contrast-enhanced CT,whereas four patients(4/29; 13.8%) with vague invasion orabutment to an adjacent organ underwent diagnostic laparoscopy.One patient(1/29; 3.4%),initially assessed as a resectable case,underwent an 'open and closure' after the tumor was found to be unresectable.Abutment to an adjacent organ(34.5%) was the most common reason for NACRT.The clinical response rate one month after NACRT was 44.8%.After NACRT,69%(20/29) of patients had a resectable tumor.Of the 20 patients with a resectable tumor,18 patients(62.1%) underwent a D2 gastrectomy.The R0 resection rate was 94.4% and two patients(2/18; 11.1%) showed a complete response.The median follow-up duration was 13.5 mo.The one-year OS and PFS rates were 72.4 and 48.9%,respectively.The one-year OS,PFS,local failure-free survival,and distant metastasis-free survival were higher in patients with a resectable tumor after NACRT(P < 0.001,P < 0.001,P < 0.001,and P =0.078,respectively).No grade 3-4 late treatment-related toxicities or postoperative mortalities were observed.CONCLUSION:NACRT with D2 gastrectomy showed a high rate of R0 resection and promising local control,which may increase the R0 resection opportunity resulting in survival benefit. | Mi Sun Kim Joon Seok Lim Woo Jin Hyung Yong Chan Lee Sun Young Rha Ki Chang Keum Woong Sub Koom | 2015 | World Journal of Gastroenterology2015，21，9： | 15 |
| 2 | Postoperative adjuvant chemoradiotherapy in D2-dissected gastric cancer: Is radiotherapy necessary after D2-dissection?显示文摘Studies from the Far East have demonstrated that D2-dissection is superior to D0/1-dissection. The effect of postoperative chemoradiotherapy(CRT) after D2-dissection has not been accepted due to the lack of D2-dissection in Western countries, as well as the potential harmful effect of radiotherapy. In the current NCCN guideline, adjuvant chemotherapy alone is recommended in D2-dissected patients. However, three recent prospective randomized controlled trials in South Korea and China(ARTIST, NCC and Multicenter IMRT Trials) demonstrated that adjuvant CRT can be safely administered to D2-dissected patients with notable benefits. To identify the role of radiotherapy(RT) in the D2-dissected postoperative setting, clinical research attempts should include(1) identification of high-risk patients for loco-regional recurrence who might benefit from CRT;(2) modification of RT target volume based on the findings that failure patterns should be different after D1- and D2-dissection; and(3) integration of new RT techniques to decrease treatment-related toxicity. The present paper is a review of recent studies addressing these fields. Well-designed prospective randomized studies are needed to clearly define the role of adjuvant CRT in D2-dissected gastric cancer, however, future clinical studies should also focus on answering these questions. | Jee Suk Chang Woong Sub Koom Youngin Lee Hong In Yoon Hyung Sik Lee | 2014 | World Journal of Gastroenterology2014，20，36： | 5 |
| 3 | Patterns of regional recurrence after curative D2 resection for stage III (N3) gastric cancer: Implications for postoperative radiotherapy显示文摘 | Jee Suk Chang Joon Seok Lim Sung Hoon Noh Woo Jin Hyung Ji Yeong An Yong Chan Lee Sun Young Rha Chang Geol Lee Woong Sub Koom | 2012 | Radiotherapy and Oncology2012，，3： | 4 |
| 4 | Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer显示文摘Objective:The aim of this study is to develop a nomogram for prediction of pathologic complete remission(p CR)after preoperative chemoradiotherapy(CRT)for rectal cancer.Methods:m RNA expression levels of seven molecular markers[p53,p21,Ki-67,vascular endothelial growth factor(VEGF),CD133,CD24,CD44]were measured by reverse transcriptase polymerase chain reaction(RTPCR)in 120 rectal cancers.Endoscopic findings of clinical complete remission(c CR)and biologic variables were used to construct nomogram in the training group(n=80),which was validated in the validation group(n=40).Results:m RNA expression levels of four markers(p53,p21,Ki67,CD133)correlated with p CR(24/80,30.0%)in the training group.Low expression of p53 and/or high expression of p21,Ki67 and CD133 showed greater p CR rate.p CR was shown in 18(69.2%)of 26 cases showing endoscopic c CR in the training group.Higher p CR rate was