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| 1 | Jaundice associated pruritis:A review of pathophysiology and treatment显示文摘To review the underlying pathophysiology and currently available treatments for pruritis associated with jaundice.English language literature was reviewed using MEDLINE,Pub Med,EMBASE and clinicaltrials.gov for papers and trails addressing the pathophysiology and potential treatments for pruritis associated with jaundice.Recent advances in the understanding of the peripheral anatomy of itch transmission have defined a histamine stimulated pathway and a cowhage stimulated pathway with sensation conveyed centrally via the contralateral spinothalamic tract.Centrally,cowhage andhistamine stimulated neurons terminate widely within the thalamus and sensorimotor cortex.The causative factors for itch in jaundice have not been clarified although endogenous opioids,serotonin,steroid and lysophosphatidic acid all play a role.Current guidelines for the treatment of itching in jaundice recommend initial management with biliary drainage where possible and medical management with ursodeoxycholic acid,followed by cholestyramine,rifampicin,naltrexone and sertraline.Other than biliary drainage no single treatment has proved universally effective.Pruritis associated with jaundice is a common but poorly understood condition for which biliary drainage is the most effective therapy.Pharmacological therapy has advanced but remains variably effective. | Ramez Bassari Jonathan B Koea | 2015 | World Journal of Gastroenterology2015，21，5： | 5 |
| 2 | Radiation risks associated with serial imaging in colorectal cancer patients:Should we worry?显示文摘To provide an overview of the radiation related cancer risk associated with multiple computed tomographic scans required for follow up in colorectal cancer patients.A literature search of the PubMed and Cochrane Library databases was carried out and limited to the last 10 years from December 2012.Inclusion criteria were studies where computed tomographic scans or radiation from other medical imaging modalities were used and the risks associated with ionizing radiation reported.Thirty-six studies were included for appraisal with no randomized controlled trials.Thirty-four of the thirty-six studies showed a positive association between medical imaging radiation and increased risk of cancer.The radiation dose absorbed and cancer risk was greater in children and young adults than in older patients.Most studies included in the review used a linear,nothreshold model to calculate cancer risks and this may not be applicable at low radiation doses.Many studies are retrospective and ensuring complete follow up on thousands of patients is difficult.There was a minor increased risk of cancer from ionizing radiation in medical imaging studies.The radiation risks of low dose exposure(<50 milli-Sieverts)are uncertain.A clinically justified scan in the context of colorectal cancer is likely to provide more benefits than harm but current guidelines for patient follow up will need to be revised to accommodate a more aggressive approach to treating metastatic disease. | Jeong Suk Oh Jonathan B Koea | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 3 | Serum platelet-activating factor acetylhydrolase activity:Relationship with metabolic syndrome in women with history of gestational diabetes mellitus显示文摘 | Derbent A Kargili A Koea C | | 0，，： | 1 |
| 4 | Anabolic and cardiovascu-lar effects of recombinant human growth hormone in surgic aql pa-tients with sepsis 显示文摘 | Koea JB Breier BH Douglas RG | 1996 | Br J Surg1996，83，： | 1 |
| 5 | Possible role for IGF - Ⅰ: Evidence in sheep for in vivo regulation of IGF - Ⅰ mediated protein anabolism 显示文摘 | KOEA J B BREIER B H SHAW J H F | 1992 | Endocrinology1992，130，： | 1 |
| 6 | Gastric cancer in young patients:demographic,clinicopathological,and prognostic factors in 92 patients显示文摘 | Koea JB Karpeh MS Brennan MF | | 0，，05： | 1 |
| 7 | Inflammatory pseudotumor of the liver:demographics,diagnosis, and the case for nonoperative management显示文摘 | Broadhurst GW Rodgers MS | 2003 | J Am coll surg2003，196，2： | 1 |
| 8 | Parathyroid cancer:biology and management显示文摘 | Koea JB Shaw JH | 1999 | Surg Oncol1999，8，： | 1 |
| 9 | Solitary necrotic nodule of the liver: a riddle that is difficult to answer 显示文摘 | Koea J Taylor G Miller M | 2003 | J Gastrointest Surg2003，7，5： | 1 |
| 10 | Differential Diagnosis of Stenosing Lesions at the Hepatic Hilus显示文摘 | Jonathan Koea M.D. Andrew Holden Kai Chau John McCall M.D | 2004 | World Journal of Surgery2004，，5： | 1 |
| 11 | Late tourniquet re- lease and drain clamping reduces postoperative blood loss in total knee arthroplasty显示文摘 | Yildiz C Koea K Kocak N etal | 2014 | HSS J2014，10，1： | 1 |
| 12 | Parathyroid cancer biology and management显示文摘 | Koea JB Shaw JH | 1999 | Surg Oncol1999，8，3： | 1 |
| 13 | Solitary necrotic nodule of the liver:a reddle that is diffcult to answer显示文摘 | Koea J Taylor G Miller M | 2003 | J Gastrointest Surg2003，7，5： | 1 |
| 14 | Papillary Phenotype Confers Improved Survival After Resection of Hilar Cholangiocarcinoma显示文摘 | William R. Jarnagin Wilbur Bowne David S. Klimstra Leah Ben-Porat Kevin Roggin Karina Cymes Yuman Fong Ronald P. DeMatteo Michael D?Angelica Jonathan Koea Leslie H. Blumgart | 2005 | Annals of Surgery2005，，5： | 1 |
| 15 | Metabolic basis for the management of the septic surgical patient显示文摘 | Koea JB | 1993 | World J Surg1993，17，2： | 1 |
| 16 | Parathyroid cancer: biology and management显示文摘 | KOEA JB SHAW JH | 1999 | Surg Oncol1999，8，： | 1 |
| 17 | Deep vein thrombosis and systemic inflammatory response: a pilot trial显示文摘 | Reiter M Bucek RA Koea N | 2003 | Wien Klin Woehenschr2003，115，34： | 1 |
| 18 | Differential diagnosis of stenosing lesions at the hepatic hilus 显示文摘 | KOEA J HOLDEN A CHAU K | 2004 | World J Surg2004，28，5： | 1 |
| 19 | Is routine placement of surgical drains necessary after elective hepatectomy? results from a single institution显示文摘 | Aldameh A McCall JL Koea JB | 2005 | J Gastrointest Surg2005，9，5： | 1 |
| 20 | Kast track liver tesection; theeffect of a comprehensive care package and analgesia with single dosein trathecal morphine with gabapentin or continuous epidural analgesia显示文摘 | Koea JB Young Y Gunn K | 2009 | HPB Surg2009，161，12： | 1 |
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