demonstrated in lower tumor location than middle tumor(19/49,38.8%vs.5/31,16.1%).A nomogram for prediction of p CR was developed from the multivariate prediction model using these six variables,which showed good discrimination ability in the training group[area under the curve(AUC)=0.945]and validation group(AUC=0.922).The calibration plot showed good agreement between actual and predicted p CR in both patient groups.Conclusions:Nomogram for assessment of p CR can be useful for making treatment decisions after CRT according to predicted responses. | Hyuk Hur Min Soo Cho Woong Sub Koom Joon Seok Lim Tae Il Kim Joong Bae Ahn Hoguen Kim Nam Kyu Kim | 2020 | Chinese Journal of Cancer Research2020，32，2： | 2 |
| 5 | Angiostatin expression in non-small cell lung cancer 显示文摘 | Volm M Mattem J Koom gi R | 2000 | Clinical Cancer Research2000，6，8： | 1 |
| 6 | Pathologic Complete Response of Primary Tumor Following Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Long-term Outcomes and Prognostic Significance of Pathologic Nodal Status (KROG 09-01)显示文摘 | Seung-Gu Yeo Dae Yong Kim Tae Hyun Kim Hee Jin Chang Jae Hwan Oh Won Park Doo Ho Choi Heerim Nam Jun-Sang Kim Moon-June Cho Jong Hoon Kim Jin-hong Park Min Kyu Kang Woong Sub Koom Jae-Sung Kim Taek-Keun Nam Eui Kyu Chie Jung Soo Kim Kyung-Ja Lee | 2010 | Annals of Surgery2010，，6： | 1 |
| 7 | Clinical relevance of three subtypes of primary sinonasal lymphoma characterized by immunophenotypic analysis显示文摘 | Kim G E Koom W S Yang W I | 2004 | Head Neck2004，26，7： | 1 |
| 8 | Chinese green tea lowers choleste rollevel through an increase in fecal lipid excretion显示文摘 | KooM w | 2000 | Life Sei2000，66，5： | 1 |
| 9 | Angiocentric T-cell and NK/T-eell lymphomas: radiotherapeutie viewpoints 显示文摘 | Koom WS Chung E J Yang WI | 2004 | Int J Radiat Oneol Biol Phys2004，59，： | 1 |
| 10 | Defining the target volume for post-operative radiotherapy after D2 dissection in gastric cancer by CT-based vessel-guided delineation<!-- CT-based vessel-guided target volume delineation -->显示文摘 | Hong In Yoon Jee Suk Chang Joon Seok Lim Sung Hoon Noh Woo Jin Hyung Ji Yeong An Yong Chan Lee Sun Young Rha Kyung Hwan Kim Woong Sub Koom | 2013 | Radiotherapy and Oncology2013，，： | 1 |
| 11 | Correlations of 3T DCE-MRI quantitative parameters with microvessel density in a human-colorectal-cancer xenograft mouse model显示文摘 | Ahn SJ An CS Koom WS | 2011 | Korean J Radiol2011，12，6： | 1 |
| 12 | SMART (simultaneous modula- ted accelerated radiotherapy) for locally advanced nasopharyngeal ear- einomas显示文摘 | Koom WS Kim TH Shin KH | 2008 | Head Neck2008，30，2： | 1 |
| 13 | Angelica sinensis modulates migarationand proliferation of gastric epithelial cells 显示文摘 | Ye Y N Koom W Li Y | 2001 | Life Sci2001，68，8： | 1 |
| 14 | The significance of ICG - R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma显示文摘 | HONG IN YOON WOONG SUB KOOM LK JAE LEE | 2012 | Liver Inter- national2012，32，7： | 1 |
| 15 | Clinical relevance of three subtypes of primary sinonasal lymphoma characterized by immunophenotypic analysis显示文摘 | Gwi Eon Kim Woong Sub Koom Woo-lck Yang | | 0，，： | 1 |
| 16 | Clinical relevance of three subtypes of primary sinonasal lymphoma characterized by immunophenotypicanalysis显示文摘 | KIM G E KOOM W S YANG W I | 2004 | Head Neck2004，26，： | 1 |
| 17 | Association of vascular endothelial growth factor expression with intratumoural microvessel density and tumor cell proliferation in human epidermoid lung carcinoma显示文摘 | Mattern J Koomgi R Volm M | 1996 | Br J Cancer1996，73，7： | 1 |
| 18 | Influence of injected mass and ionic strength on retention of water soluble polymers and proteins in hollow-fiber flow field-flow fractionation显示文摘 | Wijnhoven J E G J Koom J P Poppe H | 1996 | J Chromatography1996，732，： | 1 |
| 19 | Computed tomography based high dose rate intracavitary brachytherapy for uterine cervieal cancer:Preliminary demonstration of correlation between dose volume Parmneters and rectal mucosal changes observed byflexible sigmoidoscopy 显示文摘 | Woong Sub Koom Dae Kyung Sohn | 2007 | Int J Radiaon Oncol Biol Phys2007，68，5： | 1 |
| 20 | Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer显示文摘 | Volm M Koom(a)gi R Mattern J | 1997 | Int J Cancer1997，74，1： | 1 |
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